Brief Information of the Cell Line and Protein
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Synonyms
NIH/3T3
NIH-3T3
NIH3T3
3T3
3T3NIH
3T3-Swiss
Swiss-3T3
Swiss/3T3
Swiss 3T3
Swiss3T3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0594
Protein ID: PT01263 , Vascular endothelial growth factor receptor 2
 Protein Info 
Gene Name KDR
Organism Mus musculus, Mouse
Protein Classification Kinase
Uniprot ID P35918
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000035
 Cell Line Info 
 Protein ID: PT01263
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0109499
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C21H18F3N7O
  1
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0197301
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea
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C21H17ClF3N7O
  1
1
IC50 = 49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0112397
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-(3-chlorophenyl)urea
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C20H18ClN7O
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0308614
 Compound Info 
1-[5-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)-2-methylphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C22H20F3N7O
  1
1
IC50 = 52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109501
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
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C21H17F4N7O
  1
1
IC50 = 121 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0344975
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
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C21H20FN7O
  1
1
IC50 = 311 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0112398
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea
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C21H17F4N7O
  1
1
IC50 = 345 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0112394
 Compound Info 
1-[3-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
   Show/Hide
C21H18F3N7O
  1
1
IC50 = 790 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0202470
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[2-fluoro-3-(trifluoromethyl)phenyl]urea
   Show/Hide
C21H17F4N7O
  1
1
IC50 = 1520 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109498
 Compound Info 
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
   Show/Hide
C21H18F3N7O
  1
1
IC50 = 2440 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS