| Compound ID |
Compound Name |
Compound Formula |
|
CP0560870
|
6-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydronaphthalen-1(2H)-one
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|
C18H17F3N4O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0515037
|
N4-cyclopropyl-N2-(quinolin-6-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
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|
C17H14F3N5
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0515043
|
N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
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|
C15H13F3N6
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0555696
|
N2-(1H-benzo[d][1,2,3]triazol-6-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
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|
C14H12F3N7
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0576718
|
N4-cyclopropyl-N2-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
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|
C17H17F3N4O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0489042
|
US10266549, Example 349
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|
C16H17F3N4O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0535130
|
N4-cyclopropyl-N2-(quinoxalin-6-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
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|
C16H13F3N6
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0558779
|
N-(4-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide
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|
C18H18F3N5O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0495717
|
N4-cyclopropyl-N2-(5-methoxypyridin-3-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
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|
C14H14F3N5O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0515040
|
US10266549, Example 158a
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|
C16H15F3N4O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0558848
|
N4-cyclopropyl-N2-(1H-indazol-5-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
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|
C15H13F3N6
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0515042
|
N4-cyclopropyl-N2-(quinolin-3-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
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|
C17H14F3N5
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0495718
|
US10266549, Example 161a
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|
C16H15F3N6
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0537630
|
US10266549, Example 208a
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|
C15H12F3N5O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0540134
|
US10266549, Example 304a
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|
C14H14F3N5
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0553085
|
N2-(benzo[d][1,3]dioxol-5-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
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|
C15H13F3N4O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0560871
|
N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluoromethyl) pyrimidine-2,4-diamine
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|
C16H14F3N5
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0515038
|
US10266549, Example 152a
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|
C15H13F3N6
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0540140
|
N-(cyclopropanecarbonyl)-N-(4-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide
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|
C22H22F3N5O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0535131
|
N4-cyclopropyl-N2-(4-ethyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
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|
C17H19F3N6O
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0569808
|
US10266549, Example 182a
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|
C13H11F3N6
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0489044
|
US10266549, Example 221a
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|
C12H11F3N6
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0555697
|
N4-cyclopropyl-N2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
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|
C15H11F5N4O2
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0515041
|
2-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenol
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|
C14H13F3N4O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0331654
|
2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide
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|
C21H21BrN4O5
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0569864
|
US10266549, Example 165b
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|
C12H9F3N4O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0382724
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C49H54BF2N7O7
|
1
|
| 1 |
Kd = 135 nM
|
|
|
|
CP0382649
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C50H56BF2N7O7
|
1
|
| 1 |
Kd = 311 nM
|
|
|
