General Information of the Compound
Compound ID
CP0417022
Compound Name
N-[(4-fluorophenyl)methyl]-3-methyl-6-oxo-1-(7H-purin-6-yl)-5,7-dihydro-4H-pyrazolo[3,4-b]pyridine-4-carboxamide
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Structure
Formula
C20H17FN8O2
Molecular Weight
420.408
Canonical SMILES
Cc1nn(c2NC(=O)CC(C(=O)NCc3ccc(F)cc3)c12)-c1ncnc2nc[nH]c12
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InChI
InChI=1S/C20H17FN8O2/c1-10-15-13(20(31)22-7-11-2-4-12(21)5-3-11)6-14(30)27-18(15)29(28-10)19-16-17(24-8-23-16)25-9-26-19/h2-5,8-9,13H,6-7H2,1H3,(H,22,31)(H,27,30)(H,23,24,25,26)
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InChIKey
WNTADKMPXADTAU-UHFFFAOYSA-N
Physicochemical Property
logP
1.72832
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
130.48
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137636773
ChEMBL ID
CHEMBL4059978
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03123, G-protein coupled receptor 39
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
EC50 = 1216 nM
   TI
   LI
   LO
   TS