| Compound ID |
Compound Name |
Compound Formula |
|
CP0426527
|
2-[2-(4-bromo-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19BrN4O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0868669
|
US9133168, Example 9e
Show/Hide
|
C19H19F3N4OS2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0906775
|
US9133168, Example 34a
Show/Hide
|
C19H19ClF2N4O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0134138
|
2-[2-(4-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19ClN4O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0431538
|
2-[2-(4-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0573851
|
US8993565, 147
Show/Hide
|
C18H18F2N4O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0553919
|
US9133168, Example 2e
Show/Hide
|
C19H22N4OS2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0362492
|
BDBM50447090
Show/Hide
|
C18H19FN4O3
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0450213
|
2-[2-(2-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0155508
|
2-[2-(5-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19FN4O3
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0490109
|
US9133168, Example 3e
Show/Hide
|
C19H22N4O2S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0308576
|
4-morpholin-4-yl-2-[2-oxo-2-[4-(trifluoromethyl)-2,3-dihydroindol-1-yl]ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C19H19F3N4O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0561421
|
US8993565, 74
Show/Hide
|
C16H16FIN4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0958075
|
US8993565, 115
Show/Hide
|
C21H27N5O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0574807
|
US8993565, 94
Show/Hide
|
C18H18F2N4O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0945629
|
US8993565, 120
Show/Hide
|
C20H24N4O4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0957280
|
US9133168, Example 8e
Show/Hide
|
C19H19F3N4O2S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0704953
|
2-{2-[(2R)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)-pyrimidin-4(3H)-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0906777
|
US9133168, Example 11b
Show/Hide
|
C21H23FN4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0922767
|
US9133168, Example 28b
Show/Hide
|
C19H21ClN4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0308574
|
2-[2-(3-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0575553
|
US8993565, 90
Show/Hide
|
C18H17FN4O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0477834
|
US9133168, Example 5c
Show/Hide
|
C20H23ClN4O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0424140
|
US8993565, 105
Show/Hide
|
C18H18N4O3S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0566212
|
US9133168, Example 5a
Show/Hide
|
C19H21FN4O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0887072
|
US8993565, 125
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0506968
|
US8993565, 84
Show/Hide
|
C18H18N4O4
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0698887
|
2-{2-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0176436
|
2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-3-methyl-6-morpholin-4-ylpyrimidin-4-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0134136
|
BDBM50447097
Show/Hide
|
C20H24N4O3
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
|
CP0557559
|
US8993565, 142
Show/Hide
|
C16H17BrN4O4
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0419361
|
US9133168, Example 1e
Show/Hide
|
C19H22N4O2S
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0571023
|
US9133168, Example 1a
Show/Hide
|
C18H18F2N4O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0160090
|
N-(3-bromophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H17BrN4O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0321394
|
N-(3,4-difluorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H16F2N4O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0514982
|
US8993565, 112
Show/Hide
|
C22H29N5O4
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0577780
|
US8993565, 7
Show/Hide
|
C14H16N4O3S
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0553918
|
US9133168, Example 19d
Show/Hide
|
C24H23FN4O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0511950
|
US8993565, 107
Show/Hide
|
C23H31N5O4
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0134137
|
4-morpholin-4-yl-2-[2-oxo-2-(4-phenyl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C24H24N4O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0503835
|
US9133168, Example 42d
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0566155
|
US9133168, Example 29b
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0520696
|
US8993565, 86
Show/Hide
|
C20H23FN4O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0553801
|
US8993565, 114
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0881074
|
US8993565, 136
Show/Hide
|
C21H27N5O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0490108
|
US9133168, Example 11d
Show/Hide
|
C23H29N5O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0567063
|
US9133168, Example 1d
Show/Hide
|
C20H22N4O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0954699
|
US8993565, 106
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0554177
|
US8993565, 151
Show/Hide
|
C16H17N5O6
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0913554
|
US9133168, Example 41c
Show/Hide
|
C19H21FN4O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0906766
|
US9133168, Example 16d
Show/Hide
|
C21H24N4O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0512114
|
US9133168, Example 6e
Show/Hide
|
C19H21FN4O2S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0553895
|
US9133168, Example 6d
Show/Hide
|
C25H26N4O4
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0472815
|
US9133168, Example 7e
Show/Hide
|
C19H21ClN4O2S
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0443678
|
US8993565, 138
Show/Hide
|
C19H23FN4O5
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0550574
|
US8993565, 95
Show/Hide
|
C18H19FN4O3
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0559134
|
US9133168, Example 4c
Show/Hide
|
C21H25ClN4O3
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0007893
|
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
Show/Hide
|
C23H27N7O3S2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0500219
|
US9133168, Example 15d
Show/Hide
|
C21H23ClN4O3
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0957362
|
US8993565, 145
Show/Hide
|
C23H31N5O3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0120245
|
N-(3-methylphenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C17H20N4O3
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0563841
|
US8993565, 131
Show/Hide
|
C19H21ClN4O3
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0477835
|
US9133168, Example 4e
Show/Hide
|
C20H24N4O2S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0538966
|
US8993565, 19
Show/Hide
|
C20H26N4O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0556021
|
US8993565, 104
Show/Hide
|
C19H21ClN4O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0571480
|
US9133168, Example 14d
Show/Hide
|
C24H23ClN4O3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0547703
|
US8993565, 102
Show/Hide
|
C19H21FN4O3
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0547705
|
US8993565, 149
Show/Hide
|
C18H19ClN4O4
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0550576
|
US8993565, 109
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0536302
|
US8993565, 121
Show/Hide
|
C20H24N4O4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0470174
|
US9133168, Example 30b
Show/Hide
|
C20H23FN4O3
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0567064
|
US9133168, Example 9d
Show/Hide
|
C19H20F2N4O4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0402563
|
US9133168, Example 7c
Show/Hide
|
C21H25FN4O3
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0539897
|
US8993565, 153
Show/Hide
|
C17H17F3N4O4
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0479406
|
US8993565, 59
Show/Hide
|
C17H18F2N4O4
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 417 nM
|
|
|
|
CP0479407
|
US8993565, 5
Show/Hide
|
C16H16F2N4O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0572404
|
US8993565, 116
Show/Hide
|
C19H21BrN4O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0479338
|
US9133168, Example 39d
Show/Hide
|
C24H24N4O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0557392
|
US9133168, Example 8c
Show/Hide
|
C20H23FN4O3
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0338973
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-3-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0308575
|
4-morpholin-4-yl-2-[2-oxo-2-[4-(trifluoromethoxy)-2,3-dihydroindol-1-yl]ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0567654
|
US9133168, Example 36a
Show/Hide
|
C19H21ClN4O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0561489
|
US8993565, 108
Show/Hide
|
C19H24N4O5
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0567655
|
US9133168, Example 37a
Show/Hide
|
C19H21BrN4O3
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0577784
|
US8993565, 92
Show/Hide
|
C18H18F2N4O3
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0887073
|
US8993565, 126
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0963835
|
US9133168, Example 12c
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0506966
|
US8993565, 31
Show/Hide
|
C17H19FN4O3
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0147577
|
2-[2-(4-methoxy-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0557573
|
US8993565, 41
Show/Hide
|
C17H19FN4O3
|
2
|
| 1 |
IC50 = 60 nM
|
|
|
| 2 |
IC50 = 290 nM
|
|
|
|
CP0504067
|
US9133168, Example 8d
Show/Hide
|
C20H22F2N4O4
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0441991
|
US8993565, 127
Show/Hide
|
C19H20F2N4O3
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0413339
|
US9133168, Example 11e
Show/Hide
|
C19H21FN4O2S
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0555613
|
US8993565, 93
Show/Hide
|
C17H18FIN4O3
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0402566
|
US9133168, Example 4d
Show/Hide
|
C20H21F3N4O3
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0550572
|
US8993565, 53
Show/Hide
|
C16H15F3N4O3
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0347349
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-2-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0464481
|
US8993565, 54
Show/Hide
|
C17H16F4N4O4
|
2
|
| 1 |
IC50 = 67 nM
|
|
|
| 2 |
IC50 = 807 nM
|
|
|
|
CP0956769
|
US8993565, 137
Show/Hide
|
C21H27N5O3
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0539894
|
US8993565, 128
Show/Hide
|
C19H20F2N4O3
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0563249
|
US8993565, 75
Show/Hide
|
C18H18F4N4O4
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0514983
|
US8993565, 130
Show/Hide
|
C19H20N4O3S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0450756
|
US8993565, 58
Show/Hide
|
C18H22N4O4
|
2
|
| 1 |
IC50 = 71 nM
|
|
|
| 2 |
IC50 = 760 nM
|
|
|
|
CP0556460
|
US8993565, 27
Show/Hide
|
C15H16FN5O3
