Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT04583 , Prokineticin receptor 1
Gene Name PROKR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q8TCW9
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT04583
 
Compound ID Compound Name Compound Formula
CP0457451
1-(2-(5-(4-chlorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H24ClN7O3
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0469781
1-(2-(1,5-bis(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O4
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0527532
1-(2-(5-(3,4-dichlorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H23Cl2N7O3
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0481722
1-(2-(1-(4-hydroxybenzyl)-5-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H25N7O4
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0418705
1-(2-(5-(4-fluorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H24FN7O3
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0398342
1-(2-(5-(3,4-dichlorobenzyl)-1-(4-(difluoromethoxy)benzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H21Cl2F2N7O3
 1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CP0521460
1-(2-(5-(4-methoxybenzyl)-1-((6-methoxypyridin-3-yl)methyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H26N8O4
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0473857
1-(2-(5-(4-cyanobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H24N8O3
 1
1
IC50 = 318 nM
   TI
   LI
   LO
   TS
CP0398349
1-(2-(5-benzyl-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H25N7O3
 1
1
IC50 = 336 nM
   TI
   LI
   LO
   TS
CP0528579
1-(2-(1-(4-methoxybenzyl)-5-(4-methoxyphenethyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C23H29N7O4
 1
1
IC50 = 461 nM
   TI
   LI
   LO
   TS
CP0439772
1-(2-(5-(3,4-dichlorobenzyl)-4,6-dioxo-1-(4-propoxybenzyl)-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C23H27Cl2N7O3
 1
1
IC50 = 515 nM
   TI
   LI
   LO
   TS
CP0439770
1-(2-(5-(4-hydroxybenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C21H25N7O4
 1
1
IC50 = 1160 nM
   TI
   LI
   LO
   TS
CP0472246
1-(3-(5-(3,4-dichlorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)propyl)guanidine
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C22H25Cl2N7O3
 1
1
IC50 = 1210 nM
   TI
   LI
   LO
   TS
CP0481723
1-(2-(5-(4-chlorobenzyl)-1-(furan-3-yl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C17H18ClN7O3
 1
1
IC50 = 1870 nM
   TI
   LI
   LO
   TS
CP0374102
1-(2-(5-butyl-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C18H27N7O3
 1
1
IC50 = 2180 nM
   TI
   LI
   LO
   TS
CP0506014
1-(2-(1-(4-methoxybenzyl)-4,6-dioxo-5-phenethyl-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O3
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0473761
1-(2-(5-(furan-2-yl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C18H21N7O4
 1
1
IC50 = 2590 nM
   TI
   LI
   LO
   TS
CP0481672
1-(2-(5-(4-fluorobenzyl)-1-(4-methoxyphenethyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H26FN7O3
 1
1
IC50 = 2860 nM
   TI
   LI
   LO
   TS
CP0396957
1-(2-(5-(4-methoxybenzyl)-1-((4-methoxycyclohexyl)methyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H33N7O4
 1
1
IC50 = 3260 nM
   TI
   LI
   LO
   TS
CP0473763
1-(2-(5-(3-methoxybenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O4
 1
1
IC50 = 3690 nM
   TI
   LI
   LO
   TS
CP0538028
1-(2-(1-benzyl-5-(4-chloro-2-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C20H22ClN7O2
 1
1
IC50 = 4780 nM
   TI
   LI
   LO
   TS
CP0473764
1-(2-(5-(3,4-dichlorobenzyl)-1-hexyl-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C19H27Cl2N7O2
 1
1
IC50 = 6510 nM
   TI
   LI
   LO
   TS
CP0418706
1-(2-(5-(2-methoxybenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C22H27N7O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0439771
1-(2-(5-(4-fluorobenzyl)-1-(4-nitrobenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C20H21FN8O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0439774
1-(2-(5-benzyl-1-(4-fluorobenzyl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
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C20H22FN7O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS