Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT06160 , Neuropeptides B/W receptor type 1
Gene Name NPBWR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P48145
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT06160
 
Compound ID Compound Name Compound Formula
CP0448010
5-chloro-4-(4-ethoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C23H19ClN2O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0142294
5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C24H17ClN2O3
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0508312
5-chloro-4-(4-methoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C22H17ClN2O3
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0433913
5-chloro-4-(4-methoxyphenoxy)-2-[(2-methylnaphthalen-1-yl)methyl]pyridazin-3-one
   Show/Hide
C23H19ClN2O3
 1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
CP0465668
5-chloro-4-(4-methoxyphenoxy)-2-[(2-pyrazol-1-ylphenyl)methyl]pyridazin-3-one
   Show/Hide
C21H17ClN4O3
 1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
CP0448009
5-chloro-4-(4-ethylphenoxy)-2-(9H-fluoren-9-yl)pyridazin-3-one
   Show/Hide
C25H19ClN2O2
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0517981
5-chloro-2-[(2,6-dimethylphenyl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C20H19ClN2O3
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0433912
5-chloro-4-(4-ethoxyphenoxy)-2-(9H-fluoren-9-yl)pyridazin-3-one
   Show/Hide
C25H19ClN2O3
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0450489
5-chloro-4-(4-ethylphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C23H19ClN2O2
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0448823
5-chloro-2-[(2-ethylphenyl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C20H19ClN2O3
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0286870
5-chloranyl-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C19H17ClN2O3
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0425639
2-[4-chloro-5-(4-methoxyphenoxy)-6-oxopyridazin-1-yl]-N,N-diphenylacetamide
   Show/Hide
C25H20ClN3O4
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0469124
5-chloro-4-(3,4-dimethoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C23H19ClN2O4
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0448008
2-(anthracen-9-ylmethyl)-5-chloro-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C26H19ClN2O3
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0433910
5-chloro-2-[(2-methoxynaphthalen-1-yl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C23H19ClN2O4
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0444798
5-chloro-4-(3-fluoro-4-methoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C22H16ClFN2O3
 1
1
IC50 = 360 nM
   TI
   LI
   LO
   TS
CP0517979
5-chloro-2-[(4-fluoronaphthalen-1-yl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C22H16ClFN2O3
 1
1
IC50 = 360 nM
   TI
   LI
   LO
   TS
CP0425638
5-chloro-4-(4-methoxyphenoxy)-2-[[2-(trifluoromethyl)phenyl]methyl]pyridazin-3-one
   Show/Hide
C19H14ClF3N2O3
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0433908
5-chloro-2-(3-chlorobenzo[b][1,4]benzoxazepin-6-yl)-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C24H15Cl2N3O4
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0433909
5-chloro-4-(4-methoxyphenoxy)-2-[(4-methylnaphthalen-1-yl)methyl]pyridazin-3-one
   Show/Hide
C23H19ClN2O3
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0497483
5-chloro-4-(4-methoxyphenoxy)-2-[(2-methylphenyl)methyl]pyridazin-3-one
   Show/Hide
C19H17ClN2O3
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0433907
5-chloro-2-[(3,5-dimethylphenyl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C20H19ClN2O3
 1
1
IC50 = 410 nM
   TI
   LI
   LO
   TS
CP0437439
5-chloro-4-(4-methylsulfanylphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C22H17ClN2O2S
 1
1
IC50 = 430 nM
   TI
   LI
   LO
   TS
CP0448002
5-chloro-4-(4-methoxyphenoxy)-2-(2-oxo-3,3-diphenylpropyl)pyridazin-3-one
   Show/Hide
C26H21ClN2O4
 1
1
IC50 = 430 nM
   TI
   LI
   LO
   TS
CP0485410
5-chloro-4-(2,3-dihydro-1-benzofuran-5-yloxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C23H17ClN2O3
 1
1
IC50 = 430 nM
   TI
   LI
   LO
   TS
CP0448001
ethyl 2-[4-chloro-5-(4-methoxyphenoxy)-6-oxopyridazin-1-yl]-2-naphthalen-1-ylacetate
   Show/Hide
C25H21ClN2O5
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0448000
2-benzo[b][1,4]benzoxazepin-6-yl-5-chloro-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C24H16ClN3O4
 1
1
IC50 = 490 nM
   TI
   LI
   LO
   TS
CP0454963
5-chloro-2-(8-chloropyrido[2,3-b][1,5]benzoxazepin-5-yl)-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C23H14Cl2N4O4
 1
1
IC50 = 530 nM
   TI
   LI
   LO
   TS
CP0489906
5-chloro-2-(naphthalen-1-ylmethyl)-4-(4-propan-2-yloxyphenoxy)pyridazin-3-one
   Show/Hide
C24H21ClN2O3
 1
1
IC50 = 530 nM
   TI
   LI
   LO
   TS
CP0450488
5-chloro-4-(4-methoxyphenoxy)-2-[(2-phenylphenyl)methyl]pyridazin-3-one
   Show/Hide
C24H19ClN2O3
 1
1
IC50 = 540 nM
   TI
   LI
   LO
   TS
CP0450487
5-chloro-4-(4-methoxyphenoxy)-2-(2-oxo-1,2-diphenylethyl)pyridazin-3-one
   Show/Hide
C25H19ClN2O4
 1
1
IC50 = 580 nM
   TI
   LI
   LO
   TS
CP0425637
5-chloro-2-[(4-chlorophenyl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C18H14Cl2N2O3
 1
1
IC50 = 590 nM
   TI
   LI
   LO
   TS
CP0447998
5-chloro-4-(3-methoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C22H17ClN2O3
 1
1
IC50 = 610 nM
   TI
   LI
   LO
   TS
CP0447999
5-chloro-2-[(3,4-dimethylphenyl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C20H19ClN2O3
 1
1
IC50 = 610 nM
   TI
   LI
   LO
   TS
CP0425636
5-chloro-4-(2-fluoro-4-methoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C22H16ClFN2O3
 1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
CP0509893
5-chloro-4-(4-methoxyphenoxy)-2-[(2-propan-2-ylphenyl)methyl]pyridazin-3-one
   Show/Hide
C21H21ClN2O3
 1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
CP0450486
5-chloro-4-(4-methoxyphenoxy)-2-[(2-methoxyphenyl)methyl]pyridazin-3-one
   Show/Hide
C19H17ClN2O4
 1
1
IC50 = 670 nM
   TI
   LI
   LO
   TS
CP0517978
5-chloro-4-[4-(hydroxymethyl)phenoxy]-2-(2-methylphenyl)pyridazin-3-one
   Show/Hide
C18H15ClN2O3
 1
1
IC50 = 730 nM
   TI
   LI
   LO
   TS
CP0448536
5-chloro-4-(4-methoxyphenoxy)-2-[2-(2-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]pyridazin-3-one
   Show/Hide
C22H20ClN3O4
 1
1
IC50 = 780 nM
   TI
   LI
   LO
   TS
CP0450485
2-benzyl-5-chloro-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C18H15ClN2O3
 1
1
IC50 = 780 nM
   TI
   LI
   LO
   TS
CP0517977
4-(1-benzofuran-5-yloxy)-5-chloro-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C23H15ClN2O3
 1
1
IC50 = 820 nM
   TI
   LI
   LO
   TS
CP0425635
5-chloro-4-(2,3-dihydro-1H-inden-5-yloxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C24H19ClN2O2
 1
1
IC50 = 830 nM
   TI
   LI
   LO
   TS
CP0437440
5-chloro-4-(3-ethoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C23H19ClN2O3
 1
1
IC50 = 980 nM
   TI
   LI
   LO
   TS
CP0447997
5-chloro-4-(4-methoxyphenoxy)-2-[[4-(trifluoromethyl)phenyl]methyl]pyridazin-3-one
   Show/Hide
C19H14ClF3N2O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0425634
5-chloro-2-(naphthalen-1-ylmethyl)-4-(4-propoxyphenoxy)pyridazin-3-one
   Show/Hide
C24H21ClN2O3
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0382767
methyl 2-[[4-chloro-5-(4-methoxyphenoxy)-6-oxopyridazin-1-yl]methyl]benzoate
   Show/Hide
C20H17ClN2O5
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0444799
2-[[4-chloro-5-(4-methoxyphenoxy)-6-oxopyridazin-1-yl]methyl]benzonitrile
   Show/Hide
C19H14ClN3O3
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0447996
5-chloro-4-(4-methoxyphenoxy)-2-[(3-methylphenyl)methyl]pyridazin-3-one
   Show/Hide
C19H17ClN2O3
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0447994
5-chloro-4-(4-methoxyphenoxy)-2-(naphthalen-2-ylmethyl)pyridazin-3-one
   Show/Hide
C22H17ClN2O3
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0489905
5-chloranyl-4-(4-methoxyphenoxy)-2-[(4-methylphenyl)methyl]pyridazin-3-one
   Show/Hide
C19H17ClN2O3
 1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0447993
5-chloro-2-(naphthalen-1-ylmethyl)-4-(3,4,5-trimethoxyphenoxy)pyridazin-3-one
   Show/Hide
C24H21ClN2O5
 1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0517976
5-chloro-4-(4-methoxyphenoxy)-2-[[3-(trifluoromethyl)phenyl]methyl]pyridazin-3-one
   Show/Hide
C19H14ClF3N2O3
 1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0497482
5-chloro-4-(4-methoxyphenoxy)-2-(1-naphthalen-1-ylethyl)pyridazin-3-one
   Show/Hide
C23H19ClN2O3
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0447992
2-[(4-bromonaphthalen-1-yl)methyl]-5-chloro-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C22H16BrClN2O3
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0465388
6-[4-chloro-5-(4-methoxyphenoxy)-6-oxopyridazin-1-yl]benzo[c][1]benzazepin-11-one
   Show/Hide
C25H16ClN3O4
 1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0447990
5-chloro-2-(2-hydroxy-1-naphthalen-1-ylethyl)-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C23H19ClN2O4
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0456277
5-chloro-4-(4-methoxyphenoxy)-2-(9H-xanthen-9-yl)pyridazin-3-one
   Show/Hide
C24H17ClN2O4
 1
1
IC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0517975
5-chloro-4-(4-methoxyphenoxy)-2-(quinolin-5-ylmethyl)pyridazin-3-one
   Show/Hide
C21H16ClN3O3
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0447989
5-chloro-2-(cyclopentylmethyl)-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C17H19ClN2O3
 1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0517974
5-chloro-4-(4-methoxyphenoxy)-2-[(4-methoxyphenyl)methyl]pyridazin-3-one
   Show/Hide
C19H17ClN2O4
 1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0514896
5-chloro-4-(4-methoxyphenoxy)-2-(2-naphthalen-1-ylethyl)pyridazin-3-one
   Show/Hide
C23H19ClN2O3
 1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0425633
5-chloro-4-[4-(hydroxymethyl)phenoxy]-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C22H17ClN2O3
 1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0447988
5-chloro-2-(naphthalen-1-ylmethyl)-4-[4-(trifluoromethoxy)phenoxy]pyridazin-3-one
   Show/Hide
C22H14ClF3N2O3
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0447987
5-chloro-4-(3-ethylphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
   Show/Hide
C23H19ClN2O2
 1
1
IC50 = 8500 nM
   TI
   LI
   LO
   TS
CP0395996
5-chloro-4-(4-methoxyphenoxy)-2-[(4-phenylphenyl)methyl]pyridazin-3-one
   Show/Hide
C24H19ClN2O3
 1
1
IC50 = 9400 nM
   TI
   LI
   LO
   TS
CP0425625
5-chloro-4-(4-methoxyphenoxy)-2-[(4-propan-2-ylphenyl)methyl]pyridazin-3-one
   Show/Hide
C21H21ClN2O3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0450484
[2-[4-chloro-5-(4-methoxyphenoxy)-6-oxopyridazin-1-yl]-2-naphthalen-1-ylethyl] acetate
   Show/Hide
C25H21ClN2O5
 1
1
IC50 = 11600 nM
   TI
   LI
   LO
   TS
CP0425624
5-chloro-4-(4-methoxyphenoxy)-2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)pyridazin-3-one
   Show/Hide
C26H21ClN2O3
 1
1
IC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0447986
5-chloro-4-(4-methoxyphenoxy)-2-[naphthalen-1-yl(phenyl)methyl]pyridazin-3-one
   Show/Hide
C28H21ClN2O3
 1
1
IC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0425640
methyl 4-[5-chloro-2-(naphthalen-1-ylmethyl)-3-oxopyridazin-4-yl]oxybenzoate
   Show/Hide
C23H17ClN2O4
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0450490
5-chloro-2-(9H-fluoren-9-yl)-4-(4-propoxyphenoxy)pyridazin-3-one
   Show/Hide
C26H21ClN2O3
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0499268
5-chloro-2-(9H-fluoren-9-yl)-4-[4-(trifluoromethoxy)phenoxy]pyridazin-3-one
   Show/Hide
C24H14ClF3N2O3
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0514076
2-benzo[b][1,4]benzothiazepin-6-yl-5-chloro-4-(4-methoxyphenoxy)pyridazin-3-one
   Show/Hide
C24H16ClN3O3S
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS