Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT06639 , C-C chemokine receptor type 5
Gene Name CCR5
Organism Macaca fascicularis, Crab-eating macaque, Cynomolgus monkey
Protein Classification Membrane receptor
Uniprot ID P61814
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT06639
 
Compound ID Compound Name Compound Formula
CP0405010
(2,6-Dimethyl-phenyl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C32H39N3O
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0405004
(2,4-dimethylpyridin-3-yl)(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C30H37N5O
 1
1
IC50 = 0.8 nM
   TI
   LI
   LO
   TS
CP0405005
(2,4-Dimethyl-pyridin-3-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C31H38N4O
 1
1
IC50 = 1.1 nM
   TI
   LI
   LO
   TS
CP0525662
(2,6-dimethylphenyl)(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C31H38N4O
 1
1
IC50 = 1.1 nM
   TI
   LI
   LO
   TS
CP0433169
(4,6-Dimethyl-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C30H37N5O
 1
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
CP0440545
3-({[1'-(2,4-Dimethyl-1-oxy-pyridine-3-carbonyl)-4'-methyl-[1,4']bipiperidinyl-4-yl]-phenyl-amino}-methyl)-benzonitrile
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C33H39N5O2
 1
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
CP0405009
(4-(4-(benzyl(phenyl)amino)piperidin-1-yl)-4-methylpiperidin-1-yl)(2,6-dimethylphenyl)methanone
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C33H41N3O
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0454308
(3,5-dichloropyridin-4-yl)(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C28H31Cl2N5O
 1
1
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0403557
(2,4-Dimethyl-1-oxy-pyridin-3-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C31H38N4O2
 1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
CP0440554
(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)(naphthalen-1-yl)methanone
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C33H36N4O
 1
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0525661
(3,5-dichloro-1-oxy-pyridin-4-yl)-[4'-methyl-4-(phenyl-pyridin-3-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone
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C28H31Cl2N5O2
 1
1
IC50 = 4.2 nM
   TI
   LI
   LO
   TS
CP0377973
[4-[4-(N-benzylanilino)piperidin-1-yl]-4-methylpiperidin-1-yl]-(2,4-dimethyl-1-oxidopyridin-1-ium-3-yl)methanone
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C32H40N4O2
 1
1
IC50 = 5.1 nM
   TI
   LI
   LO
   TS
CP0036979
(2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(phenyl-pyridin-3-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone
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C30H37N5O2
 2
1
IC50 = 8.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 64 nM
   TI
   LI
   LO
   TS
CP0484065
(2,6-dimethylphenyl)(4-methyl-4-(4-(phenyl(pyridin-4-yl)amino)piperidin-1-yl)piperidin-1-yl)methanone
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C31H38N4O
 1
1
IC50 = 9.8 nM
   TI
   LI
   LO
   TS
CP0398191
(4,6-dimethyl-1-oxy-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone
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C30H37N5O2
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0509933
(2,4-dimethyl-1-oxy-pyridin-3-yl)-[4'-methyl-4-(phenyl-pyridin-2-yl-amino)-[1,4']bipiperidinyl-1'-yl]-methanone
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C30H37N5O2
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0433168
(4-methyl-4-(4-(phenyl(pyridin-3-yl)amino)piperidin-1-yl)piperidin-1-yl)(3-methylpyridin-2-yl)methanone
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C29H35N5O
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0405008
2,4-dimethyl-1-oxy-pyridin-3-yl)-{4'-methyl-4-[(2-methyl-thiazol-4-ylmethyl)-phenyl-amino]-[1,4']bipiperidinyl-1'-yl}-methanone
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C30H39N5O2S
 1
1
IC50 = 107 nM
   TI
   LI
   LO
   TS