General Information of the Protein
Protein ID
PT07140
Protein Name
Ataxin-2
Secondarily
Protein Name
Spinocerebellar ataxia type 2 protein homolog
Gene Name
ATXN2
Secondarily
Gene Name
Atx2
Sca2
Sequence
MRSSTAAVQRPAAGDPEPRRPAGWAARRSLPRTARRGGRGGAVAYPSAGPPPRGPGAPPRGPRSPPCASDCFGSNGHGASRPGSRRLLGVCGPPRPFVVVLLALAPAATPARACPPGVRASPPRSGVSSSARPAPGCPRPACEPVYGPLTMSLKPQPQPPAPATGRKPGGGLLSSPGAAPASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLFKCSDFVVVQFKDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELELENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNCSDREGHGPNTRDNKYIPPGQRNREVLSWGSGRQSSPRMGQPGPGSMPSRAASHTSDFNPNAGSDQRVVNGGVPWPSPCPSHSSRPPSRYQSGPNSLPPRAATHTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGPKAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL
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Organism
Mus musculus, Mouse
Protein Classification
Unclassified protein
Function
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
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Uniprot ID
Primary ID:
O70305

Secondarily ID:
P97421
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Ensembl ID
ENSG00000204842
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0579067
 Compound Info 
[4-[[4-[[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]phenyl]boronic acid
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C26H27BN2O5
  1
1
IC50 = 35 nM
 Bioactivity Info 
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CP0516642
 Compound Info 
(2S)-1-benzyl-5-oxo-N-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
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C32H37BN2O5
  1
1
IC50 = 50 nM
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CP0473097
 Compound Info 
(2S)-1-[(4-fluorophenyl)methyl]-5-oxo-N-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
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C32H36BFN2O5
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0535033
 Compound Info 
(2R)-1-benzyl-5-oxo-N-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
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C32H37BN2O5
  1
1
IC50 = 180 nM
 Bioactivity Info 
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CP0577193
 Compound Info 
(2S)-1-benzyl-N-[[4-[[4-(hydroxycarbamoyl)phenyl]methoxy]phenyl]methyl]-5-oxopyrrolidine-2-carboxamide
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C27H27N3O5
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0562217
 Compound Info 
4-[[4-[[[(2S)-1-[(4-fluorophenyl)methyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C27H27FN2O4
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0574906
 Compound Info 
4-[[4-[[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C27H26N2O5
  1
1
IC50 = 4500 nM
 Bioactivity Info 
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CP0487603
 Compound Info 
(2S)-N,1-dibenzyl-5-oxopyrrolidine-2-carboxamide
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C19H20N2O2
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0516643
 Compound Info 
(2S)-1-benzyl-5-oxo-N-[[4-[(1-phenyltriazol-4-yl)methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
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C28H27N5O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0516645
 Compound Info 
4-[[4-[[(2S)-2-(benzylcarbamoyl)pyrrolidin-1-yl]methyl]phenoxy]methyl]benzoic acid
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C27H28N2O4
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0526858
 Compound Info 
4-[[4-[[[(2S)-1-[(4-bromophenyl)methyl]-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C27H25BrN2O5
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0526859
 Compound Info 
(2S)-1-benzyl-N-[(4-hydroxyphenyl)methyl]-5-oxopyrrolidine-2-carboxamide
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C19H20N2O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0535034
 Compound Info 
4-[[4-[[(2S)-2-(imidazol-1-ylmethyl)-5-oxopyrrolidin-1-yl]methyl]phenoxy]methyl]benzoic acid
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C23H23N3O4
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0535035
 Compound Info 
4-[[4-[[[(2S)-1-benzylpyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C27H28N2O4
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0538246
 Compound Info 
(2S)-5-oxo-N-[[4-[(4-sulfamoylphenyl)methoxy]phenyl]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxamide
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C27H26F3N3O5S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0539268
 Compound Info 
(2S)-1-benzyl-5-oxo-N-[[4-(pyridin-4-ylmethoxy)phenyl]methyl]pyrrolidine-2-carboxamide
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C25H25N3O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0540006
 Compound Info 
(2S)-1-benzyl-5-oxo-N-[[4-[(4-sulfamoylphenyl)methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
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C26H27N3O5S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0553257
 Compound Info 
4-[[4-[[[(2R)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C27H26N2O5
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0554546
 Compound Info 
4-[[4-[[[(2S)-1-[(4-fluorophenyl)methyl]-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C27H25FN2O5
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0554547
 Compound Info 
4-[[4-[[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C20H20N2O5
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0554548
 Compound Info 
(2S)-1-benzyl-5-oxo-N-[(4-phenylmethoxyphenyl)methyl]pyrrolidine-2-carboxamide
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C26H26N2O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0558712
 Compound Info 
methyl 4-[[4-[[(2S)-2-(imidazol-1-ylmethyl)-5-oxopyrrolidin-1-yl]methyl]phenoxy]methyl]benzoate
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C24H25N3O4
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0559730
 Compound Info 
(2S)-1-[(4-fluorophenyl)methyl]-5-oxo-N-[[4-[(4-sulfamoylphenyl)methoxy]phenyl]methyl]pyrrolidine-2-carboxamide
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C26H26FN3O5S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0562218
 Compound Info 
4-[[4-[[[(2R)-1-[(4-fluorophenyl)methyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C27H27FN2O4
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0570874
 Compound Info 
methyl 4-[[4-[[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoate
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C28H28N2O5
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0570875
 Compound Info 
N-[[(2S)-1-benzyl-5-oxopyrrolidin-2-yl]methyl]-4-sulfamoylbenzamide
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C19H21N3O4S
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0574907
 Compound Info 
4-[[4-[[(2S)-2-(benzylcarbamoyl)-5-oxopyrrolidin-1-yl]methyl]phenoxy]methyl]benzoic acid
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C27H26N2O5
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0577192
 Compound Info 
4-[[4-[[[(2S)-5-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]methyl]benzoic acid
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C28H25F3N2O5
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0927951
 Compound Info 
(S)-N-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-1-benzyl-5-oxopyrrolidine-2-carboxamide
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C27H26N6O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0931028
 Compound Info 
(S)-4-(2-(4-((4-((1-benzyl-5-oxopyrrolidine-2-carboxamido)methyl)phenoxy)methyl)benzamido)ethyl)-1H-imidazol-3-ium chloride
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C32H34ClN5O4
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0940000
 Compound Info 
(S)-4-(2-(4-((4-((1-(4-fluorobenzyl)-5-oxopyrrolidine-2-carboxamido)methyl)phenoxy)methyl)benzamido)ethyl)-1H-imidazol-3-ium chloride
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C32H33ClFN5O4
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0947331
 Compound Info 
(S)-1-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-N-benzyl-5-oxopyrrolidine-2-carboxamide
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C27H26N6O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0947337
 Compound Info 
(S)-N-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-1-(4-fluorobenzyl)-5-oxopyrrolidine-2-carboxamide
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C27H25FN6O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0958787
 Compound Info 
(S)-1-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-N-benzylpyrrolidine-2-carboxamide
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C27H28N6O2
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0968372
 Compound Info 
(S)-N-(4-((4-(2H-tetrazol-5-yl)benzyl)oxy)benzyl)-1-benzylpyrrolidine-2-carboxamide
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C27H28N6O2
  1
1
IC50 > 5000 nM
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