General Information of the Protein
Protein ID
PT06093
Protein Name
Small conductance calcium-activated potassium channel protein 2
Secondarily
Protein Name
KCa2.2
Gene Name
KCNN2
Sequence
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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Organism
Rattus norvegicus, Rat
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Calcium-activated potassium channel
Function
Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:8781233, PubMed:20562108). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
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Uniprot ID
P70604
Ensembl ID
ENSG00000080709
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0563721
3-[(1R,4S,7R,12R,15S,18S,21S,27S,30S,36S,39R,44R,47S,50S,53S,56S,59R,66S,69S,75S,80S,83S,86S)-4,36-bis(4-aminobutyl)-7-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl]-47-(2-amino-2-oxoethyl)-44-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]-75-[(2S)-butan-2-yl]-15,53,56-tris(3-carbamimidamidopropyl)-66,80-bis(2-carboxyethyl)-18,86-bis(hydroxymethyl)-21,27,30,50,83-pentakis(2-methylpropyl)-2,5,13,16,19,22,25,28,31,34,37,45,48,51,54,57,65,68,71,74,77,78,81,84,87-pentacosaoxo-9,10,41,42,61,62-hexathia-3,6,14,17,20,23,26,29,32,35,38,46,49,52,55,58,64,67,70,73,76,79,82,85,88-pentacosazatricyclo[37.24.14.1112,59]octaoctacontan-69-yl]propanoic acid
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C146H238N44O41S6
 1
1
EC50 = 0.024 nM
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CP0952928
Apamin
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C79H131N31O24S4
 1
1
EC50 = 0.027 nM
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CP0965644
Scyllatoxin
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C142H236N44O40S7
 1
1
EC50 = 0.29 nM
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CP0495333
N-(5-chloro-2-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 2
1
EC50 = 91 nM
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2
EC50 = 640 nM
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CP0488487
N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 2
1
EC50 = 110 nM
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2
EC50 = 990 nM
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CP0488747
N-(2,5-difluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15F2N5
 1
1
EC50 = 1890 nM
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CP0568687
N-(4-chloro-2-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 1
1
EC50 = 1990 nM
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CP0495334
N-(2-chloro-5-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15ClFN5
 1
1
EC50 = 2970 nM
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CP0571132
N-[3-chloro-4-(trifluoromethyl)phenyl]-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C17H15ClF3N5
 1
1
EC50 = 3270 nM
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CP0542557
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine
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C17H16F3N5
 1
1
EC50 = 3450 nM
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CP0577979
N-(3-chloro-4-fluorophenyl)-6-methyl-2-(2-methyl-1,3-oxazol-4-yl)pyrimidin-4-amine
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C15H12ClFN4O
 1
1
EC50 = 3590 nM
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CP0572066
N-(3-chloro-4-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)-4-methylpyridazin-3-amine
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C16H15ClFN5
 1
1
EC50 = 4320 nM
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CP0533728
N-(5-chloro-2-fluorophenyl)-6-methyl-2-(4-methylimidazol-1-yl)pyrimidin-4-amine
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C15H13ClFN5
 1
1
EC50 = 4510 nM
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CP0577977
N-(2,3-difluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H15F2N5
 1
1
EC50 = 5030 nM
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CP0579234
4-N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidine-4,6-diamine
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C15H14ClFN6
 1
1
EC50 = 6590 nM
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CP0423346
N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C16H23N5
 1
1
EC50 = 7480 nM
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CP0543742
N-(5-chloro-2-fluorophenyl)-6-methyl-2-(2-methyl-1,3-oxazol-4-yl)pyrimidin-4-amine
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C15H12ClFN4O
 1
1
EC50 = 13770 nM
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CP0578211
3-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]-4-fluorobenzoic acid
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C17H16FN5O2
 1
1
EC50 > 30000 nM
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CP0577978
N-(3-chloro-4-fluorophenyl)-6-methyl-2-(4-methylimidazol-1-yl)pyrimidin-4-amine
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C15H13ClFN5
 1
1
EC50 = 38810 nM
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CP0542558
2-(3,5-dimethylpyrazol-1-yl)-N-(4-methoxycyclohexyl)-6-methylpyrimidin-4-amine
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C17H25N5O
 1
1
EC50 = 49720 nM
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CP0488486
4-N-(2-chloro-5-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0488746
(2S)-3-(4-cyanophenyl)-2-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]propanoic acid
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C20H20N6O2
 1
1
EC50 > 100000 nM
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CP0534039
4-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]cyclohexane-1,4-diamine
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C16H24N6
 1
1
EC50 > 100000 nM
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CP0543737
4-N-[3-chloro-4-(trifluoromethyl)phenyl]-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C16H14ClF3N6
 1
1
EC50 > 100000 nM
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CP0546040
4-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]cyclohexan-1-ol
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C16H23N5O
 1
1
EC50 > 100000 nM
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CP0546041
[4-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]cyclohexyl]methanol
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C17H25N5O
 1
1
EC50 > 100000 nM
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CP0546042
(2S)-2-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]-3-(4-hydroxyphenyl)propanoic acid
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C19H21N5O3
 1
1
EC50 > 100000 nM
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CP0568688
4-N-(4-chloro-2-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0569645
N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]-5,6-dimethoxy-1H-benzimidazol-2-amine
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C19H21N7O2
 1
1
EC50 > 100000 nM
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CP0569647
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-(4-nitrophenyl)pyrimidin-4-amine
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C16H16N6O2
 1
1
EC50 > 100000 nM
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CP0570039
(2S)-3-(3,4-difluorophenyl)-2-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]propanoic acid
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C19H19F2N5O2
 1
1
EC50 > 100000 nM
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CP0570041
4-N-(2,5-difluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14F2N6
 1
1
EC50 > 100000 nM
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CP0571131
2-(3,5-dimethylpyrazol-1-yl)-N-(4-fluorocyclohexyl)-6-methylpyrimidin-4-amine
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C16H22FN5
 1
1
EC50 > 100000 nM
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CP0571133
4-N-(3-chlorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H15ClN6
 1
1
EC50 > 100000 nM
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CP0577976
4-[[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amino]benzenethiol
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C16H17N5S
 1
1
EC50 > 100000 nM
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CP0578210
N-[3-chloro-5-(trifluoromethyl)phenyl]-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
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C17H15ClF3N5
 1
1
EC50 > 100000 nM
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CP0578212
4-N-(3-chloro-4-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0578286
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-(4-nitrocyclohexyl)pyrimidin-4-amine
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C16H22N6O2
 1
1
EC50 > 100000 nM
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CP0578287
2-(3,5-dimethylpyrazol-1-yl)-6-methyl-N-[2-(4-nitrophenyl)ethyl]pyrimidin-4-amine
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C18H20N6O2
 1
1
EC50 > 100000 nM
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CP0578288
4-N-(5-chloro-2-fluorophenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidine-2,4-diamine
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C15H14ClFN6
 1
1
EC50 > 100000 nM
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CP0867692
1,1'-(1,3-phenylenebis(methylene))bis(8-isopropyl-2-methylisoquinolinium)iodide
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C34H38I2N2
 1
1
IC50 = 1600 nM
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