Brief Information of the Compound and Protein
Compound Name
1-[4-(4-amino-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea
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PubChem ID
CID: 15941395
SID: 22392804
Canonical SMILES
Nc1ncnc2NCCC(=Nc12)c1ccc(NC(=O)Nc2ccc(F)c(c2)C(F)(F)F)cc1
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Compound Formula C21H17F4N7O
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
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Kinase
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Protein Kinase
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TK protein kinase group
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Tyrosine protein kinase VEGFR family
Uniprot ID
P35918
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
IC50 = 345 nM
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