INCB-018424

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-morpholin-4-ylethyl)thieno[3,2-c]pyridine-7-carboxamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-methoxyethyl)thieno[3,2-c]pyridine-7-carboxamide

3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

4-amino-2-[4-(2-cyanopropan-2-yl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-piperidin-1-ylethyl)thieno[3,2-c]pyridine-7-carboxamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(3-morpholin-4-ylpropyl)thieno[3,2-c]pyridine-7-carboxamide

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-[2-(dimethylamino)ethyl]thieno[3,2-c]pyridine-7-carboxamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-hydroxyethyl)thieno[3,2-c]pyridine-7-carboxamide

4-amino-2-(4-tert-butylphenyl)-N-methylthieno[3,2-c]pyridine-7-carboxamide

4-amino-N-methyl-2-[4-(trifluoromethoxy)phenyl]thieno[3,2-c]pyridine-7-carboxamide

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(1H-pyrazol-4-yl)pyridin-2-amine

4-amino-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

4-amino-N-methyl-2-(4-methylphenyl)thieno[3,2-c]pyridine-7-carboxamide

(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(3-piperazin-1-ylphenyl)pyridin-2-amine

4-amino-N-methyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(3-piperidin-4-ylphenyl)pyridin-2-amine

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(4-piperazin-1-ylphenyl)pyridin-2-amine

4-amino-N-ethyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(4-piperidin-4-ylphenyl)pyridin-2-amine

4-amino-N-methyl-2-phenylthieno[3,2-c]pyridine-7-carboxamide

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(oxan-4-yl)pyrazol-4-yl]pyridin-2-amine

4-amino-2-(4-morpholin-4-ylphenyl)-N-phenylthieno[3,2-c]pyridine-7-carboxamide

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (11a)

4-amino-N-benzyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

3-[1-(2,6-dichloro-3-fluorophenyl)propoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(5-piperazin-1-ylpyridin-3-yl)pyridin-2-amine

3-N-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridine-2,3-diamine

3-(1-phenylethoxy)-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

3-[1-(2,6-dichlorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-phenylpyridin-2-amine

2-hydroxy-1-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]ethanone

(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-(3-methyl-1,2-thiazol-5-yl)piperidine-1-carboxamide

3-[(2,6-dichloro-3-fluorophenyl)methoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

N-methyl-N-[(3R,4R)-4-methyl-1-(2,2,2-trifluoroethylsulfonyl)piperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(6-piperazin-1-ylpyridin-3-yl)pyridin-2-amine

4-amino-N,N-dimethyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

4-amino-N-tert-butyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

N-[(3R,4R)-1-[(2,3-difluorophenyl)methyl]-4-methylpiperidin-3-yl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-pyridin-3-ylpyridin-2-amine

3-(1-cyclohexylethoxy)-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide

5-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]-2-phenylmethoxybenzoic acid

5-[4-[[5-amino-3-[4-(methylcarbamoyl)anilino]-1,2,4-triazole-1-carbonyl]amino]phenyl]-2-phenylmethoxybenzoic acid

3-[4-[[5-amino-3-[4-(methylcarbamoyl)anilino]-1,2,4-triazole-1-carbonyl]amino]phenyl]-5-phenylmethoxybenzoic acid

3-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]-5-phenylmethoxybenzoic acid

4-[[5-amino-1-[2,6-difluoro-4-[2-(prop-2-enoylamino)ethyl]benzoyl]-1,2,4-triazol-3-yl]amino]-N-methylbenzamide

(S)-2-(3-(4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)ureido)-4-oxo-4-phenylbutanoic acid

4-[[5-amino-1-[2,6-difluoro-3-[2-(prop-2-enoylamino)ethyl]benzoyl]-1,2,4-triazol-3-yl]amino]-N-methylbenzamide

3-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]benzoic acid

4-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]pyridine-2-carboxylic acid

4-[[5-amino-1-[2,6-difluoro-3-[2-(prop-2-enoylamino)ethoxy]benzoyl]-1,2,4-triazol-3-yl]amino]-N-methylbenzamide

4-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]benzoic acid

4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]-N-methylbenzamide

(S)-2-(3-(4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)ureido)-4-phenylbutanoic acid

(E)-3-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]prop-2-enoic acid

2-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]-1,3-oxazole-4-carboxylic acid

2-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenoxy]acetic acid

5-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]furan-2-carboxylic acid

1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b

4-[[5-amino-1-[3-[2-[[(E)-but-2-enoyl]amino]ethyl]-2,6-difluorobenzoyl]-1,2,4-triazol-3-yl]amino]-N-methylbenzamide

(S)-2-(3-(4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)ureido)-5-phenylpentanoic acid

N-((4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamoyl)-O-benzyl-L-serine

2-[4-[[5-amino-3-(4-cyanoanilino)-1,2,4-triazole-1-carbonyl]amino]phenoxy]acetic acid

5-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]pyridine-3-carboxylic acid

4-[[5-amino-1-[2,6-difluoro-3-[(prop-2-enoylamino)methyl]benzoyl]-1,2,4-triazol-3-yl]amino]-N-methylbenzamide

(S)-2-(3-(4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)ureido)-3-(naphthalen-2-yl)propanoic acid

6-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]pyridine-2-carboxylic acid

({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

6-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]pyrazine-2-carboxylic acid

((4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamoyl)-L-tryptophan

methyl 2-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenoxy]acetate

2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one

((4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamoyl)-L-phenylalanine

((4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamoyl)-L-asparagine

(S)-2-(3-(4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)ureido)-3-(naphthalen-1-yl)propanoic acid

2-[3-[[5-amino-3-(4-cyanoanilino)-1,2,4-triazole-1-carbonyl]amino]phenoxy]acetic acid

((4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamoyl)-L-histidine

5-amino-N-phenyl-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carboxamide

5-[4-[[5-amino-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbonyl]amino]phenyl]-1,3,4-oxadiazole-2-carboxylic acid

((4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamoyl)-D-phenylalanine

5-amino-N-pyridin-3-yl-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carboxamide

((4-((2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamoyl)-L-glutamine

1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3k

4-[4-[(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]anilino]-4-oxobutanoic acid

2-[[4-[(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl]carbamoylamino]acetic acid

5-amino-N-pyridin-2-yl-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carboxamide

5-amino-N-methyl-N-phenyl-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carboxamide