Compound ID |
Compound Name |
Compound Formula |
CP0067898
|
N-[3-chloro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
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|
C18H19ClN6O2S
|
2
|
1 |
EC50 = 0.06 nM
|
|
|
2 |
EC50 = 0.8 nM
|
|
|
CP0459579
|
N-[4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
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|
C18H20N6O2S
|
2
|
1 |
EC50 = 0.18 nM
|
|
|
2 |
EC50 = 3 nM
|
|
|
CP0481893
|
N-[3-fluoro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]acetamide
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|
C19H19FN6O
|
2
|
1 |
EC50 = 0.35 nM
|
|
|
2 |
EC50 = 1 nM
|
|
|
CP0386379
|
N-[4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]acetamide
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|
C19H20N6O
|
2
|
1 |
EC50 = 0.55 nM
|
|
|
2 |
EC50 = 5 nM
|
|
|
CP0492475
|
4-N-[(2,4-dichlorophenyl)methyl]-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
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|
C17H15Cl2N5
|
1
|
1 |
EC50 = 0.8 nM
|
|
|
CP0481193
|
4-[(4-fluorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C19H16FN7O2
|
2
|
1 |
EC50 = 1 nM
|
|
|
2 |
EC50 = 126 nM
|
|
|
CP0077262
|
4-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C21H18FN7O4
|
2
|
1 |
EC50 = 1.5 nM
|
|
|
2 |
EC50 = 30 nM
|
|
|
CP0493465
|
4-cyclopentyloxy-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C17H19N7O2
|
2
|
1 |
EC50 = 2 nM
|
|
|
2 |
EC50 = 62 nM
|
|
|
CP0539267
|
4-[(2-chlorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C19H16ClN7O2
|
2
|
1 |
EC50 = 2 nM
|
|
|
2 |
EC50 = 47 nM
|
|
|
CP0566540
|
4-[2-(4-methoxyphenyl)ethoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C21H21N7O3
|
2
|
1 |
EC50 = 2 nM
|
|
|
2 |
EC50 = 70 nM
|
|
|
CP0394092
|
3-methyl-4-(2-phenylethoxy)-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C20H19N7O2
|
2
|
1 |
EC50 = 3 nM
|
|
|
2 |
EC50 = 40 nM
|
|
|
CP0406731
|
4-[2-(4-fluorophenyl)-2-oxoethoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C20H16FN7O3
|
2
|
1 |
EC50 = 3 nM
|
|
|
2 |
EC50 = 973 nM
|
|
|
CP0482133
|
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]-2-phenylacetamide
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|
C20H18N8O2
|
2
|
1 |
EC50 = 3 nM
|
|
|
2 |
EC50 = 418 nM
|
|
|
CP0510975
|
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]benzamide
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|
C19H16N8O2
|
2
|
1 |
EC50 = 3 nM
|
|
|
2 |
EC50 = 158 nM
|
|
|
CP0557900
|
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]-2-thiophen-2-ylacetamide
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|
C18H16N8O2S
|
2
|
1 |
EC50 = 3 nM
|
|
|
2 |
EC50 = 244 nM
|
|
|
CP0666282
|
ZINC CHLORIDE
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|
Cl2Zn
|
1
|
1 |
EC50 = 3.6 nM
|
|
|
CP0402779
|
4-[(2-fluorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C19H16FN7O2
|
2
|
1 |
EC50 = 4 nM
|
|
|
2 |
EC50 = 78 nM
|
|
|
CP0413648
|
3-methyl-4-(2-methylpropoxy)-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C16H19N7O2
|
2
|
1 |
EC50 = 4 nM
|
|
|
2 |
EC50 = 111 nM
|
|
|
CP0417022
|
N-[(4-fluorophenyl)methyl]-3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
Show/Hide
|
C20H17FN8O2
|
2
|
1 |
EC50 = 4 nM
|
|
|
2 |
EC50 = 1216 nM
|
|
|
CP0447466
|
[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl] 4-fluorobenzoate
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|
C19H14FN7O3
|
2
|
1 |
EC50 = 4 nM
|
|
|
2 |
EC50 = 245 nM
|
|
|
CP0466672
|
4-[[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]oxymethyl]benzonitrile
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|
C20H16N8O2
|
2
|
1 |
EC50 = 4 nM
|
|
|
2 |
EC50 = 60 nM
|
|
|
CP0482130
|
4-[(2,4-dichlorophenyl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C19H15Cl2N7O2
|
2
|
1 |
EC50 = 4 nM
|
|
|
2 |
EC50 = 243 nM
|
|
|
CP0456998
|
3-methyl-4-[(4-propan-2-ylphenyl)methoxy]-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C22H23N7O2
|
2
|
1 |
EC50 = 5 nM
|
|
|
2 |
EC50 = 1690 nM
|
|
|
CP0482131
|
4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C18H18N8O3
|
1
|
1 |
EC50 = 5 nM
|
|
|
CP0482132
|
N-[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]-2-phenylbutanamide
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|
C22H22N8O2
|
2
|
1 |
EC50 = 5 nM
|
|
|
2 |
EC50 = 79 nM
|
|
|
CP0509588
|
N-benzyl-3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
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|
C20H18N8O2
|
2
|
1 |
EC50 = 5 nM
|
|
|
2 |
EC50 = 2931 nM
|
|
|
CP0478965
|
[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl] 2-phenylacetate
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|
C20H17N7O3
|
2
|
1 |
EC50 = 6 nM
|
|
|
2 |
EC50 = 381 nM
|
|
|
CP0476843
|
N-(1,3-benzodioxol-5-ylmethyl)-3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
Show/Hide
|
C21H18N8O4
|
2
|
1 |
EC50 = 7 nM
|
|
|
2 |
EC50 = 791 nM
|
|
|
CP0409478
|
2-[[3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-4-yl]oxymethyl]benzonitrile
Show/Hide
|
C20H16N8O2
|
2
|
1 |
EC50 = 8 nM
|
|
|
2 |
EC50 = 127 nM
|
|
|
CP0481194
|
3-methyl-4-octoxy-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
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|
C20H27N7O2
|
2
|
1 |
EC50 = 8 nM
|
|
|
2 |
EC50 = 388 nM
|
|
|
CP0107678
|
4-(2-chloro-4-fluorophenyl)-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C18H13ClFN7O
|
2
|
1 |
EC50 = 9 nM
|
|
|
2 |
EC50 = 280 nM
|
|
|
CP0409480
|
3-methyl-4-[2-(5-methylpyrazol-1-yl)ethoxy]-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C18H19N9O2
|
2
|
1 |
EC50 = 10 nM
|
|
|
2 |
EC50 = 1622 nM
|
|
|
CP0477638
|
3-methyl-6-oxo-N-phenyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
Show/Hide
|
C19H16N8O2
|
1
|
1 |
EC50 = 10 nM
|
|
|
CP0448155
|
4-N-(cyclohexylmethyl)-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
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|
C17H23N5
|
1
|
1 |
EC50 = 11 nM
|
|
|
CP0519169
|
2-N-methyl-6-pyridin-2-yl-4-N-[[4-(trifluoromethoxy)phenyl]methyl]pyrimidine-2,4-diamine
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|
C18H16F3N5O
|
1
|
1 |
EC50 = 13 nM
|
|
|
CP0463104
|
4-N-[(4-chlorophenyl)methyl]-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C17H16ClN5
|
1
|
1 |
EC50 = 15 nM
|
|
|
CP0413647
|
3-methyl-1-(7H-purin-6-yl)-4-(2-pyrazol-1-ylethoxy)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C17H17N9O2
|
2
|
1 |
EC50 = 16 nM
|
|
|
2 |
EC50 = 2265 nM
|
|
|
CP0456999
|
4-[2-(3,5-dimethylpyrazol-1-yl)ethoxy]-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C19H21N9O2
|
2
|
1 |
EC50 = 16 nM
|
|
|
2 |
EC50 = 2004 nM
|
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CP0402780
|
3-methyl-4-(4-propan-2-yloxyphenyl)-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C21H21N7O2
|
2
|
1 |
EC50 = 18 nM
|
|
|
2 |
EC50 = 2700 nM
|
|
|
CP0458699
|
N,3-dimethyl-6-oxo-1-(7H-purin-6-yl)-N-(1,3-thiazol-2-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
Show/Hide
|
C17H15N9O2S
|
2
|
1 |
EC50 = 18 nM
|
|
|
2 |
EC50 = 3304 nM
|
|
|
CP0492476
|
4-N-[1-(4-chlorophenyl)cyclobutyl]-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C20H20ClN5
|
1
|
1 |
EC50 = 25 nM
|
|
|
CP0515155
|
N-methyl-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]benzamide
Show/Hide
|
C19H20N6O
|
1
|
1 |
EC50 = 30 nM
|
|
|
CP0540431
|
N,3-dimethyl-6-oxo-N-phenyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
Show/Hide
|
C20H18N8O2
|
2
|
1 |
EC50 = 32 nM
|
|
|
2 |
EC50 = 5224 nM
|
|
|
CP0481892
|
2-N-methyl-4-N-[(4-methylsulfonylphenyl)methyl]-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C18H19N5O2S
|
1
|
1 |
EC50 = 36 nM
|
|
|
CP0418268
|
4-N-[(4-chlorophenyl)methyl]-6-pyridin-2-yl-2-N-(2,2,2-trifluoroethyl)pyrimidine-2,4-diamine
Show/Hide
|
C18H15ClF3N5
|
1
|
1 |
EC50 = 60 nM
|
|
|
CP0481890
|
4-N-(2,2-dimethylpropyl)-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C15H21N5
|
1
|
1 |
EC50 = 73 nM
|
|
|
CP0481891
|
N-[(4-chlorophenyl)methyl]-2-methyl-6-pyridin-2-ylpyrimidin-4-amine
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|
C17H15ClN4
|
1
|
1 |
EC50 = 81 nM
|
|
|
CP0519167
|
2-N-methyl-6-pyridin-2-yl-4-N-(pyridin-4-ylmethyl)pyrimidine-2,4-diamine
Show/Hide
|
C16H16N6
|
1
|
1 |
EC50 = 87 nM
|
|
|
CP0418306
|
4-N-(cyclopropylmethyl)-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C14H17N5
|
1
|
1 |
EC50 = 164 nM
|
|
|
CP0406989
|
2-(1,3-benzothiazol-2-yl)-4-(3-hydroxypropyliminomethyl)-5-phenyl-1H-pyrazol-3-one
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|
C20H18N4O2S
|
1
|
1 |
EC50 = 200 nM
|
|
|
CP0409475
|
5-tert-butyl-N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide
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|
C15H18N4O3
|
1
|
1 |
EC50 = 240 nM
|
|
|
CP0409474
|
8-[(2E)-2-[(2,4-dihydroxyphenyl)methylidene]hydrazinyl]-1,3-dimethyl-7-prop-2-enyl-8,9-dihydropurine-2,6-dione
Show/Hide
|
C17H20N6O4
|
1
|
1 |
EC50 = 340 nM
|
|
|
CP0481192
|
4-(2,4-difluorophenyl)-3-methyl-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C18H13F2N7O
|
1
|
1 |
EC50 = 460 nM
|
|
|
CP0549616
|
4-N-(cyclopropylmethyl)-6-pyridin-2-yl-2-N-[[4-(trifluoromethoxy)phenyl]methyl]pyrimidine-2,4-diamine
Show/Hide
|
C21H20F3N5O
|
1
|
1 |
EC50 = 600 nM
|
|
|
CP0482129
|
(3E)-3-[(4,6-dianilino-1,3,5-triazin-2-yl)hydrazinylidene]propane-1,2-diol
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|
C18H19N7O2
|
1
|
1 |
EC50 = 750 nM
|
|
|
CP0481191
|
N-[(E)-1-(4-aminophenyl)ethylideneamino]-3-hydroxynaphthalene-2-carboxamide
Show/Hide
|
C19H17N3O2
|
1
|
1 |
EC50 = 1100 nM
|
|
|
CP0398850
|
N-methyl-N-[4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]acetamide
Show/Hide
|
C20H22N6O
|
1
|
1 |
EC50 = 1181 nM
|
|
|
CP0519168
|
4-N-(cyclopropylmethyl)-2-N-(2-methoxyethyl)-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C16H21N5O
|
1
|
1 |
EC50 = 2204 nM
|
|
|
CP0477637
|
4-[4-[(3-chlorophenoxy)methyl]phenyl]-1-(4,6-dimethylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C26H24ClN5O2
|
1
|
1 |
EC50 = 3000 nM
|
|
|
CP0418305
|
4-N-(cyclopropylmethyl)-2-N-(2,2-dimethylpropyl)-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C18H25N5
|
1
|
1 |
EC50 = 5000 nM
|
|
|
CP0463948
|
4-(2,4-difluorophenyl)-1-(4,6-dimethylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4H-pyrazolo[3,4-b]pyridin-6-one
Show/Hide
|
C19H17F2N5O
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0549615
|
N-(cyclopropylmethyl)-6-pyridin-2-ylpyrimidin-4-amine
Show/Hide
|
C13H14N4
|
1
|
1 |
EC50 = 22000 nM
|
|
|
CP0386399
|
4-N-(cyclopropylmethyl)-2-N,2-N-dimethyl-6-pyridin-2-ylpyrimidine-2,4-diamine
Show/Hide
|
C15H19N5
|
1
|
1 |
EC50 > 25000 nM
|
|
|