| Compound ID |
Compound Name |
Compound Formula |
|
CP0467595
|
(3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)phenyl)methanol
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|
C19H12Cl2F3N5OS
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0506318
|
2-N-(2,6-dichlorophenyl)-7-N-(4-pyrrolidin-1-ylsulfonylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C21H18Cl2N6O2S2
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0399364
|
7-N-(4-tert-butylphenyl)-2-N-(2,6-dichlorophenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C21H19Cl2N5S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0486397
|
2-N-(2,6-dichlorophenyl)-5-N-(2-methylpropyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
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|
C22H19Cl2F3N6S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0378966
|
2-N-(2-chloro-6-methylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C19H13ClF3N5S
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0399930
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-methyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C19H11Cl3F3N5S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0480317
|
2-(4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)phenyl)-2-methylpropanoic acid
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|
C21H17Cl2N5O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0422280
|
2-N-(2,6-dichlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C18H10Cl2F3N5S
|
3
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
| 3 |
IC50 = 6 nM
|
|
|
|
CP0465748
|
2-N-(2,6-dichlorophenyl)-7-N-(4-propan-2-ylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C20H17Cl2N5S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0474067
|
5-N-(cyclopropylmethyl)-2-N-(2,6-dichlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
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|
C22H17Cl2F3N6S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0480313
|
2-N-(2,6-dichlorophenyl)-7-N-(4-methylsulfonylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C18H13Cl2N5O2S2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0377966
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-cyclohexyl)-amide
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|
C20H31ClN4O
|
2
|
| 1 |
IC50 = 3.9 nM
|
|
|
| 2 |
IC50 = 17.2 nM
|
|
|
|
CP0378967
|
2-N-(2,6-dichlorophenyl)-7-N-[6-(trifluoromethyl)pyridin-3-yl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C17H9Cl2F3N6S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0512600
|
US9422293, 374
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|
C31H37F3N6OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0449002
|
4-(3-Bromo-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
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|
C19H23BrN4O
|
2
|
| 1 |
IC50 = 4.6 nM
|
|
|
| 2 |
IC50 = 27.1 nM
|
|
|
|
CP0122651
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
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|
C20H25ClN4O
|
2
|
| 1 |
IC50 = 4.8 nM
|
|
|
| 2 |
IC50 = 34.9 nM
|
|
|
|
CP0473883
|
2-N-(2,6-dimethylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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|
C20H16F3N5S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0378968
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H9Cl3F3N5S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0480314
|
2-N-(2,6-dichlorophenyl)-5-N-propan-2-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C21H17Cl2F3N6S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0406833
|
US9422293, 215
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|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0413283
|
US9422293, 235
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|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0413284
|
US9422293, 237
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|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0479618
|
US9422293, 322
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|
C26H25F6N5O4S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0481148
|
US9422293, 253
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|
C30H37F3N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0482798
|
US9422293, 236
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0545602
|
US9422293, 214
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|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0550752
|
US9422293, 244
Show/Hide
|
C26H26F6N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0480318
|
2-N-(2,6-dichlorophenyl)-5-N-(2-morpholin-4-ylethyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C24H22Cl2F3N7OS
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0438555
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C21H25F3N4O
|
2
|
| 1 |
IC50 = 11.3 nM
|
|
|
| 2 |
IC50 = 57.7 nM
|
|
|
|
CP0402907
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
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|
C19H23ClN4O
|
2
|
| 1 |
IC50 = 11.5 nM
|
|
|
| 2 |
IC50 = 17.3 nM
|
|
|
|
CP0474069
|
2-N-(2,6-dichlorophenyl)-7-N-(4-methylsulfanylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H13Cl2N5S2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0494948
|
US9422293, 32
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|
C27H30N6
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0474068
|
2-N-(2-methylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H14F3N5S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0480316
|
2-N-(2,6-dichlorophenyl)-5-morpholin-4-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C22H17Cl2F3N6OS
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0527234
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-sec-butyl-phenyl)-amide
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|
C20H25ClN4O
|
2
|
| 1 |
IC50 = 17.4 nM
|
|
|
| 2 |
IC50 = 23.3 nM
|
|
|
|
CP0386113
|
2-morpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H24F6N6O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0406838
|
US9422293, 240
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|
C27H28F6N6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0413298
|
US9422293, 257
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|
C28H35F3N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0489526
|
US9422293, 164
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|
C31H38F3N7
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0495308
|
US9422293, 245
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|
C26H25ClF6N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0515416
|
US9422293, 320
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|
C32H39F3N6O3S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0515441
|
US9422293, 222
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|
C27H28F6N6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0518412
|
US9422293, 224
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|
C27H27ClF6N6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0187224
|
JNJ-39439335
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|
C25H21F3N2O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0529401
|
US9422293, 47
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|
C28H33F3N6O
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0372296
|
5-(azetidin-1-yl)-N2-(2,6-dichlorophenyl)-N7-(4-(trifluoromethyl)phenyl)thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C21H15Cl2F3N6S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0402925
|
4-(3-Methyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C20H26N4O
|
2
|
| 1 |
IC50 = 25.3 nM
|
|
|
| 2 |
IC50 = 173 nM
|
|
|
|
CP0480315
|
2-N-(2-methylsulfanylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H14F3N5S2
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0464269
|
4-(3-Difluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C20H24F2N4O
|
2
|
| 1 |
IC50 = 27.7 nM
|
|
|
| 2 |
IC50 = 61.5 nM
|
|
|
|
CP0406485
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-cyclohexyl-phenyl)-amide
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|
C22H27ClN4O
|
2
|
| 1 |
IC50 = 29.8 nM
|
|
|
| 2 |
IC50 = 91.7 nM
|
|
|
|
CP0413276
|
US9422293, 168
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|
C29H29F3N6
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0493154
|
US9422293, 239
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|
C27H28F6N6
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0518407
|
US9422293, 159
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|
C29H34F3N7O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0518487
|
US9422293, 162
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|
C29H35F3N6
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0519702
|
US9422293, 350
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|
C27H21F6N5O2S2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0526061
|
US9422293, 223
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|
C26H27F6N7
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0482811
|
2-thiomorpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H24F6N6S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0378970
|
2-N-(2,6-dichlorophenyl)-7-N-(4-methylphenyl)-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H13Cl2N5S
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0378971
|
2-N-(2-chlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H11ClF3N5S
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0490273
|
2-N-(2,6-dichlorophenyl)-5-piperidin-1-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C23H19Cl2F3N6S
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0526783
|
2-N-(2,6-dichlorophenyl)-5-N,5-N-diethyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C22H19Cl2F3N6S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0515421
|
US9422293, 67B
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|
C26H30F3N5O
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0399365
|
2-N-(2,6-dichlorophenyl)-5-pyrrolidin-1-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C22H17Cl2F3N6S
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0465749
|
2-N-[2-(trifluoromethyl)phenyl]-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11F6N5S
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0413475
|
US9422293, 93B
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|
C25H26F6N6O
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0468293
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C20H23F3N4O
|
2
|
| 1 |
IC50 = 39.2 nM
|
|
|
| 2 |
IC50 = 57.5 nM
|
|
|
|
CP0413506
|
US9422293, 14
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|
C24H24Cl2F3N5
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0416066
|
2-methyl-2-(4-(2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanenitrile
Show/Hide
|
C29H32F3N7
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0444905
|
US9422293, 333
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|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0474983
|
US9422293, 378
Show/Hide
|
C26H26F6N6O2S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0486284
|
US9422293, 75B
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|
C21H18F6N6S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0486293
|
US9422293, 334
Show/Hide
|
C29H33F3N6O3S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0493153
|
US9422293, 238
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|
C26H24F8N6
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0497654
|
2-methyl-2-(4-(2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanenitrile
Show/Hide
|
C28H30F3N7O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0507285
|
US9422293, 381
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|
C25H23ClF6N6O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0518499
|
US9422293, 228
Show/Hide
|
C24H25F6N7O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0454762
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-propyl-phenyl)-amide
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|
C19H23ClN4O
|
2
|
| 1 |
IC50 = 41.6 nM
|
|
|
| 2 |
IC50 = 73 nM
|
|
|
|
CP0457532
|
2-N-(2,6-dichlorophenyl)-5-N,5-N-dimethyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C20H15Cl2F3N6S
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0465879
|
2-(4-cyclopropylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C28H29F6N7
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0479609
|
US9422293, 15
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|
C25H28F3N5
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0492903
|
2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H23F6N7O
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0516746
|
US9422293, 42
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|
C29H35F3N6
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0406834
|
US9422293, 216
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|
C27H24F6N6O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0480856
|
US9422293, 260
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0544273
|
US9422293, 292
Show/Hide
|
C27H34FN5
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0417566
|
3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)benzonitrile
Show/Hide
|
C19H9Cl2F3N6S
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0542273
|
US9422293, 62
Show/Hide
|
C22H19F6N5O
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0545603
|
US9422293, 52
Show/Hide
|
C22H19F6N5S
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0378973
|
2-N-[4-(aminomethyl)-2,6-dichlorophenyl]-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H13Cl2F3N6S
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0399257
|
2-N-(2,6-dichlorophenyl)-5-N-(2-methoxyethyl)-5-N-methyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,5,7-triamine
Show/Hide
|
C22H19Cl2F3N6OS
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0451181
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-ethyl-phenyl)-amide
Show/Hide
|
C18H21ClN4O
|
2
|
| 1 |
IC50 = 56.6 nM
|
|
|
| 2 |
IC50 = 107 nM
|
|
|
|
CP0438356
|
4-(3-Iodo-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C19H23IN4O
|
2
|
| 1 |
IC50 = 56.7 nM
|
|
|
| 2 |
IC50 = 77.4 nM
|
|
|
|
CP0388328
|
3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)benzamide
Show/Hide
|
C19H11Cl2F3N6OS
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0050997
|
N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
Show/Hide
|
C19H21ClN2O2S
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0419411
|
US9422293, 137
Show/Hide
|
C26H30F3N5
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0444920
|
US9422293, 170
Show/Hide
|
C25H19F6N7
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0451337
|
US9422293, 342
Show/Hide
|
C27H21F6N5O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0479621
|
US9422293, 343
Show/Hide
|
C25H25F6N5O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0480868
|
US9422293, 363
Show/Hide
|
C26H25F6N5O3S2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0490167
|
US9422293, 355
Show/Hide
|
C24H23F6N5S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0501434
|
N,N-dimethyl-4-[[2-piperidin-1-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]benzenesulfonamide
Show/Hide
|
C27H32F3N7O2S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0501436
|
US9422293, 229
Show/Hide
|
C25H25ClF6N6O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0416063
|
2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H24F6N6
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0381458
|
2-(4-isobutylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C29H33F6N7
|
3
|
| 1 |
IC50 = 63 nM
|
|
|
| 2 |
IC50 = 89 nM
|
|
|
| 3 |
IC50 = 330 nM
|
|
|
|
CP0374497
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
Show/Hide
|
C17H16ClF3N4O
|
2
|
| 1 |
IC50 = 63.5 nM
|
|
|
| 2 |
IC50 = 81.4 nM
|
|
|
|
CP0519186
|
2-(azetidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H22F6N6
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0444903
|
US9422293, 310
Show/Hide
|
C27H27F6N5O
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0480871
|
N,N-dimethyl-4-[[2-morpholin-4-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]benzenesulfonamide
Show/Hide
|
C26H30F3N7O3S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0492918
|
US9422293, 157
Show/Hide
|
C26H25F7N6
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0493152
|
US9422293, 194
Show/Hide
|
C26H27F6N7
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0515440
|
2-(piperidin-1-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H24F6N8
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0399258
|
N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-amine
Show/Hide
|
C20H15F6N5
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0518498
|
US9422293, 48
Show/Hide
|
C26H31F3N6
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0388486
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-methylsulfonyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11Cl3F3N5O2S2
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0413282
|
US9422293, 234
Show/Hide
|
C25H25F6N7
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0444921
|
US9422293, 175
Show/Hide
|
C30H35F3N6O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0518488
|
US9422293, 171
Show/Hide
|
C29H29F3N6
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0465803
|
US9422293, 95B
Show/Hide
|
C25H24F6N6
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0416064
|
2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H25F6N7
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0451350
|
US9422293, 45
Show/Hide
|
C23H21ClF6N6
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0478109
|
US9422293, 259
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0480855
|
US9422293, 390
Show/Hide
|
C25H24ClF6N7
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0482800
|
US9422293, 242
Show/Hide
|
C26H24F8N6
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0502126
|
2-(4-(2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propan-2-ol
Show/Hide
|
C28H33F3N6O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0550735
|
US9422293, 76B
Show/Hide
|
C23H21F6N5O
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0470067
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
Show/Hide
|
C17H16ClF3N4O2
|
2
|
| 1 |
IC50 = 93.2 nM
|
|
|
| 2 |
IC50 = 261 nM
|
|
|
|
CP0495300
|
US9422293, 3
Show/Hide
|
C27H30F3N5
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0472370
|
tert-butyl 3-[methyl-[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]amino]piperidine-1-carboxylate
Show/Hide
|
C32H37F6N7O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0413278
|
US9422293, 196
Show/Hide
|
C24H25F6N7O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0479610
|
2-methyl-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C22H19F6N5
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0492557
|
US9422293, 231
Show/Hide
|
C24H21ClF6N6
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0501443
|
US9422293, 290
Show/Hide
|
C27H31F3N6O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0501444
|
US9422293, 324
Show/Hide
|
C29H33F3N6O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0549196
|
US9422293, 254
Show/Hide
|
C29H38F3N7
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0565736
|
US9422293, 160
Show/Hide
|
C26H29F3N6S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0399360
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C24H13Cl3F3N5S
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0413275
|
US9422293, 147
Show/Hide
|
C28H28F3N5O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0480870
|
US9422293, 376
Show/Hide
|
C29H33F3N6O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0481140
|
US9422293, 200
Show/Hide
|
C29H36F3N7
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0520517
|
2-(4-(2-isopropyl-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propan-2-ol
Show/Hide
|
C26H30F3N5O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0542267
|
US9422293, 33
Show/Hide
|
C30H36N6
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0542271
|
US9422293, 213
Show/Hide
|
C24H24F6N6O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0561264
|
US9422293, 136
Show/Hide
|
C23H23F3N6O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0460307
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-ethyl-phenyl)-amide
Show/Hide
|
C19H21F3N4O
|
2
|
| 1 |
IC50 = 111 nM
|
|
|
| 2 |
IC50 = 121 nM
|
|
|
|
CP0378972
|
7-N-[3-chloro-4-(trifluoromethyl)phenyl]-2-N-(2,6-dichlorophenyl)-5-methylsulfanyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11Cl3F3N5S2
|
1
|
| 1 |
IC50 = 113 nM
|
|
|
|
CP0461770
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-butyl-phenyl)-amide
Show/Hide
|
C20H25ClN4O
|
2
|
| 1 |
IC50 = 117 nM
|
|
|
| 2 |
IC50 = 203 nM
|
|
|
|
CP0480319
|
2-N-(2,6-dichlorophenyl)-5-(4-propan-2-ylpiperazin-1-yl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C25H24Cl2F3N7S
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0474958
|
US9422293, 296
Show/Hide
|
C28H37N5O2S
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0493147
|
US9422293, 163
Show/Hide
|
C29H34F3N7
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0493392
|
US9422293, 393
Show/Hide
|
C27H28ClF3N6O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0501445
|
US9422293, 329
Show/Hide
|
C29H33F3N6O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0516342
|
US9422293, 218
Show/Hide
|
C23H23F6N7
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0472372
|
2-(4-cyclopentylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C30H33F6N7
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0445131
|
US9422293, 80B
Show/Hide
|
C23H20ClF6N5O
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0480869
|
US9422293, 366
Show/Hide
|
C25H25F6N5S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0488609
|
US9422293, 141
Show/Hide
|
C26H28F3N5
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0493146
|
US9422293, 161
Show/Hide
|
C27H31F3N6
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0493149
|
US9422293, 172
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0515422
|
US9422293, 282
Show/Hide
|
C23H25F3N6O2S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0516745
|
US9422293, 22
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0556231
|
US9422293, 143
Show/Hide
|
C27H31F3N6O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0445126
|
US9422293, 153
Show/Hide
|
C26H21F6N5S
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0495311
|
2-(4-isopropylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C28H31F6N7
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 386 nM
|
|
|
|
CP0501431
|
2-phenyl-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H21F6N5
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0512598
|
2-methyl-2-(4-(2-(piperidin-1-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanoic acid
Show/Hide
|
C29H33F3N6O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0445022
|
US9422293, 341
Show/Hide
|
C24H23F6N5O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0480860
|
US9422293, 37
Show/Hide
|
C26H28N6
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0481139
|
US9422293, 197
Show/Hide
|
C23H21F6N7
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0490933
|
US9422293, 335
Show/Hide
|
C29H33F3N6O4S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0493143
|
US9422293, 149
Show/Hide
|
C25H19F6N5S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0495310
|
US9422293, 55B
Show/Hide
|
C24H22F6N6
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0499648
|
US9422293, 268
Show/Hide
|
C27H26F6N6
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0515415
|
US9422293, 128
Show/Hide
|
C24H22ClF6N5
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0451456
|
US9422293, 383
Show/Hide
|
C29H35F3N6O
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0499652
|
US9422293, 314
Show/Hide
|
C28H31F3N6O4S
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0518260
|
2-(4-cyclobutylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C29H31F6N7
|
1
|
| 1 |
IC50 = 161 nM
|
|
|
|
CP0399933
|
2-N-(2,6-dichlorophenyl)-7-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C17H11Cl2N5S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0474806
|
US9422293, 102
Show/Hide
|
C32H31F6N7
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0474816
|
US9422293, 337
Show/Hide
|
C26H25F6N5O
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0494954
|
US9422293, 233
Show/Hide
|
C26H25ClF6N6
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0501437
|
US9422293, 241
Show/Hide
|
C24H20F8N6
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0572451
|
US9422293, 291
Show/Hide
|
C24H22F6N6O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0444910
|
US9422293, 321
Show/Hide
|
C29H33F3N6O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0492921
|
US9422293, 269
Show/Hide
|
C29H32F6N6
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0512599
|
US9422293, 373
Show/Hide
|
C29H35F3N6OS
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0518511
|
US9422293, 72B
Show/Hide
|
C22H22F3N7O2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0501842
|
2-(4-(pentan-3-yl)piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C30H35F6N7
|
1
|
| 1 |
IC50 = 185 nM
|
|
|
|
CP0461098
|
4-(3-Nitro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C19H23N5O3
|
2
|
| 1 |
IC50 = 190 nM
|
|
|
| 2 |
IC50 = 245 nM
|
|
|
|
CP0479620
|
US9422293, 339
Show/Hide
|
C26H25F6N5O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0499649
|
US9422293, 275
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0507324
|
US9422293, 94B
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0518507
|
US9422293, 122
Show/Hide
|
C27H38F3N5
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0520871
|
US9422293, 140
Show/Hide
|
C24H22F7N5
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0535980
|
US9422293, 362
Show/Hide
|
C24H23F6N5O3S2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0550660
|
US9422293, 345
Show/Hide
|
C23H21F6N5O
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0399259
|
2-N-(2,6-dichlorophenyl)-7-N-[3-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10Cl2F3N5S
|
1
|
| 1 |
IC50 = 192 nM
|
|
|
|
CP0451528
|
US9422293, 150
Show/Hide
|
C25H19F6N5S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0543805
|
US9422293, 272
Show/Hide
|
C25H26F6N6
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0550726
|
US9422293, 11
Show/Hide
|
C24H23F6N5O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0454730
|
4-(3-Formyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C20H24N4O2
|
2
|
| 1 |
IC50 = 201 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0377757
|
2-(4-(2-methoxyethyl)piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C28H31F6N7O
|
1
|
| 1 |
IC50 = 207 nM
|
|
|
|
CP0515437
|
US9422293, 173
Show/Hide
|
C26H19ClF6N6
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0451357
|
US9422293, 212
Show/Hide
|
C25H24F6N6O2S
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0465750
|
2-N-(2-methylsulfonylphenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H14F3N5O2S2
|
1
|
| 1 |
IC50 = 221 nM
|
|
|
|
CP0461058
|
4-(3-Ethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C21H28N4O
|
2
|
| 1 |
IC50 = 230 nM
|
|
|
| 2 |
IC50 = 828 nM
|
|
|
|
CP0465884
|
tert-butyl 2-[[[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]amino]methyl]piperidine-1-carboxylate
Show/Hide
|
C32H37F6N7O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0486282
|
US9422293, 54
Show/Hide
|
C27H22F6N6
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0497600
|
US9422293, 129
Show/Hide
|
C27H29F3N6
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0515425
|
US9422293, 380
Show/Hide
|
C26H27F3N6O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0549197
|
US9422293, 61B
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0465883
|
tert-butyl 3-[[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]amino]piperidine-1-carboxylate
Show/Hide
|
C31H35F6N7O2
|
1
|
| 1 |
IC50 = 239 nM
|
|
|
|
CP0444925
|
US9422293, 91B
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0445125
|
US9422293, 144
Show/Hide
|
C25H19F6N5O
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0480853
|
US9422293, 353
Show/Hide
|
C28H23F6N5S
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0480862
|
US9422293, 145
Show/Hide
|
C28H28F3N5O
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0499653
|
US9422293, 319
Show/Hide
|
C26H25F6N5O3S
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0501432
|
2-N,2-N-dimethyl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C23H22F6N6
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0384132
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carbothioic acid (4-tert-butyl-phenyl)-amide
Show/Hide
|
C21H25F3N4S
|
2
|
| 1 |
IC50 = 246 nM
|
|
|
| 2 |
IC50 = 441 nM
|
|
|
|
CP0474803
|
US9422293, 354
Show/Hide
|
C27H27F6N5S
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0480867
|
US9422293, 360
Show/Hide
|
C27H27F6N5O2S2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0492904
|
US9422293, 44
Show/Hide
|
C22H21F6N7
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0515866
|
US9422293, 328
Show/Hide
|
C30H35F3N6O
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0479848
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide
Show/Hide
|
C23H21F3N4O2
|
2
|
| 1 |
IC50 = 258 nM
|
|
|
| 2 |
IC50 = 916 nM
|
|
|
|
CP0416065
|
2-isopropyl-N-(5-(trifluoromethyl)pyrazin-2-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C22H21F6N7
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0444927
|
US9422293, 274
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0474817
|
US9422293, 340
Show/Hide
|
C25H23F6N5O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0377755
|
2-(4-methylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C26H27F6N7
|
2
|
| 1 |
IC50 = 270 nM
|
|
|
| 2 |
IC50 = 506 nM
|
|
|
|
CP0463770
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid naphthalen-2-ylamide
Show/Hide
|
C20H19ClN4O
|
2
|
| 1 |
IC50 = 278 nM
|
|
|
| 2 |
IC50 = 479 nM
|
|
|
|
CP0476952
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-iodo-phenyl)-amide
Show/Hide
|
C16H16ClIN4O
|
2
|
| 1 |
IC50 = 285 nM
|
|
|
| 2 |
IC50 = 310 nM
|
|
|
|
CP0460755
|
4-(3-Cyano-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C20H23N5O
|
2
|
| 1 |
IC50 = 287 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0444924
|
US9422293, 206
Show/Hide
|
C27H31F3N6S
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0474804
|
US9422293, 356
Show/Hide
|
C24H23F6N5OS
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0474807
|
US9422293, 394
Show/Hide
|
C26H28ClF3N6O
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0479736
|
US9422293, 289
Show/Hide
|
C27H34N6O2
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0478111
|
US9422293, 325
Show/Hide
|
C27H27F6N5O
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0444913
|
US9422293, 23
Show/Hide
|
C23H22F6N6
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0413294
|
US9422293, 104
Show/Hide
|
C24H23F6N5S
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0445024
|
2-(4-(2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propan-2-ol
Show/Hide
|
C27H31F3N6O2
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0480866
|
US9422293, 359
Show/Hide
|
C28H23F6N5O2S2
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0482793
|
US9422293, 201
Show/Hide
|
C27H33F3N6
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0479616
|
US9422293, 372
Show/Hide
|
C29H35F3N6S
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0492954
|
US9422293, 96
Show/Hide
|
C25H26F3N5O
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0515199
|
US9422293, 103
Show/Hide
|
C25H26F3N5O2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0517232
|
US9422293, 29
Show/Hide
|
C23H19F3N6
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0550737
|
US9422293, 261
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0495315
|
US9422293, 87
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0490971
|
US9422293, 34
Show/Hide
|
C27H27F3N6
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0512607
|
US9422293, 308
Show/Hide
|
C27H27F6N5O3S
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0402539
|
2-isopropyl-7-(3-(methylsulfonyl)pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H26F3N5O2S
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0445127
|
US9422293, 167
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0495320
|
2-(2-(piperidin-1-yl)-4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)pyridine-3-sulfonamide
Show/Hide
|
C25H28F3N7O2S
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0481149
|
US9422293, 59B
Show/Hide
|
C26H26F6N6O
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0499623
|
US9422293, 46
Show/Hide
|
C22H22BrF3N6
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0512597
|
US9422293, 166
Show/Hide
|
C26H25F7N6
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0413467
|
US9422293, 217
Show/Hide
|
C23H21F6N7
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0413507
|
US9422293, 43B
Show/Hide
|
C22H21F6N7
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0550738
|
US9422293, 265
Show/Hide
|
C25H24F6N6O
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0486373
|
US9422293, 338
Show/Hide
|
C27H27F6N5O
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0465881
|
N-[1-[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]pyrrolidin-3-yl]acetamide
Show/Hide
|
C27H27F6N7O
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0445132
|
US9422293, 266
Show/Hide
|
C24H25F6N7
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0451537
|
US9422293, 243
Show/Hide
|
C25H22F8N6
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0555951
|
US9422293, 312
Show/Hide
|
C27H27F6N5O2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0563437
|
US9422293, 252
Show/Hide
|
C29H36F3N7
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0518259
|
N-methyl-N-[1-[4-[4-(trifluoromethyl)anilino]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-2-yl]pyrrolidin-3-yl]acetamide
Show/Hide
|
C28H29F6N7O
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0444912
|
US9422293, 6
Show/Hide
|
C30H30F3N5
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0518515
|
US9422293, 97
Show/Hide
|
C24H23F3N6
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0530193
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-bromo-phenyl)-amide
Show/Hide
|
C16H16BrClN4O
|
2
|
| 1 |
IC50 = 491 nM
|
|
|
| 2 |
IC50 = 1010 nM
|
|
|
|
CP0481137
|
US9422293, 4
Show/Hide
|
C23H21ClF3N5
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0515867
|
US9422293, 331
Show/Hide
|
C25H23F6N5O4S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0529403
|
US9422293, 118
Show/Hide
|
C25H27F4N5
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0394538
|
2-(4-ethylpiperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 506 nM
|
|
|
|
CP0490937
|
US9422293, 19
Show/Hide
|
C23H20F6N6
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0492902
|
US9422293, 31
Show/Hide
|
C23H27ClN6
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0494957
|
US9422293, 248
Show/Hide
|
C28H33F3N6
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0397141
|
2-N-(2,6-dichlorophenyl)-2-N-methyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H12Cl2F3N5S
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0402597
|
US9422293, 284
Show/Hide
|
C26H34N6
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0474985
|
US9422293, 387
Show/Hide
|
C27H29F3N6O2
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0488612
|
US9422293, 152
Show/Hide
|
C27H31F3N6O2S
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0498327
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid p-tolylamide
Show/Hide
|
C18H19F3N4O
|
2
|
| 1 |
IC50 = 556 nM
|
|
|
| 2 |
IC50 = 1551 nM
|
|
|
|
CP0413279
|
US9422293, 204
Show/Hide
|
C23H21F6N5S
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0550740
|
US9422293, 313
Show/Hide
|
C26H25F6N5O2
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0465798
|
US9422293, 124
Show/Hide
|
C25H27ClF3N5
|
1
|
| 1 |
IC50 = 570 nM
|
|
|
|
CP0384074
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carbothioic acid (4-isopropyl-phenyl)-amide
Show/Hide
|
C20H23F3N4S
|
2
|
| 1 |
IC50 = 575 nM
|
|
|
| 2 |
IC50 = 872 nM
|
|
|
|
CP0413296
|
US9422293, 109
Show/Hide
|
C23H22Cl2F3N5
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0478050
|
US9422293, 77B
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0381456
|
(S)-2-(3-(dimethylamino)pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 586 nM
|
|
|
|
CP0460315
|
4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)benzenesulfonamide
Show/Hide
|
C17H12Cl2N6O2S2
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0451529
|
US9422293, 156
Show/Hide
|
C27H29F3N6O
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0477022
|
US9422293, 326
Show/Hide
|
C28H29F6N5O
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0444909
|
US9422293, 317
Show/Hide
|
C26H25F6N5O3S
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0517235
|
US9422293, 125
Show/Hide
|
C25H26Cl2F3N5
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0561630
|
US9422293, 65B
Show/Hide
|
C26H28F3N7
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0511645
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-chloro-phenyl)-amide
Show/Hide
|
C16H16Cl2N4O
|
2
|
| 1 |
IC50 = 655 nM
|
|
|
| 2 |
IC50 = 2669 nM
|
|
|
|
CP0479619
|
US9422293, 323
Show/Hide
|
C28H31F3N6O2
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0526072
|
US9422293, 278
Show/Hide
|
C28H24F6N6
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0413479
|
US9422293, 273
Show/Hide
|
C27H28F6N6O2
|
1
|
| 1 |
IC50 = 680 nM
|
|
|
|
CP0413297
|
US9422293, 255
Show/Hide
|
C27H29Cl2F3N6
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0474957
|
US9422293, 221
Show/Hide
|
C26H26ClF6N7
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0516791
|
US9422293, 146
Show/Hide
|
C25H19F6N5O
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0490934
|
US9422293, 351
Show/Hide
|
C28H23F6N5S
|
1
|
| 1 |
IC50 = 750 nM
|
|
|
|
CP0494947
|
US9422293, 25
Show/Hide
|
C29H28F3N5O
|
1
|
| 1 |
IC50 = 770 nM
|
|
|
|
CP0494953
|
US9422293, 207
Show/Hide
|
C25H28F3N5O2S
|
1
|
| 1 |
IC50 = 770 nM
|
|
|
|
CP0526060
|
US9422293, 182
Show/Hide
|
C25H28F3N5O
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0481138
|
US9422293, 176
Show/Hide
|
C26H20F6N6
|
1
|
| 1 |
IC50 = 810 nM
|
|
|
|
CP0493150
|
US9422293, 181
Show/Hide
|
C27H32F3N5O
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0542266
|
US9422293, 385
Show/Hide
|
C27H28F4N6O2
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0567766
|
US9422293, 151
Show/Hide
|
C24H26F3N5
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0444926
|
US9422293, 270
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0495309
|
US9422293, 249
Show/Hide
|
C27H31F3N6
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0526071
|
US9422293, 271
Show/Hide
|
C26H26F6N6O2
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0518514
|
US9422293, 86
Show/Hide
|
C23H25F3N6
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0372297
|
2-N-(2,6-dichlorophenyl)-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[4,5-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10Cl2F3N5S
|
1
|
| 1 |
IC50 = 864 nM
|
|
|
|
CP0477023
|
US9422293, 327
Show/Hide
|
C24H24F6N6O
|
1
|
| 1 |
IC50 = 890 nM
|
|
|
|
CP0492556
|
US9422293, 50B
Show/Hide
|
C22H22ClF3N6
|
1
|
| 1 |
IC50 = 910 nM
|
|
|
|
CP0488615
|
US9422293, 66B
Show/Hide
|
C30H37F3N6
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0550725
|
US9422293, 10
Show/Hide
|
C24H23F6N5
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0492920
|
US9422293, 108
Show/Hide
|
C25H26Cl2F3N5
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0564118
|
US9422293, 230
Show/Hide
|
C25H27Cl2F3N6O
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0520868
|
US9422293, 12
Show/Hide
|
C25H27F4N5
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0520872
|
US9422293, 88
Show/Hide
|
C23H23F3N6O2
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0550736
|
US9422293, 81B
Show/Hide
|
C23H25F3N6O
|
1
|
| 1 |
IC50 = 970 nM
|
|
|
|
CP0479328
|
US9422293, 101B
Show/Hide
|
C24H23F6N5O2S
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0479734
|
US9422293, 83
Show/Hide
|
C24H27F3N6
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0515414
|
US9422293, 123
Show/Hide
|
C25H27ClF3N5
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0445128
|
US9422293, 169
Show/Hide
|
C26H19ClF6N6
|
1
|
| 1 |
IC50 = 1010 nM
|
|
|
|
CP0394540
|
(R)-2-(3-(dimethylamino)pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 1042 nM
|
|
|
|
CP0474959
|
US9422293, 297
Show/Hide
|
C27H31F3N6O2S
|
1
|
| 1 |
IC50 = 1080 nM
|
|
|
|
CP0512596
|
US9422293, 21
Show/Hide
|
C26H25F3N6
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0528666
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide
Show/Hide
|
C16H16ClN5O3
|
2
|
| 1 |
IC50 = 1106 nM
|
|
|
| 2 |
IC50 > 25000 nM
|
|
|
|
CP0444902
|
US9422293, 305
Show/Hide
|
C23H24F3N5O2S2
|
1
|
| 1 |
IC50 = 1120 nM
|
|
|
|
CP0416067
|
4-(2-isopropyl-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)-N,N-dimethylbenzenesulfonamide
Show/Hide
|
C25H29F3N6O2S
|
1
|
| 1 |
IC50 = 1140 nM
|
|
|
|
CP0482791
|
US9422293, 190
Show/Hide
|
C25H19F6N7
|
1
|
| 1 |
IC50 = 1160 nM
|
|
|
|
CP0465882
|
2-(4-(4-(4-(trifluoromethyl)phenylamino)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-2-yl)piperazin-1-yl)ethanol
Show/Hide
|
C27H29F6N7O
|
1
|
| 1 |
IC50 = 1161 nM
|
|
|
|
CP0413480
|
US9422293, 316
Show/Hide
|
C32H39F3N6O
|
1
|
| 1 |
IC50 = 1180 nM
|
|
|
|
CP0488626
|
US9422293, 364
Show/Hide
|
C29H25F6N5S
|
1
|
| 1 |
IC50 = 1180 nM
|
|
|
|
CP0529404
|
US9422293, 126
Show/Hide
|
C26H30F3N5O
|
1
|
| 1 |
IC50 = 1190 nM
|
|
|
|
CP0386112
|
4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C21H18F6N6
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0474960
|
US9422293, 306
Show/Hide
|
C22H21ClF3N5OS
|
1
|
| 1 |
IC50 = 1210 nM
|
|
|
|
CP0517234
|
US9422293, 119
Show/Hide
|
C25H27BrF3N5
|
1
|
| 1 |
IC50 = 1220 nM
|
|
|
|
CP0490969
|
7-(3-chloropyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C20H17ClF3N5
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0518512
|
US9422293, 79B
Show/Hide
|
C24H28F3N7
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0518766
|
US9422293, 13
Show/Hide
|
C25H27ClF3N5
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0545522
|
US9422293, 264
Show/Hide
|
C28H33F3N6O
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0480864
|
US9422293, 347
Show/Hide
|
C26H27F3N6O
|
1
|
| 1 |
IC50 = 1320 nM
|
|
|
|
CP0445129
|
US9422293, 179
Show/Hide
|
C26H27F6N5O
|
1
|
| 1 |
IC50 = 1340 nM
|
|
|
|
CP0382521
|
2-N-(pyridin-2-ylmethyl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H23F6N7
|
1
|
| 1 |
IC50 = 1342 nM
|
|
|
|
CP0494952
|
US9422293, 199
Show/Hide
|
C27H33F3N6
|
1
|
| 1 |
IC50 = 1360 nM
|
|
|
|
CP0503054
|
4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-butyl-phenyl)-amide
Show/Hide
|
C21H25F3N4O
|
2
|
| 1 |
IC50 = 1365 nM
|
|
|
| 2 |
IC50 = 5181 nM
|
|
|
|
CP0518506
|
US9422293, 38
Show/Hide
|
C23H28N6
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0489542
|
US9422293, 377
Show/Hide
|
C27H31F3N6
|
1
|
| 1 |
IC50 = 1410 nM
|
|
|
|
CP0413301
|
US9422293, 309
Show/Hide
|
C30H33F6N5O
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0507325
|
US9422293, 263
Show/Hide
|
C24H23F6N7O
|
1
|
| 1 |
IC50 = 1460 nM
|
|
|
|
CP0451538
|
US9422293, 58B
Show/Hide
|
C28H31F6N7
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0413280
|
US9422293, 220
Show/Hide
|
C25H26F6N8
|
1
|
| 1 |
IC50 = 1520 nM
|
|
|
|
CP0545595
|
US9422293, 361
Show/Hide
|
C24H23F6N5O2S2
|
1
|
| 1 |
IC50 = 1530 nM
|
|
|
|
CP0472371
|
2-N-methyl-2-N-piperidin-3-yl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 = 1540 nM
|
|
|
|
CP0515426
|
2-methyl-2-(4-(2-morpholino-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)propanoic acid
Show/Hide
|
C28H31F3N6O3
|
1
|
| 1 |
IC50 = 1540 nM
|
|
|
|
CP0539865
|
US9422293, 188
Show/Hide
|
C23H21ClF6N6
|
1
|
| 1 |
IC50 = 1590 nM
|
|
|
|
CP0494946
|
US9422293, 336
Show/Hide
|
C28H29F6N5O
|
1
|
| 1 |
IC50 = 1640 nM
|
|
|
|
CP0565732
|
US9422293, 262
Show/Hide
|
C25H25F6N7O
|
1
|
| 1 |
IC50 = 1640 nM
|
|
|
|
CP0372298
|
2-N,7-N-bis[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11F6N5S
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0515442
|
US9422293, 226
Show/Hide
|
C26H28ClF6N7
|
1
|
| 1 |
IC50 = 1730 nM
|
|
|
|
CP0486285
|
US9422293, 78B
Show/Hide
|
C23H22F3N7
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0413299
|
US9422293, 267
Show/Hide
|
C29H32F6N6
|
1
|
| 1 |
IC50 = 1870 nM
|
|
|
|
CP0475722
|
2-isopropyl-N-(6-methoxy-5-(trifluoromethyl)pyridin-2-yl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C24H24F6N6O
|
1
|
| 1 |
IC50 = 1930 nM
|
|
|
|
CP0475723
|
2-(4-(2-isopropyl-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-ylamino)phenyl)-2-methylpropanoic acid
Show/Hide
|
C27H30F3N5O2
|
1
|
| 1 |
IC50 = 1950 nM
|
|
|
|
CP0486281
|
US9422293, 251
Show/Hide
|
C26H27Cl2F3N6
|
1
|
| 1 |
IC50 = 1980 nM
|
|
|
|
CP0488360
|
US9422293, 300
Show/Hide
|
C28H34F3N7O2S
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0515209
|
US9422293, 174
Show/Hide
|
C28H32F3N5O2
|
1
|
| 1 |
IC50 = 2010 nM
|
|
|
|
CP0475724
|
5-chloro-6-(2-isopropyl-4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)nicotinic acid
Show/Hide
|
C24H23ClF3N5O2
|
1
|
| 1 |
IC50 = 2020 nM
|
|
|
|
CP0444904
|
US9422293, 332
Show/Hide
|
C29H31F6N5O
|
1
|
| 1 |
IC50 = 2040 nM
|
|
|
|
CP0451527
|
US9422293, 142
Show/Hide
|
C26H25F3N6O
|
1
|
| 1 |
IC50 = 2090 nM
|
|
|
|
CP0507323
|
US9422293, 193
Show/Hide
|
C25H26F6N8
|
1
|
| 1 |
IC50 = 2110 nM
|
|
|
|
CP0493142
|
US9422293, 148
Show/Hide
|
C23H22F3N7S
|
1
|
| 1 |
IC50 = 2170 nM
|
|
|
|
CP0539862
|
US9422293, 165
Show/Hide
|
C26H30F3N7
|
1
|
| 1 |
IC50 = 2250 nM
|
|
|
|
CP0523543
|
2-N-[(1-methylpiperidin-2-yl)methyl]-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C28H31F6N7
|
1
|
| 1 |
IC50 = 2277 nM
|
|
|
|
CP0515210
|
US9422293, 205
Show/Hide
|
C25H27F3N6S
|
1
|
| 1 |
IC50 = 2280 nM
|
|
|
|
CP0479615
|
US9422293, 349
Show/Hide
|
C27H21F6N5S
|
1
|
| 1 |
IC50 = 2350 nM
|
|
|
|
CP0465799
|
US9422293, 183
Show/Hide
|
C25H25F6N5O
|
1
|
| 1 |
IC50 = 2370 nM
|
|
|
|
CP0499622
|
US9422293, 35
Show/Hide
|
C27H24F6N6
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0413287
|
US9422293, 63B
Show/Hide
|
C22H21Cl2F3N6
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0465880
|
2-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C29H34F6N8
|
1
|
| 1 |
IC50 = 2600 nM
|
|
|
|
CP0483362
|
US9422293, 370
Show/Hide
|
C33H35F3N6S
|
1
|
| 1 |
IC50 = 2610 nM
|
|
|
|
CP0479735
|
US9422293, 281
Show/Hide
|
C24H27F3N6O2S
|
1
|
| 1 |
IC50 = 2620 nM
|
|
|
|
CP0464263
|
2-N-phenyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H12F3N5S
|
1
|
| 1 |
IC50 = 2680 nM
|
|
|
|
CP0490175
|
US9422293, 82B
Show/Hide
|
C25H27F3N6
|
1
|
| 1 |
IC50 = 2800 nM
|
|
|
|
CP0515151
|
US9422293, 187
Show/Hide
|
C22H24F3N7
|
1
|
| 1 |
IC50 = 2850 nM
|
|
|
|
CP0528688
|
2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)nicotinamide
Show/Hide
|
C21H19F3N6O
|
1
|
| 1 |
IC50 = 2940 nM
|
|
|
|
CP0451453
|
US9422293, 299
Show/Hide
|
C28H32F3N7O2S
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0399260
|
methyl 3,5-dichloro-4-[[7-[4-(trifluoromethyl)anilino]-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino]benzoate
Show/Hide
|
C20H12Cl2F3N5O2S
|
1
|
| 1 |
IC50 = 3190 nM
|
|
|
|
CP0486283
|
US9422293, 68B
Show/Hide
|
C24H25F3N6O2
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0481126
|
US9422293, 348
Show/Hide
|
C21H18F6N6O2S
|
1
|
| 1 |
IC50 = 3220 nM
|
|
|
|
CP0493144
|
US9422293, 155
Show/Hide
|
C24H22F7N5
|
1
|
| 1 |
IC50 = 3280 nM
|
|
|
|
CP0465800
|
US9422293, 209
Show/Hide
|
C23H21F6N5O2S
|
1
|
| 1 |
IC50 = 3450 nM
|
|
|
|
CP0419429
|
US9422293, 293
Show/Hide
|
C21H17F3N6
|
1
|
| 1 |
IC50 = 3490 nM
|
|
|
|
CP0535998
|
US9422293, 115
Show/Hide
|
C25H24ClF6N5
|
1
|
| 1 |
IC50 = 3790 nM
|
|
|
|
CP0526196
|
US9422293, 74B
Show/Hide
|
C21H18F6N6S
|
1
|
| 1 |
IC50 = 3900 nM
|
|
|
|
CP0444923
|
US9422293, 195
Show/Hide
|
C25H28F6N8
|
1
|
| 1 |
IC50 = 4320 nM
|
|
|
|
CP0413288
|
US9422293, 70B
Show/Hide
|
C23H25F3N6
|
1
|
| 1 |
IC50 = 4400 nM
|
|
|
|
CP0377758
|
2-N-[2-(dimethylamino)ethyl]-2-N-methyl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C26H29F6N7
|
1
|
| 1 |
IC50 = 4449 nM
|
|
|
|
CP0406839
|
US9422293, 57B
Show/Hide
|
C27H26F6N6O2
|
1
|
| 1 |
IC50 = 5500 nM
|
|
|
|
CP0489658
|
US9422293, 315
Show/Hide
|
C28H30F6N6O
|
1
|
| 1 |
IC50 = 5520 nM
|
|
|
|
CP0529417
|
US9422293, 73B
Show/Hide
|
C23H23Cl2F3N6
|
1
|
| 1 |
IC50 = 6700 nM
|
|
|
|
CP0544416
|
US9422293, 116
Show/Hide
|
C24H24F6N6
|
1
|
| 1 |
IC50 = 7030 nM
|
|
|
|
CP0386114
|
2-(piperazin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H25F6N7
|
2
|
| 1 |
IC50 = 7200 nM
|
|
|
| 2 |
IC50 > 5000 nM
|
|
|
|
CP0416068
|
7-(3-(methylsulfonyl)pyridin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C21H20F3N5O2S
|
1
|
| 1 |
IC50 = 8520 nM
|
|
|
|
CP0550739
|
US9422293, 301
Show/Hide
|
C22H22F3N5O2S
|
1
|
| 1 |
IC50 = 8970 nM
|
|
|
|
CP0482792
|
US9422293, 198
Show/Hide
|
C23H25F3N6
|
1
|
| 1 |
IC50 = 9160 nM
|
|
|
|
CP0416069
|
2-(4-(4-(trifluoromethyl)phenylamino)-8,9-dihydro-5H-pyrimido[5,4-d]azepin-7(6H)-yl)pyridine-3-sulfonamide
Show/Hide
|
C20H19F3N6O2S
|
1
|
| 1 |
IC50 = 9460 nM
|
|
|
|
CP0489524
|
7-(pyrimidin-2-yl)-N-(4-(trifluoromethyl)phenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C19H17F3N6
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0512605
|
US9422293, 295
Show/Hide
|
C20H17F4N5
|
1
|
| 1 |
IC50 = 10430 nM
|
|
|
|
CP0451536
|
US9422293, 211
Show/Hide
|
C24H21F6N5O4S
|
1
|
| 1 |
IC50 = 11400 nM
|
|
|
|
CP0480861
|
US9422293, 120
Show/Hide
|
C24H24Cl2F3N5
|
1
|
| 1 |
IC50 = 12050 nM
|
|
|
|
CP0481142
|
US9422293, 202
Show/Hide
|
C25H28F3N5S
|
1
|
| 1 |
IC50 = 12420 nM
|
|
|
|
CP0520869
|
US9422293, 117
Show/Hide
|
C25H25F6N5
|
1
|
| 1 |
IC50 = 13490 nM
|
|
|
|
CP0495304
|
US9422293, 127
Show/Hide
|
C26H29F3N6O
|
1
|
| 1 |
IC50 = 19200 nM
|
|
|
|
CP0413295
|
US9422293, 105
Show/Hide
|
C21H22F3N7
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0480852
|
US9422293, 344
Show/Hide
|
C21H17F6N5O
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0481146
|
US9422293, 107
Show/Hide
|
C21H22F3N7
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0481147
|
US9422293, 227
Show/Hide
|
C26H30Cl2F3N7
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0488611
|
US9422293, 208
Show/Hide
|
C27H31F3N6O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0492560
|
2-(1,1-dioxo-1,4-thiazinan-4-yl)-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine
Show/Hide
|
C25H24F6N6O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0494958
|
US9422293, 71B
Show/Hide
|
C22H24F3N7O2S
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0499651
|
US9422293, 311
Show/Hide
|
C27H28F6N6O
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0501433
|
US9422293, 121
Show/Hide
|
C24H25ClF3N5
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0515195
|
US9422293, 84
Show/Hide
|
C24H26F3N5
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
|
CP0388331
|
2-N-(2,6-dichlorophenyl)-7-N-methyl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H12Cl2F3N5S
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0372299
|
7-N-[4-(trifluoromethyl)phenyl]-2-N-[3-(trifluoromethyl)pyridin-2-yl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10F6N6S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0372300
|
2-N-(2,6-dichlorophenyl)-4-N-[4-(trifluoromethyl)phenyl]-1,3-benzothiazole-2,4-diamine
Show/Hide
|
C20H12Cl2F3N3S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0378976
|
(4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)phenyl)(pyrrolidin-1-yl)methanone
Show/Hide
|
C22H18Cl2N6OS
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0399261
|
4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)benzamide
Show/Hide
|
C18H12Cl2N6OS
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0399935
|
3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino)thiazolo[5,4-d]pyrimidin-2-ylamino)benzoic acid
Show/Hide
|
C19H10Cl2F3N5O2S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0399936
|
N-(2,6-dichlorophenyl)-7-[4-(trifluoromethyl)phenyl]sulfanyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Show/Hide
|
C18H9Cl2F3N4S2
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0460311
|
2-N-(2,6-dichlorophenyl)-7-N-[2-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C18H10Cl2F3N5S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0460313
|
4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]pyrimidin-7-ylamino)benzoic acid
Show/Hide
|
C18H11Cl2N5O2S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0467594
|
2-N-(2,6-dichlorophenyl)-5-piperazin-1-yl-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C22H18Cl2F3N7S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0474070
|
7-(4-tert-butylphenoxy)-N-(2,6-dichlorophenyl)thiazolo[5,4-d]pyrimidin-2-amine
Show/Hide
|
C21H18Cl2N4OS
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0480321
|
2-N-[3-(trifluoromethyl)phenyl]-7-N-[4-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Show/Hide
|
C19H11F6N5S
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0377759
|
2-N-methyl-2-N-(1-methylpiperidin-3-yl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C28H31F6N7
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0382523
|
2-(3-(methylamino)pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C26H27F6N7
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0394539
|
2-(3-aminopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine
Show/Hide
|
C25H25F6N7
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0472373
|
2-N-methyl-2-N-[(1-methylpiperidin-2-yl)methyl]-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C29H33F6N7
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0523542
|
2-N-(1-methylpiperidin-3-yl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0527081
|
2-N-(piperidin-2-ylmethyl)-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C27H29F6N7
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0533170
|
2-N-piperidin-3-yl-4-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-2,4-diamine
Show/Hide
|
C26H27F6N7
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0400420
|
US9422293, 318
Show/Hide
|
C29H31F6N5O3S
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0413281
|
US9422293, 232
Show/Hide
|
C24H23Cl2F3N6
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0444922
|
US9422293, 180
Show/Hide
|
C28H30F6N6O
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0451338
|
US9422293, 365
Show/Hide
|
C28H29F6N5S
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0451339
|
US9422293, 367
Show/Hide
|
C25H25F6N5OS
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0479622
|
US9422293, 352
Show/Hide
|
C32H33F3N6S
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0480857
|
US9422293, 287
Show/Hide
|
C24H22ClF6N5
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0480863
|
US9422293, 346
Show/Hide
|
C22H20F6N6O
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0489655
|
US9422293, 371
Show/Hide
|
C32H39F3N6S
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0492922
|
US9422293, 280
Show/Hide
|
C28H24F6N6
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0495319
|
US9422293, 286
Show/Hide
|
C26H31BrClN5
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0499650
|
US9422293, 279
Show/Hide
|
C28H24F6N6
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0512606
|
US9422293, 303
Show/Hide
|
C23H21ClF3N5O2S
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0515419
|
N-[6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-2-piperidin-1-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine
Show/Hide
|
C26H27F6N7O
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0516766
|
US9422293, 285
Show/Hide
|
C27H31ClF3N5
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0519506
|
US9422293, 256
Show/Hide
|
C26H28Cl2F3N7
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0535991
|
US9422293, 375
Show/Hide
|
C24H23F6N5S
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0536001
|
US9422293, 203
Show/Hide
|
C22H18ClF6N5S
|
1
|
| 1 |
IC50 > 6670 nM
|
|
|
|
CP0413272
|
US9422293, 18
Show/Hide
|
C23H19F3N6
|
1
|
| 1 |
IC50 > 6700 nM
|
|
|
|
CP0413293
|
US9422293, 98
Show/Hide
|
C22H20Cl2F3N5S
|
1
|
| 1 |
IC50 > 6700 nM
|
|
|
|
CP0419424
|
US9422293, 85
Show/Hide
|
C24H24F3N5O2
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1
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| 1 |
IC50 > 6700 nM
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CP0465801
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US9422293, 53
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C22H19F6N5O2S
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1
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| 1 |
IC50 > 6700 nM
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CP0465802
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US9422293, 90B
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C25H23F6N7O
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1
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| 1 |
IC50 > 6700 nM
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CP0515196
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US9422293, 89
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C25H28F3N5O2S
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1
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| 1 |
IC50 > 6700 nM
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CP0517231
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US9422293, 28
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C19H17F3N6
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1
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| 1 |
IC50 > 6700 nM
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CP0526062
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US9422293, 64
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C24H24F6N6O
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1
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| 1 |
IC50 > 6700 nM
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CP0550661
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US9422293, 26
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C20H16F6N6
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1
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| 1 |
IC50 > 6700 nM
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CP0390351
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2-[3,5-difluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C23H27F5N4O3S
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1
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| 1 |
Ki = 0.1 nM
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