| Compound ID |
Compound Name |
Compound Formula |
|
CP0001158
|
US9284315, BEZ-235
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|
C30H23N5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0579027
|
(4S,5S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0577015
|
(3aS,6aS)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]oxazol-2-one
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|
C18H18F3N7O4
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0576744
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-methyl-1,3-oxazolidin-2-one
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|
C17H18F3N7O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0576748
|
(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one
Show/Hide
|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0545313
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-1,3-oxazolidin-2-one
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|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0577684
|
5-[6-(7-methoxy-2,3-dihydro-1,4-benzoxazin-4-yl)-2-morpholin-4-ylpyrimidin-4-yl]pyrimidin-2-amine
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|
C21H23N7O3
|
1
|
| 1 |
IC50 = 101 nM
|
|
|
|
CP0125999
|
2-amino-5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-1H-pyrimidin-6-one
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|
C16H21N7O3
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0545315
|
(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0576745
|
(5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
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|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0007893
|
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
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|
C23H27N7O3S2
|
1
|
| 1 |
IC50 = 146 nM
|
|
|
|
CP0548467
|
(4S,5S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 147 nM
|
|
|
|
CP0546964
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]pyrrolidin-2-one
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|
C18H19F3N6O2
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0576741
|
(5S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
Show/Hide
|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0576740
|
3-[6-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
C16H16F3N7O3
|
1
|
| 1 |
IC50 = 184 nM
|
|
|
|
CP0188346
|
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyrimidin-2-amine
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|
C17H20F3N7O2
|
1
|
| 1 |
IC50 = 191 nM
|
|
|
|
CP0579376
|
3-[6-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-oxazinan-2-one
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|
C17H18F3N7O3
|
1
|
| 1 |
IC50 = 203 nM
|
|
|
|
CP0548095
|
2-[(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-methyl-2-oxo-1,3-oxazolidin-4-yl]acetonitrile
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|
C19H19F3N8O3
|
1
|
| 1 |
IC50 = 237 nM
|
|
|
|
CP0543348
|
(4R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-1,3-oxazolidin-2-one
Show/Hide
|
C17H18F3N7O4
|
1
|
| 1 |
IC50 = 264 nM
|
|
|
|
CP0543347
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-5,5-dimethyl-1,3-oxazolidin-2-one
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|
C19H22F3N7O4
|
1
|
| 1 |
IC50 = 278 nM
|
|
|
|
CP0573794
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-[(1S)-1-hydroxyethyl]-1,3-oxazolidin-2-one
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|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 285 nM
|
|
|
|
CP0568134
|
(4S)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one
Show/Hide
|
C18H20F3N7O4
|
1
|
| 1 |
IC50 = 331 nM
|
|
|
|
CP0568135
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]imidazolidin-2-one
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|
C17H18F3N7O2
|
1
|
| 1 |
IC50 = 391 nM
|
|
|
|
CP0577685
|
3-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-oxazolidin-2-one
Show/Hide
|
C17H17F3N6O3
|
1
|
| 1 |
IC50 = 443 nM
|
|
|
|
CP0001930
|
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
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|
C18H21F3N6O2
|
1
|
| 1 |
IC50 = 523 nM
|
|
|
|
CP0576738
|
2-amino-5-[6-[2-(2-hydroxyethyl)morpholin-4-yl]-2-morpholin-4-ylpyrimidin-4-yl]pyridine-4-carbonitrile
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|
C20H25N7O3
|
1
|
| 1 |
IC50 = 811 nM
|
|
|
|
CP0116130
|
N-[4-methyl-5-(2-propan-2-yl-1,3-thiazol-4-yl)-1,3-thiazol-2-yl]acetamide
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|
C12H15N3OS2
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0173899
|
(2S,4S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-4-hydroxypyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H23N5O3S2
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0574438
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1,3-dimethylurea
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|
C17H20F3N7O2
|
1
|
| 1 |
IC50 = 1405 nM
|
|
|
|
CP0552713
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]piperidin-2-one
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|
C19H21F3N6O2
|
1
|
| 1 |
IC50 = 1540 nM
|
|
|
|
CP0579375
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-3-phenylimidazolidin-2-one
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|
C23H22F3N7O2
|
1
|
| 1 |
IC50 = 1580 nM
|
|
|
|
CP0545312
|
(4S)-3-[4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-morpholin-4-ylpyrimidin-2-yl]-4-methyl-1,3-oxazolidin-2-one
Show/Hide
|
C18H19F3N6O3
|
1
|
| 1 |
IC50 = 1979 nM
|
|
|
|
CP0008405
|
(2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C19H22F3N5O2S
|
1
|
| 1 |
IC50 = 2200 nM
|
|
|
|
CP0576737
|
5-(2,6-dimorpholin-4-ylpyridin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
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|
C19H22F3N5O2
|
1
|
| 1 |
IC50 = 2485 nM
|
|
|
|
CP0109038
|
(2S)-1-N-[5-(2-tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
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|
C18H24N6O2S
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
|
CP0574436
|
5-[2-morpholin-4-yl-6-(2-phenylmorpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
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|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 4035 nM
|
|
|
|
CP0054686
|
(2S,4R)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-4-hydroxypyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H23N5O3S2
|
1
|
| 1 |
IC50 = 4500 nM
|
|
|
|
CP0041061
|
(2S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-2-methylpyrrolidine-1,2-dicarboxamide
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|
C18H25N5O2S2
|
1
|
| 1 |
IC50 = 5600 nM
|
|
|
|
CP0041055
|
(2S,4R)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-4-fluoropyrrolidine-1,2-dicarboxamide
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|
C17H22FN5O2S2
|
1
|
| 1 |
IC50 = 5800 nM
|
|
|
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CP0579116
|
[(3R)-4-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]morpholin-3-yl]methanol
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|
C19H23F3N6O3
|
1
|
| 1 |
IC50 = 5800 nM
|
|
|
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CP0568133
|
1-[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]-1-(2-hydroxyethyl)-3-methylurea
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|
C18H22F3N7O3
|
1
|
| 1 |
IC50 = 5865 nM
|
|
|
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CP0101472
|
(2S,3S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-3-hydroxypyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H23N5O3S2
|
1
|
| 1 |
IC50 = 6200 nM
|
|
|
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CP0054680
|
(2S,3S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-3-methylpyrrolidine-1,2-dicarboxamide
Show/Hide
|
C18H25N5O2S2
|
1
|
| 1 |
IC50 = 8100 nM
|
|
|
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CP0552712
|
5-[6-(1,1-dioxo-1,4-thiazinan-4-yl)-2-morpholin-4-ylpyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
Show/Hide
|
C18H21F3N6O3S
|
1
|
| 1 |
IC50 = 8220 nM
|
|
|
|
CP0574440
|
2-[[6-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-yl]amino]-3-phenylpropan-1-ol
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|
C23H25F3N6O2
|
1
|
| 1 |
IC50 = 9290 nM
|
|
|
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CP0041010
|
(2S,4S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-4-(dimethylamino)pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C19H28N6O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0041058
|
(2S,4R)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-4-(dimethylamino)pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C19H28N6O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0041059
|
(2S)-1-N-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H19FN4O4S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0041060
|
(2S)-1-N-[5-[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C16H22N6O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0041063
|
(2S)-2-methyl-1-N-[4-methyl-5-[2-[1-(trifluoromethyl)cyclopropyl]-1,3-thiazol-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C18H20F3N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0054682
|
(2S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H23N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0054683
|
(2S)-1-N-[4-methyl-5-(2-propan-2-yl-1,3-thiazol-4-yl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C16H21N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0055475
|
(2S)-1-N-[4-methyl-5-(2-pentan-3-yl-1,3-thiazol-4-yl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C18H25N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
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|
|
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CP0059185
|
(2S)-1-N-[5-(2-cyclobutyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H21N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0095468
|
(2S)-1-N-[4-methyl-5-[2-(1-methylcyclopropyl)-1,3-thiazol-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H21N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
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|
|
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CP0106216
|
(2S)-1-N-[5-[2-(2-fluorophenyl)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C19H18FN5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0106217
|
(2S)-1-N-[4-methyl-5-[2-[1-(trifluoromethyl)cyclopropyl]-1,3-thiazol-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H18F3N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0116148
|
(2S,3R)-3-methyl-1-N-[4-methyl-5-[2-[1-(trifluoromethyl)cyclopropyl]-1,3-thiazol-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C18H20F3N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0116166
|
(2S,3R)-3-hydroxy-1-N-[4-methyl-5-[2-[1-(trifluoromethyl)cyclopropyl]-1,3-thiazol-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H18F3N5O3S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0127180
|
(2S,4R)-4-(dimethylamino)-1-N-[4-methyl-5-[2-(1-methylcyclopropyl)-1,3-thiazol-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C19H26N6O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0186275
|
(2S)-1-N-[4-methyl-5-(2-pyridin-3-yl-1,3-thiazol-4-yl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C18H18N6O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0186276
|
(1S,5R)-2-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-2-azabicyclo[3.1.0]hexane-1,2-dicarboxamide
Show/Hide
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C18H23N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0235671
|
(2S)-1-N-[5-[2-(dimethylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C15H20N6O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0357025
|
(2S)-1-N-[5-[2-(cyclopropylmethyl)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C17H21N5O2S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0545314
|
(4S,5R)-3-[4-[2-amino-4-(trifluoromethyl)pyrimidin-5-yl]-6-morpholin-4-ylpyrimidin-2-yl]-5-methyl-4-[(1-oxo-1,4-thiazinan-4-yl)methyl]-1,3-oxazolidin-2-one
Show/Hide
|
C22H27F3N8O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
