Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02031 , Voltage-dependent N-type calcium channel subunit alpha-1B
Gene Name CACNA1B
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q00975
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02031
 
Compound ID Compound Name Compound Formula
CP0073910
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole
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C25H29ClN2O2
 3
1
IC50 = 1 nM
   TI
   LI
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   TS
2
IC50 = 16 nM
   TI
   LI
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   TS
3
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0466330
2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-1-yl]-N,N-diethylaniline
   Show/Hide
C28H36ClN3O
 3
1
IC50 = 1 nM
   TI
   LI
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   TS
2
IC50 = 100 nM
   TI
   LI
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3
IC50 = 590 nM
   TI
   LI
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   TS
CP0513331
4-[2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]benzonitrile
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C26H29N3O2
 3
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
2
IC50 = 85 nM
   TI
   LI
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3
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0434577
5-(4-ethoxyphenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole
   Show/Hide
C27H34N2O3
 3
1
IC50 = 2 nM
   TI
   LI
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   TS
2
IC50 = 29 nM
   TI
   LI
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3
IC50 = 61 nM
   TI
   LI
   LO
   TS
CP0513330
5-(4-chlorophenyl)-3-[(2S,6S)-2,6-dimethyloxan-4-yl]-1-(2-methoxyphenyl)pyrazole
   Show/Hide
C23H25ClN2O2
 2
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 61000 nM
   TI
   LI
   LO
   TS
CP0539006
5-(4-chlorophenyl)-3-(2,2-dimethyloxan-4-yl)-1-(2-methoxyphenyl)pyrazole
   Show/Hide
C23H25ClN2O2
 3
1
IC50 = 2 nM
   TI
   LI
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   TS
2
IC50 = 55 nM
   TI
   LI
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   TS
3
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0390009
CHEMBL4278633
   Show/Hide
C23H25ClN2O2
 3
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 12 nM
   TI
   LI
   LO
   TS
3
IC50 = 91 nM
   TI
   LI
   LO
   TS
CP0411637
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyl-3H-pyran-4-yl)pyrazole
   Show/Hide
C25H27ClN2O2
 2
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 26000 nM
   TI
   LI
   LO
   TS
CP0411636
2-ethoxy-5-[2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]pyridine
   Show/Hide
C26H33N3O3
 3
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
2
IC50 = 44 nM
   TI
   LI
   LO
   TS
3
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0360352
5-(5-chlorothiophen-3-yl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole
   Show/Hide
C23H27ClN2O2S
 3
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
2
IC50 = 28 nM
   TI
   LI
   LO
   TS
3
IC50 = 62 nM
   TI
   LI
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   TS
CP0536326
5-[2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]-2-methylpyridine
   Show/Hide
C25H31N3O2
 2
1
IC50 = 6 nM
   TI
   LI
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   TS
2
IC50 = 13000 nM
   TI
   LI
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   TS
CP0411639
4-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-1-yl]pyridine
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C23H26ClN3O
 2
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
2
IC50 = 22000 nM
   TI
   LI
   LO
   TS
CP0466329
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-[(2S,4R)-2-propan-2-yloxan-4-yl]pyrazole
   Show/Hide
C24H27ClN2O2
 2
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
2
IC50 = 55000 nM
   TI
   LI
   LO
   TS
CP0547863
2-chloro-4-[2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-3-yl]pyridine
   Show/Hide
C24H28ClN3O2
 3
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
2
IC50 = 250 nM
   TI
   LI
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   TS
3
IC50 = 740 nM
   TI
   LI
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   TS
CP0411638
2-[5-(4-chlorophenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazol-1-yl]pyridine
   Show/Hide
C23H26ClN3O
 2
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
2
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0395593
(1R,4S,8R,10S,13S,16S,19S,22S,25R,30R,33S,36S,39S,42S,45S,47R,51S,54R,57S,60S,63R,68R,71S,74S,78R,80S,86S,89S)-68-amino-36,71-bis(4-aminobutyl)-N-[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-22,51-bis(2-amino-2-oxoethyl)-33,60-bis(3-carbamimidamidopropyl)-8,47,78-trihydroxy-13,39-bis[(1R)-1-hydroxyethyl]-4,16,57,74,86,89-hexakis(hydroxymethyl)-19,42-bis[(4-hydroxyphenyl)methyl]-2,5,11,14,17,20,23,32,35,38,41,44,50,53,56,59,62,69,72,75,81,84,87,90,97-pentacosaoxo-27,28,65,66,93,94-hexathia-3,6,12,15,18,21,24,31,34,37,40,43,49,52,55,58,61,70,73,76,82,85,88,91,96-pentacosazahexacyclo[52.37.4.225,63.06,10.045,49.076,80]heptanonacontane-30-carboxamide
   Show/Hide
C120H182N38O43S6
 2
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0539007
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-[(2R,4R)-2-propan-2-yloxan-4-yl]pyrazole
   Show/Hide
C24H27ClN2O2
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0155446
N-cyclopropyl-N-[1-[4-methylsulfonyl-2-(trifluoromethyl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
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C24H24F6N2O5S2
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0421384
2-[(1R,4S,7S,13S,19S,22R,27R,30S,33S,36S,39S,42S,45S,52R)-22-amino-4,13,19-tris(4-aminobutyl)-52-[[(2S,3R)-1-[[2-[[(2S)-1-[[(4R,7S,13S,16S,19R)-7-(4-aminobutyl)-16-(3-carbamimidamidopropyl)-4-carbamoyl-13-(hydroxymethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-42-(3-carbamimidamidopropyl)-45-(hydroxymethyl)-33-[(4-hydroxyphenyl)methyl]-7-methyl-39-(2-methylpropyl)-36-(2-methylsulfanylethyl)-3,6,9,12,15,18,21,29,32,35,38,41,44,47,54-pentadecaoxo-24,25,49,50-tetrathia-2,5,8,11,14,17,20,28,31,34,37,40,43,46,53-pentadecazabicyclo[25.20.7]tetrapentacontan-30-yl]acetic acid
   Show/Hide
C102H172N36O32S7
 3
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
2
IC50 = 48 nM
   TI
   LI
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   TS
3
IC50 = 49 nM
   TI
   LI
   LO
   TS
CP0149085
N-cyclopropyl-N-[1-[2-methylsulfonyl-4-(trifluoromethyl)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H24F6N2O5S2
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0455392
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(oxan-4-yl)pyrazole
   Show/Hide
C21H21ClN2O2
 2
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
2
IC50 = 30000 nM
   TI
   LI
   LO
   TS
CP0252823
N-cyclopropyl-N-[1-[4-methylsulfonyl-2-(trifluoromethoxy)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H24F6N2O6S2
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0918275
trans-rac-N-(-1-(2-chloro-4-(methylsulfonyl)benzoyl)-2-methylazetidin-3-yl)-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C22H22ClF3N2O5S2
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0210706
N-cyclopropyl-N-[1-[(2,6-dimethoxyphenyl)methyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H29F3N2O4S
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0961678
(2-(methylsulfonyl)-4-(trifluoromethyl)phenyl)(8-(3-(trifluoromethyl)phenylsulfonyl)-2,8-diazaspiro[4.5]decan-2-yl)methanone
   Show/Hide
C24H24F6N2O5S2
 1
1
IC50 = 72 nM
   TI
   LI
   LO
   TS
CP0099926
[4-methylsulfonyl-2-(trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)phenyl]sulfonylpropan-2-yl]piperidin-1-yl]methanone
   Show/Hide
C24H25F6NO6S2
 1
1
IC50 = 92 nM
   TI
   LI
   LO
   TS
CP0073247
N-cyclopropyl-N-[1-[2-(trifluoromethoxy)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H22F6N2O4S
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0270343
N-[1-[(2,6-dimethoxyphenyl)methyl]piperidin-4-yl]-N-propyl-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H31F3N2O4S
 2
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
2
IC50 = 4800 nM
   TI
   LI
   LO
   TS
CP0961679
(5-fluoro-2-(methylsulfonyl)phenyl)(8-(3-(trifluoromethyl)phenylsulfonyl)-2,8-diazaspiro[4.5]decan-2-yl)methanone
   Show/Hide
C23H24F4N2O5S2
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0160264
N-cyclopropyl-N-[1-[3-(dimethylamino)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H28F3N3O3S
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0905126
N-cyclopropyl-N-(1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl)azetidin-3-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C22H20F6N2O5S2
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0065921
N-[1-(2-chloro-4-methylsulfonylbenzoyl)piperidin-4-yl]-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H24ClF3N2O5S2
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0266617
N-cyclopropyl-N-[1-[4-(trifluoromethoxy)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H22F6N2O4S
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0926471
(4-(methylsulfonyl)-2-(trifluoromethyl)phenyl)(8-(3-(trifluoromethyl)phenylsulfonyl)-2,8-diazaspiro[4.5]decan-2-yl)methanone
   Show/Hide
C24H24F6N2O5S2
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0067668
N-[1-(2-chloro-5-methylsulfonylbenzoyl)piperidin-4-yl]-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H24ClF3N2O5S2
 1
1
IC50 = 340 nM
   TI
   LI
   LO
   TS
CP0155447
N-cyclopropyl-N-[1-(2-fluoro-4-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H24F4N2O5S2
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0895759
(4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-((3-(trifluoromethyl)phenylsulfonyl)methyl)piperidin-1-yl)methanone
   Show/Hide
C22H21F6NO6S2
 1
1
IC50 = 360 nM
   TI
   LI
   LO
   TS
CP0087807
N-cyclopropyl-N-[1-[3-(trifluoromethoxy)benzoyl]piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H22F6N2O4S
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0910715
rac-N-cyclopropyl-N-(1-(5-fluoro-2-(methylsulfonyl)benzoyl)pyrrolidin-3-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C22H22F4N2O5S2
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0193853
methyl 3-[4-[cyclopropyl-[3-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]benzoate
   Show/Hide
C24H25F3N2O5S
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0905127
cis-rac-N-cyclopropyl-N-(-1-(5-fluoro-2-(methylsulfonyl)benzoyl)-2-methylazetidin-3-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C22H22F4N2O5S2
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0233866
4-[4-[cyclopropyl-[3-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]-3-(trifluoromethoxy)benzamide
   Show/Hide
C24H23F6N3O5S
 1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
CP0874334
trans-rac-N-cyclopropyl-N-(-1-(5-fluoro-2-(methylsulfonyl)benzoyl)-2-methylazetidin-3-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C22H22F4N2O5S2
 1
1
IC50 = 430 nM
   TI
   LI
   LO
   TS
CP0100761
N-[1-(4-cyano-2-methylsulfonylbenzoyl)piperidin-4-yl]-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H24F3N3O5S2
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0860225
N-methyl-N-(1-(2-(methylsulfonyl)benzoyl)piperidin-4-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C21H23F3N2O5S2
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0851138
N-ethyl-N-(1-(2-(trifluoromethoxy)benzoyl)piperidin-4-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C22H22F6N2O4S
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0065933
(5-fluoro-2-methylsulfonylphenyl)-[4-[2-[3-(trifluoromethyl)phenyl]sulfonylpropan-2-yl]piperidin-1-yl]methanone
   Show/Hide
C23H25F4NO5S2
 1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS
CP0070249
N-cyclopropyl-N-[1-(5-fluoro-2-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H24F4N2O5S2
 1
1
IC50 = 560 nM
   TI
   LI
   LO
   TS
CP0210703
N-cyclopropyl-N-[1-(2-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H25F3N2O5S2
 1
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
CP0067670
N-[1-(5-cyano-2-methylsulfonylbenzoyl)piperidin-4-yl]-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H24F3N3O5S2
 1
1
IC50 = 670 nM
   TI
   LI
   LO
   TS
CP0860226
N-cyclopropyl-N-(1-(5-fluoro-2-(methylsulfonyl)benzoyl)-4-methylpiperidin-4-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C24H26F4N2O5S2
 1
1
IC50 = 710 nM
   TI
   LI
   LO
   TS
CP0067672
4-[4-[cyclopropyl-[3-(trifluoromethyl)phenyl]sulfonylamino]piperidine-1-carbonyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C24H23F6N3O4S
 1
1
IC50 = 760 nM
   TI
   LI
   LO
   TS
CP0926472
N-cyclopropyl-N-(1-(5-fluoro-2-(methylsulfonyl)benzoyl)azetidin-3-yl)-3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C21H20F4N2O5S2
 1
1
IC50 = 970 nM
   TI
   LI
   LO
   TS
CP0547737
N-cyclopropyl-N-[1-(5-fluoro-2-methylsulfonylbenzoyl)piperidin-4-yl]-3-(trifluoromethoxy)benzenesulfonamide
   Show/Hide
C23H24F4N2O6S2
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0493570
N-cyclopropyl-2-fluoro-N-[1-(5-fluoro-2-methylsulfonylbenzoyl)piperidin-4-yl]-5-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C23H23F5N2O5S2
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0894014
3-(trifluoromethyl)benzenesulfonamide
   Show/Hide
C7H6F3NO2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0538180
4-[3-(diaminomethylideneamino)propoxy]-N-[2-(4-fluorophenoxy)phenyl]benzamide;hydrochloride
   Show/Hide
C23H24ClFN4O3
 1
1
IC50 = 34000 nM
   TI
   LI
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   TS