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0557557
|
US8993565, 91
Show/Hide
|
C18H20N4O4
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0577781
|
US8993565, 13
Show/Hide
|
C16H16F2N4O3
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0484941
|
US9133168, Example 5e
Show/Hide
|
C20H24N4O2S
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0160092
|
N-(3-fluorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H17FN4O3
|
2
|
| 1 |
IC50 = 74 nM
|
|
|
| 2 |
IC50 = 570 nM
|
|
|
|
CP0539892
|
US8993565, 87
Show/Hide
|
C16H17FN4O4
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0464469
|
US8993565, 123
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0537488
|
US8993565, 61
Show/Hide
|
C16H15Cl2FN4O3
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0557574
|
US8993565, 76
Show/Hide
|
C17H17F3N4O3
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0271062
|
N-(3-chloro-4-fluorophenyl)-2-(1-methyl-4-morpholin-4-yl-6-oxopyrimidin-2-yl)acetamide
Show/Hide
|
C17H18ClFN4O3
|
2
|
| 1 |
IC50 = 79 nM
|
|
|
| 2 |
IC50 = 202 nM
|
|
|
|
CP0881073
|
US8993565, 72
Show/Hide
|
C19H23FN4O3
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0120251
|
N-(3-bromo-4-fluorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H16BrFN4O3
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0160091
|
N-(3-bromo-4-fluorophenyl)-2-(1-methyl-4-morpholin-4-yl-6-oxopyrimidin-2-yl)acetamide
Show/Hide
|
C17H18BrFN4O3
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0147576
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-4-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0160089
|
N-(3-chlorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H17ClN4O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0490107
|
US9133168, Example 46c
Show/Hide
|
C19H19N5O3
|
1
|
| 1 |
IC50 = 101 nM
|
|
|
|
CP0562472
|
US8993565, 1
Show/Hide
|
C12H17N3O4
|
1
|
| 1 |
IC50 = 102 nM
|
|
|
|
CP0910856
|
US9133168, Example 7d
Show/Hide
|
C26H35N5O3
|
1
|
| 1 |
IC50 = 102 nM
|
|
|
|
CP0504068
|
US9133168, Example 22d
Show/Hide
|
C23H28N4O4
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0566213
|
US9133168, Example 8a
Show/Hide
|
C20H23FN4O3
|
1
|
| 1 |
IC50 = 107 nM
|
|
|
|
CP0569253
|
US9133168, Example 33d
Show/Hide
|
C22H27N5O4
|
1
|
| 1 |
IC50 = 111 nM
|
|
|
|
CP0186647
|
N-(4-fluoro-3-methoxyphenyl)-2-(1-methyl-4-morpholin-4-yl-6-oxopyrimidin-2-yl)acetamide
Show/Hide
|
C18H21FN4O4
|
1
|
| 1 |
IC50 = 115 nM
|
|
|
|
CP0186645
|
N-(3-chloro-4-fluorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H16ClFN4O3
|
1
|
| 1 |
IC50 = 116 nM
|
|
|
|
CP0506967
|
US8993565, 71
Show/Hide
|
C23H27N5O5
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 5375 nM
|
|
|
|
CP0567698
|
US9133168, Example 9a
Show/Hide
|
C20H23FN4O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0308577
|
2-[2-(5-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19ClN4O3
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0524439
|
US8993565, 124
Show/Hide
|
C19H21FN4O3
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0504065
|
US9133168, Example 5b
Show/Hide
|
C18H19ClF2N4O3
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0186646
|
N-(3,4-difluorophenyl)-2-(1-methyl-4-morpholin-4-yl-6-oxopyrimidin-2-yl)acetamide
Show/Hide
|
C17H18F2N4O3
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0479408
|
US8993565, 66
Show/Hide
|
C16H16BrFN4O3
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0463387
|
US9133168, Example 41d
Show/Hide
|
C18H21N5O3
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0180687
|
2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H20N4O3
|
1
|
| 1 |
IC50 = 133 nM
|
|
|
|
CP0561425
|
US8993565, 82
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
IC50 = 133 nM
|
|
|
|
CP0450755
|
US8993565, 56
Show/Hide
|
C16H17IN4O3
|
1
|
| 1 |
IC50 = 137 nM
|
|
|
|
CP0413332
|
US9133168, Example 35a
Show/Hide
|
C19H21ClN4O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0556082
|
US8993565, 4
Show/Hide
|
C18H23N5O3
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0556461
|
US8993565, 49
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
IC50 = 146 nM
|
|
|
|
CP0512757
|
US8993565, 42
Show/Hide
|
C17H17N5O4
|
2
|
| 1 |
IC50 = 148 nM
|
|
|
| 2 |
IC50 = 400 nM
|
|
|
|
CP0419360
|
US9133168, Example 21d
Show/Hide
|
C22H26N4O4
|
1
|
| 1 |
IC50 = 155 nM
|
|
|
|
CP0567061
|
US9133168, Example 31b
Show/Hide
|
C20H24N4O4
|
1
|
| 1 |
IC50 = 156 nM
|
|
|
|
CP0557416
|
US9133168, Example 3a
Show/Hide
|
C19H20F2N4O3
|
1
|
| 1 |
IC50 = 158 nM
|
|
|
|
CP0402567
|
2-[2-[4-(4-methylpiperazin-1-yl)-2,3-dihydroindol-1-yl]-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H30N6O3
|
1
|
| 1 |
IC50 = 167 nM
|
|
|
|
CP0120249
|
N-(4-fluoro-3-methylphenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C17H19FN4O3
|
1
|
| 1 |
IC50 = 171 nM
|
|
|
|
CP0539896
|
US8993565, 133
Show/Hide
|
C22H28FN5O4
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0518180
|
US8993565, 146
Show/Hide
|
C17H19N5O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0479377
|
US8993565, 48
Show/Hide
|
C18H18N4O3
|
1
|
| 1 |
IC50 = 184 nM
|
|
|
|
CP0520555
|
US8993565, 150
Show/Hide
|
C17H20N4O4
|
1
|
| 1 |
IC50 = 189 nM
|
|
|
|
CP0315540
|
1-[3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)phenyl]-4,4,4-trifluorobutan-1-one
Show/Hide
|
C26H32BrF3N8O
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0563839
|
US8993565, 119
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0442908
|
US8993565, 70
Show/Hide
|
C18H21FN4O3
|
1
|
| 1 |
IC50 = 195 nM
|
|
|
|
CP0503834
|
US9133168, Example 23d
Show/Hide
|
C23H29N5O3
|
1
|
| 1 |
IC50 = 196 nM
|
|
|
|
CP0572411
|
US8993565, 36
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0556473
|
US8993565, 98
Show/Hide
|
C17H17F3N4O3
|
1
|
| 1 |
IC50 = 219 nM
|
|
|
|
CP0555182
|
US9133168, Example 10e
Show/Hide
|
C19H21FN4O2S
|
1
|
| 1 |
IC50 = 221 nM
|
|
|
|
CP0450754
|
US8993565, 52
Show/Hide
|
C19H21FN4O3
|
1
|
| 1 |
IC50 = 227 nM
|
|
|
|
CP0537490
|
US8993565, 148
Show/Hide
|
C19H23N5O3
|
1
|
| 1 |
IC50 = 234 nM
|
|
|
|
CP0567060
|
US9133168, Example 23b
Show/Hide
|
C20H17FN4O2
|
1
|
| 1 |
IC50 = 244 nM
|
|
|
|
CP0450211
|
US8993565, 24
Show/Hide
|
C17H16FN5O3
|
1
|
| 1 |
IC50 = 247 nM
|
|
|
|
CP0556080
|
US8993565, 69
Show/Hide
|
C17H19BrN4O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0479336
|
US9133168, Example 17d
Show/Hide
|
C24H32N6O5S
|
1
|
| 1 |
IC50 = 259 nM
|
|
|
|
CP0450214
|
US8993565, 97
Show/Hide
|
C18H19F3N4O3
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0520572
|
US8993565, 45
Show/Hide
|
C17H19FN4O4
|
1
|
| 1 |
IC50 = 261 nM
|
|
|
|
CP0379787
|
2-[2-[4-[(4-methylpiperazin-1-yl)methyl]-2,3-dihydroindol-1-yl]-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C24H32N6O3
|
1
|
| 1 |
IC50 = 272 nM
|
|
|
|
CP0539893
|
US8993565, 110
Show/Hide
|
C20H24N4O4
|
1
|
| 1 |
IC50 = 278 nM
|
|
|
|
CP0550573
|
US8993565, 60
Show/Hide
|
C16H15F3N4O3
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0538968
|
US8993565, 111
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 301 nM
|
|
|
|
CP0563842
|
US8993565, 140
Show/Hide
|
C18H20N4O6
|
1
|
| 1 |
IC50 = 302 nM
|
|
|
|
CP0524441
|
US8993565, 44
Show/Hide
|
C19H24N4O4
|
1
|
| 1 |
IC50 = 308 nM
|
|
|
|
CP0160094
|
N-(4-fluoro-3-methoxyphenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C17H19FN4O4
|
1
|
| 1 |
IC50 = 318 nM
|
|
|
|
CP0160088
|
N-(4-fluorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H17FN4O3
|
1
|
| 1 |
IC50 = 321 nM
|
|
|
|
CP0271065
|
2-(1-methyl-4-morpholin-4-yl-6-oxopyrimidin-2-yl)-N-phenylacetamide
Show/Hide
|
C17H20N4O3
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0442926
|
US8993565, 47
Show/Hide
|
C17H16F4N4O3
|
1
|
| 1 |
IC50 = 346 nM
|
|
|
|
CP0424152
|
US8993565, 22
Show/Hide
|
C19H24N4O3
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0470173
|
US9133168, Example 12b
Show/Hide
|
C19H15FN4O2
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0553803
|
US8993565, 144
Show/Hide
|
C18H19FN4O5
|
1
|
| 1 |
IC50 = 432 nM
|
|
|
|
CP0553802
|
US8993565, 143
Show/Hide
|
C18H21N5O4
|
1
|
| 1 |
IC50 = 473 nM
|
|
|
|
CP0555576
|
US8993565, 38
Show/Hide
|
C17H18F2N4O4
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0949761
|
US8993565, 122
Show/Hide
|
C19H21N5O4
|
1
|
| 1 |
IC50 = 503 nM
|
|
|
|
CP0402561
|
US9133168, Example 4a
Show/Hide
|
C19H21FN4O3
|
1
|
| 1 |
IC50 = 503 nM
|
|
|
|
CP0479337
|
US9133168, Example 20d
Show/Hide
|
C25H34N6O3
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0556025
|
US8993565, 62
Show/Hide
|
C18H20N4O4
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0539895
|
US8993565, 132
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
IC50 = 533 nM
|
|
|
|
CP0555600
|
US8993565, 43
Show/Hide
|
C17H17F3N4O4
|
1
|
| 1 |
IC50 = 549 nM
|
|
|
|
CP0556024
|
US8993565, 34
Show/Hide
|
C16H15F3N4O3
|
1
|
| 1 |
IC50 = 609 nM
|
|
|
|
CP0521294
|
US8993565, 11
Show/Hide
|
C17H20N4O4
|
1
|
| 1 |
IC50 = 632 nM
|
|
|
|
CP0450210
|
US8993565, 73
Show/Hide
|
C18H21FN4O4
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0556022
|
US8993565, 113
Show/Hide
|
C22H23N5O4
|
1
|
| 1 |
IC50 = 664 nM
|
|
|
|
CP0322941
|
3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-5-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(2-pyrrolidin-1-ylethyl)aniline
Show/Hide
|
C25H31BrN10O
|
1
|
| 1 |
IC50 = 665 nM
|
|
|
|
CP0550575
|
US8993565, 99
Show/Hide
|
C19H21N5O3
|
1
|
| 1 |
IC50 = 666 nM
|
|
|
|
CP0512758
|
US8993565, 77
Show/Hide
|
C16H15F3N4O3
|
1
|
| 1 |
IC50 = 698 nM
|
|
|
|
CP0192555
|
3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-5-(2-methylpropoxy)-N-(2-pyrrolidin-1-ylethyl)aniline
Show/Hide
|
C26H37BrN8O
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0271060
|
N-(2-fluorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H17FN4O3
|
1
|
| 1 |
IC50 = 727 nM
|
|
|
|
CP0146240
|
3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-N-(2-pyrrolidin-1-ylethyl)-5-(2,2,2-trifluoroethoxymethyl)aniline
Show/Hide
|
C25H32BrF3N8O
|
1
|
| 1 |
IC50 = 730 nM
|
|
|
|
CP0450208
|
US8993565, 12
Show/Hide
|
C16H16F2N4O3
|
1
|
| 1 |
IC50 = 737 nM
|
|
|
|
CP0160093
|
N-(3-methoxyphenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C17H20N4O4
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0426528
|
US8993565, 152
Show/Hide
|
C17H17N5O4
|
1
|
| 1 |
IC50 = 938 nM
|
|
|
|
CP0519535
|
US9133168, Example 2a
Show/Hide
|
C20H22F2N4O3
|
1
|
| 1 |
IC50 = 938 nM
|
|
|
|
CP0073616
|
1-[3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)phenyl]propan-1-one
Show/Hide
|
C25H33BrN8O
|
1
|
| 1 |
IC50 = 976 nM
|
|
|
|
CP0563840
|
US8993565, 129
Show/Hide
|
C18H20N4O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0518178
|
US8993565, 30
Show/Hide
|
C15H17N5O3
|
1
|
| 1 |
IC50 = 1030 nM
|
|
|
|
CP0151040
|
3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-chloro-2-methyl-N-(2-pyrrolidin-1-ylethyl)aniline
Show/Hide
|
C22H28BrClN8
|
1
|
| 1 |
IC50 = 1271 nM
|
|
|
|
CP0556458
|
US8993565, 20
Show/Hide
|
C18H20N4O5
|
1
|
| 1 |
IC50 = 1314 nM
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|
|
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CP0963834
|
US9133168, Example 27b
Show/Hide
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C19H21FN4O4
|
1
|
| 1 |
IC50 = 1332 nM
|
|
|
|
CP0260401
|
N-(4-chlorophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H17ClN4O3
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0424150
|
US8993565, 17
Show/Hide
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C17H17F3N4O3
|
1
|
| 1 |
IC50 = 1481 nM
|
|
|
|
CP0479404
|
US8993565, 40
Show/Hide
|
C18H22N4O3
|
1
|
| 1 |
IC50 = 1494 nM
|
|
|
|
CP0967807
|
US8993565, 39
Show/Hide
|
C18H21FN4O4
|
1
|
| 1 |
IC50 = 1763 nM
|
|
|
|
CP0247186
|
methyl 3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)benzoate
Show/Hide
|
C24H31BrN8O2
|
1
|
| 1 |
IC50 = 1843 nM
|
|
|
|
CP0556472
|
US8993565, 81
Show/Hide
|
C18H21FN4O4
|
1
|
| 1 |
IC50 = 1940 nM
|
|
|
|
CP0237101
|
3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-(3,3-dimethylbutyl)-2-methyl-N-(2-pyrrolidin-1-ylethyl)aniline
Show/Hide
|
C28H41BrN8
|
1
|
| 1 |
IC50 = 1982 nM
|
|
|
|
CP0577779
|
US8993565, 67
Show/Hide
|
C13H19N3O4
|
1
|
| 1 |
IC50 = 2207 nM
|
|
|
|
CP0426552
|
US8993565, 26
Show/Hide
|
C17H17N5O3
|
1
|
| 1 |
IC50 = 2287 nM
|
|
|
|
CP0520550
|
US8993565, 46
Show/Hide
|
C23H31N5O5
|
1
|
| 1 |
IC50 = 2498 nM
|
|
|
|
CP0504066
|
US9133168, Example 24b
Show/Hide
|
C19H14F2N4O2
|
1
|
| 1 |
IC50 = 2855 nM
|
|
|
|
CP0557558
|
US8993565, 139
Show/Hide
|
C17H18N6O3
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0402562
|
US9133168, Example 13b
Show/Hide
|
C20H17FN4O3
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0321393
|
N-(2-methylphenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C17H20N4O3
|
1
|
| 1 |
IC50 = 3498 nM
|
|
|
|
CP0272288
|
5-chloro-3-[4-(3-ethyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-N-(2-pyrrolidin-1-ylethyl)aniline
Show/Hide
|
C24H33ClN8
|
1
|
| 1 |
IC50 = 3589 nM
|
|
|
|
CP0511945
|
US8993565, 32
Show/Hide
|
C16H18N4O4
|
1
|
| 1 |
IC50 = 3635 nM
|
|
|
|
CP0248530
|
N-[3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-chloro-2-methylphenyl]-N',N'-dimethylethane-1,2-diamine
Show/Hide
|
C20H26BrClN8
|
1
|
| 1 |
IC50 = 4285 nM
|
|
|
|
CP0260402
|
methyl 2-fluoro-5-[[2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetyl]amino]benzoate
Show/Hide
|
C18H19FN4O5
|
1
|
| 1 |
IC50 = 5865 nM
|
|
|
|
CP0271063
|
N-(4-fluoro-3-nitrophenyl)-2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)acetamide
Show/Hide
|
C16H16FN5O5
|
1
|
| 1 |
IC50 = 6155 nM
|
|
|
|
CP0521295
|
US8993565, 65
Show/Hide
|
C16H17FN4O4
|
1
|
| 1 |
IC50 = 6460 nM
|
|
|
|
CP0479405
|
US8993565, 50
Show/Hide
|
C16H17FN4O4
|
1
|
| 1 |
IC50 = 6721 nM
|
|
|
|
CP0146238
|
3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-N-phenyl-5-(2-pyrrolidin-1-ylethylamino)benzamide
Show/Hide
|
C29H34BrN9O
|
1
|
| 1 |
IC50 = 7811 nM
|
|
|
|
CP0125121
|
N-[5-chloro-3-[4-(3-ethyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methylphenyl]-N',N'-dimethylethane-1,2-diamine
Show/Hide
|
C22H31ClN8
|
1
|
| 1 |
IC50 = 9026 nM
|
|
|
|
CP0073613
|
3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-ethoxy-2-methyl-N-(2-pyrrolidin-1-ylethyl)aniline
Show/Hide
|
C24H33BrN8O
|
1
|
| 1 |
IC50 = 9067 nM
|
|
|
|
CP0424151
|
US8993565, 21
Show/Hide
|
C17H18N4O5
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0450209
|
US8993565, 35
Show/Hide
|
C17H19FN4O4
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0479403
|
US8993565, 37
Show/Hide
|
C16H18N4O4
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0577778
|
US8993565, 55
Show/Hide
|
C18H22N4O5
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0537489
|
US8993565, 64
Show/Hide
|
C17H17FN4O5
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
