Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT06057 , Beta-3 adrenergic receptor
Gene Name ADRB3
Organism Canis lupus familiaris, Dog, Canis familiaris
Protein Classification Membrane receptor
Uniprot ID O02662
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT06057
 
Compound ID Compound Name Compound Formula
CP0389986
4-((2R)-2-{[(2R)-2-Hydroxy-2-phenylethyl]amino}propyl)-3-isopropoxy-4-biphenylcarboxylic acid
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C27H31NO4
 1
1
EC50 = 0.19 nM
   TI
   LI
   LO
   TS
CP0135429
(4R)-2-amino-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide
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C25H28N4O2S
 1
1
EC50 = 0.19 nM
   TI
   LI
   LO
   TS
CP0375142
4-((2R)-2-{[(2R)-2-Hydroxy-2-(3-pyridinyl)ethyl]amino}propyl)-3-propoxy-4-biphenylcarboxylic acid
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C26H30N2O4
 1
1
EC50 = 0.51 nM
   TI
   LI
   LO
   TS
CP0845051
4'-(2-{[(2R)-2-Hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylsulfanyl)-N-(methylsulfonyl)biphenyl-4-carboxamide Hydrochloride
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C27H33ClN2O4S2
 1
1
EC50 = 0.68 nM
   TI
   LI
   LO
   TS
CP0882007
4'-(2-{[(2R)-2-Hydroxy-2-phenylethyl]amino}ethyl)-3-isobutyl-N-(methylsulfonyl)biphenyl-4-carboxamide Hydrochloride
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C28H35ClN2O4S
 1
1
EC50 = 0.88 nM
   TI
   LI
   LO
   TS
CP0881981
4'-(2-{[(2R)-2-(4-Aminophenyl)-2-hydroxyethyl]amino}ethyl)-3-(cyclohexyloxy)-N-(methylsulfonyl)biphenyl-4-carboxamide Dihydrochloride
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C30H39Cl2N3O5S
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0037154
(R)-4'-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethyl)-3-isopropoxybiphenyl-4-carboxylic acid
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C26H28ClNO4
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0217241
4'-(2-((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-ylamino)ethyl)-3-isopropoxy-N-(methylsulfonyl)biphenyl-4-carboxamide
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C28H34N2O6S
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0845050
4'-(2-{[(2R)-2-Hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)-N-(methylsulfonyl)biphenyl-4-carboxamide Dihydrochloride
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C27H35Cl2N3O4S
 1
1
EC50 = 1.1 nM
   TI
   LI
   LO
   TS
CP0372880
(R)-4'-(2-(2-hydroxy-2-phenylethylamino)ethyl)-3-(isopropylthio)biphenyl-4-carboxylic acid
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C26H29NO3S
 1
1
EC50 = 1.2 nM
   TI
   LI
   LO
   TS
CP0418059
(R)-3-(cyclohexyloxy)-4'-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)biphenyl-4-carboxylic acid
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C28H32N2O4
 1
1
EC50 = 1.3 nM
   TI
   LI
   LO
   TS
CP0900959
3-(Cyclohexyloxy)-4'-(2-{[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino}ethyl)-N-(methylsulfonyl)biphenyl-4-carboxamide Dihydrochloride
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C29H37Cl2N3O5S
 1
1
EC50 = 1.4 nM
   TI
   LI
   LO
   TS
CP0459677
(R)-5-(3-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethyl)phenoxy)-2-pivalamidobenzoic acid
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C28H31ClN2O5
 1
1
EC50 = 1.6 nM
   TI
   LI
   LO
   TS
CP0504190
(R)-5-(3-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethyl)phenoxy)-2-(2-oxopyrrolidin-1-yl)benzoic acid
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C27H27ClN2O5
 1
1
EC50 = 1.9 nM
   TI
   LI
   LO
   TS
CP0375139
(R)-4'-(2-(2-hydroxy-2-phenylethylamino)ethyl)-3-isobutylbiphenyl-4-carboxylic acid
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C27H31NO3
 1
1
EC50 = 2.2 nM
   TI
   LI
   LO
   TS
CP0877318
4'-(2-{[(2R)-2-(4-Aminophenyl)-2-hydroxyethyl]amino}ethyl)-3-isopropoxy-N-(methylsulfonyl)biphenyl-4-carboxamide Dihydrochloride
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C27H35Cl2N3O5S
 1
1
EC50 = 2.512 nM
   TI
   LI
   LO
   TS
CP0137177
(R)-4'-(2-(2-hydroxy-2-phenylethylamino)ethyl)-3-isopropoxybiphenyl-4-carboxylic acid
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C26H29NO4
 1
1
EC50 = 2.9 nM
   TI
   LI
   LO
   TS
CP0849245
4'-(2-{[(2R)-2-Hydroxy-2-phenylethyl]amino}ethyl)-N-(methylsulfonyl)-3-phenoxybiphenyl-4-carboxamide Hydrochloride
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C30H31ClN2O5S
 1
1
EC50 = 2.9 nM
   TI
   LI
   LO
   TS
CP0474560
(R)-4'-(2-(2-(4-aminopyridin-3-yl)-2-hydroxyethylamino)ethyl)-3-isobutylbiphenyl-4-carboxylic acid
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C26H31N3O3
 1
1
EC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0467666
(R)-5-(3-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethyl)phenoxy)-2-isopropoxybenzoic acid
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C26H28ClNO5
 1
1
EC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0375138
4-(2-{[(2R)-2-(6-Amino-3-pyridinyl)-2-hydroxyethyl]amino}ethyl)-3-isobutyl-4-biphenylcarboxylic acid
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C26H31N3O3
 1
1
EC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0484975
4-(2-{[(1S,2R)-2-Hydroxy-1-methyl-2-phenylethyl]amino}ethyl)-3-isopropoxy-4-biphenylcarboxylic acid
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C27H31NO4
 1
1
EC50 = 3.7 nM
   TI
   LI
   LO
   TS
CP0135426
(4R)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide
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C24H26N4O2S
 1
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
CP0399297
(R)-4'-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)-3-isopropoxybiphenyl-4-carboxylic acid
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C25H28N2O4
 2
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0434840
4'-(2-{[(2R)-2-(6-Aminopyridin-3-yl)-2-hydroxyethyl]amino}ethyl)-3-isopropoxy-N-(methylsulfonyl)biphenyl-4-carboxamide
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C26H32N4O5S
 1
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
CP0105650
KRP-114V
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C26H28N4O3
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0105651
(6S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide
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C24H27N5O2
 1
1
EC50 = 22 nM
   TI
   LI
   LO
   TS
CP0493893
4-((S)-7-((R)-2-(4-chlorophenyl)-2-hydroxyethylamino)-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid
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C25H24ClNO3
 1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0156740
(R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide
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C31H27F3N4O3S2
 1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0288880
ethyl 2-[[(6S)-6-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]oxy]acetate
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C23H28ClNO4
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0156745
(2S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(6-oxopyridazin-1-yl)propanamide
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C25H28N4O3
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0372774
5-[((7S)-7-{[(2R)-2-(6-Chloro-3-pyridinyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic Acid
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C25H25ClN2O5
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0105652
N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(6-oxopyridazin-1-yl)acetamide
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C24H26N4O3
 1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS