| Compound ID |
Compound Name |
Compound Formula |
|
CP0392107
|
US8748435, 39
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|
C27H39N5
|
1
|
| 1 |
IC50 = 20 nM
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|
|
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CP0408534
|
(2R)-3-[4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]propane-1,2-diol
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|
C27H37N5O2
|
2
|
| 1 |
IC50 = 21 nM
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|
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| 2 |
IC50 = 67 nM
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CP0471818
|
3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-1-piperidin-4-ylpropan-1-ol
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|
C25H34N4O
|
1
|
| 1 |
IC50 = 24 nM
|
|
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CP0411513
|
4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-2-one
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|
C24H29N5O
|
2
|
| 1 |
IC50 = 27 nM
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|
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| 2 |
IC50 = 890 nM
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CP0404255
|
2-ethyl-5,7-dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]pyrazolo[1,5-a]pyrimidine
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|
C27H37N5
|
1
|
| 1 |
IC50 = 43 nM
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|
|
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CP0456411
|
1-[2-[1-[4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]phenyl]triazol-4-yl]ethyl]piperidin-4-ol
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|
C27H39N7O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
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CP0389066
|
4-[3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propyl]piperidin-4-ol
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|
C25H34N4O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
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CP0392108
|
3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-1-piperazin-1-ylpropan-1-one
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|
C24H31N5O
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
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CP0411514
|
4-[3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propyl]-1-propan-2-ylpiperidin-4-ol
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|
C28H40N4O
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0392109
|
US8748435, 35
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|
C24H28N6O
|
2
|
| 1 |
IC50 = 67 nM
|
|
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| 2 |
IC50 = 70 nM
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|
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CP0541187
|
1-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-2-one
Show/Hide
|
C24H29N5O
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
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CP0389075
|
2-ethyl-6,8-dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[1,2-b]pyridazine
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|
C27H37N5
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0314508
|
US8748435, 40
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|
C27H37N5
|
2
|
| 1 |
IC50 = 110 nM
|
|
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| 2 |
IC50 = 114 nM
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CP0476127
|
N-(2,2-dimethylpropyl)-2-methoxy-N-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]pyrimidin-4-amine
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|
C27H39N5O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
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CP0538713
|
N-[4-(dimethylamino)butyl]-4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]benzamide
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|
C25H39N5O
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
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CP0493673
|
5-(dimethylamino)-N-[4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]phenyl]pentanamide
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|
C25H39N5O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
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CP0568726
|
2-chloro-N-(2,2-dimethylpropyl)-N-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]pyrimidin-4-amine
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|
C26H36ClN5
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
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CP0476126
|
N-(2,2-dimethylpropyl)-2,6-dimethyl-N-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine
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|
C28H43N5
|
1
|
| 1 |
IC50 = 330 nM
|
|
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CP0562315
|
2-chloro-N-(2,2-dimethylpropyl)-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine
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|
C29H42ClN5
|
1
|
| 1 |
IC50 = 360 nM
|
|
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CP0476917
|
2-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]-5-piperazin-1-yl-1,3,4-oxadiazole
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|
C23H27N7O
|
1
|
| 1 |
IC50 = 368 nM
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|
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CP0568724
|
N-(2,2-dimethylpropyl)-2-methyl-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine
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|
C30H45N5
|
1
|
| 1 |
IC50 = 380 nM
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|
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CP0408466
|
N-(2,2-dimethylpropyl)-2,6-dimethyl-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine
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|
C31H47N5
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
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CP0493671
|
2,5,7-trimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
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|
C26H35N5
|
1
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| 1 |
IC50 = 410 nM
|
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|
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CP0110282
|
4-[2,2-dimethylpropyl-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]amino]pyrimidine-2-carbonitrile
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|
C30H42N6
|
1
|
| 1 |
IC50 = 490 nM
|
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|
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CP0562314
|
N-(2,2-dimethylpropyl)-2-methoxy-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine
Show/Hide
|
C30H45N5O
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
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CP0560423
|
5,7-dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]-2-propylimidazo[4,5-b]pyridine
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|
C28H39N5
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
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CP0568725
|
N-(2,2-dimethylpropyl)-2,6-dimethyl-N-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]pyrimidin-4-amine
Show/Hide
|
C28H41N5
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
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CP0396270
|
4-[2,2-dimethylpropyl-[[4-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]phenyl]methyl]amino]pyrimidine-2-carbonitrile
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|
C27H36N6
|
1
|
| 1 |
IC50 = 1930 nM
|
|
|
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CP0408465
|
5,7-dimethyl-2-propan-2-yl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
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|
C28H39N5
|
1
|
| 1 |
IC50 = 2440 nM
|
|
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CP0562313
|
N-(2,2-dimethylpropyl)-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]-6-(trifluoromethyl)pyrimidin-4-amine
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|
C30H42F3N5
|
1
|
| 1 |
IC50 = 2970 nM
|
|
|
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CP0464868
|
4-N-(2,2-dimethylpropyl)-2-N,2-N-dimethyl-4-N-[[4-[(E)-3-(4-piperidin-1-ylpiperidin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidine-2,4-diamine
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|
C31H48N6
|
1
|
| 1 |
IC50 = 4800 nM
|
|
|
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CP0558235
|
5,7-dimethyl-2-(2-methylpropyl)-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
Show/Hide
|
C29H41N5
|
1
|
| 1 |
IC50 = 7310 nM
|
|
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CP0493672
|
2-ethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
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|
C25H33N5
|
1
|
| 1 |
IC50 = 9100 nM
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|
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CP0560424
|
6-ethyl-2,4-dimethyl-7-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]pyrrolo[2,3-d]pyrimidine
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|
C27H37N5
|
1
|
| 1 |
IC50 = 11600 nM
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