Brief Information of the Cell Line and Protein
Cell Line ID: CL000025 , HEK-293T
Synonyms
Hek293T
HEK-293T
HEK 293T
HEK-293-T
HEK 293 T
293-T
293 T
293T
Human Embryonic Kidney 293T
293tsA1609neo
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0063
Protein ID: PT01592 , Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Gene Name DYRK1A
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q13627
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000025  Protein ID: PT01592
 
Compound ID Compound Name Compound Formula
CP0473089
N-butyl-6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridine-3-carboxamide
   Show/Hide
C28H35Cl2N5O2
 1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
CP0542093
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N-(3-methylbutyl)-1,5-naphthyridine-3-carboxamide
   Show/Hide
C29H37Cl2N5O2
 1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
CP0542099
N-butyl-6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-(morpholin-4-ylmethyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxamide
   Show/Hide
C30H37Cl2N5O3
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0353318
US9067937, 28
   Show/Hide
C25H28Cl2N4O2
 1
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
CP0475242
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N-pentyl-1,5-naphthyridine-3-carboxamide
   Show/Hide
C29H37Cl2N5O2
 1
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
CP0391210
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N-ethyl-1,5-naphthyridine-3-carboxamide
   Show/Hide
C26H31Cl2N5O2
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0532274
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N-(2-methylpropyl)-1,5-naphthyridine-3-carboxamide
   Show/Hide
C28H35Cl2N5O2
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0542091
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N-methyl-1,5-naphthyridine-3-carboxamide
   Show/Hide
C25H29Cl2N5O2
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0542092
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N-propyl-1,5-naphthyridine-3-carboxamide
   Show/Hide
C27H33Cl2N5O2
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0542096
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-[(1-methylpiperidin-4-yl)amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C23H24Cl2N4O3
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0391212
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-(morpholin-4-ylmethyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C28H32Cl2N4O4
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0542090
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C26H30Cl2N4O3
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0532276
ethyl 4-[[4-(aminomethyl)cyclohexyl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C24H26Cl2N4O3
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0532277
ethyl 4-[(4-aminocyclohexyl)amino]-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C23H24Cl2N4O3
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0460911
4-[[3-acetyl-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-4-yl]amino]cyclohexane-1-carboxamide
   Show/Hide
C23H22Cl2N4O3
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0571421
ethyl 4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-6-(4-hydroxy-3,5-dimethylphenyl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C28H36N4O3
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0532273
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridine-3-carboxamide
   Show/Hide
C24H27Cl2N5O2
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0542094
ethyl 4-[[4-(acetamidomethyl)cyclohexyl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C26H28Cl2N4O4
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0539999
N-[[4-[[6-(3,5-dichloro-4-hydroxyphenyl)-3-(hydroxymethyl)-1,5-naphthyridin-4-yl]amino]cyclohexyl]methyl]acetamide
   Show/Hide
C24H26Cl2N4O3
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0531733
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-[4-[(dimethylamino)methyl]anilino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C26H24Cl2N4O3
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0542103
ethyl 6-(2-aminopyridin-4-yl)-4-[[4-(morpholin-4-ylmethyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C27H34N6O3
 1
1
EC50 = 37 nM
   TI
   LI
   LO
   TS
CP0542100
CHEMBL4643088
   Show/Hide
C25H26Cl2N4O4
 1
1
EC50 = 43 nM
   TI
   LI
   LO
   TS
CP0473088
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridine-3-carbonitrile
   Show/Hide
C24H25Cl2N5O
 1
1
EC50 = 45 nM
   TI
   LI
   LO
   TS
CP0542102
6-(2-aminopyridin-4-yl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N-ethyl-1,5-naphthyridine-3-carboxamide
   Show/Hide
C25H33N7O
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0391213
