| Compound ID |
Compound Name |
Compound Formula |
|
CP0033135
|
N-[2-[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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C27H30F3N7O3S
|
1
|
| 1 |
IC50 < 0.5 nM
|
|
|
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CP0554977
|
N-methyl-N-[2-[2-(4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]methanesulfonamide
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|
C25H27F3N6O3S
|
1
|
| 1 |
IC50 = 0.94 nM
|
|
|
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CP0004106
|
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one
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|
C28H26N4O3
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
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CP0477193
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N-[2-[2-(1,3-benzodioxol-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C22H20F3N5O4S
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
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CP0482093
|
N-[2-[2-(3,5-dimethoxyanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C23H24F3N5O4S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
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CP0482204
|
N-[2-[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C28H32F3N7O4S
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
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CP0554976
|
N-[2-[2-[3-methoxy-5-(trifluoromethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C23H21F6N5O3S
|
1
|
| 1 |
IC50 = 890 nM
|
|
|
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CP0559668
|
N-methyl-N-[2-[5-(trifluoromethyl)-2-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]methanesulfonamide
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|
C22H19F6N5O2S
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
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CP0417586
|
N-methyl-N-[2-[2-(3-phenoxyanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]methanesulfonamide
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|
C27H24F3N5O3S
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0537924
|
N-[2-[2-(2,4-dimethylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C23H24F3N5O2S
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0417585
|
N-[2-[2-(4-fluoro-2-methylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C22H21F4N5O2S
|
1
|
| 1 |
IC50 = 9100 nM
|
|
|
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CP0437299
|
N-[2-[2-[4-chloro-3-(trifluoromethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C22H18ClF6N5O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0458290
|
N-methyl-N-[2-[5-(trifluoromethyl)-2-[4-(trifluoromethyl)anilino]pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]methanesulfonamide
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|
C22H19F6N5O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0482203
|
N-methyl-N-[2-[2-(2-morpholin-4-ylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]methanesulfonamide
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|
C25H27F3N6O3S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0509688
|
N-[2-[2-[4-methoxy-3-(trifluoromethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
Show/Hide
|
C23H21F6N5O3S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0509689
|
N-[2-[2-(3,5-dimethylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C23H24F3N5O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0509690
|
N-[2-[2-(4-chloro-2-methylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C22H21ClF3N5O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0509692
|
N-[2-[2-(4-anilinoanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C27H25F3N6O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0538413
|
N-[2-[2-(2-chloro-4-methylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
Show/Hide
|
C22H21ClF3N5O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0549023
|
N-[2-[2-[2-methoxy-5-(trifluoromethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
Show/Hide
|
C23H21F6N5O3S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0559086
|
N-[2-[2-[3,5-bis(trifluoromethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
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|
C23H18F9N5O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0563550
|
N-[2-[2-(4-chloro-2,5-dimethoxyanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
Show/Hide
|
C23H23ClF3N5O4S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0567484
|
N-[2-[2-(3,4-dimethylanilino)-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
Show/Hide
|
C23H24F3N5O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
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CP0477192
|
N-[2-[2-[3-chloro-5-(trifluoromethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
Show/Hide
|
C22H18ClF6N5O2S
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0382724
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C49H54BF2N7O7
|
1
|
| 1 |
Kd = 313 nM
|
|
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CP0382649
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3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
Show/Hide
|
C50H56BF2N7O7
|
1
|
| 1 |
Kd = 559 nM
|
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