Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT03123 , G-protein coupled receptor 39
Gene Name GPR39
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID O43194
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT03123
 
Compound ID Compound Name Compound Formula
CP0067898
N-[3-chloro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
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C18H19ClN6O2S
 2
1
EC50 = 0.06 nM
   TI
   LI
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2
EC50 = 0.8 nM
   TI
   LI
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   TS
CP0459579
N-[4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
   Show/Hide
C18H20N6O2S
 2
1
EC50 = 0.18 nM
   TI
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2
EC50 = 3 nM
   TI
   LI
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   TS
CP0481893
N-[3-fluoro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]acetamide
   Show/Hide
C19H19FN6O
 2
1
EC50 = 0.35 nM
   TI
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2
EC50 = 1 nM
   TI
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CP0386379
N-[4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]acetamide
   Show/Hide
C19H20N6O
 2
1
EC50 = 0.55 nM
   TI
   LI
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2
EC50 = 5 nM
   TI
   LI
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   TS
CP0492475
4-N-[(2,4-dichlorophenyl)methyl]-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C17H15Cl2N5
 1
1
EC50 = 0.8 nM
   TI
   LI
   LO
   TS
CP0481193
4-[(4-fluorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C19H16FN7O2
 2
1
EC50 = 1 nM
   TI
   LI
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2
EC50 = 126 nM
   TI
   LI
   LO
   TS
CP0077262
4-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C21H18FN7O4
 2
1
EC50 = 1.5 nM
   TI
   LI
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   TS
2
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0493465
4-cyclopentyloxy-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C17H19N7O2
 2
1
EC50 = 2 nM
   TI
   LI
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2
EC50 = 62 nM
   TI
   LI
   LO
   TS
CP0539267
4-[(2-chlorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C19H16ClN7O2
 2
1
EC50 = 2 nM
   TI
   LI
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   TS
2
EC50 = 47 nM
   TI
   LI
   LO
   TS
CP0566540
4-[2-(4-methoxyphenyl)ethoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C21H21N7O3
 2
1
EC50 = 2 nM
   TI
   LI
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   TS
2
EC50 = 70 nM
   TI
   LI
   LO
   TS
CP0394092
3-methyl-4-(2-phenylethoxy)-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C20H19N7O2
 2
1
EC50 = 3 nM
   TI
   LI
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2
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0406731
4-[2-(4-fluorophenyl)-2-oxoethoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C20H16FN7O3
 2
1
EC50 = 3 nM
   TI
   LI
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2
EC50 = 973 nM
   TI
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CP0482133
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]-2-phenylacetamide
   Show/Hide
C20H18N8O2
 2
1
EC50 = 3 nM
   TI
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2
EC50 = 418 nM
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   TS
CP0510975
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]benzamide
   Show/Hide
C19H16N8O2
 2
1
EC50 = 3 nM
   TI
   LI
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2
EC50 = 158 nM
   TI
   LI
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   TS
CP0557900
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]-2-thiophen-2-ylacetamide
   Show/Hide
C18H16N8O2S
 2
1
EC50 = 3 nM
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2
EC50 = 244 nM
   TI
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CP0666282
ZINC CHLORIDE
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Cl2Zn
 1
1
EC50 = 3.6 nM
   TI
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CP0402779
4-[(2-fluorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C19H16FN7O2
 2
1
EC50 = 4 nM
   TI
   LI
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   TS
2
EC50 = 78 nM
   TI
   LI
   LO
   TS
CP0413648
3-methyl-4-(2-methylpropoxy)-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C16H19N7O2
 2
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
EC50 = 111 nM
   TI
   LI
   LO
   TS
CP0417022
N-[(4-fluorophenyl)methyl]-3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
   Show/Hide
C20H17FN8O2
 2
1
EC50 = 4 nM
   TI
   LI
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   TS
2
EC50 = 1216 nM
   TI
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   TS
CP0447466
