Brief Information of the Cell Line and Protein
Cell Line ID: CL000017 , HeLa
Synonyms
HELA
Hela
He La
He-La
HeLa-CCL2
Henrietta Lacks cells
Helacyton gartleri
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0030
Protein ID: PT01128 , Tyrosine-protein kinase receptor UFO
Gene Name AXL
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P30530
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000017  Protein ID: PT01128
 
Compound ID Compound Name Compound Formula
CP0396159
1-(6-chloroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
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C22H23ClN8O
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0469674
1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
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C21H23ClN8OS
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0411764
1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpiperidin-4-yl)phenyl)-1H-1,2,4-triazole-3,5-diamine
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C24H28N8O2
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0085680
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-fluorophenyl]-1-thieno[3,2-d]pyrimidin-4-yl-1,2,4-triazole-3,5-diamine
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C25H28FN9S
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0226100
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-thieno[3,2-d]pyrimidin-4-yl-1,2,4-triazole-3,5-diamine
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C25H29N9S
 1
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
CP0474897
1-(6-fluoroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
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C22H23FN8O
 1
1
EC50 = 22 nM
   TI
   LI
   LO
   TS
CP0411762
1-(6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-triazole-3,5-diamine
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C21H26N8O
 1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0544861
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-1-(difluoromethyl)-1H-pyrazole-4-carboxamide
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C22H23ClN8O
 1
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
CP0411763
1-([1]benzothiolo[3,2-d]pyrimidin-4-yl)-3-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-triazole-3,5-diamine
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C24H24N8OS
 1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0226098
1-(6,7-dimethoxyquinazolin-4-yl)-3-N-[4-(4-methylpiperazin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine
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C23H27N9O2
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0396158
[5-amino-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)anilino]-1,2,4-triazol-1-yl]-(4-morpholin-4-ylphenyl)methanone
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C25H30FN7O3
 1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS
CP0116703
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl)-1,2,4-triazole-3,5-diamine
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C28H30N10S
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0423177
1-(2-methylquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
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C23H26N8O
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0563230
1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpiperidin-3-yloxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
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C24H28N8O3
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0423178
3-N-[4-(4-cyclohexylpiperazin-1-yl)-3-fluorophenyl]-1-(6,7-dimethoxyquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
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C28H34FN9O2
 1
1
EC50 = 55 nM
   TI
   LI
   LO
   TS
CP0356105
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-fluorophenyl]-1-(7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
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C26H30FN9S
 1
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
CP0476449
N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(6,7-dimethoxyquinazolin-4-yl)-1H-1,2,4-triazole-3,5-diamine
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C24H27ClN8O3
 1
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
CP0072335
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-chlorophenyl]-1-(6,7-dimethoxyquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
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C29H34ClN9O2
 1
1
EC50 = 68 nM
   TI
   LI
   LO
   TS
CP0544860
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-chlorophenyl]-1-(6-tert-butylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
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C29H36ClN9S
 1
1
EC50 = 84 nM
   TI
   LI
   LO
   TS
CP0072336
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-chlorophenyl]-1-thieno[2,3-d]pyrimidin-4-yl-1,2,4-triazole-3,5-diamine
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C25H28ClN9S
 1
1
EC50 = 85 nM
   TI
   LI
   LO
   TS
CP0396160
3-N-[4-[4-[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]piperazin-1-yl]-3-chlorophenyl]-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
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C26H29Cl2N9S
 1
1
EC50 = 136 nM
   TI
   LI
   LO
   TS
CP0562939
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
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C26H30ClN9S
 1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
CP0423179
1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-((S)-3-(dimethylamino) pyrrolidin-1-yl)phenyl)-1H-1,2,4-triazole-3,5-diamine
   Show/Hide
C24H29N9O2
 1
1
EC50 = 193 nM
   TI
   LI
   LO
   TS
CP0396161
3-N-[4-[4-[(1R,2R,4S)-2-bicyclo[2.2.1]heptanyl]piperazin-1-yl]-3-chlorophenyl]-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
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C26H29Cl2N9S
 1
1
EC50 = 216 nM
   TI
   LI
   LO
   TS
CP0567112
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(6-fluoroquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
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C27H30FN9
 1
1
EC50 = 253 nM
   TI
   LI
   LO
   TS
CP0558883
N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine
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C19H22FN7O
 1
1
EC50 = 334 nM
   TI
   LI
   LO
   TS
CP0274212
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-isoquinolin-1-yl-1,2,4-triazole-3,5-diamine
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C28H32N8
 1
1
EC50 = 350 nM
   TI
   LI
   LO
   TS
CP0235825
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(2-methylquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
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C28H33N9
 1
1
EC50 = 397 nM
   TI
   LI
   LO
   TS
CP0356104
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(6-chloroquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
   Show/Hide
C27H30ClN9
 1
1
EC50 = 485 nM
   TI
   LI
   LO
   TS