General Information of the Compound
Compound ID
CP0425633
Compound Name
5-chloro-4-[4-(hydroxymethyl)phenoxy]-2-(naphthalen-1-ylmethyl)pyridazin-3-one
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Structure
Formula
C22H17ClN2O3
Molecular Weight
392.842
Canonical SMILES
OCc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
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InChI
InChI=1S/C22H17ClN2O3/c23-20-12-24-25(13-17-6-3-5-16-4-1-2-7-19(16)17)22(27)21(20)28-18-10-8-15(14-26)9-11-18/h1-12,26H,13-14H2
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InChIKey
AVMGWMFSIPBMIB-UHFFFAOYSA-N
Physicochemical Property
logP
4.3828
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
64.35
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 50904442
SID: 163512240
ChEMBL ID
CHEMBL2314290
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06160, Neuropeptides B/W receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4400 nM
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