[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl] 4-fluorobenzoate
   Show/Hide
C19H14FN7O3
 2
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
EC50 = 245 nM
   TI
   LI
   LO
   TS
CP0466672
4-[[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]oxymethyl]benzonitrile
   Show/Hide
C20H16N8O2
 2
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
EC50 = 60 nM
   TI
   LI
   LO
   TS
CP0482130
4-[(2,4-dichlorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C19H15Cl2N7O2
 2
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
EC50 = 243 nM
   TI
   LI
   LO
   TS
CP0456998
3-methyl-4-[(4-propan-2-ylphenyl)methoxy]-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C22H23N7O2
 2
1
EC50 = 5 nM
   TI
   LI
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   TS
2
EC50 = 1690 nM
   TI
   LI
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   TS
CP0482131
4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C18H18N8O3
 1
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
CP0482132
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]-2-phenylbutanamide
   Show/Hide
C22H22N8O2
 2
1
EC50 = 5 nM
   TI
   LI
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   TS
2
EC50 = 79 nM
   TI
   LI
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   TS
CP0509588
N-benzyl-3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
   Show/Hide
C20H18N8O2
 2
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
2
EC50 = 2931 nM
   TI
   LI
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   TS
CP0478965
[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl] 2-phenylacetate
   Show/Hide
C20H17N7O3
 2
1
EC50 = 6 nM
   TI
   LI
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2
EC50 = 381 nM
   TI
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   TS
CP0476843
N-(1,3-benzodioxol-5-ylmethyl)-3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
   Show/Hide
C21H18N8O4
 2
1
EC50 = 7 nM
   TI
   LI
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   TS
2
EC50 = 791 nM
   TI
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CP0409478
2-[[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]oxymethyl]benzonitrile
   Show/Hide
C20H16N8O2
 2
1
EC50 = 8 nM
   TI
   LI
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2
EC50 = 127 nM
   TI
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   TS
CP0481194
3-methyl-4-octoxy-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C20H27N7O2
 2
1
EC50 = 8 nM
   TI
   LI
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2
EC50 = 388 nM
   TI
   LI
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   TS
CP0107678
4-(2-chloro-4-fluorophenyl)-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C18H13ClFN7O
 2
1
EC50 = 9 nM
   TI
   LI
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2
EC50 = 280 nM
   TI
   LI
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   TS
CP0409480
3-methyl-4-[2-(5-methylpyrazol-1-yl)ethoxy]-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C18H19N9O2
 2
1
EC50 = 10 nM
   TI
   LI
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   TS
2
EC50 = 1622 nM
   TI
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CP0477638
3-methyl-6-oxo-N-phenyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
   Show/Hide
C19H16N8O2
 1
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
CP0448155
4-N-(cyclohexylmethyl)-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C17H23N5
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0519169
2-N-methyl-6-pyridin-2-yl-4-N-[[4-(trifluoromethoxy)phenyl]methyl]pyrimidine-2,4-diamine
   Show/Hide
C18H16F3N5O
 1
1
EC50 = 13 nM
   TI
   LI
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   TS
CP0463104
4-N-[(4-chlorophenyl)methyl]-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C17H16ClN5
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0413647
3-methyl-1-(7H-purin-6-yl)-4-(2-pyrazol-1-ylethoxy)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C17H17N9O2
 2
1
EC50 = 16 nM
   TI
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2
EC50 = 2265 nM
   TI
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CP0456999
4-[2-(3,5-dimethylpyrazol-1-yl)ethoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C19H21N9O2
 2
1
EC50 = 16 nM
   TI
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2
EC50 = 2004 nM
   TI
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CP0402780
3-methyl-4-(4-propan-2-yloxyphenyl)-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C21H21N7O2
 2
1
EC50 = 18 nM
   TI
   LI
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2
EC50 = 2700 nM
   TI
   LI
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CP0458699
N,3-dimethyl-6-oxo-1-(7H-purin-6-yl)-N-(1,3-thiazol-2-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
   Show/Hide
C17H15N9O2S
 2
1
EC50 = 18 nM
   TI
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2
EC50 = 3304 nM
   TI
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CP0492476
4-N-[1-(4-chlorophenyl)cyclobutyl]-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C20H20ClN5
 1
1
EC50 = 25 nM
   TI
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   TS
CP0515155
N-methyl-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]benzamide
   Show/Hide
C19H20N6O
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0540431
N,3-dimethyl-6-oxo-N-phenyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
   Show/Hide
C20H18N8O2
 2
1
EC50 = 32 nM
   TI
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2
EC50 = 5224 nM
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CP0481892
2-N-methyl-4-N-[(4-methylsulfonylphenyl)methyl]-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C18H19N5O2S
 1
1
EC50 = 36 nM
   TI
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   TS
CP0418268
4-N-[(4-chlorophenyl)methyl]-6-pyridin-2-yl-2-N-(2,2,2-trifluoroethyl)pyrimidine-2,4-diamine
   Show/Hide
C18H15ClF3N5
 1
1
EC50 = 60 nM
   TI
   LI
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   TS
CP0481890
4-N-(2,2-dimethylpropyl)-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C15H21N5
 1
1
EC50 = 73 nM
   TI
   LI
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   TS
CP0481891
N-[(4-chlorophenyl)methyl]-2-methyl-6-pyridin-2-ylpyrimidin-4-amine
   Show/Hide
C17H15ClN4
 1
1
EC50 = 81 nM
   TI
   LI
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   TS
CP0519167
2-N-methyl-6-pyridin-2-yl-4-N-(pyridin-4-ylmethyl)pyrimidine-2,4-diamine
   Show/Hide
C16H16N6
 1
1
EC50 = 87 nM
   TI
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   TS
CP0418306
4-N-(cyclopropylmethyl)-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C14H17N5
 1
1
EC50 = 164 nM
   TI
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   TS
CP0406989
2-(1,3-benzothiazol-2-yl)-4-(3-hydroxypropyliminomethyl)-5-phenyl-1H-pyrazol-3-one
   Show/Hide
C20H18N4O2S
 1
1
EC50 = 200 nM
   TI
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CP0409475
5-tert-butyl-N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide
   Show/Hide
C15H18N4O3
 1
1
EC50 = 240 nM
   TI
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CP0409474
8-[(2E)-2-[(2,4-dihydroxyphenyl)methylidene]hydrazinyl]-1,3-dimethyl-7-prop-2-enyl-8,9-dihydropurine-2,6-dione
   Show/Hide
C17H20N6O4
 1
1
EC50 = 340 nM
   TI
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   TS
CP0481192
4-(2,4-difluorophenyl)-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C18H13F2N7O
 1
1
EC50 = 460 nM
   TI
   LI
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   TS
CP0549616
4-N-(cyclopropylmethyl)-6-pyridin-2-yl-2-N-[[4-(trifluoromethoxy)phenyl]methyl]pyrimidine-2,4-diamine
   Show/Hide
C21H20F3N5O
 1
1
EC50 = 600 nM
   TI
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   TS
CP0482129
(3E)-3-[(4,6-dianilino-1,3,5-triazin-2-yl)hydrazinylidene]propane-1,2-diol
   Show/Hide
C18H19N7O2
 1
1
EC50 = 750 nM
   TI
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CP0481191
N-[(E)-1-(4-aminophenyl)ethylideneamino]-3-hydroxynaphthalene-2-carboxamide
   Show/Hide
C19H17N3O2
 1
1
EC50 = 1100 nM
   TI
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CP0398850
N-methyl-N-[4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]acetamide
   Show/Hide
C20H22N6O
 1
1
EC50 = 1181 nM
   TI
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   TS
CP0519168
4-N-(cyclopropylmethyl)-2-N-(2-methoxyethyl)-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C16H21N5O
 1
1
EC50 = 2204 nM
   TI
   LI
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   TS
CP0477637
4-[4-[(3-chlorophenoxy)methyl]phenyl]-1-(4,6-dimethylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C26H24ClN5O2
 1
1
EC50 = 3000 nM
   TI
   LI
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   TS
CP0418305
4-N-(cyclopropylmethyl)-2-N-(2,2-dimethylpropyl)-6-pyridin-2-ylpyrimidine-2,4-diamine
   Show/Hide
C18H25N5
 1
1
EC50 = 5000 nM
   TI
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   TS
CP0463948
4-(2,4-difluorophenyl)-1-(4,6-dimethylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
   Show/Hide
C19H17F2N5O
 1
1
EC50 > 10000 nM
   TI
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   TS
CP0549615
N-(cyclopropylmethyl)-6-pyridin-2-ylpyrimidin-4-amine
   Show/Hide
C13H14N4
 1
1
EC50 = 22000 nM
   TI
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CP0386399
4-N-(cyclopropylmethyl)-2-N,2-N-dimethyl-6-pyridin-2-ylpyrimidine-2,4-diamine
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C15H19N5
 1
1
EC50 > 25000 nM
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