Compound ID |
Compound Name |
Compound Formula |
CP0396159
|
1-(6-chloroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C22H23ClN8O
|
1
|
1 |
EC50 = 4 nM
|
|
|
CP0469674
|
1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C21H23ClN8OS
|
1
|
1 |
EC50 = 12 nM
|
|
|
CP0411764
|
1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpiperidin-4-yl)phenyl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C24H28N8O2
|
1
|
1 |
EC50 = 16 nM
|
|
|
CP0085680
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-fluorophenyl]-1-thieno[3,2-d]pyrimidin-4-yl-1,2,4-triazole-3,5-diamine
Show/Hide
|
C25H28FN9S
|
1
|
1 |
EC50 = 20 nM
|
|
|
CP0226100
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-thieno[3,2-d]pyrimidin-4-yl-1,2,4-triazole-3,5-diamine
Show/Hide
|
C25H29N9S
|
1
|
1 |
EC50 = 21 nM
|
|
|
CP0474897
|
1-(6-fluoroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C22H23FN8O
|
1
|
1 |
EC50 = 22 nM
|
|
|
CP0411762
|
1-(6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-triazole-3,5-diamine
Show/Hide
|
C21H26N8O
|
1
|
1 |
EC50 = 23 nM
|
|
|
CP0544861
|
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-1-(difluoromethyl)-1H-pyrazole-4-carboxamide
Show/Hide
|
C22H23ClN8O
|
1
|
1 |
EC50 = 27 nM
|
|
|
CP0411763
|
1-([1]benzothiolo[3,2-d]pyrimidin-4-yl)-3-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-triazole-3,5-diamine
Show/Hide
|
C24H24N8OS
|
1
|
1 |
EC50 = 28 nM
|
|
|
CP0226098
|
1-(6,7-dimethoxyquinazolin-4-yl)-3-N-[4-(4-methylpiperazin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine
Show/Hide
|
C23H27N9O2
|
1
|
1 |
EC50 = 39 nM
|
|
|
CP0396158
|
[5-amino-3-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)anilino]-1,2,4-triazol-1-yl]-(4-morpholin-4-ylphenyl)methanone
Show/Hide
|
C25H30FN7O3
|
1
|
1 |
EC50 = 47 nM
|
|
|
CP0116703
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C28H30N10S
|
1
|
1 |
EC50 = 52 nM
|
|
|
CP0423177
|
1-(2-methylquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C23H26N8O
|
1
|
1 |
EC50 = 52 nM
|
|
|
CP0563230
|
1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpiperidin-3-yloxy)phenyl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C24H28N8O3
|
1
|
1 |
EC50 = 52 nM
|
|
|
CP0423178
|
3-N-[4-(4-cyclohexylpiperazin-1-yl)-3-fluorophenyl]-1-(6,7-dimethoxyquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C28H34FN9O2
|
1
|
1 |
EC50 = 55 nM
|
|
|
CP0356105
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-fluorophenyl]-1-(7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C26H30FN9S
|
1
|
1 |
EC50 = 62 nM
|
|
|
CP0476449
|
N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(6,7-dimethoxyquinazolin-4-yl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C24H27ClN8O3
|
1
|
1 |
EC50 = 62 nM
|
|
|
CP0072335
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-chlorophenyl]-1-(6,7-dimethoxyquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C29H34ClN9O2
|
1
|
1 |
EC50 = 68 nM
|
|
|
CP0544860
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-chlorophenyl]-1-(6-tert-butylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C29H36ClN9S
|
1
|
1 |
EC50 = 84 nM
|
|
|
CP0072336
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]-3-chlorophenyl]-1-thieno[2,3-d]pyrimidin-4-yl-1,2,4-triazole-3,5-diamine
Show/Hide
|
C25H28ClN9S
|
1
|
1 |
EC50 = 85 nM
|
|
|
CP0396160
|
3-N-[4-[4-[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]piperazin-1-yl]-3-chlorophenyl]-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C26H29Cl2N9S
|
1
|
1 |
EC50 = 136 nM
|
|
|
CP0562939
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C26H30ClN9S
|
1
|
1 |
EC50 = 170 nM
|
|
|
CP0423179
|
1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-((S)-3-(dimethylamino) pyrrolidin-1-yl)phenyl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C24H29N9O2
|
1
|
1 |
EC50 = 193 nM
|
|
|
CP0396161
|
3-N-[4-[4-[(1R,2R,4S)-2-bicyclo[2.2.1]heptanyl]piperazin-1-yl]-3-chlorophenyl]-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C26H29Cl2N9S
|
1
|
1 |
EC50 = 216 nM
|
|
|
CP0567112
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(6-fluoroquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C27H30FN9
|
1
|
1 |
EC50 = 253 nM
|
|
|
CP0558883
|
N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine
Show/Hide
|
C19H22FN7O
|
1
|
1 |
EC50 = 334 nM
|
|
|
CP0274212
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-isoquinolin-1-yl-1,2,4-triazole-3,5-diamine
Show/Hide
|
C28H32N8
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0235825
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(2-methylquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C28H33N9
|
1
|
1 |
EC50 = 397 nM
|
|
|
CP0356104
|
3-N-[4-[4-(2-bicyclo[2.2.1]heptanyl)piperazin-1-yl]phenyl]-1-(6-chloroquinazolin-4-yl)-1,2,4-triazole-3,5-diamine
Show/Hide
|
C27H30ClN9
|
1
|
1 |
EC50 = 485 nM
|
|
|