Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01325 , Melanocortin receptor 3
Gene Name MC3R
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P41968
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01325
 
Compound ID Compound Name Compound Formula
CP0404503
(3S)-N-[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-iodophenyl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C36H42IN9O4
 1
1
Activity = 75 nM
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CP0045108
(4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid
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C77H109N21O19S
 3
1
EC50 = 1.1 nM
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2
EC50 = 2.7 nM
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3
IC50 = 19 nM
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CP0411217
(3S,11S,14S,17S,20R,23S)-3-[[(2S)-2-acetamidohexanoyl]amino]-20-benzyl-17-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-2,5,13,16,19,22-hexaoxo-1,6,12,15,18,21-hexazabicyclo[21.3.0]hexacosane-11-carboxamide
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C49H69N13O9
 1
1
EC50 = 5.1 nM
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CP0374300
(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(4H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
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C50H69N15O9
 1
1
EC50 = 5.4 nM
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CP0430472
((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-3-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C29H31F2N3O2
 1
1
EC50 = 65 nM
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CP0374304
((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C29H31F2N3O2
 1
1
EC50 = 71 nM
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CP0400320
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N,1-di(propan-2-yl)pyrazole-4-carboxamide
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C37H56F2N6O2
 2
1
EC50 = 79 nM
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2
IC50 = 870 nM
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CP0382832
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylpyridazine-3-carboxamide
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C35H50F2N6O2
 2
1
EC50 = 90 nM
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2
IC50 = 770 nM
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CP0083436
N-[(1S)-1-[2-[1-[(3S,4R)-4-(4-bromo-2-fluorophenyl)-1-tert-butylpyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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C31H40BrClFN3O2
 1
1
EC50 = 97.4 nM
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CP0161427
N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2-fluoro-4-methoxyphenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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C32H43ClFN3O3
 1
1
EC50 = 156.7 nM
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CP0202447
N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(4-chloro-2-fluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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C31H40Cl2FN3O2
 1
1
EC50 = 249.9 nM
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CP0844893
Ac-Nle4-cyclo(Asp5-His6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
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C56H70N12O9
 2
1
EC50 = 370 nM
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2
IC50 = 1400 nM
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CP0400031
((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C28H30F2N4O2
 1
1
EC50 = 490 nM
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CP0374305
((3R,4S)-1-cyclobutyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C28H34F2N2O2
 1
1
EC50 = 500 nM
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CP0374301
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(3-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C28H35F3N2O2
 1
1
EC50 = 570 nM
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CP0383465
((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-4-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C28H30F2N4O2
 1
1
EC50 = 600 nM
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CP0283823
2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
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C33H38ClF2N3O3
 1
1
EC50 = 766.7 nM
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CP0400321
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-4-methylpentyl]-N-propan-2-ylacetamide
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C30H48F2N4O2
 2
1
EC50 = 880 nM
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2
IC50 = 4700 nM
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CP0162604
N-[(1S)-1-[2-[1-[(3R,4S)-4-(4-bromo-2-fluorophenyl)-1-tert-butylpyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
   Show/Hide
C31H40BrClFN3O2
 1
1
EC50 = 917.5 nM
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CP0378171
(S)-4-Methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
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C31H48FN5O3
 1
1
EC50 = 990 nM
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CP0849936
(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol Hydrochloride
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C28H37ClF2N2O2
 1
1
EC50 = 1160 nM
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CP0394757
Ac-Nle4-cyclo(Asp5-His6-D-4,4'-Bip-Pro8-Trp9-Lys10)-NH2
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C56H69N11O9
 2
1
EC50 = 1400 nM
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2
IC50 > 1500 nM
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CP0382833
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylmethanesulfonamide
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C31H50F2N4O3S
 2
1
EC50 = 1800 nM
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2
IC50 = 3600 nM
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CP0400322
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylacetamide
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C32H50F2N4O2
 2
1
EC50 = 2000 nM
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2
IC50 = 6500 nM
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CP0400328
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-4-methylpentyl]-N-propan-2-ylmethanesulfonamide
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C29H48F2N4O3S
 2
1
EC50 = 2500 nM
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2
IC50 = 4900 nM
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CP0877838
(S)-1-Methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
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C31H50Cl2FN5O3
 1
1
EC50 = 2900 nM
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CP0845107
(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-4-(4-fluorophenyl)-3,5-dimethylpiperidin-4-ol Hydrochloride
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C28H36ClF3N2O2
 1
1
EC50 = 3050 nM
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CP0430471
((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-(pyridin-2-yl)piperidin-1-yl)methanone
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C27H29F2N5O2
 1
1
EC50 = 3660 nM
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CP0401418
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(4-chlorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C28H35ClF2N2O2
 1
1
EC50 = 3680 nM
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CP0849935
(3R,4R,5S)-4-Cyclopropyl-1-{[(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl]carbonyl}-3,5-dimethylpiperidin-4-ol Hydrochloride
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C25H31ClF2N4O2
 1
1
EC50 = 4130 nM
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CP0462856
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(2,6-difluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C28H34F4N2O2
 1
1
EC50 = 4570 nM
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CP0845516
(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-propylpiperidin-4-ol Hydrochloride
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C25H33ClF2N4O2
 1
1
EC50 = 7480 nM
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CP0391042
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(2,4-difluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C28H34F4N2O2
 1
1
EC50 = 10700 nM
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CP0383468
((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C27H34F2N2O2
 1
1
EC50 = 11600 nM
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CP0391026
((3S,4R)-4-(2,4-difluorophenyl)-1-ethylpyrrolidin-3-yl)((3S,4R,5R)-4-(3-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C26H31F3N2O2
 1
1
EC50 > 13500 nM
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CP0402318
((3R,4S)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C29H36F2N2O3
 1
1
EC50 > 14500 nM
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CP0858960
(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-methylpyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol Hydrochloride
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C25H31ClF2N2O2
 1
1
EC50 > 19100 nM
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CP0374312
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-propylpiperidin-1-yl)methanone
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C25H38F2N2O2
 1
1
EC50 > 24700 nM
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CP0383467
((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C24H28F2N2O2
 1
1
EC50 > 25200 nM
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CP0374303
((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C28H30F2N4O2
 1
1
EC50 > 26700 nM
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CP0374306
((3R,4S)-1-cyclopropyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C27H32F2N2O2
 1
1
EC50 > 33300 nM
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CP0402317
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-(pyridin-2-yl)piperidin-1-yl)methanone
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C27H35F2N3O2
 1
1
EC50 > 33300 nM
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CP0401674
((3S,4R)-4-(2,4-difluorophenyl)-1-methylpyrrolidin-3-yl)((3S,4R,5R)-4-(4-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C25H29F3N2O2
 1
1
EC50 > 33400 nM
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CP0876570
Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bic7-Pip8-Trp9-Lys10)-NH2
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C59H88N10O9
 2
1
EC50 > 500 nM
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2
IC50 > 1000 nM
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CP0425195
Ac-Nle4-cyclo(Asp5-His6-D-Tyr(Et)-Pro8-Trp9-Lys10)-NH2
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C51H68N12O10
 2
1
EC50 > 2500 nM
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2
IC50 > 10000 nM
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CP0394150
Ac-Nle4-cyclo(Asp5-His6-D-Phe(4-Cl)-Pro8-Trp9-Lys10)-NH2
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C49H63ClN12O9
 2
1
EC50 > 5000 nM
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2
IC50 > 20000 nM
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CP0374314
((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C28H36F2N2O2
 1
1
EC50 > 5720 nM
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CP0405831
1-[(R)-2-[((1R,2R)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C36H49ClN4O3
 1
1
IC50 = 32 nM
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CP0378160
(3S,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-chlorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
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C32H50ClN5O3
 1
1
IC50 = 33 nM
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CP0497448
1-[2-[((R)-3-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C36H49ClN4O3
 1
1
IC50 = 48 nM
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CP0490759
1-[2-[((R)-1-Amino-indane-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C35H47ClN4O3
 1
1
IC50 = 83 nM
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CP0493433
1-[(2R)-2-[(5-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulene-6-carbonyl)amino]-3-(4-chlorophenyl)propanoyl]-N-tert-butyl-4-cyclohexylpiperidine-4-carboxamide
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C37H51ClN4O3
 1
1
IC50 = 97 nM
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CP0150320
1-[(R)-2-[((1S,2S)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C36H49ClN4O3
 1
1
IC50 = 120 nM
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CP0466894
1-[(R)-2-[((1S,2S)-1-Amino-1-methyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C37H51ClN4O3
 1
1
IC50 = 170 nM
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CP0376350
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-(((R)-4-methyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C35H45ClN4O4
 1
1
IC50 = 210 nM
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   TS
CP0451850
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((4,4-dimethyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
   Show/Hide
C36H47ClN4O4
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0462980
(3R,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-diethylpiperazine-1-carboxamide
   Show/Hide
C34H54FN5O3
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0876125
Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
   Show/Hide
C55H70N10O9
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0432760
(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(1,1-dioxo-1lambda*6*-isothiazolidin-2-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
   Show/Hide
C34H45ClN4O4S
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0376349
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((N-isopropylmethan-2-ylsulfonamido)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
   Show/Hide
C35H49ClN4O4S
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0378159
(3R,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-diethylpiperazine-1-carboxamide
   Show/Hide
C34H54FN5O3
 1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
CP0497207
(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(6-oxo-7-oxa-5-aza-spiro[3.4]oct-5-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
   Show/Hide
C37H47ClN4O4
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0406610
(1S,4R,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
   Show/Hide
C34H51FN4O3
 1
1
IC50 = 410 nM
   TI
   LI
   LO
   TS
CP0501131
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
   Show/Hide
C34H43ClN4O4
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0382075
(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(5-oxo-6-oxa-4-aza-spiro[2.4]hept-4-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
   Show/Hide
C36H45ClN4O4
 1
1
IC50 = 490 nM
   TI
   LI
   LO
   TS
CP0495900
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-oxoimidazolidin-1-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
   Show/Hide
C34H44ClN5O3
 1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CP0378167
(1S,4R,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-2-azabicyclo[2.2.2]octane-6-carboxamide
   Show/Hide
C33H49FN4O3
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0406608
(1S,4S,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
   Show/Hide
C33H49FN4O3
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0376348
ethyl N-[[1-[(2R)-3-(4-chlorophenyl)-2-[[(3R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]amino]propanoyl]-4-cyclohexylpiperidin-4-yl]methyl]-N-propan-2-ylcarbamate
   Show/Hide
C37H51ClN4O4
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0878544
Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C54H68N10O9
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0315803
(3S,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
   Show/Hide
C32H50FN5O3
 1
1
IC50 = 650 nM
   TI
   LI
   LO
   TS
CP0376351
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((3-methyl-2-oxoimidazolidin-1-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
   Show/Hide
C35H46ClN5O3
 1
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
CP0422856
(3S,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
   Show/Hide
C32H50FN5O3
 1
1
IC50 = 740 nM
   TI
   LI
   LO
   TS
CP0376413
(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(5,5-dimethyl-1,1-dioxo-1lambda*6*-isothiazolidin-2-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
