| Compound ID |
Compound Name |
Compound Formula |
|
CP0409974
|
(2R,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-[3-(trifluoromethyl)phenyl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C30H26F6N4O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0410890
|
(2R,3R)-2-(2,4-difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C29H25F5N4O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0476835
|
(2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-pentan-3-yl-3-(3,3,3-trifluoropropyl)butanediamide
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|
C28H33F3N4O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0529363
|
US9427442, 10
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|
C28H28ClF5N4O3
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0399659
|
(2R,3R)-2-(4-fluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C29H26F4N4O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0409975
|
(2R,3R)-2-(3,5-difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C29H25F5N4O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0476836
|
(2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-pentan-3-ylbutanediamide
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|
C29H38N4O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0566534
|
(2R,3R)-2-(3,4-difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C29H25F5N4O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0561236
|
US9427442, 11
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|
C28H28F6N4O3
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0519679
|
US9427442, 18
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|
C25H25F5N4O3
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0561238
|
US9427442, 13
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|
C27H26ClF5N4O3
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0518667
|
US9427442, 8
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|
C28H29F5N4O4
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0561154
|
US9427442, 19
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|
C26H25F7N4O3
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0399658
|
(2S,3R)-3-(2,2-dimethylpropyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-pentan-3-ylbutanediamide
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|
C30H40N4O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0410889
|
(2R,3R)-2-(3-methyl-1,2-oxazol-4-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C27H26F3N5O4
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0428750
|
(2R,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-[3-(trifluoromethoxy)phenyl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C30H26F6N4O4
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0542514
|
(2R,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-(3-methylphenyl)-3-(3,3,3-trifluoropropyl)butanediamide
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|
C30H29F3N4O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0556713
|
US9427442, 1
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|
C28H29F5N4O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0486300
|
US9427442, 22
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|
C26H25ClF6N4O3
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0539483
|
US9427442, 9
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|
C28H28F6N4O3
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0419410
|
US9427442, 25
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|
C28H30F4N4O3
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0539484
|
US9427442, 24
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|
C26H26ClF5N4O3
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0552247
|
US9427442, 7
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|
C30H31F5N4O4
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0486923
|
(2R,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-phenyl-3-(3,3,3-trifluoropropyl)butanediamide
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|
C29H27F3N4O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0402631
|
US9427442, 3
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|
C31H32F6N4O4
|
1
|
| 1 |
IC50 = 4.2 nM
|
|
|
|
CP0419462
|
US9427442, 15
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|
C27H27F5N4O3
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0419464
|
US9427442, 5
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|
C28H28ClF5N4O3
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0402632
|
US9427442, 14
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|
C27H26F6N4O3
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0412022
|
US9273014, Comparative Compound 47
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|
C28H35ClN4O3
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0515744
|
US9427442, 23
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|
C26H25ClF6N4O3
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0556307
|
US9427442, 12
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|
C30H31F5N4O3
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0466215
|
US9427442, 17
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|
C26H28F4N4O4
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
|
CP0561153
|
US9427442, 16
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|
C25H27F4N5O4
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0561237
|
US9427442, 2
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|
C29H31F5N4O4
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0553703
|
US9427442, 21
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|
C27H29F5N4O4
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
|
|
CP0471072
|
(2R,3R)-2-(4-methoxyphenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
Show/Hide
|
C30H29F3N4O4
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0486299
|
US9427442, 20
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|
C25H25ClF4N4O3
|
1
|
| 1 |
IC50 = 10.8 nM
|
|
|
|
CP0537195
|
US9427442, 4
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|
C29H29ClF6N4O3
|
1
|
| 1 |
IC50 = 11.9 nM
|
|
|
|
CP0428820
|
US9273014, Comparative Compound 48
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|
C29H36N4O3
|
1
|
| 1 |
IC50 = 12.3 nM
|
|
|
|
CP0542515
|
(2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-propyl-3-(2,2,2-trifluoroethyl)butanediamide
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|
C25H27F3N4O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0561235
|
US9427442, 6
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|
C26H25F5N4O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0472376
|
(2R,3R)-2-(1,2-oxazol-4-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C25H22F3N5O4
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0491589
|
US9273014, Comparative Compound 46
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|
C27H31ClN4O3
|
1
|
| 1 |
IC50 = 42.4 nM
|
|
|
|
CP0481233
|
(2R,3R)-2-(5-methyl-1,2-oxazol-3-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
Show/Hide
|
C27H26F3N5O4
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0004510
|
US9273014, Comparative Compound 45
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|
C27H34N4O3
|
1
|
| 1 |
IC50 = 64.1 nM
|
|
|
|
CP0400691
|
(2R,3R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C26H25F3N6O4
|
1
|
| 1 |
IC50 = 169 nM
|
|
|
|
CP0399657
|
(2R,3R)-2-(1,3-oxazol-4-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
Show/Hide
|
C25H22F3N5O4
|
1
|
| 1 |
IC50 = 231 nM
|
|
|
|
CP0381969
|
(2R,3R)-2-(1,2,4-oxadiazol-3-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide
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|
C24H21F3N6O4
|
1
|
| 1 |
IC50 = 1190 nM
|
|
|
|
CP0480596
|
(2R,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-(3-methylsulfonylphenyl)-3-(3,3,3-trifluoropropyl)butanediamide
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|
C30H29F3N4O5S
|
1
|
| 1 |
IC50 = 2060 nM
|
|
|
