Brief Information of the Cell Line and Protein
Cell Line ID: CL000043 , U2OS
Synonyms
U-2 OS
U-2OS
U-2-OS
U2-OS
U20-S
U20S
2T
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0042
Protein ID: PT00910 , Peroxisome proliferator-activated receptor alpha
Gene Name PPARA
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID Q07869
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000043  Protein ID: PT00910
 
Compound ID Compound Name Compound Formula
CP0421773
methyl 7-[2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C24H21NO6
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0491340
methyl 7-[2-[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C23H18FNO6
 1
1
EC50 = 70 nM
   TI
   LI
   LO
   TS
CP0491338
methyl 7-[2-[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C23H20FNO6
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0491370
methyl 7-[2-[2-(4-tert-butylphenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C27H29NO6
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0434891
7-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-2-oxo-chroman-3-carboxylic acid methyl ester
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C23H21NO6
 1
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
CP0491337
methyl 7-[2-[5-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C24H20F3NO6
 1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
CP0421777
methyl 7-[2-[2-(3-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C23H20FNO6
 1
1
EC50 = 720 nM
   TI
   LI
   LO
   TS
CP0491339
methyl 7-[2-[5-methyl-2-(4-phenylphenyl)-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C29H25NO6
 1
1
EC50 = 910 nM
   TI
   LI
   LO
   TS
CP0502423
methyl 7-[2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C24H23NO6
 1
1
EC50 = 910 nM
   TI
   LI
   LO
   TS
CP0417458
methyl 7-[2-[5-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C24H18F3NO6
 1
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0434894
methyl 7-[2-[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C24H23NO7
 1
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0421785
methyl 7-[2-[5-methyl-2-(4-phenylphenyl)-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C29H23NO6
 1
1
EC50 = 1230 nM
   TI
   LI
   LO
   TS
CP0507965
methyl 7-[2-[2-(3-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C23H18FNO6
 1
1
EC50 = 1290 nM
   TI
   LI
   LO
   TS
CP0434889
methyl 7-[2-[5-methyl-2-(3-methylphenyl)-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C24H23NO6
 1
1
EC50 = 1550 nM
   TI
   LI
   LO
   TS
CP0421776
methyl 7-[2-[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C24H21NO7
 1
1
EC50 = 1620 nM
   TI
   LI
   LO
   TS
CP0434893
methyl 7-[2-[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxo-3,4-dihydrochromene-3-carboxylate
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C24H23NO7
 1
1
EC50 = 1740 nM
   TI
   LI
   LO
   TS
CP0387527
methyl 7-[2-[2-(4-tert-butylphenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C27H27NO6
 1
1
EC50 = 2290 nM
   TI
   LI
   LO
   TS
CP0502422
methyl 7-[2-[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-2-oxochromene-3-carboxylate
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C24H21NO7
 1
1
EC50 = 5250 nM
   TI
   LI
   LO
   TS
CP0012720
2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid
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C14H14ClN3O2S
 1
1
EC50 = 12000 nM
   TI
   LI
   LO
   TS