Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02692 , Aldo-keto reductase family 1 member C3
Gene Name AKR1C3
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P42330
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02692
 
Compound ID Compound Name Compound Formula
CP0106946
[4-(2-hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methyl-1H-indol-2-yl)methanone
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C19H26N2O2
 1
1
IC50 = 0.34 nM
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CP0500706
[4-(2-hydroxy-2-methylpropyl)piperidin-1-yl]-(1H-indol-2-yl)methanone
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C18H24N2O2
 1
1
IC50 = 2.1 nM
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CP0039437
(2'R,8R,9S,13S,14S)-5',5',13-trimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C24H32O2
 1
1
IC50 = 2.9 nM
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CP0514842
[4-(2-hydroxyethyl)piperidin-1-yl]-(1H-indol-2-yl)methanone
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C16H20N2O2
 1
1
IC50 = 4.5 nM
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CP0423104
(8R,9S,13S,14S,17R)-5',13-Dimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro [cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C23H30O2
 1
1
IC50 = 6.1 nM
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CP0423107
(2'S,8R,9S,13S,14S)-13-methyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C22H28O2
 1
1
IC50 = 10 nM
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CP0434130
[4-(2-hydroxypropyl)piperidin-1-yl]-(1H-indol-2-yl)methanone
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C17H22N2O2
 1
1
IC50 = 12 nM
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CP0514840
1-[1-(1H-indole-2-carbonyl)piperidin-4-yl]propan-2-one
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C17H20N2O2
 1
1
IC50 = 13 nM
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CP0423105
(2'R,8R,9S,13S,14S)-3-hydroxy-5',13-dimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C23H30O3
 1
1
IC50 = 16 nM
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CP0435092
(2'R,8R,9S,13S,14S)-3-hydroxy-4',13-dimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C23H30O3
 1
1
IC50 = 19 nM
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CP0042980
(2'S,8R,9S,13S,14S)-3-hydroxy-13-methyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C22H28O3
 1
1
IC50 = 20 nM
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CP0288236
(2'R,8R,9S,13S,14S)-3-hydroxy-5',5',13-trimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C24H32O3
 1
1
IC50 = 28 nM
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CP0477344
1H-indol-2-yl-[4-(2-methoxyethyl)piperidin-1-yl]methanone
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C17H22N2O2
 1
1
IC50 = 33 nM
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CP0456265
[4-(2-hydroxyethyl)piperidin-1-yl]-(5-methyl-1H-indol-2-yl)methanone
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C17H22N2O2
 1
1
IC50 = 37 nM
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CP0386167
(2'S,8R,9S,13S,14S)-3-hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-oxepan]-7'-one
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C23H30O3
 1
1
IC50 = 42 nM
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CP0423106
(2'R,8R,9S,13S,14S)-3-hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C22H26O3
 1
1
IC50 = 49 nM
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CP0493503
(4bS,6aS,6bS,11aS,12aS,12bR)-2-Hydroxy-6a-methyl-4b,5,6,6a,6b,9,10,11,11a,12,12a,12b,13,14-tetradecahydro-7-oxa-azuleno[2,1-a]phenanthren-8-one
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C22H28O3
 1
1
IC50 = 66 nM
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CP0528246
(R/S)-(2'R,8R,9S,13S,14S)-methyl 3-hydroxy-13-methyl-6'-oxo-3',4',5',6,6',7,8,9,11,12,13,14,15,16-tetradecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-5'-carboxylate
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C24H30O5
 1
1
IC50 = 72 nM
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CP0515891
(R/S)-(2'R,8R,9S,13S,14S)-5'-allyl-3-hydroxy-13-methyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
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C25H32O3
 1
1
IC50 = 107 nM
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CP0406756
[3-(2-hydroxyethyl)azetidin-1-yl]-(1H-indol-2-yl)methanone
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C14H16N2O2
 1
1
IC50 = 140 nM
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CP0456263
[4-(3-hydroxypropyl)piperidin-1-yl]-(5-methyl-1H-indol-2-yl)methanone
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C18H24N2O2
 1
1
IC50 = 160 nM
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CP0540634
[2-(2-hydroxyethyl)piperidin-1-yl]-(1H-indol-2-yl)methanone
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C16H20N2O2
 1
1
IC50 = 230 nM
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CP0473676
[4-(2-hydroxyethyl)piperazin-1-yl]-(5-methyl-1H-indol-2-yl)methanone
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C16H21N3O2
 1
1
IC50 = 770 nM
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CP0482368
[4-(hydroxymethyl)piperidin-1-yl]-(5-methyl-1H-indol-2-yl)methanone
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C16H20N2O2
 1
1
IC50 = 790 nM
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CP0514841
[3-(2-hydroxyethyl)pyrrolidin-1-yl]-(1H-indol-2-yl)methanone
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C15H18N2O2
 1
1
IC50 = 1100 nM
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CP0540334
N-(5-hydroxypentyl)-1H-indole-2-carboxamide
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C14H18N2O2
 1
1
IC50 = 1200 nM
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CP0508890
[3-(2-hydroxyethyl)piperidin-1-yl]-(1H-indol-2-yl)methanone
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C16H20N2O2
 1
1
IC50 = 2100 nM
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CP0375966
3,6-dihydro-2H-pyridin-1-yl-(5-methyl-1H-indol-2-yl)methanone
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C15H16N2O
 1
1
IC50 = 2800 nM
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CP0540333
2-[1-(5-methyl-1H-indole-2-carbonyl)piperidin-4-yl]acetic acid
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C17H20N2O3
 1
1
IC50 > 10000 nM
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