Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT03126 , Kelch-like ECH-associated protein 1
 Protein Info 
Gene Name KEAP1
Organism Homo sapiens, Human
Protein Classification Unclassified protein
Uniprot ID Q14145
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006
 Cell Line Info 
 Protein ID: PT03126
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0446048
 Compound Info 
(3S)-3-[5-fluoro-3-(1,2-thiazol-5-yl)pyridin-2-yl]-3-methoxy-5,5-dimethyl-6-oxocyclohexene-1-carbonitrile
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C18H16FN3O2S
  1
1
EC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0575413
 Compound Info 
3-[5-fluoro-3-(1-methylpyrazol-4-yl)pyridin-2-yl]-3-methoxy-5,5-dimethyl-6-oxocyclohexene-1-carbonitrile
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C19H19FN4O2
  1
1
EC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0538369
 Compound Info 
3-(3-bromo-5-fluoropyridin-2-yl)-3-methoxy-5,5-dimethyl-6-oxocyclohexene-1-carbonitrile
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C15H14BrFN2O2
  1
1
EC50 = 6 nM
 Bioactivity Info 
   TI
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CP0391316
 Compound Info 
3-[5-fluoro-3-(2-methyl-1,3-thiazol-5-yl)pyridin-2-yl]-3-methoxy-5,5-dimethyl-6-oxocyclohexene-1-carbonitrile
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C19H18FN3O2S
  1
1
EC50 = 7 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0569721
 Compound Info 
3-[3-(difluoromethoxy)-5-fluoropyridin-2-yl]-3-methoxy-5,5-dimethyl-6-oxocyclohexene-1-carbonitrile
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C16H15F3N2O3
  1
1
EC50 = 8 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0547525
 Compound Info 
(5S)-5-[3-(difluoromethyl)pyridin-2-yl]-5-methoxy-8-oxospiro[2.5]oct-6-ene-7-carbonitrile
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C16H14F2N2O2
  1
1
EC50 = 14 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0543914
 Compound Info 
5-[3-(difluoromethyl)-5-fluoropyridin-2-yl]-5-methoxy-8-oxospiro[2.5]oct-6-ene-7-carbonitrile
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C16H13F3N2O2
  1
1
EC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416251
 Compound Info 
3-methoxy-5,5-dimethyl-6-oxo-3-[3-(trifluoromethyl)pyridin-2-yl]cyclohexene-1-carbonitrile
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C16H15F3N2O2
  1
1
EC50 = 24 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0484405
 Compound Info 
(3S)-3-[3-(difluoromethyl)-5-fluoropyridin-2-yl]-3-methoxy-5,5-dimethyl-6-oxocyclohexene-1-carbonitrile
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C16H15F3N2O2
  1
1
EC50 = 33 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0469356
 Compound Info 
US11479539, Compound 22
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C15H15BrN2O2
  1
1
EC50 = 45 nM
 Bioactivity Info 
   TI
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CP0471821
 Compound Info 
3-methoxy-5,5-dimethyl-3-[3-(1-methylpyrazol-4-yl)pyridin-2-yl]-6-oxocyclohexene-1-carbonitrile
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C19H20N4O2
  1
1
EC50 = 56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0467695
 Compound Info 
US11479539, Compound 25
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C19H20N4O2
  1
1
EC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS