Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT06093 , Small conductance calcium-activated potassium channel protein 2
Gene Name KCNN2
Organism Rattus norvegicus, Rat
Protein Classification Ion channel
Uniprot ID P70604
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT06093
 
Compound ID Compound Name Compound Formula
CP0563721
3-[(1R,4S,7R,12R,15S,18S,21S,27S,30S,36S,39R,44R,47S,50S,53S,56S,59R,66S,69S,75S,80S,83S,86S)-4,36-bis(4-aminobutyl)-7-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl]-47-(2-amino-2-oxoethyl)-44-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]-75-[(2S)-butan-2-yl]-15,53,56-tris(3-carbamimidamidopropyl)-66,80-bis(2-carboxyethyl)-18,86-bis(hydroxymethyl)-21,27,30,50,83-pentakis(2-methylpropyl)-2,5,13,16,19,22,25,28,31,34,37,45,48,51,54,57,65,68,71,74,77,78,81,84,87-pentacosaoxo-9,10,41,42,61,62-hexathia-3,6,14,17,20,23,26,29,32,35,38,46,49,52,55,58,64,67,70,73,76,79,82,85,88-pentacosazatricyclo[37.24.14.1112,59]octaoctacontan-69-yl]propanoic acid
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C146H238N44O41S6
 1
1
EC50 = 0.024 nM
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CP0952928
Apamin
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C79H131N31O24S4
 1
1
EC50 = 0.027 nM
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CP0965644
Scyllatoxin
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C142H236N44O40S7
 1
1
EC50 = 0.29 nM
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CP0495333
N-(5-chloro-2-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 2
1
EC50 = 91 nM
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2
EC50 = 640 nM
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CP0488487
N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 2
1
EC50 = 110 nM
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2
EC50 = 990 nM
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CP0488747
N-(2,5-difluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15F2N5
 1
1
EC50 = 1890 nM
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CP0568687
N-(4-chloro-2-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 1
1
EC50 = 1990 nM
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CP0495334
N-(2-chloro-5-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 1
1
EC50 = 2970 nM
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CP0571132
N-[3-chloro-4-(trifluoromethyl)phenyl]-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C17H15ClF3N5
 1
1
EC50 = 3270 nM
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CP0542557
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine
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C17H16F3N5
 1
1
EC50 = 3450 nM
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CP0577979
N-(3-chloro-4-fluorophenyl)-6-methyl-2-(2-methyl-1,3-oxazol-4-yl)pyrimidin-4-amine
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C15H12ClFN4O
 1
1
EC50 = 3590 nM
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CP0572066
N-(3-chloro-4-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)-4-methylpyridazin-3-amine
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C16H15ClFN5
 1
1
EC50 = 4320 nM
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CP0533728
N-(5-chloro-2-fluorophenyl)-6-methyl-2-(4-methylimidazol-1-yl)pyrimidin-4-amine
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C15H13ClFN5
 1
1
EC50 = 4510 nM
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CP0577977
N-(2,3-difluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15F2N5
 1
1
EC50 = 5030 nM
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CP0579234
4-N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidine-4,6-diamine
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C15H14ClFN6
 1
1
EC50 = 6590 nM
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CP0423346
N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H23N5
 1
1
EC50 = 7480 nM
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CP0543742
N-(5-chloro-2-fluorophenyl)-6-methyl-2-(2-methyl-1,3-oxazol-4-yl)pyrimidin-4-amine
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C15H12ClFN4O
 1
1
EC50 = 13770 nM
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CP0578211
3-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]-4-fluorobenzoic acid
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C17H16FN5O2
 1
1
EC50 > 30000 nM
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CP0577978
N-(3-chloro-4-fluorophenyl)-6-methyl-2-(4-methylimidazol-1-yl)pyrimidin-4-amine
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C15H13ClFN5
 1
1
EC50 = 38810 nM
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CP0542558
2-(3,5-dimethylpyrazol-1-yl)-N-(4-methoxycyclohexyl)-6-methylpyrimidin-4-amine
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C17H25N5O
 1
1
EC50 = 49720 nM
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CP0488486
4-N-(2-chloro-5-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0488746
(2S)-3-(4-cyanophenyl)-2-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]propanoic acid
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C20H20N6O2
 1
1
EC50 > 100000 nM
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CP0534039
4-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]cyclohexane-1,4-diamine
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C16H24N6
 1
1
EC50 > 100000 nM
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CP0543737
4-N-[3-chloro-4-(trifluoromethyl)phenyl]-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C16H14ClF3N6
 1
1
EC50 > 100000 nM
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CP0546040
4-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]cyclohexan-1-ol
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C16H23N5O
 1
1
EC50 > 100000 nM
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CP0546041
[4-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]cyclohexyl]methanol
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C17H25N5O
 1
1
EC50 > 100000 nM
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CP0546042
(2S)-2-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]-3-(4-hydroxyphenyl)propanoic acid
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C19H21N5O3
 1
1
EC50 > 100000 nM
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CP0568688
4-N-(4-chloro-2-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0569645
N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]-5,6-dimethoxy-1H-benzimidazol-2-amine
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C19H21N7O2
 1
1
EC50 > 100000 nM
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CP0569647
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-(4-nitrophenyl)pyrimidin-4-amine
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C16H16N6O2
 1
1
EC50 > 100000 nM
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CP0570039
(2S)-3-(3,4-difluorophenyl)-2-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]propanoic acid
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C19H19F2N5O2
 1
1
EC50 > 100000 nM
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CP0570041
4-N-(2,5-difluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14F2N6
 1
1
EC50 > 100000 nM
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CP0571131
2-(3,5-dimethylpyrazol-1-yl)-N-(4-fluorocyclohexyl)-6-methylpyrimidin-4-amine
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C16H22FN5
 1
1
EC50 > 100000 nM
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CP0571133
4-N-(3-chlorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H15ClN6
 1
1
EC50 > 100000 nM
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CP0577976
4-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]benzenethiol
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C16H17N5S
 1
1
EC50 > 100000 nM
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CP0578210
N-[3-chloro-5-(trifluoromethyl)phenyl]-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C17H15ClF3N5
 1
1
EC50 > 100000 nM
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CP0578212
4-N-(3-chloro-4-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0578286
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-(4-nitrocyclohexyl)pyrimidin-4-amine
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C16H22N6O2
 1
1
EC50 > 100000 nM
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CP0578287
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-[2-(4-nitrophenyl)ethyl]pyrimidin-4-amine
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C18H20N6O2
 1
1
EC50 > 100000 nM
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CP0578288
4-N-(5-chloro-2-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0867692
1,1'-(1,3-phenylenebis(methylene))bis(8-isopropyl-2-methylisoquinolinium)iodide
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C34H38I2N2
 1
1
IC50 = 1600 nM
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