| Compound ID |
Compound Name |
Compound Formula |
|
CP0073242
|
3-amino-N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
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|
C24H25N5O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0393126
|
(1R,3R)-3-amino-N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0555861
|
3-amino-N-[3-(quinolin-5-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
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|
C23H24N6O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0180547
|
(1R,3S)-3-amino-N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0073246
|
3-amino-N-[3-(2-methoxyanilino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
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|
C21H25N5O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0393124
|
methyl 3-[[5-[(3-aminocyclohexanecarbonyl)amino]-1H-indazol-3-yl]amino]benzoate
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|
C22H25N5O3
|
1
|
| 1 |
IC50 = 183 nM
|
|
|
|
CP0476222
|
3-amino-N-[3-(quinolin-4-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
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|
C23H24N6O
|
1
|
| 1 |
IC50 = 239 nM
|
|
|
|
CP0486132
|
N-[5-[(3-aminocyclohexanecarbonyl)amino]-1H-indazol-3-yl]benzamide
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|
C21H23N5O2
|
1
|
| 1 |
IC50 = 242 nM
|
|
|
|
CP0519753
|
3-amino-N-[3-[3-(trifluoromethyl)anilino]-1H-indazol-5-yl]cyclohexane-1-carboxamide
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|
C21H22F3N5O
|
1
|
| 1 |
IC50 = 288 nM
|
|
|
|
CP0073243
|
N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]piperidine-4-carboxamide
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|
C23H23N5O
|
1
|
| 1 |
IC50 = 315 nM
|
|
|
|
CP0489042
|
US10266549, Example 349
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|
C16H17F3N4O2
|
1
|
| 1 |
IC50 = 328 nM
|
|
|
|
CP0389618
|
(1S,3R)-3-amino-N-(3-amino-1H-indazol-5-yl)cyclohexane-1-carboxamide
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|
C14H19N5O
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0486134
|
3-amino-N-(3-amino-1H-indazol-5-yl)cyclohexane-1-carboxamide
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
IC50 = 368 nM
|
|
|
|
CP0482635
|
3-amino-N-[3-(4-bromoanilino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
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|
C20H22BrN5O
|
1
|
| 1 |
IC50 = 416 nM
|
|
|
|
CP0478300
|
3-amino-N-[3-[(4-methoxyphenyl)methylamino]-1H-indazol-5-yl]cyclohexane-1-carboxamide
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|
C22H27N5O2
|
1
|
| 1 |
IC50 = 477 nM
|
|
|
|
CP0930412
|
N-(3-amino-1H-indazol-5-yl)piperidine-4-carboxamide
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|
C13H17N5O
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0495717
|
N4-cyclopropyl-N2-(5-methoxypyridin-3-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
Show/Hide
|
C14H14F3N5O
|
1
|
| 1 |
IC50 = 582 nM
|
|
|
|
CP0515043
|
N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
Show/Hide
|
C15H13F3N6
|
1
|
| 1 |
IC50 = 585 nM
|
|
|
|
CP0486160
|
3-amino-N-[3-(quinolin-8-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
Show/Hide
|
C23H24N6O
|
1
|
| 1 |
IC50 = 589 nM
|
|
|
|
CP0393122
|
N-(3-amino-1H-indazol-5-yl)piperidine-3-carboxamide
Show/Hide
|
C13H17N5O
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0540134
|
US10266549, Example 304a
Show/Hide
|
C14H14F3N5
|
1
|
| 1 |
IC50 = 679 nM
|
|
|
|
CP0515037
|
N4-cyclopropyl-N2-(quinolin-6-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
Show/Hide
|
C17H14F3N5
|
1
|
| 1 |
IC50 = 739 nM
|
|
|
|
CP0331654
|
2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide
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|
C21H21BrN4O5
|
1
|
| 1 |
IC50 = 785 nM
|
|
|
|
CP0389619
|
3-amino-N-[3-(2-fluoroanilino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
Show/Hide
|
C20H22FN5O
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0960352
|
N-(3-amino-1H-indazol-5-yl)piperidine-2-carboxamide
Show/Hide
|
C13H17N5O
