Brief Information of the Cell Line and Protein
Cell Line ID: CL000065 , HEK293-EBNA
Synonyms
293 c18
293c18
HEK 293 c18
HEK-293 c18
HEK293-EBNA1
HEK-293-EBNA
HEK 293-EBNA
HEK 293 EBNA
HEK293EBNA
293 EBNA
293-EBNA1
293-EBNA
293/EBNA
293EBNA
EBNA-293
EBNA293
293E
HEK293E
HEK/EBNA
HEK-EBNA
HEK.EBNA
293/EBNA-1
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_6974
Protein ID: PT01199 , Neuromedin-K receptor
Gene Name TACR3
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P29371
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000065  Protein ID: PT01199
 
Compound ID Compound Name Compound Formula
CP0421692
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H28ClF6N3O2
 1
1
Ki = 0.74 nM
   TI
   LI
   LO
   TS
CP0372175
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H28ClF6N3O3
 1
1
Ki = 0.91 nM
   TI
   LI
   LO
   TS
CP0493083
N-[6-[bis(2-hydroxyethyl)amino]-4-(2-chlorophenyl)pyridin-3-yl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide
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C28H28ClF6N3O3
 1
1
Ki = 0.91 nM
   TI
   LI
   LO
   TS
CP0505757
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((2-hydroxyethyl)(3-hydroxypropyl)amino)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H30ClF6N3O3
 1
1
Ki = 0.95 nM
   TI
   LI
   LO
   TS
CP0452244
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H28ClF6N3O3
 1
1
Ki = 1.12 nM
   TI
   LI
   LO
   TS
CP0406062
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((2S,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H28ClF6N3O3
 1
1
Ki = 1.48 nM
   TI
   LI
   LO
   TS
CP0520519
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((2-hydroxyethyl)(methyl)amino)pyridin-3-yl)-N,2-dimethylpropanamide
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C27H26ClF6N3O2
 1
1
Ki = 2.91 nM
   TI
   LI
   LO
   TS
CP0405951
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((2-hydroxyethyl)(propyl)amino)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H30ClF6N3O2
 1
1
Ki = 5.4 nM
   TI
   LI
   LO
   TS
CP0452243
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((R)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C28H26ClF6N3O2
 1
1
Ki = 6.87 nM
   TI
   LI
   LO
   TS
CP0520518
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((R)-2-(hydroxymethyl)pyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H28ClF6N3O2
 1
1
Ki = 7.27 nM
   TI
   LI
   LO
   TS
CP0504349
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((S)-2-(hydroxymethyl)piperidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C30H30ClF6N3O2
 1
1
Ki = 7.72 nM
   TI
   LI
   LO
   TS
CP0504348
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C28H26ClF6N3O2
 1
1
Ki = 8.38 nM
   TI
   LI
   LO
   TS
CP0452242
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-(2-hydroxyethylamino)pyridin-3-yl)-N,2-dimethylpropanamide
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C26H24ClF6N3O2
 1
1
Ki = 11.36 nM
   TI
   LI
   LO
   TS
CP0507252
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-(ethyl(2-hydroxyethyl)amino)pyridin-3-yl)-N,2-dimethylpropanamide
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C28H28ClF6N3O2
 1
1
Ki = 12.22 nM
   TI
   LI
   LO
   TS
CP0372173
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-(3-hydroxypiperidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C29H28ClF6N3O2
 1
1
Ki = 15.1 nM
   TI
   LI
   LO
   TS
CP0497498
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((R)-2-(hydroxymethyl)piperidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C30H30ClF6N3O2
 1
1
Ki = 29.73 nM
   TI
   LI
   LO
   TS
CP0372174
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-((2S,4R)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl)pyridin-3-yl)-N,2-dimethylpropanamide
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C31H32ClF6N3O3
 1
1
Ki = 29.79 nM
   TI
   LI
   LO
   TS
CP0421691
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-chlorophenyl)-6-(2-methoxyethylamino)pyridin-3-yl)-N,2-dimethylpropanamide
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C27H26ClF6N3O2
 1
1
Ki = 93.25 nM
   TI
   LI
   LO
   TS
CP0487728
2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-((3R,4S)-1-(4-(methylsulfonyl)piperazine-1-carbonyl)-4-phenylpyrrolidin-3-yl)propanamide
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C29H34F6N4O4S
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0388686
2-(3,5-bis(trifluoromethyl)phenyl)-N-((3R,4S)-4-(4-fluorophenyl)-1-(4-(methylsulfonyl)piperazine-1-carbonyl)pyrrolidin-3-yl)-N,2-dimethylpropanamide
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C29H33F7N4O4S
 1
1
Ki = 165 nM
   TI
   LI
   LO
   TS
CP0469253
(3R,4S)-3-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(4-fluorophenyl)-N,N-bis(2-hydroxyethyl)pyrrolidine-1-carboxamide
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C28H32F7N3O4
 1
1
Ki = 192 nM
   TI
   LI
   LO
   TS
CP0388685
(3R,4S)-3-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(4-fluorophenyl)-N-(2-hydroxyethyl)pyrrolidine-1-carboxamide
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C26H28F7N3O3
 1
1
Ki = 298 nM
   TI
   LI
   LO
   TS
CP0487727
N-[(3R,4S)-1-(4-acetylpiperazine-1-carbonyl)-4-(4-fluorophenyl)pyrrolidin-3-yl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide
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C30H33F7N4O3
 1
1
Ki = 370 nM
   TI
   LI
   LO
   TS
CP0528786
((3R,4S)-3-((3,5-bis(trifluoromethyl)benzyl)(methyl)amino)-4-phenylpyrrolidin-1-yl)(4-(methylsulfonyl)piperazin-1-yl)methanone
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C26H30F6N4O3S
 1
1
Ki = 1300 nM
   TI
   LI
   LO
   TS