Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide
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 PubChem ID
CID: 129281909
Canonical SMILES
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N1CCCN(C)CC1
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Compound Formula C29H36ClN7O4S
Compound Structure
Protein Name
 Protein Info 
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  4
1
GI50 = 1 nM
   TI
   LI
   LO
   TS
2
GI50 = 6.9 nM
   TI
   LI
   LO
   TS
3
GI50 = 29 nM
   TI
   LI
   LO
   TS
4
GI50 = 460 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  4
1
IC50 = 0.59 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.82 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.92 nM
   TI
   LI
   LO
   TS
4
IC50 = 1 nM
   TI
   LI
   LO
   TS