Brief Information of the Cell Line and Protein
Cell Line ID: CL000018 , HL-60
Synonyms
HL 60
HL.60
HL60
Human Leukemia-60
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0002
Protein ID: PT03572 , Methionine synthase
Gene Name MTR
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID Q99707
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000018  Protein ID: PT03572
 
Compound ID Compound Name Compound Formula
CP0499743
(2S)-2-[[3-bromo-4-[[2,4-diamino-5-(2,3-dibromopropyl)-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
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C23H28Br3N7O5
 1
1
IC50 = 1430 nM
   TI
   LI
   LO
   TS
CP0335321
(2S)-2-[[4-[acetyl-[(2,4-diamino-5-formyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid
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C23H27N7O7
 1
1
IC50 = 1730 nM
   TI
   LI
   LO
   TS
CP0533498
2-chloro-1-[2,4-diamino-6-[2-(4-ethylphenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C19H24ClN5O
 3
1
IC50 = 4460 nM
   TI
   LI
   LO
   TS
2
IC50 = 7640 nM
   TI
   LI
   LO
   TS
3
IC50 = 12100 nM
   TI
   LI
   LO
   TS
CP0527717
2-chloro-1-[2,4-diamino-6-[2-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C17H19ClFN5O
 1
1
IC50 = 4990 nM
   TI
   LI
   LO
   TS
CP0553019
2-chloro-1-[2,4-diamino-6-[2-(4-methylphenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C18H22ClN5O
 1
1
IC50 = 5660 nM
   TI
   LI
   LO
   TS
CP0194830
(2S)-2-[[4-[(2,4-diamino-5-formyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
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C22H27N7O6
 1
1
IC50 = 8110 nM
   TI
   LI
   LO
   TS
CP0560734
2-chloro-1-[2,4-diamino-6-[2-(4-tert-butylphenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C21H28ClN5O
 1
1
IC50 = 13500 nM
   TI
   LI
   LO
   TS
CP0570005
2-chloro-1-[2,4-diamino-6-[2-(4-chlorophenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C17H19Cl2N5O
 1
1
IC50 = 14900 nM
   TI
   LI
   LO
   TS
CP0450144
(2S)-2-[[4-[(2,4-diamino-5-prop-2-enyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl-prop-2-enylamino]benzoyl]amino]pentanedioic acid
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C26H33N7O5
 1
1
IC50 = 15870 nM
   TI
   LI
   LO
   TS
CP0493586
(2S)-2-[[3-bromo-4-[(2,4-diamino-5-prop-2-enyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
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C23H28BrN7O5
 1
1
IC50 = 21000 nM
   TI
   LI
   LO
   TS
CP0534353
(2S)-2-[[4-[(2,4-diamino-5-prop-2-enyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
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C23H29N7O5
 1
1
IC50 = 27830 nM
   TI
   LI
   LO
   TS
CP0542490
2-chloro-1-[2,4-diamino-6-[2-(4-propan-2-ylphenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C20H26ClN5O
 1
1
IC50 = 45900 nM
   TI
   LI
   LO
   TS
CP0572576
2-bromo-1-[2,4-diamino-6-[2-(4-methylphenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C18H22BrN5O
 1
1
IC50 = 48000 nM
   TI
   LI
   LO
   TS
CP0560735
2-chloro-1-[2,4-diamino-6-[2-(2-methoxyphenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
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C18H22ClN5O2
 1
1
IC50 = 51500 nM
   TI
   LI
   LO
   TS
CP0260606
(2S)-2-[[4-[[2,4-diamino-5-(4-methylphenyl)sulfonyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl]methyl-methylamino]benzoyl]amino]pentanedioic acid
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C28H33N7O7S
 1
1
IC50 = 55000 nM
   TI
   LI
   LO
   TS
CP0300787
(2S)-2-[[4-(11,13-diamino-2,4,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10,12-trien-4-yl)benzoyl]amino]pentanedioic acid
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C21H25N7O5
 1
1
IC50 = 66380 nM
   TI
   LI
   LO
   TS
CP0525893
(2S)-2-[[4-[(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
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C20H25N7O5
 1
1
IC50 = 87910 nM
   TI
   LI
   LO
   TS
CP0057302
(2S)-2-[[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
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C20H21N7O5
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0194829
(2S)-2-[[4-[(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
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C21H27N7O5
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0339485
(2S)-2-[[4-[(2,4-diamino-5-prop-2-enyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
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C24H31N7O5
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0339778
(2S)-2-[[4-[acetyl-[(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid
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C22H27N7O6
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS