| Compound ID |
Compound Name |
Compound Formula |
|
CP0415983
|
3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
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C18H22F3N3O4S
|
1
|
| 1 |
IC50 > 6700 nM
|
|
|
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CP0448164
|
(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C26H23Cl2N9O3S
|
1
|
| 1 |
Ki = 6.53 nM
|
|
|
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CP0406220
|
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C21H22ClN9O3S
|
1
|
| 1 |
Ki = 9.64 nM
|
|
|
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CP0039348
|
(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
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|
C12H16N6O4
|
1
|
| 1 |
Ki = 14.1 nM
|
|
|
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CP0406164
|
(1S,2R,3S,4R,5S)-4-[2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C23H24ClN9O3S
|
1
|
| 1 |
Ki = 14.2 nM
|
|
|
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CP0108871
|
(1S,2R,3S,4R,5S)-4-[5-[2-(5-chlorothiophen-2-yl)ethynyl]-7-(ethylamino)imidazo[4,5-b]pyridin-3-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C22H22ClN5O3S
|
1
|
| 1 |
Ki = 16.2 nM
|
|
|
|
CP0077413
|
(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
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|
C15H20ClN5O4
|
1
|
| 1 |
Ki = 17 nM
|
|
|
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CP0169089
|
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-N-cyclopropyl-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide
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|
C22H27ClN6O3
|
1
|
| 1 |
Ki = 29.5 nM
|
|
|
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CP0448165
|
(1S,2R,3S,4R,5S)-2,3-dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyrimidin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamide
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|
C20H21N11O3
|
1
|
| 1 |
Ki = 334 nM
|
|
|
|
CP0266843
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C20H26ClN5O2
|
1
|
| 1 |
Ki = 385 nM
|
|
|
|
CP0362924
|
(2R,3R,4S,5R)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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|
C17H23N5O4
|
1
|
| 1 |
Ki = 424 nM
|
|
|
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CP0440591
|
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-(2-hydroxyethyl)bicyclo[3.1.0]hexane-1-carboxamide
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|
C21H27ClN6O4
|
1
|
| 1 |
Ki = 447 nM
|
|
|
|
CP0266847
|
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-1-(chloromethyl)bicyclo[3.1.0]hexane-2,3-diol
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|
C19H23Cl2N5O2
|
1
|
| 1 |
Ki = 503 nM
|
|
|
|
CP0049200
|
(2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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|
C15H21N5O4
|
1
|
| 1 |
Ki = 534 nM
|
|
|
|
CP0169097
|
(1R,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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|
C19H24ClN5O3
|
1
|
| 1 |
Ki = 574 nM
|
|
|
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CP0139868
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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|
C21H28ClN5O3
|
1
|
| 1 |
Ki = 612 nM
|
|
|
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CP0139864
|
(2R,3R,4S,5R)-2-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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|
C19H26ClN5O4
|
1
|
| 1 |
Ki = 653 nM
|
|
|
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CP0354472
|
(2R,3R,4S,5S)-2-[6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(ethylsulfanylmethyl)oxolane-3,4-diol
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|
C21H31N5O3S
|
1
|
| 1 |
Ki = 718 nM
|
|
|
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CP0204638
|
(2R,3R,4S,5R)-2-[6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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|
C19H27N5O4
|
1
|
| 1 |
Ki = 897 nM
|
|
|
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CP0169091
|
(1R,2R,3S,4R,5S)-4-[6-[di(cyclobutyl)methylamino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
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|
C21H29N5O3
|
1
|
| 1 |
Ki = 918 nM
|
|
|
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CP0139869
|
(1S,2R,3S,4R,5S)-1-(chloromethyl)-4-[6-[di(cyclobutyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C21H28ClN5O2
|
1
|
| 1 |
Ki = 934 nM
|
|
|
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CP0169100
|
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C18H22ClN5O2
|
1
|
| 1 |
Ki = 1060 nM
|
|
|
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CP0139866
|
(2R,3R,4S,5S)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol
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|
C17H22ClN5O3
|
1
|
| 1 |
Ki = 1560 nM
|
|
|
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CP0169092
|
(1S,2R,3S,4R,5S)-4-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-1-(chloromethyl)bicyclo[3.1.0]hexane-2,3-diol
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|
C21H27Cl2N5O2
|
1
|
| 1 |
Ki = 1560 nM
|
|
|
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CP0169090
|
(2S,3S,4R,5R)-2-(chloromethyl)-5-[6-[di(cyclobutyl)methylamino]purin-9-yl]oxolane-3,4-diol
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|
C19H26ClN5O3
|
1
|
| 1 |
Ki = 2110 nM
|
|
|
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CP0534305
|
(2R,3R,4S,5S)-2-[6-[[(1R,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol
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|
C17H22ClN5O3
|
1
|
| 1 |
Ki = 2410 nM
|
|
|
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CP0204629
|
(1S,2R,3S,4R,5S)-4-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-1-[(2-fluorophenyl)sulfanylmethyl]bicyclo[3.1.0]hexane-2,3-diol
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|
C27H31ClFN5O2S
|
1
|
| 1 |
Ki = 7440 nM
|
|
|
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CP0065233
|
4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid
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|
C14H14N4O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
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CP0069838
|
(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
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|
C26H26N6O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
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CP0420800
|
8-[4-[4-(4-chlorophenyl)piperazin-1-yl]sulfonylphenyl]-3-methyl-1-propyl-7H-purine-2,6-dione
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|
C25H27ClN6O4S
|
1
|
| 1 |
Ki > 1000 nM
|
|
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CP0420803
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8-[4-[4-(4-bromophenyl)piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
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|
C24H25BrN6O4S
|
1
|
| 1 |
Ki > 1000 nM
|
|
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CP0420820
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8-[4-[4-(3-fluorophenyl)piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
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|
C24H25FN6O4S
|
1
|
| 1 |
Ki > 1000 nM
|
|
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CP0424466
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8-[4-[4-[(3-bromophenyl)methyl]piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
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|
C25H27BrN6O4S
|
1
|
| 1 |
Ki > 1000 nM
|
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