| Compound ID |
Compound Name |
Compound Formula |
|
CP0507566
|
3-(4-ethoxyphenyl)-N-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]triazolo[4,5-d]pyrimidin-5-amine
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|
C21H25N9O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0548561
|
3-(4-methoxyphenyl)-N-[(3R)-1-pyridin-4-ylpyrrolidin-3-yl]triazolo[4,5-d]pyrimidin-5-amine
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|
C20H20N8O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0553235
|
5-fluoro-2-[5-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]triazolo[4,5-d]pyrimidin-3-yl]benzonitrile
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|
C20H19FN10
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0548555
|
N-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-(1-methylpyrazol-3-yl)triazolo[4,5-d]pyrimidin-5-amine
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|
C17H21N11
|
1
|
| 1 |
IC50 = 165 nM
|
|
|
|
CP0451009
|
N-[4-(aminomethyl)cyclohexyl]-3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-amine
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|
C18H23N7O
|
1
|
| 1 |
IC50 = 368 nM
|
|
|
|
CP0451006
|
4-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclohexane-1,4-diamine
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|
C17H21N7O
|
1
|
| 1 |
IC50 = 549 nM
|
|
|
|
CP0444137
|
(1R,3R)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
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|
C16H19N7O
|
1
|
| 1 |
IC50 = 736 nM
|
|
|
|
CP0451007
|
(1S,3S)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
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|
C16H19N7O
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0551813
|
(1S,3R)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
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|
C16H19N7O
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0955839
|
(1R,3R)-N3-[3-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
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|
C17H20N6O
|
1
|
| 1 |
IC50 = 7160 nM
|
|
|
|
CP0451008
|
3-(4-methoxyphenyl)-N-[(3S)-1-pyridin-4-ylpyrrolidin-3-yl]triazolo[4,5-d]pyrimidin-5-amine
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|
C20H20N8O
|
1
|
| 1 |
IC50 = 8600 nM
|
|
|
|
CP0552747
|
(1R,3S)-3-N-[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]cyclopentane-1,3-diamine
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|
C16H19N7O
|
1
|
| 1 |
IC50 = 9360 nM
|
|
|
|
CP0551811
|
(1R,3R)-3-N-[1-(4-methoxyphenyl)triazolo[4,5-c]pyridin-6-yl]cyclopentane-1,3-diamine
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|
C17H20N6O
|
1
|
| 1 |
IC50 = 13500 nM
|
|
|
|
CP0095473
|
US10525036, Example GDC-0994
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|
C21H18ClFN6O2
|
1
|
| 1 |
IC50 = 21800 nM
|
|
|
|
CP0553236
|
[4-[[3-(4-methoxyphenyl)triazolo[4,5-d]pyrimidin-5-yl]amino]cyclohexyl]methanol
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|
C18H22N6O2
|
1
|
| 1 |
IC50 = 26000 nM
|
|
|
|
CP0554919
|
(1R,3S)-3-N-[1-(4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-6-yl]cyclopentane-1,3-diamine
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|
C17H20N6O
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0560233
|
(1R,3R)-3-N-[9-(4-methoxyphenyl)purin-2-yl]cyclopentane-1,3-diamine
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|
C17H20N6O
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