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-(dimethylcarbamoyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C26H28Cl2N4O4
 1
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
CP0532278
N-butyl-6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-(morpholine-4-carbonyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxamide
   Show/Hide
C30H35Cl2N5O4
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0414605
CHEMBL4645197
   Show/Hide
C25H32N6O2
 1
1
EC50 = 59 nM
   TI
   LI
   LO
   TS
CP0542098
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-piperazin-1-yl-1,5-naphthyridine-3-carboxylate
   Show/Hide
C21H20Cl2N4O3
 1
1
EC50 = 73 nM
   TI
   LI
   LO
   TS
CP0532279
2-[4-[[6-(3,5-dichloro-4-hydroxyphenyl)-3-(hydroxymethyl)-1,5-naphthyridin-4-yl]amino]cyclohexyl]acetamide
   Show/Hide
C23H24Cl2N4O3
 1
1
EC50 = 74 nM
   TI
   LI
   LO
   TS
CP0391214
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-(morpholine-4-carbonyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C28H30Cl2N4O5
 1
1
EC50 = 97 nM
   TI
   LI
   LO
   TS
CP0542095
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-(hydroxymethyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C24H25Cl2N3O4
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0542097
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-morpholin-4-yl-1,5-naphthyridine-3-carboxylate
   Show/Hide
C21H19Cl2N3O4
 1
1
EC50 = 105 nM
   TI
   LI
   LO
   TS
CP0471038
ethyl 6-(2-aminopyridin-4-yl)-4-[[4-(pyrrolidin-1-ylmethyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C27H34N6O2
 1
1
EC50 = 108 nM
   TI
   LI
   LO
   TS
CP0391217
ethyl 6-(2-aminopyridin-4-yl)-4-[[4-(piperidin-1-ylmethyl)cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C28H36N6O2
 1
1
EC50 = 114 nM
   TI
   LI
   LO
   TS
CP0540000
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-(4-methylpiperidin-1-yl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C23H23Cl2N3O3
 1
1
EC50 = 123 nM
   TI
   LI
   LO
   TS
CP0534227
N-butyl-4-[(4-carbamoylcyclohexyl)amino]-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridine-3-carboxamide
   Show/Hide
C26H29Cl2N5O3
 1
1
EC50 = 175 nM
   TI
   LI
   LO
   TS
CP0534210
ethyl 6-(3,5-dichloro-4-hydroxyphenyl)-4-piperidin-1-yl-1,5-naphthyridine-3-carboxylate
   Show/Hide
C22H21Cl2N3O3
 1
1
EC50 = 203 nM
   TI
   LI
   LO
   TS
CP0417540
ethyl 4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-6-pyridin-4-yl-1,5-naphthyridine-3-carboxylate
   Show/Hide
C25H31N5O2
 1
1
EC50 = 223 nM
   TI
   LI
   LO
   TS
CP0391215
ethyl 4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-6-(4-hydroxyphenyl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C26H32N4O3
 1
1
EC50 = 300 nM
   TI
   LI
   LO
   TS
CP0532275
6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-N,N-dimethyl-1,5-naphthyridine-3-carboxamide
   Show/Hide
C26H31Cl2N5O2
 1
1
EC50 = 354 nM
   TI
   LI
   LO
   TS
CP0532280
ethyl 4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-6-(2-oxo-1H-pyridin-4-yl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C25H31N5O3
 1
1
EC50 = 383 nM
   TI
   LI
   LO
   TS
CP0526899
[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-morpholin-4-ylmethanone
   Show/Hide
C28H33Cl2N5O3
 1
1
EC50 = 641 nM
   TI
   LI
   LO
   TS
CP0540001
4-[[6-(3,5-dichloro-4-hydroxyphenyl)-3-(hydroxymethyl)-1,5-naphthyridin-4-yl]amino]cyclohexane-1-carboxamide
   Show/Hide
C22H22Cl2N4O3
 1
1
EC50 = 678 nM
   TI
   LI
   LO
   TS
CP0542101
4-[8-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-7-ethoxycarbonyl-1,5-naphthyridin-2-yl]benzoic acid
   Show/Hide
C27H32N4O4
 1
1
EC50 = 990 nM
   TI
   LI
   LO
   TS
CP0414604
ethyl 4-[(4-carbamoylcyclohexyl)amino]-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C24H24Cl2N4O4
 1
1
EC50 = 1252 nM
   TI
   LI
   LO
   TS
CP0534217
ethyl 4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-6-(6-oxo-1H-pyridin-3-yl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C25H31N5O3
 1
1
EC50 = 1336 nM
   TI
   LI
   LO
   TS
CP0571422
ethyl 4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-6-(2-methylpyridin-4-yl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C26H33N5O2
 1
1
EC50 = 1530 nM
   TI
   LI
   LO
   TS
CP0391216
CHEMBL4649108
   Show/Hide
C26H33N5O2
 1
1
EC50 = 2095 nM
   TI
   LI
   LO
   TS
CP0540003
ethyl 6-(4-carbamoylphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C27H33N5O3
 1
1
EC50 = 4656 nM
   TI
   LI
   LO
   TS
CP0391211
CHEMBL4633517
   Show/Hide
C24H25Cl2N3O3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0540002
ethyl 6-(3,5-dichlorophenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridine-3-carboxylate
   Show/Hide
C26H30Cl2N4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0571423
ethyl 4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-6-(2,6-dimethylpyridin-4-yl)-1,5-naphthyridine-3-carboxylate
   Show/Hide
C27H35N5O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS