Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT00577 , Histamine receptor H3
 Protein Info 
Gene Name HRH3
Organism Macaca mulatta, Rhesus macaque
Protein Classification Membrane receptor
Uniprot ID Q865E1
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011
 Cell Line Info 
 Protein ID: PT00577
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0540768
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclohexanecarboxamide
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C23H35N3O
  1
1
Ki = 0.39 nM
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CP0070912
 Compound Info 
3,5-dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-4-carboxamide
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C22H30N4O2
  1
1
Ki = 0.4 nM
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CP0492985
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclopentanecarboxamide
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C22H33N3O
  1
1
Ki = 0.5 nM
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CP0476801
 Compound Info 
2,2,3,3-tetramethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclopropane-1-carboxamide
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C24H37N3O
  1
1
Ki = 0.55 nM
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CP0500998
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]bicyclo[2.2.1]heptane-2-carboxamide
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C24H35N3O
  1
1
Ki = 0.55 nM
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CP0476800
 Compound Info 
2-cyclopentyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]acetamide
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C23H35N3O
  1
1
Ki = 0.85 nM
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CP0107784
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxane-4-carboxamide
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C22H33N3O2
  1
1
Ki = 0.97 nM
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CP0462174
 Compound Info 
3-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-5-carboxamide
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C21H28N4O2
  1
1
Ki = 1.1 nM
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CP0484202
 Compound Info 
6-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]pyridine-2-carboxamide
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C23H30N4O
  1
1
Ki = 1.4 nM
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CP0436027
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]furan-3-carboxamide
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C21H27N3O2
  1
1
Ki = 1.8 nM
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CP0406979
 Compound Info 
1-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(thiophen-2-ylmethyl)urea
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C21H28N4OS
  1
1
Ki = 1.9 nM
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CP0087368
 Compound Info 
5-fluoro-2-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]benzamide
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C24H30FN3O
  1
1
Ki = 2.5 nM
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CP0509429
 Compound Info 
3,4-difluoro-N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]benzenesulfonamide
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C21H26F2N4O2S
  1
1
Ki = 2.5 nM
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CP0525020
 Compound Info 
N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]benzamide
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C22H28N4O
  1
1
Ki = 3 nM
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CP0475033
 Compound Info 
2-cyclopentyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]acetamide
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C22H33N3O
  1
1
Ki = 3.1 nM
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CP0380162
 Compound Info 
1-(2,4-difluorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]urea
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C21H25F2N3O2
  1
1
Ki = 3.4 nM
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CP0406982
 Compound Info 
1-(3,5-dichlorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]urea
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C21H25Cl2N3O2
  1
1
Ki = 3.4 nM
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CP0553880
 Compound Info 
N-[2-methyl-4-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxane-4-carboxamide
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C22H33N3O2
  1
1
Ki = 3.9 nM
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CP0484201
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]furan-2-carboxamide
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C21H27N3O2
  1
1
Ki = 3.9 nM
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CP0489114
 Compound Info 
1-cyclohexyl-3-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C22H34N4O
  1
1
Ki = 4.1 nM
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CP0540854
 Compound Info 
N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]naphthalene-1-carboxamide
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C26H30N4O
  1
1
Ki = 4.2 nM
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CP0380999
 Compound Info 
1-cyclohexyl-3-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H36N4O
  1
1
Ki = 4.6 nM
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CP0537690
 Compound Info 
2-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,3-oxazole-4-carboxamide
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C21H28N4O2
  1
1
Ki = 4.6 nM
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CP0484124
 Compound Info 
5-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1H-pyrazole-3-carboxamide
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C21H29N5O
  1
1
Ki = 4.7 nM
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CP0517271
 Compound Info 
N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]-2-phenylacetamide
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C23H30N4O
  1
1
Ki = 4.9 nM
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CP0567287
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperidine-1-carboxamide
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C21H32N4O
  1
1
Ki = 6 nM
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CP0948376
 Compound Info 
N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)tetrahydro-2H-pyran-4-carboxamide
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C22H33N3O2
  1
1
Ki = 6.8 nM
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CP0374981
 Compound Info 
1-[(3,5-dichlorophenyl)methyl]-3-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H28Cl2N4O
  1
1
Ki = 7.1 nM
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CP0553879
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C21H31N3O2
  1
1
Ki = 7.33 nM
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CP0438205
 Compound Info 
N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C21H31N3O2
  1
1
Ki = 7.34 nM
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CP0375427
 Compound Info 
1-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(thiophen-2-ylmethyl)urea
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C22H30N4OS
  1
1
Ki = 8.4 nM
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CP0848190
 Compound Info 
2-cyclopentyl-N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)acetamide
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C23H35N3O
  1
1
Ki = 8.4 nM
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CP0432603
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C20H29N3O2
  1
1
Ki = 8.7 nM
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CP0856213
