| Compound ID |
Compound Name |
Compound Formula |
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CP0927704
|
2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-((R)-1-((1r,4R)-4-(3-(difluoromethoxy)azetidin-1-yl)cyclohexyl)ethyl)-1H-indole-3-carboxamide
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C30H38F2N4O3S
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
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CP0863013
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1-((R)-1-((1r,4R)-4-(3-(trifluoromethoxy)azetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
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|
C30H37F3N4O3S
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
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CP0922322
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1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-5-fluoro-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
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|
C31H40FN5O3S
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
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CP0943512
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1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
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|
C31H41N5O3S
|
1
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| 1 |
EC50 = 1.8 nM
|
|
|
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CP0862916
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1-((R)-1-((1r,4R)-4-(3-methoxyazetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
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|
C30H40N4O3S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
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CP0903572
|
1-((R)-1-((2r,5R)-5-(dimethylamino)-1,3-dioxan-2-yl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
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|
C26H34N4O4S
|
1
|
| 1 |
EC50 = 2.4 nM
|
|
|
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CP0941409
|
2-methyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidyl]ethyl]indole-3-carboxamide
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|
C27H33F3N4O2S
|
1
|
| 1 |
EC50 = 2.5 nM
|
|
|
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CP0914645
|
1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-7-fluoro-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
Show/Hide
|
C32H41FN4O3S
|
1
|
| 1 |
EC50 = 3.4 nM
|
|
|
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CP0863014
|
1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
Show/Hide
|
C32H42N4O3S
|
1
|
| 1 |
EC50 = 3.5 nM
|
|
|
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CP0943513
|
5-chloro-1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
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|
C31H40ClN5O3S
|
1
|
| 1 |
EC50 = 3.5 nM
|
|
|
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CP0947972
|
2-methyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(1R)-1-[1-(oxetan-3-yl)-4-piperidyl]ethyl]indole-3-carboxamide
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|
C28H36N4O3S
|
1
|
| 1 |
EC50 = 5.1 nM
|
|
|
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CP0922323
|
1-((R)-1-((1s,4S)-4-(3,3-difluoroazetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
Show/Hide
|
C29H36F2N4O2S
|
1
|
| 1 |
EC50 = 5.9 nM
|
|
|
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CP0944995
|
7-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-6-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
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|
C30H40N6O3S
|
1
|
| 1 |
EC50 = 6.3 nM
|
|
|
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CP0863016
|
2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-((R)-1-((1r,4R)-4-(oxetan-3-ylamino)cyclohexyl)ethyl)-1H-indole-3-carboxamide
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|
C29H38N4O3S
|
1
|
| 1 |
EC50 = 6.7 nM
|
|
|
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CP0751486
|
(R)-1-(1-(1-(2,2-Difluoropropyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
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|
C28H36F2N4O3
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
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CP0863015
|
1-[(1R)-1-[1-(2-hydroxy-2-methyl-propyl)-4-piperidyl]ethyl]-2-methyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]indole-3-carboxamide
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|
C29H40N4O3S
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0231582
|
Cpi-1205
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|
C27H33F3N4O3
|
2
|
| 1 |
EC50 = 28 nM
|
|
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| 2 |
EC50 = 32 nM
|
|
|
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CP0833865
|
(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methyl-1-(1-(1-(2,2,3,3-tetrafluoropropyl)piperidin-4-yl)-ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C28H34F4N4O3
|
1
|
| 1 |
EC50 = 38 nM
|
|
|
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CP0802164
|
(R)-1-(1-(1-(2,2-Difluoroethyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
Show/Hide
|
C27H34F2N4O3
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
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CP0903571
|
N-[(4-ethylsulfanyl-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidyl]ethyl]indole-3-carboxamide
Show/Hide
|
C28H35F3N4O2S
|
1
|
| 1 |
EC50 = 45.3 nM
|
|
|
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CP0912030
|
(R)-N-((4-(cyclobutylthio)-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C30H37F3N4O2S
|
1
|
| 1 |
EC50 = 48.5 nM
|
|
|
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CP0677621
|
(R)-1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
Show/Hide
|
C27H36N4O5S
|
2
|
| 1 |
EC50 = 80 nM
|
|
|
| 2 |
IC50 = 80 nM
|
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|
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CP0863012
|
(R)-N-((4-chloro-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C26H30ClF3N4O2
|
1
|
| 1 |
EC50 < 100 nM
|
|
|
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CP0903295
|
Isopropyl (R)-4-(1-(3-(((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-1H-indol-1-yl)ethyl)-piperidine-1-carboxylate
Show/Hide
|
C29H38N4O5
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
