Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT07140 , Ataxin-2
Gene Name ATXN2
Organism Mus musculus, Mouse
Protein Classification Unclassified protein
Uniprot ID O70305
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT07140
 
Compound ID Compound Name Compound Formula
CP0579067
[4-[[4-[[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]phenyl]boronic acid
   Show/Hide
C26H27BN2O5
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0516642
(2S)-1-benzyl-5-oxo-N-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C32H37BN2O5
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0473097
(2S)-1-[(4-fluorophenyl)methyl]-5-oxo-N-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C32H36BFN2O5
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0535033
(2R)-1-benzyl-5-oxo-N-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C32H37BN2O5
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0577193
(2S)-1-benzyl-N-[[4-[[4-(hydroxycarbamoyl)phenyl]methoxy]phenyl]methyl]-5-oxopyrrolidine-2-carboxamide
   Show/Hide
C27H27N3O5
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0562217
4-[[4-[[[(2S)-1-[(4-fluorophenyl)methyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H27FN2O4
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0574906
4-[[4-[[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H26N2O5
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0487603
(2S)-N,1-dibenzyl-5-oxopyrrolidine-2-carboxamide
   Show/Hide
C19H20N2O2
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0516643
(2S)-1-benzyl-5-oxo-N-[[4-[(1-phenyltriazol-4-yl)methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C28H27N5O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0516645
4-[[4-[[(2S)-2-(benzylcarbamoyl)pyrrolidin-1-yl]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H28N2O4
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0526858
4-[[4-[[[(2S)-1-[(4-bromophenyl)methyl]-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H25BrN2O5
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0526859
(2S)-1-benzyl-N-[(4-hydroxyphenyl)methyl]-5-oxopyrrolidine-2-carboxamide
   Show/Hide
C19H20N2O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0535034
4-[[4-[[(2S)-2-(imidazol-1-ylmethyl)-5-oxopyrrolidin-1-yl]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C23H23N3O4
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0535035
4-[[4-[[[(2S)-1-benzylpyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H28N2O4
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0538246
(2S)-5-oxo-N-[[4-[(4-sulfamoylphenyl)methoxy]phenyl]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C27H26F3N3O5S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0539268
(2S)-1-benzyl-5-oxo-N-[[4-(pyridin-4-ylmethoxy)phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C25H25N3O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0540006
(2S)-1-benzyl-5-oxo-N-[[4-[(4-sulfamoylphenyl)methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C26H27N3O5S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0553257
4-[[4-[[[(2R)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H26N2O5
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0554546
4-[[4-[[[(2S)-1-[(4-fluorophenyl)methyl]-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H25FN2O5
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0554547
4-[[4-[[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C20H20N2O5
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0554548
(2S)-1-benzyl-5-oxo-N-[(4-phenylmethoxyphenyl)methyl]pyrrolidine-2-carboxamide
   Show/Hide
C26H26N2O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0558712
methyl 4-[[4-[[(2S)-2-(imidazol-1-ylmethyl)-5-oxopyrrolidin-1-yl]methyl]phenoxy]methyl]benzoate
   Show/Hide
C24H25N3O4
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0559730
(2S)-1-[(4-fluorophenyl)methyl]-5-oxo-N-[[4-[(4-sulfamoylphenyl)methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C26H26FN3O5S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0562218
4-[[4-[[[(2R)-1-[(4-fluorophenyl)methyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H27FN2O4
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0570874
methyl 4-[[4-[[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoate
   Show/Hide
C28H28N2O5
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0570875
N-[[(2S)-1-benzyl-5-oxopyrrolidin-2-yl]methyl]-4-sulfamoylbenzamide
   Show/Hide
C19H21N3O4S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0574907
4-[[4-[[(2S)-2-(benzylcarbamoyl)-5-oxopyrrolidin-1-yl]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C27H26N2O5
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0577192
4-[[4-[[[(2S)-5-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C28H25F3N2O5
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0927951
(S)-N-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-1-benzyl-5-oxopyrrolidine-2-carboxamide
   Show/Hide
C27H26N6O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0931028
(S)-4-(2-(4-((4-((1-benzyl-5-oxopyrrolidine-2-carboxamido)methyl)phenoxy)methyl)benzamido)ethyl)-1H-imidazol-3-ium chloride
   Show/Hide
C32H34ClN5O4
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0940000
(S)-4-(2-(4-((4-((1-(4-fluorobenzyl)-5-oxopyrrolidine-2-carboxamido)methyl)phenoxy)methyl)benzamido)ethyl)-1H-imidazol-3-ium chloride
   Show/Hide
C32H33ClFN5O4
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0947331
(S)-1-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-N-benzyl-5-oxopyrrolidine-2-carboxamide
   Show/Hide
C27H26N6O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0947337
(S)-N-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-1-(4-fluorobenzyl)-5-oxopyrrolidine-2-carboxamide
   Show/Hide
C27H25FN6O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0958787
(S)-1-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-N-benzylpyrrolidine-2-carboxamide
   Show/Hide
C27H28N6O2
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0968372
(S)-N-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-1-benzylpyrrolidine-2-carboxamide
   Show/Hide
C27H28N6O2
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS