Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01058 , Disintegrin and metalloproteinase domain-containing protein 17
Gene Name ADAM17
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P78536
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01058
 
Compound ID Compound Name Compound Formula
CP0099182
1-benzoyl-4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-N-hydroxypiperidine-4-carboxamide
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C24H26N2O6S
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0109727
4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-N-hydroxypiperidine-4-carboxamide
   Show/Hide
C17H22N2O5S
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0145051
alpha-sulfone piperidine hydroxamate, 11c
   Show/Hide
C25H27N3O6S
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0167483
alpha-sulfone piperidine hydroxamate, 11g
   Show/Hide
C28H33N3O7S
 1
1
IC50 < 1 nM
   TI
   LI
   LO
   TS
CP0280627
alpha-sulfone piperidine hydroxamate, 11e
   Show/Hide
C30H29N3O6S
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0140030
4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-1-N,1-N-diethyl-4-N-hydroxypiperidine-1,4-dicarboxamide
   Show/Hide
C22H32N4O5S
 1
1
IC50 < 1 nM
   TI
   LI
   LO
   TS
CP0305781
alpha-sulfone piperidine hydroxamate, 11m
   Show/Hide
C24H27N3O7S2
 1
1
IC50 = 1.2 nM
   TI
   LI
   LO
   TS
CP0140019
beta-sulfonyl hydroxamate analogue, 7
   Show/Hide
C22H31N3O6S
 1
1
IC50 = 1.6 nM
   TI
   LI
   LO
   TS
CP0069922
1-acetyl-4-[(4-but-2-ynoxyphenyl)sulfonylmethyl]-N-hydroxypiperidine-4-carboxamide
   Show/Hide
C19H24N2O6S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0128762
alpha-sulfone piperidine hydroxamate, 11b
   Show/Hide
C24H25N3O6S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0128763
BMCL193445 Compound 2d
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C22H30N2O7S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0136342
alpha-sulfone piperidine hydroxamate, 11d
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C27H31N3O6S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0280595
alpha-sulfone piperidine hydroxamate, 11f
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C29H28N4O6S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0294906
alpha-sulfone piperidine hydroxamate, 11h
   Show/Hide
C26H30N4O6S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0159744
4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxy-1-(propane-2-sulfonyl)piperidine-4-carboxamide
   Show/Hide
C20H29N3O6S2
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0162166
4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxy-1-(2-methylpropanoyl)piperidine-4-carboxamide
   Show/Hide
C21H29N3O5S
 1
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0178548
(3S)-4-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
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C17H23N3O4S2
 1
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0172727
4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxy-1-[(2-methylphenyl)carbonyl]piperidine-4-carboxamide
   Show/Hide
C25H29N3O5S
 1
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
CP0305780
alpha-sulfone piperidine hydroxamate, 11i
   Show/Hide
C28H34N4O6S
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0058694
4-({[4-(but-2-yn-1-yloxy)benzene]sulfonyl}methyl)-N-hydroxy-1-(propane-2-sulfonyl)piperidine-4-carboxamide
   Show/Hide
C20H28N2O7S2
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0162899
beta-sulfonyl hydroxamate analogue, 11
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C23H33N3O6S
 1
1
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
CP0144364
4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxy-1-(2-methylbutanoyl)piperidine-4-carboxamide
   Show/Hide
C22H31N3O5S
 1
1
IC50 = 3.5 nM
   TI
   LI
   LO
   TS
CP0162165
N-hydroxy-4-({[4-(pent-3-yn-2-yloxy)benzene]sulfonyl}methyl)-1-(propane-2-sulfonyl)piperidine-4-carboxamide
   Show/Hide
C21H30N2O7S2
 1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
CP0140017
4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxy-1-(pyridin-4-ylmethyl)piperidine-4-carboxamide
   Show/Hide
C23H28N4O4S
 1
1
IC50 = 6.4 nM
   TI
   LI
   LO
   TS
CP0095876
(3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
   Show/Hide
C17H22N2O5S2
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0128764
alpha-sulfone piperidine hydroxamate, 11k
   Show/Hide
C29H30N4O5S
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0197688
alpha-sulfone piperidine hydroxamate, 11n
   Show/Hide
C26H31N3O7S2
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0144366
beta-sulfonyl hydroxamate analogue, 12
   Show/Hide
C22H31N3O7S
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0145050
alpha-sulfone piperidine hydroxamate, 11j
   Show/Hide
C24H27N3O5S
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0235263
N-hydroxy-4-[({4-[(2-methylpent-3-yn-2-yl)oxy]benzene}sulfonyl)methyl]-1-(propane-2-sulfonyl)piperidine-4-carboxamide
   Show/Hide
C22H32N2O7S2
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0167464
alpha-sulfone piperidine hydroxamate, 11a
   Show/Hide
C23H25N3O5S
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0322487
alpha-sulfone piperidine hydroxamate, 1b
   Show/Hide
C18H22N2O6S
 1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CP0146657
4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxypiperidine-4-carboxamide
   Show/Hide
C17H23N3O4S
 1
1
IC50 = 64.5 nM
   TI
   LI
   LO
   TS
CP0128765
alpha-sulfone piperidine hydroxamate, 11l
   Show/Hide
C30H29Cl2N3O5S
 1
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
CP0336169
alpha-sulfone piperidine hydroxamate, 1c
   Show/Hide
C23H24N2O6S
 1
1
IC50 = 73 nM
   TI
   LI
   LO
   TS
CP0294905
alpha-sulfone piperidine hydroxamate, 1d
   Show/Hide
C21H28N2O7S
 1
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
CP0294907
alpha-sulfone piperidine hydroxamate, 1e
   Show/Hide
C23H24Cl2N2O5S
 1
1
IC50 = 149 nM
   TI
   LI
   LO
   TS
CP0136340
alpha-sulfone piperidine hydroxamate, 1a
   Show/Hide
C16H20N2O5S
 1
1
IC50 = 201 nM
   TI
   LI
   LO
   TS