| Compound ID |
Compound Name |
Compound Formula |
|
CP0574638
|
4-fluoro-2-methoxy-3-(1-methylpiperidin-4-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H27FN4O2
|
1
|
| 1 |
IC50 = 0.49 nM
|
|
|
|
CP0871866
|
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide
Show/Hide
|
C29H36ClN7O4S
|
4
|
| 1 |
IC50 = 0.59 nM
|
|
|
| 2 |
IC50 = 0.82 nM
|
|
|
| 3 |
IC50 = 0.92 nM
|
|
|
| 4 |
IC50 = 1 nM
|
|
|
|
CP0066933
|
1256580-46-7
Show/Hide
|
C30H34N4O2
|
4
|
| 1 |
IC50 = 0.59 nM
|
|
|
| 2 |
IC50 = 0.96 nM
|
|
|
| 3 |
IC50 = 1.5 nM
|
|
|
| 4 |
IC50 = 3.9 nM
|
|
|
|
CP0013877
|
CERITINIB
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|
C28H36ClN5O3S
|
4
|
| 1 |
IC50 = 0.61 nM
|
|
|
| 2 |
IC50 = 1.1 nM
|
|
|
| 3 |
IC50 = 1.6 nM
|
|
|
| 4 |
IC50 = 1.9 nM
|
|
|
|
CP0567459
|
4-fluoro-3-[1-(2-hydroxyethyl)piperidin-4-yl]-2-methoxy-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H29FN4O3
|
1
|
| 1 |
IC50 = 0.62 nM
|
|
|
|
CP0469153
|
3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-2-propyl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H31N5O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0516998
|
2-bromo-3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C24H24BrN5O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0562774
|
4-fluoro-2-methoxy-3-[1-(oxan-4-yl)piperidin-4-yl]-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C30H33FN4O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0516995
|
4-fluoro-2-methoxy-11-oxo-5-propan-2-yl-3-(3,3,4-trimethylpiperazin-1-yl)-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H30FN5O2
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0535134
|
5-cyclohexyl-2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C28H31N5O2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0571388
|
2-ethyl-3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H29N5O
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0742340
|
4-Fluoro-5-isopropyl-2-methoxy-11-oxo-3-(cis-3,4,5-trimethylpiperazin-1-yl)-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H30FN5O2
|
4
|
| 1 |
IC50 = 2.2 nM
|
|
|
| 2 |
IC50 = 6.3 nM
|
|
|
| 3 |
IC50 = 8.8 nM
|
|
|
| 4 |
IC50 = 8.9 nM
|
|
|
|
CP0901836
|
(R)-3-(3,4-Dimethylpiperazin-1-yl)-4-fluoro-5-isopropyl-2-methoxy-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H28FN5O2
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0564089
|
3-(4-methylpiperazin-1-yl)-2-(2-methylpropyl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C28H33N5O
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0568438
|
4-fluoro-2-methoxy-11-oxo-5-propan-2-yl-3-(1-propan-2-ylpiperidin-4-yl)-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C28H31FN4O2
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0575035
|
3-(3,3-dimethylpiperazin-1-yl)-4-fluoro-2-methoxy-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H28FN5O2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0955650
|
3-(cis-3,5-Dimethylpiperazin-1-yl)-4-fluoro-5-isopropyl-2-methoxy-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H28FN5O2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0572307
|
3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-2-propoxy-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H31N5O2
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0946112
|
(R)-4-Fluoro-5-isopropyl-2-methoxy-3-(3-methylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C25H26FN5O2
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0537182
|
4-fluoro-2-methoxy-3-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C29H32FN5O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0571387
|
2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0966853
|
(S)-3-(3,4-Dimethylpiperazin-1-yl)-4-fluoro-5-isopropyl-2-methoxy-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H28FN5O2
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0966854
|
(S)-4-Fluoro-5-isopropyl-2-methoxy-3-(3-methylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C25H26FN5O2
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0568439
|
5-cyclopentyl-2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H29N5O2
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0966135
|
5-(sec-Butyl)-2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H29N5O2
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0552727
|
2-butoxy-3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C28H33N5O2
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0567562
|
4-fluoro-2-methoxy-3-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C28H29FN4O3
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0495721
|
3-[4-(dimethylamino)piperidin-1-yl]-4-fluoro-2-methoxy-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H30FN5O2
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
|
CP0571386
|
3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-2-propan-2-yloxy-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H31N5O2
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
|
CP0550303
|
2,4-difluoro-3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C24H23F2N5O
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0964612
|
2-Methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-5-(pentan-2-yl)-6,11-dihydro-5H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H31N5O2
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0516996
|
4-fluoro-2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C25H26FN5O2
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0444301
|
(3S)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H30F3N5O5
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0537183
|
5-cyclobutyl-2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H27N5O2
|
1
|
| 1 |
IC50 = 12.7 nM
|
|
|
|
CP0575036
|
2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-5-propyl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
IC50 = 13.5 nM
|
|
|
|
CP0432571
|
(3S)-N-[[3-(trifluoromethoxy)phenyl]methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H30F3N5O5
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0490649
|
5-cyclopropyl-2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C25H25N5O2
|
1
|
| 1 |
IC50 = 16.5 nM
|
|
|
|
CP0432990
|
(3S)-N-[(3-phenylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C32H35N5O4
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0516997
|
4-fluoro-3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C24H24FN5O
|
1
|
| 1 |
IC50 = 19.8 nM
|
|
|
|
CP0495722
|
5-ethyl-2-methoxy-3-(4-methylpiperazin-1-yl)-11-oxo-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C24H25N5O2
|
1
|
| 1 |
IC50 = 20.6 nM
|
|
|
|
CP0550304
|
3-(4-methylpiperazin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 = 21.3 nM
|
|
|
|
CP0444915
|
US9428500, 52
Show/Hide
|
C37H36N4O2
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 310 nM
|
|
|
|
CP0550305
|
3-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5-propan-2-yl-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C28H31N5O2
|
1
|
| 1 |
IC50 = 28.6 nM
|
|
|
|
CP0389904
|
(3S)-N-[(3-morpholin-4-ylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C30H38N6O5
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0474951
|
US9428500, 58
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|
C34H37N5
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
|
CP0031719
|
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
Show/Hide
|
C21H22Cl2FN5O
|
4
|
| 1 |
IC50 = 34.5 nM
|
|
|
| 2 |
IC50 = 1035 nM
|
|
|
| 3 |
IC50 = 1066 nM
|
|
|
| 4 |
IC50 = 1540 nM
|
|
|
|
CP0499658
|
US9428500, 16
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|
C35H32N4
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 230 nM
|
|
|
|
CP0483734
|
3-(4-methylpiperazin-1-yl)-11-oxo-2,5-di(propan-2-yl)-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C27H31N5O
|
1
|
| 1 |
IC50 = 40.5 nM
|
|
|
|
CP0474833
|
US9428500, 24
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|
C38H32N4
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0526165
|
US9428500, 12
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|
C36H33ClN4O
|
2
|
| 1 |
IC50 = 52 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0444303
|
methyl 3-[[[(3S)-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carbonyl]amino]methyl]benzoate
Show/Hide
|
C28H33N5O6
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0504207
|
(3S)-N-[(3-nitrophenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C26H30N6O6
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0416087
|
(3S)-N-[(3-chlorophenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C26H30ClN5O4
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0474826
|
US9428500, 2
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|
C30H28N4
|
2
|
| 1 |
IC50 = 82 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0444304
|
(3S)-N-[(3-methylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H33N5O4
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0451348
|
US9428500, 13
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|
C30H27FN4
|
2
|
| 1 |
IC50 = 91 nM
|
|
|
| 2 |
IC50 = 370 nM
|
|
|
|
CP0416115
|
(3S)-N-[(4-chlorophenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C26H30ClN5O4
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0451582
|
US9428500, 10
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|
C31H30N4O
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0478480
|
US9428500, 14
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|
C31H27F3N4
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 280 nM
|
|
|
|
CP0483113
|
US9428500, 40
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|
C30H25FN4
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 890 nM
|
|
|
|
CP0492914
|
US9428500, 37
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|
C30H26N4
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 170 nM
|
|
|
|
CP0504208
|
(3S)-N-[(4-phenylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C32H35N5O4
|
1
|
| 1 |
IC50 = 138 nM
|
|
|
|
CP0451461
|
US9428500, 17
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|
C34H30N4
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 210 nM
|
|
|
|
CP0483115
|
US9428500, 23
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|
C35H30N4O
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 540 nM
|
|
|
|
CP0483116
|
US9428500, 41
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|
C30H25FN4
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
|
CP0516759
|
US9428500, 18
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|
C30H27FN4
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 460 nM
|
|
|
|
CP0479883
|
US9428500, 28
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|
C31H30N4
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 270 nM
|
|
|
|
CP0518485
|
US9428500, 11
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|
C31H27F3N4
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 260 nM
|
|
|
|
CP0478479
|
US9428500, 7
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|
C31H30N4O
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
IC50 = 1200 nM
|
|
|
|
CP0065822
|
(3S)-N-[(4-methylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H33N5O4
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0499660
|
US9428500, 34
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|
C28H26N6O2
|
2
|
| 1 |
IC50 = 180 nM
|
|
|
| 2 |
IC50 = 560 nM
|
|
|
|
CP0499659
|
US9428500, 29
Show/Hide
|
C31H31N5O2S
|
2
|
| 1 |
IC50 = 190 nM
|
|
|
| 2 |
IC50 = 440 nM
|
|
|
|
CP0464364
|
(3S)-N-[(3-phenoxyphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C32H35N5O5
|
1
|
| 1 |
IC50 = 192 nM
|
|
|
|
CP0905963
|
US9428500, 33
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|
C35H32N4O
|
2
|
| 1 |
IC50 = 230 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0516757
|
US9428500, 6
Show/Hide
|
C30H27FN4
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
|
CP0492915
|
US9428500, 39
Show/Hide
|
C31H25F3N4
|
2
|
| 1 |
IC50 = 270 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
|
CP0444914
|
US9428500, 38
Show/Hide
|
C31H28N4O
|
2
|
| 1 |
IC50 = 290 nM
|
|
|
| 2 |
IC50 = 750 nM
|
|
|
|
CP0465797
|
US9428500, 42
Show/Hide
|
C30H25ClN4
|
2
|
| 1 |
IC50 = 290 nM
|
|
|
| 2 |
IC50 = 940 nM
|
|
|
|
CP0483114
|
US9428500, 19
Show/Hide
|
C30H27ClN4
|
2
|
| 1 |
IC50 = 320 nM
|
|
|
| 2 |
IC50 = 880 nM
|
|
|
|
CP0519491
|
US9428500, 15
Show/Hide
|
C34H29FN4
|
2
|
| 1 |
IC50 = 320 nM
|
|
|
| 2 |
IC50 = 970 nM
|
|
|
|
CP0444305
|
(3S)-1-[2-(3,5-dimethoxyanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C26H31N5O3
|
1
|
| 1 |
IC50 = 325 nM
|
|
|
|
CP0389898
|
(3S)-N-[(2-methylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H33N5O4
|
1
|
| 1 |
IC50 = 341 nM
|
|
|
|
CP0451347
|
US9428500, 9
Show/Hide
|
C36H31F3N4O
|
2
|
| 1 |
IC50 = 350 nM
|
|
|
| 2 |
IC50 = 1700 nM
|
|
|
|
CP0451459
|
US9428500, 4
Show/Hide
|
C29H27N5
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0464367
|
(3S)-N-(2-phenylethyl)-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H33N5O4
|
1
|
| 1 |
IC50 = 358 nM
|
|
|
|
CP0474004
|
(3S)-N-benzyl-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C26H31N5O4
|
1
|
| 1 |
IC50 = 364 nM
|
|
|
|
CP0474827
|
US9428500, 5
Show/Hide
|
C34H30N4
|
2
|
| 1 |
IC50 = 510 nM
|
|
|
| 2 |
IC50 = 680 nM
|
|
|
|
CP0465955
|
US9428500, 26
Show/Hide
|
C37H36N4O2
|
2
|
| 1 |
IC50 = 520 nM
|
|
|
| 2 |
IC50 = 590 nM
|
|
|
|
CP0125669
|
(3S)-N-[(2-chlorophenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C26H30ClN5O4
|
1
|
| 1 |
IC50 = 587 nM
|
|
|
|
CP0536000
|
US9428500, 59
Show/Hide
|
C33H36N6
|
2
|
| 1 |
IC50 = 690 nM
|
|
|
| 2 |
IC50 = 1000 nM
|
|
|
|
CP0516771
|
US9428500, 21
Show/Hide
|
C40H41N5
|
2
|
| 1 |
IC50 = 710 nM
|
|
|
| 2 |
IC50 = 1700 nM
|
|
|
|
CP0310887
|
3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (11a)
Show/Hide
|
C21H22Cl2FN5O
|
2
|
| 1 |
IC50 = 800 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0480896
|
US9428500, 51
Show/Hide
|
C36H32N4O3
|
2
|
| 1 |
IC50 = 830 nM
|
|
|
| 2 |
IC50 = 2800 nM
|
|
|
|
CP0389896
|
(3S)-N-phenyl-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C25H29N5O4
|
1
|
| 1 |
IC50 = 833 nM
|
|
|
|
CP0519493
|
US9428500, 48
Show/Hide
|
C34H30N4O
|
2
|
| 1 |
IC50 = 840 nM
|
|
|
| 2 |
IC50 = 7200 nM
|
|
|
|
CP0571693
|
6-(4-methoxyphenyl)-4-[(E)-2-phenylethenyl]-9H-pyrido[2,3-b]indole
Show/Hide
|
C26H20N2O
|
2
|
| 1 |
IC50 = 860 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
|
CP0465793
|
US9428500, 22
Show/Hide
|
C36H36F3N5
|
2
|
| 1 |
IC50 = 880 nM
|
|
|
| 2 |
IC50 = 2900 nM
|
|
|
|
CP0499656
|
US9428500, 36
Show/Hide
|
C33H35N7O2
|
2
|
| 1 |
IC50 = 890 nM
|
|
|
| 2 |
IC50 = 8500 nM
|
|
|
|
CP0492665
|
US9428500, 8
Show/Hide
|
C35H32N4O
|
2
|
| 1 |
IC50 = 900 nM
|
|
|
| 2 |
IC50 = 2200 nM
|
|
|
|
CP0453058
|
(3S)-1-[2-(3-ethylanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C26H31N5O
|
1
|
| 1 |
IC50 = 912 nM
|
|
|
|
CP0480895
|
US9428500, 49
Show/Hide
|
C33H28FN5
|
2
|
| 1 |
IC50 = 920 nM
|
|
|
| 2 |
IC50 = 1800 nM
|
|
|
|
CP0550181
|
6-[4-(4,4-dimethylpiperazin-4-ium-1-yl)phenyl]-4-[2-[2-(trifluoromethyl)phenyl]ethynyl]-9H-pyrido[2,3-b]indole
Show/Hide
|
C32H28F3N4+
|
2
|
| 1 |
IC50 = 970 nM
|
|
|
| 2 |
IC50 = 3000 nM
|
|
|
|
CP0483354
|
US9428500, 1
Show/Hide
|
C22H21ClN4
|
2
|
| 1 |
IC50 = 1000 nM
|
|
|
| 2 |
IC50 = 2100 nM
|
|
|
|
CP0416120
|
(3S)-1-[2-(3-methoxyanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C25H29N5O2
|
1
|
| 1 |
IC50 = 1020 nM
|
|
|
|
CP0499655
|
US9428500, 25
Show/Hide
|
C36H32N4
|
2
|
| 1 |
IC50 = 1200 nM
|
|
|
| 2 |
IC50 = 1600 nM
|
|
|
|
CP0474830
|
US9428500, 53
Show/Hide
|
C36H34N4O2
|
2
|
| 1 |
IC50 = 1300 nM
|
|
|
| 2 |
IC50 = 4300 nM
|
|
|
|
CP0465794
|
US9428500, 30
Show/Hide
|
C32H32N4
|
2
|
| 1 |
IC50 = 1400 nM
|
|
|
| 2 |
IC50 = 1500 nM
|
|
|
|
CP0571122
|
4-[(E)-2-phenylethenyl]-9H-pyrido[2,3-b]indole
Show/Hide
|
C19H14N2
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0432566
|
(3S)-1-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C26H29N5O3
|
1
|
| 1 |
IC50 = 1480 nM
|
|
|
|
CP0474828
|
US9428500, 27
Show/Hide
|
C32H32N4O
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
IC50 = 1800 nM
|
|
|
|
CP0550155
|
2-[4-[4-[4-(4-benzylphenyl)-9H-pyrido[2,3-b]indol-6-yl]phenyl]-1-methylpiperazin-1-ium-1-yl]acetic acid
Show/Hide
|
C37H35N4O2+
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
IC50 = 1800 nM
|
|
|
|
CP0503869
|
2-Amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)pyridine-3,5-dicarbonitrile
Show/Hide
|
C19H12N4OS2
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0432999
|
methyl 4-[[[(3S)-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carbonyl]amino]methyl]benzoate
Show/Hide
|
C28H33N5O6
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0416118
|
(3S)-1-[2-(3,4-dimethoxyanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C26H31N5O3
|
1
|
| 1 |
IC50 = 1730 nM
|
|
|
|
CP0564485
|
6-[4-(4-methylpiperazin-1-yl)phenyl]-N-(3-nitrophenyl)-9H-pyrido[2,3-b]indol-4-amine
Show/Hide
|
C28H26N6O2
|
2
|
| 1 |
IC50 = 1800 nM
|
|
|
| 2 |
IC50 = 1900 nM
|
|
|
|
CP0444306
|
(3S)-1-[2-(3-chloroanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C24H26ClN5O
|
1
|
| 1 |
IC50 = 2010 nM
|
|
|
|
CP0474003
|
(3S)-N-[(1R)-1-phenylethyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H33N5O4
|
1
|
| 1 |
IC50 = 2010 nM
|
|
|
|
CP0469044
|
2-(benzylthio)-4-(thiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Show/Hide
|
C21H18N2S2
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0475693
|
US9428500, 54
Show/Hide
|
C36H31F3N4
|
2
|
| 1 |
IC50 = 2100 nM
|
|
|
| 2 |
IC50 = 2200 nM
|
|
|
|
CP0465957
|
US9428500, 50
Show/Hide
|
C37H34N4O3
|
2
|
| 1 |
IC50 = 2300 nM
|
|
|
| 2 |
IC50 = 8200 nM
|
|
|
|
CP0550180
|
(4-methylpiperazin-1-yl)-[4-[4-[(E)-2-phenylethenyl]-9H-pyrido[2,3-b]indol-6-yl]phenyl]methanone
Show/Hide
|
C31H28N4O
|
1
|
| 1 |
IC50 = 2300 nM
|
|
|
|
CP0504221
|
(3S)-1-(2-anilinopyrimidin-4-yl)-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C24H27N5O
|
1
|
| 1 |
IC50 = 2320 nM
|
|
|
|
CP0516999
|
5-methyl-3-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-6H-indolo[2,3-b]quinoline-8-carbonitrile
Show/Hide
|
C26H27N5O2
|
1
|
| 1 |
IC50 = 2503 nM
|
|
|
|
CP0548482
|
(3S)-N-[(1S)-1-phenylethyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H33N5O4
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0389895
|
(3S)-N-[(4-nitrophenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C26H30N6O6
|
1
|
| 1 |
IC50 = 2930 nM
|
|
|
|
CP0464365
|
(3S)-N-phenacyl-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H31N5O5
|
1
|
| 1 |
IC50 = 2940 nM
|
|
|
|
CP0389901
|
(3S)-1-[2-(4-methoxyanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C25H29N5O2
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
|
CP0480897
|
US9428500, 55
Show/Hide
|
C36H31F3N4
|
2
|
| 1 |
IC50 = 3200 nM
|
|
|
| 2 |
IC50 = 7900 nM
|
|
|
|
CP0535990
|
US9428500, 32
Show/Hide
|
C33H44N4Si
|
2
|
| 1 |
IC50 = 3200 nM
|
|
|
| 2 |
IC50 = 7100 nM
|
|
|
|
CP0576271
|
4-(4-benzylphenyl)-6-[4-(4-prop-2-ynylpiperazin-1-yl)phenyl]-9H-pyrido[2,3-b]indole
Show/Hide
|
C37H32N4
|
2
|
| 1 |
IC50 = 3600 nM
|
|
|
| 2 |
IC50 = 6200 nM
|
|
|
|
CP0476541
|
2-(4-fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Show/Hide
|
C21H17FN2S2
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0579991
|
6-[4-(4-methylpiperazin-1-yl)phenyl]-N-(2-propan-2-ylsulfonylphenyl)-9H-pyrido[2,3-b]indol-4-amine
Show/Hide
|
C31H33N5O2S
|
2
|
| 1 |
IC50 = 4100 nM
|
|
|
| 2 |
IC50 = 4400 nM
|
|
|
|
CP0423943
|
(3R)-N-[(4-methylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C27H33N5O4
|
1
|
| 1 |
IC50 = 4120 nM
|
|
|
|
CP0516768
|
US9428500, 43
Show/Hide
|
C33H42N4Si
|
2
|
| 1 |
IC50 = 4900 nM
|
|
|
| 2 |
IC50 = 6200 nM
|
|
|
|
CP0464366
|
(3S)-1-[2-(4-chloroanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C24H26ClN5O
|
1
|
| 1 |
IC50 = 6300 nM
|
|
|
|
CP0474831
|
US9428500, 3
Show/Hide
|
C32H29F3N4
|
2
|
| 1 |
IC50 = 6400 nM
|
|
|
| 2 |
IC50 = 7600 nM
|
|
|
|
CP0389899
|
(3S)-N-(3-phenylpropyl)-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C28H35N5O4
|
1
|
| 1 |
IC50 = 6710 nM
|
|
|
|
CP0477650
|
US9428500, 56
Show/Hide
|
C37H36N4O2
|
2
|
| 1 |
IC50 = 7900 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0910273
|
US9428500, 57
Show/Hide
|
C37H36N4O3
|
2
|
| 1 |
IC50 = 8700 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0571692
|
4-(4-benzylphenyl)-6-[4-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-9H-pyrido[2,3-b]indole
Show/Hide
|
C44H42N4O3
|
2
|
| 1 |
IC50 = 9500 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0578628
|
tert-butyl 4-[4-[4-(4-benzylphenyl)-9H-pyrido[2,3-b]indol-6-yl]phenyl]piperazine-1-carboxylate
Show/Hide
|
C39H38N4O2
|
2
|
| 1 |
IC50 = 9600 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0476539
|
2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile
Show/Hide
|
C19H11ClN4OS2
|
1
|
| 1 |
IC50 = 9700 nM
|
|
|
|
CP0474836
|
US9428500, 44
Show/Hide
|
C24H22N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0569276
|
1-(4-chloro-9H-pyrido[2,3-b]indol-6-yl)-2-[2-(diethylamino)ethylsulfanyl]ethanone
Show/Hide
|
C19H22ClN3OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0571126
|
(E)-1-[4-(4-benzylphenyl)-9H-pyrido[2,3-b]indol-6-yl]-3-(dimethylamino)prop-2-en-1-one
Show/Hide
|
C29H25N3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0574474
|
4-(4-benzylphenyl)-6-[4-[4-(pyridin-3-ylmethyl)piperazin-1-yl]phenyl]-9H-pyrido[2,3-b]indole
Show/Hide
|
C40H35N5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0575921
|
methyl 2-benzyl-5-[6-[4-(4-methylpiperazin-1-yl)phenyl]-9H-pyrido[2,3-b]indol-4-yl]benzoate
Show/Hide
|
C37H34N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0966286
|
2-(hydroxy(phenyl)methyl)-4-methoxy-5-(6-(4-(4-methylpiperazin-1-yl)phenyl)-9H-pyrido[2,3-b]indol-4-yl)phenol
Show/Hide
|
C36H34N4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0548433
|
4-(4-methoxyphenyl)-9H-pyrido[2,3-b]indole
Show/Hide
|
C18H14N2O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0574572
|
N-(2-nitrophenyl)-9H-pyrido[2,3-b]indol-4-amine
Show/Hide
|
C17H12N4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0389903
|
(3S)-1-[2-(benzylamino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C25H29N5O
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0416119
|
(3S)-1-[2-(4-ethylanilino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C26H31N5O
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0444302
|
(3S)-1-[2-(methylamino)pyrimidin-4-yl]-N-[(4-methylphenyl)methyl]piperidine-3-carboxamide
Show/Hide
|
C19H25N5O
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0400670
|
2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Show/Hide
|
C22H18N2OS2
|
1
|
| 1 |
IC50 = 35000 nM
|
|
|
|
CP0548691
|
3-(4-morpholin-4-ylpiperidin-1-yl)-5,6-dihydroindolo[2,3-b]quinolin-11-one
Show/Hide
|
C24H26N4O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