 Compound Info 
N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)cyclohexanecarboxamide
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C23H35N3O
  1
1
Ki = 9 nM
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CP0501000
 Compound Info 
N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropanecarboxamide
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C20H29N3O
  1
1
Ki = 9.6 nM
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CP0422519
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropanecarboxamide
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C19H27N3O
  1
1
Ki = 9.7 nM
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CP0489113
 Compound Info 
4-methyl-N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C22H35N5O
  1
1
Ki = 10.5 nM
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CP0500862
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-4-phenylpiperazine-1-carboxamide
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C26H35N5O
  1
1
Ki = 10.6 nM
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CP0395415
 Compound Info 
2-cyclopentyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]acetamide
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C23H35N3O
  1
1
Ki = 10.7 nM
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CP0525051
 Compound Info 
1,5-dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]pyrazole-3-carboxamide
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C22H31N5O
  1
1
Ki = 10.8 nM
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CP0456099
 Compound Info 
1-cyclohexyl-3-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H36N4O
  1
1
Ki = 11.2 nM
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CP0403914
 Compound Info 
4-methyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C22H35N5O
  1
1
Ki = 12.7 nM
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CP0440508
 Compound Info 
1-acetyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-2-carboxamide
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C22H32N4O2
  1
1
Ki = 14.1 nM
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CP0541595
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)phenyl]cyclopropanecarboxamide
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C20H26F3N3O
  1
1
Ki = 14.7 nM
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CP0406981
 Compound Info 
1-[4-[2-(diethylamino)ethoxy]phenyl]-3-[4-(2-methylpropoxy)phenyl]thiourea
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C23H33N3O2S
  1
1
Ki = 15.7 nM
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CP0395398
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]bicyclo[2.2.1]heptane-2-carboxamide
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C23H33N3O
  1
1
Ki = 15.7 nM
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CP0514211
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxane-4-carboxamide
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C22H33N3O2
  1
1
Ki = 17 nM
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CP0541615
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C21H31N3O2
  1
1
Ki = 17 nM
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CP0379883
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropanecarboxamide
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C20H29N3O
  1
1
Ki = 17.7 nM
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CP0380117
 Compound Info 
1-(3,5-dichloro-4-methylphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]urea
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C22H27Cl2N3O2
  1
1
Ki = 18.2 nM
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CP0248952
 Compound Info 
1-(3,5-dichlorophenyl)-3-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C22H26Cl2N4O
  1
1
Ki = 19.1 nM
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CP0956798
 Compound Info 
N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide
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C24H35N3O
  1
1
Ki = 19.9 nM
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CP0085869
 Compound Info 
1-(3,5-dichlorophenyl)-3-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H28Cl2N4O
  1
1
Ki = 22.2 nM
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CP0456100
 Compound Info 
4-acetyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C23H35N5O2
  1
1
Ki = 23 nM
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CP0380997
 Compound Info 
4-methyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C21H33N5O
  1
1
Ki = 25.7 nM
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CP0456097
 Compound Info 
1-[(3,5-dichlorophenyl)methyl]-3-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C24H30Cl2N4O
  1
1
Ki = 28.8 nM
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CP0406980
 Compound Info 
4-acetyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C22H33N5O2
  1
1
Ki = 34.1 nM
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CP0456098
 Compound Info 
3-[acetyl(methyl)amino]-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-1-carboxamide
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C23H35N5O2
  1
1
Ki = 35.5 nM
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CP0905229
 Compound Info 
2,2,3,3-tetramethyl-N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)cyclopropanecarboxamide
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C24H37N3O
  1
1
Ki = 37.3 nM
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CP0456096
 Compound Info 
1-(3,5-dichlorophenyl)-3-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H28Cl2N4O
  1
1
Ki = 43 nM
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CP0539731
 Compound Info 
1-acetyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-2-carboxamide
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C23H34N4O2
  1
1
Ki = 44.9 nM
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CP0380163
 Compound Info 
1-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(4-phenoxyphenyl)urea
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C28H32N4O2
  1
1
Ki = 46.8 nM
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CP0476802
 Compound Info 
1-acetyl-N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-2-carboxamide
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C23H34N4O2
  1
1
Ki = 57.7 nM
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CP0500999
 Compound Info 
2,2,3,3-tetramethyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropane-1-carboxamide
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C24H37N3O
  1
1
Ki = 65.5 nM
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CP0374980
 Compound Info 
3-[acetyl(methyl)amino]-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-1-carboxamide
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C24H37N5O2
  1
1
Ki = 89.7 nM
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CP0524039
 Compound Info 
1-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(4-phenoxyphenyl)urea
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C29H34N4O2
  1
1
Ki = 115.2 nM
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CP0478833
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]bicyclo[2.2.1]heptane-2-carboxamide
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C24H35N3O
  1
1
Ki = 130.3 nM
 Bioactivity Info 
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CP0407021
 Compound Info 
2,2,3,3-tetramethyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropane-1-carboxamide
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C23H35N3O
  1
1
Ki = 143.8 nM
 Bioactivity Info 
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