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CP0903296
|
(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methyl-1-(1-(1-(oxetan-3-yl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C28H36N4O4
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
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CP0922321
|
(R)-2-methyl-N-((6-methyl-2-oxo-4-(phenylthio)-1,2-dihydropyridin-3-yl)methyl)-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C32H35F3N4O2S
|
1
|
| 1 |
EC50 = 181 nM
|
|
|
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CP0802162
|
Ethyl (R)-2-(4-(1-(3-(((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-1H-indol-1-yl)ethyl)-piperidin-1-yl)acetate
Show/Hide
|
C29H38N4O5
|
1
|
| 1 |
EC50 = 260 nM
|
|
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CP0774010
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(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methyl-1-(1-(1-(3,3,3-trifluoropropyl)piperidin-4-yl)-ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C28H35F3N4O3
|
1
|
| 1 |
EC50 = 290 nM
|
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CP0833864
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(R)-1-(1-(1-Isobutyrylpiperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
Show/Hide
|
C29H38N4O4
|
1
|
| 1 |
EC50 = 420 nM
|
|
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CP0958193
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(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methyl-1-(1-(1-methylpiperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C26H34N4O3
|
1
|
| 1 |
EC50 = 470 nM
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CP0751487
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(R)-1-(1-(1-(Dimethylcarbamoyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
Show/Hide
|
C28H37N5O4
|
1
|
| 1 |
EC50 = 930 nM
|
|
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CP0959692
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(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C25H32N4O3
|
1
|
| 1 |
EC50 = 1100 nM
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CP0914653
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2-methyl-N-[(6-methyl-4-methylsulfinyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidyl]ethyl]indole-3-carboxamide
Show/Hide
|
C27H33F3N4O3S
|
1
|
| 1 |
EC50 > 304 nM
|
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CP0950711
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2-methyl-N-[(6-methyl-4-methylsulfonyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidyl]ethyl]indole-3-carboxamide
Show/Hide
|
C27H33F3N4O4S
|
1
|
| 1 |
EC50 > 304 nM
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CP0903588
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N-[(6-methoxy-4-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidyl]ethyl]indole-3-carboxamide
Show/Hide
|
C27H33F3N4O3
|
1
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| 1 |
EC50 > 1000 nM
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CP0912031
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N-[(6-chloro-4-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidyl]ethyl]indole-3-carboxamide
Show/Hide
|
C26H30ClF3N4O2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
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CP0004161
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US10155002, Compound 44
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|
C34H44N4O4
|
1
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| 1 |
IC50 = 20 nM
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CP0677622
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(R)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-2-methyl-1H-indole-3-carboxamide
Show/Hide
|
C27H36N4O4S
|
1
|
| 1 |
IC50 = 59 nM
|
|
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CP0719407
|
(R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C25H31N3O4
|
1
|
| 1 |
IC50 = 75 nM
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CP0663934
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(R)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C25H31N3O3
|
1
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| 1 |
IC50 = 98 nM
|
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CP0659753
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(R)-1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-2-methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
Show/Hide
|
C29H40N4O4S
|
1
|
| 1 |
IC50 = 266 nM
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CP0032236
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1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide
Show/Hide
|
C31H38N6O2
|
1
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| 1 |
IC50 = 280 nM
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CP0677625
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(R)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-phenylethyl)-1H-indole-3-carboxamide
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
IC50 = 484 nM
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CP0659754
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(R)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-methylpiperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Show/Hide
|
C26H34N4O2
|
1
|
| 1 |
IC50 = 568 nM
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CP0281730
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N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(2R)-1-methoxypropan-2-yl]-2-methylindole-3-carboxamide
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|
C22H27N3O3
|
1
|
| 1 |
IC50 = 703 nM
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CP0124360
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1-butan-2-yl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylindole-3-carboxamide
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C22H27N3O2
|
1
|
| 1 |
IC50 = 929 nM
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CP0704307
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(R)-1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-2-methyl-N-((6-methyl-2-oxo-4-(2,2,2-trifluoroethoxy)-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
Show/Hide
|
C28H35F3N4O5S
|
1
|
| 1 |
IC50 = 1080 nM
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|
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