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0537630
|
US10266549, Example 208a
Show/Hide
|
C15H12F3N5O
|
1
|
| 1 |
IC50 = 1021 nM
|
|
|
|
CP0555696
|
N2-(1H-benzo[d][1,2,3]triazol-6-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
Show/Hide
|
C14H12F3N7
|
1
|
| 1 |
IC50 = 1168 nM
|
|
|
|
CP0535131
|
N4-cyclopropyl-N2-(4-ethyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
Show/Hide
|
C17H19F3N6O
|
1
|
| 1 |
IC50 = 1215 nM
|
|
|
|
CP0558779
|
N-(4-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide
Show/Hide
|
C18H18F3N5O
|
1
|
| 1 |
IC50 = 1327 nM
|
|
|
|
CP0560870
|
6-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydronaphthalen-1(2H)-one
Show/Hide
|
C18H17F3N4O
|
1
|
| 1 |
IC50 = 1361 nM
|
|
|
|
CP0535130
|
N4-cyclopropyl-N2-(quinoxalin-6-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
Show/Hide
|
C16H13F3N6
|
1
|
| 1 |
IC50 = 1464 nM
|
|
|
|
CP0558848
|
N4-cyclopropyl-N2-(1H-indazol-5-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
Show/Hide
|
C15H13F3N6
|
1
|
| 1 |
IC50 = 1477 nM
|
|
|
|
CP0486133
|
4-amino-N-(3-amino-1H-indazol-5-yl)cyclohexane-1-carboxamide
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
IC50 = 1490 nM
|
|
|
|
CP0576718
|
N4-cyclopropyl-N2-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
Show/Hide
|
C17H17F3N4O2
|
1
|
| 1 |
IC50 = 1602 nM
|
|
|
|
CP0489044
|
US10266549, Example 221a
Show/Hide
|
C12H11F3N6
|
1
|
| 1 |
IC50 = 1611 nM
|
|
|
|
CP0540140
|
N-(cyclopropanecarbonyl)-N-(4-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide
Show/Hide
|
C22H22F3N5O2
|
1
|
| 1 |
IC50 = 1713 nM
|
|
|
|
CP0446858
|
N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]oxane-4-carboxamide
Show/Hide
|
C23H22N4O2
|
1
|
| 1 |
IC50 = 1830 nM
|
|
|
|
CP0515038
|
US10266549, Example 152a
Show/Hide
|
C15H13F3N6
|
1
|
| 1 |
IC50 = 1926 nM
|
|
|
|
CP0561719
|
3-hydroxy-N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
IC50 = 2220 nM
|
|
|
|
CP0478301
|
3-amino-N-(3-anilino-1H-indazol-5-yl)cyclohexane-1-carboxamide
Show/Hide
|
C20H23N5O
|
1
|
| 1 |
IC50 = 2730 nM
|
|
|
|
CP0393125
|
(1S,3R)-3-amino-N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 = 3050 nM
|
|
|
|
CP0569808
|
US10266549, Example 182a
Show/Hide
|
C13H11F3N6
|
1
|
| 1 |
IC50 = 3631 nM
|
|
|
|
CP0486162
|
3-(dimethylamino)-N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]cyclohexane-1-carboxamide
Show/Hide
|
C26H29N5O
|
1
|
| 1 |
IC50 = 4230 nM
|
|
|
|
CP0515040
|
US10266549, Example 158a
Show/Hide
|
C16H15F3N4O2
|
1
|
| 1 |
IC50 = 4475 nM
|
|
|
|
CP0478303
|
N-[3-(naphthalen-1-ylamino)-1H-indazol-5-yl]azetidine-3-carboxamide
Show/Hide
|
C21H19N5O
|
1
|
| 1 |
IC50 = 4940 nM
|
|
|
|
CP0515041
|
2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenol
Show/Hide
|
C14H13F3N4O
|
1
|
| 1 |
IC50 = 6038 nM
|
|
|
|
CP0560871
|
N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
Show/Hide
|
C16H14F3N5
|
1
|
| 1 |
IC50 = 9838 nM
|
|
|
|
CP0495718
|
US10266549, Example 161a
Show/Hide
|
C16H15F3N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0515042
|
N4-cyclopropyl-N2-(quinolin-3-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
Show/Hide
|
C17H14F3N5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0553085
|
N2-(benzo[d][1,3]dioxol-5-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
Show/Hide
|
C15H13F3N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0555697
|
N4-cyclopropyl-N2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
Show/Hide
|
C15H11F5N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0569864
|
US10266549, Example 165b
Show/Hide
|
C12H9F3N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0567008
|
4-amino-N-(3-amino-1H-indazol-5-yl)cyclohexane-1-carboxamide
Show/Hide
|
C14H19N5O
|
1
|
| 1 |
IC50 = 13960 nM
|
|
|
|
CP0482634
|
3-amino-N-(3-amino-1H-indazol-5-yl)benzamide
Show/Hide
|
C14H13N5O
|
1
|
| 1 |
IC50 = 18100 nM
|
|
|
|
CP0393123
|
3-amino-N-(1H-indazol-5-yl)cyclohexane-1-carboxamide
Show/Hide
|
C14H18N4O
|
1
|
| 1 |
IC50 = 22400 nM
|
|
|
|
CP0560459
|
4-amino-N-(3-amino-1H-indazol-5-yl)butanamide
Show/Hide
|
C11H15N5O
|
1
|
| 1 |
IC50 > 33000 nM
|
|
|
