General Information of the Compound
Compound ID
CP0575351
Compound Name
(1R,9S,12R)-13-[8-[3-(4,4-difluoropiperidin-1-yl)propylamino]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl]-12-propan-2-yl-11,13-diazatricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
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Structure
Formula
C29H36F2N8O2
Molecular Weight
566.657
Canonical SMILES
CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NCCCN2CCC(F)(F)CC2)c2nnc(C)n2n1
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InChI
InChI=1S/C29H36F2N8O2/c1-17(2)24-25-20-8-5-4-7-19(20)15-23(27(40)33-24)38(25)28(41)22-16-21(26-35-34-18(3)39(26)36-22)32-11-6-12-37-13-9-29(30,31)10-14-37/h4-5,7-8,16-17,23-25,32H,6,9-15H2,1-3H3,(H,33,40)/t23-,24+,25+/m0/s1
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InChIKey
MMNMOVIEDRHEDO-ISJGIBHGSA-N
Physicochemical Property
logP
3.22842
Rotatable Bonds
7
Heavy Atom Count
41
Polar Areas
107.76
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166631191
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03639, ATPase family AAA domain-containing protein 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS
Protein ID: PT01462, Bromodomain-containing protein 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 31622.78 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 > 31622.78 nM