General Information of the Compound
| Compound ID |
CP0004161
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| Compound Name |
US10155002, Compound 44
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| Synonyms |
(1,1'-Biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(4-morpholinylmethyl)-
1403254-99-8
E7438
EPZ 6438
EPZ-6438
EPZ6438
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
Q40W93WPE1
Tazemetostat
UNII-Q40W93WPE1
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| Structure |
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| Formula |
C34H44N4O4
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| Molecular Weight |
572.75
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| Canonical SMILES |
CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
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| InChI |
InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
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| InChIKey |
NSQSAUGJQHDYNO-UHFFFAOYSA-N
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| CAS |
1403254-99-8
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03003, Histone-lysine N-methyltransferase EZH2
Protein ID: PT03193, Polycomb protein EED
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000173 | Daudi | Homo sapiens (Human) | 1 |
| 1 |
GI50 > 10000 nM
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TI
LI
LO
TS
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| CL000178 | SU-DHL-6 | Homo sapiens (Human) | 1 |
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GI50 = 1050 nM
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TI
LI
LO
TS
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Clinical Information about the Compound
Drug 1 ( Tazemetostat )
| Drug Name | Tazemetostat | ||
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| Company | Epizyme | ||
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