General Information of the Compound
Compound ID
CP0574907
Compound Name
4-[[4-[[(2S)-2-(benzylcarbamoyl)-5-oxopyrrolidin-1-yl]methyl]phenoxy]methyl]benzoic acid
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Structure
Formula
C27H26N2O5
Molecular Weight
458.514
Canonical SMILES
OC(=O)c1ccc(COc2ccc(CN3[C@@H](CCC3=O)C(=O)NCc3ccccc3)cc2)cc1
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InChI
InChI=1S/C27H26N2O5/c30-25-15-14-24(26(31)28-16-19-4-2-1-3-5-19)29(25)17-20-8-12-23(13-9-20)34-18-21-6-10-22(11-7-21)27(32)33/h1-13,24H,14-18H2,(H,28,31)(H,32,33)/t24-/m0/s1
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InChIKey
HYHMBEPIQBIQLC-DEOSSOPVSA-N
Physicochemical Property
logP
3.7712
Rotatable Bonds
9
Heavy Atom Count
34
Polar Areas
95.94
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156021688
ChEMBL ID
CHEMBL4647271
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT07140, Ataxin-2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 5000 nM
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