   Show/Hide
C36H49ClN4O4S
 1
1
IC50 = 760 nM
   TI
   LI
   LO
   TS
CP0438966
(3R,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,4,5-trimethylpiperazine-1-carboxamide
   Show/Hide
C33H52FN5O3
 1
1
IC50 = 760 nM
   TI
   LI
   LO
   TS
CP0149367
(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide
   Show/Hide
C33H41ClN6O2
 1
1
IC50 = 761 nM
   TI
   LI
   LO
   TS
CP0451849
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-(((S)-4-methyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
   Show/Hide
C35H45ClN4O4
 1
1
IC50 = 840 nM
   TI
   LI
   LO
   TS
CP0432989
Ac-Nle4-cyclo(Asp5-His6-L-Phe-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C49H64N12O9
 1
1
IC50 = 860 nM
   TI
   LI
   LO
   TS
CP0445633
(4R,5S)-4-(4-Fluoro-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
   Show/Hide
C33H34ClFN4O3S
 1
1
IC50 = 940 nM
   TI
   LI
   LO
   TS
CP0378158
(3R,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
   Show/Hide
C32H50FN5O3
 1
1
IC50 = 970 nM
   TI
   LI
   LO
   TS
CP0422262
Ac-Nle4-cyclo(Asp5-His6-D-Phe-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C49H64N12O9
 1
1
IC50 = 990 nM
   TI
   LI
   LO
   TS
CP0391988
(1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
   Show/Hide
C34H51FN4O3
 1
1
IC50 = 1350 nM
   TI
   LI
   LO
   TS
CP0391989
(1S,4R,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
   Show/Hide
C33H49FN4O3
 1
1
IC50 = 2060 nM
   TI
   LI
   LO
   TS
CP0897048
(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
   Show/Hide
C33H36Cl2N4O3S
 1
1
IC50 = 2172 nM
   TI
   LI
   LO
   TS
CP0876424
c-Nle4-cyclo(Asp5-Tic6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
   Show/Hide
C60H72N10O9
 1
1
IC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0855549
Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bip7-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C58H74N10O9
 1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0394108
Ac-Nle4-cyclo(Asp5-His6-D-Tyr(Me)-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C50H66N12O10
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0394112
Ac-Nle4-cyclo(Asp5-His6-D-Cha-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C49H70N12O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0394115
Ac-Nle4-cyclo(Asp5-His6-D-Nle-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C46H66N12O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0394119
Ac-Nle4-cyclo(Asp5-His6-D-Glu-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C45H62N12O11
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0394120
Ac-Nle4-cyclo(Asp5-His6-D-Tic-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C51H66N12O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0425206
Ac-Nle4-cyclo(Asp5-His6-D-Nal(2)-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C53H66N12O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0432988
Ac-Nle4-cyclo(Asp5-His6-D-Tyr-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C49H64N12O10
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0433726
Ac-Nle4-cyclo(Asp5-His6-D-Gln-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C45H63N13O10
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0434012
Ac-Nle4-cyclo(Asp5-His6-D-His-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C46H62N14O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0434038
Ac-Nle4-cyclo(Asp5-His6-D-Lys-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C46H67N13O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0855105
Ac-Nle4-cyclo(Asp5-Chg6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
   Show/Hide
C58H76N10O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0876124
Ac-Nle4-cyclo(Asp5-His6-D-4-Dip-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C55H68N12O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0882669
Ac-Nle4-cyclo(Asp5-Val6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
   Show/Hide
C55H72N10O9
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0878527
Ac-Nle4-cyclo(Asp5-Phg6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
   Show/Hide
C58H70N10O9
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0879920
Ac-Nle4-cyclo(Asp5-Oic6-D-D-pBzlPhe7-Pip8-Trp9-Lys10)-NH2
   Show/Hide
C60H78N10O9
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0394111
Ac-Nle4-cyclo(Asp5-His6-D-Phe(No2)-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C49H63N13O11
 1
1
IC50 > 2000 nM
   TI
   LI
   LO
   TS
CP0433731
Ac-Nle4-cyclo(Asp5-His6-L-Tyr(Me)-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C50H66N12O10
 1
1
IC50 > 2000 nM
   TI
   LI
   LO
   TS
CP0390508
(4R,5S)-4-(4-Fluoro-phenyl)-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
   Show/Hide
C32H32ClFN4O3S
 1
1
IC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0394113
Ac-Nle4-cyclo(Asp5-His6-D-Bth-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C53H68N12O9S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0425204
Ac-Nle4-cyclo(Asp5-His6-D-Tyr-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C51H65N13O9
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0431963
Ac-Nle4-cyclo(Asp5-His6-D-2-Thi-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C47H62N12O9S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0844894
Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
   Show/Hide
C59H76N10O9
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0855016
Ac-Nle4-cyclo(Asp5-His6-D-4-Thz-Pro8-Trp9-Lys10)-NH2
   Show/Hide
C44H60N12O9S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS