2-[6-[(E)-2-[(3R,3aR,4R,5S,7aS)-6,6-difluoro-7a-hydroxy-3,5-dimethyl-1-oxo-3a,4,5,7-tetrahydro-3H-2-benzofuran-4-yl]ethenyl]pyridin-3-yl]benzonitrile

2-[6-[(E)-2-[(3R,3aR,4R,5S,7aS)-6,6-difluoro-7a-hydroxy-3,5-dimethyl-1-oxo-3a,4,5,7-tetrahydro-3H-2-benzofuran-4-yl]ethenyl]pyridin-3-yl]-6-methylbenzonitrile

(3R,3aS,4S,5R,6S,7aR)-4-[5-(3-fluorophenyl)pyridin-2-yl]-3,5,6-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-2-benzofuran-1-one

ethyl (3R,3aS,4S,5R,6R,6aS,9aR)-4-[(E)-2-[5-(2-cyanophenyl)pyridin-2-yl]ethenyl]-3,5,6-trimethyl-1-oxo-3,3a,4,5,6,6a,7,9-octahydrofuro[3,4-d]isoindole-8-carboxylate

(3R,3aS,4R,5S,7aR)-6,6-difluoro-4-[5-(3-fluorophenyl)pyridin-2-yl]-3,5-dimethyl-3,3a,4,5,7,7a-hexahydro-2-benzofuran-1-one

2-[6-[(E)-2-[(3R,3aR,4R,5S,7aS)-7a-amino-6,6-difluoro-3,5-dimethyl-1-oxo-2,3,3a,4,5,7-hexahydroisoindol-4-yl]ethenyl]pyridin-3-yl]benzonitrile

2-[6-[(E)-2-[(3R,3aS,4R,5S,7aS)-7a-amino-6,6-difluoro-3,5-dimethyl-1-oxo-3a,4,5,7-tetrahydro-3H-2-benzofuran-4-yl]ethenyl]pyridin-3-yl]benzonitrile

(3R,3aS,4S,5R,6R,6aS,9aR)-4-[(E)-2-[5-(2-cyanophenyl)pyridin-2-yl]ethenyl]-N-ethyl-3,5,6-trimethyl-1-oxo-3,3a,4,5,6,6a,7,9-octahydrofuro[3,4-d]isoindole-8-carboxamide

(3R,3aS,4S,5R,6R,6aS,9aR)-4-[(E)-2-[5-(2-cyanophenyl)pyridin-2-yl]ethenyl]-N,3,5,6-tetramethyl-1-oxo-3,3a,4,5,6,6a,7,9-octahydrofuro[3,4-d]isoindole-8-carboxamide

2-[6-[(E)-2-[(3R,3aR,4R,5S,7aS)-5-ethyl-6,6-difluoro-7a-hydroxy-3-methyl-1-oxo-3a,4,5,7-tetrahydro-3H-2-benzofuran-4-yl]ethenyl]pyridin-3-yl]benzonitrile

(3R,3aR,4R,5S,7aS)-6,6-difluoro-4-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7a-hydroxy-3,5-dimethyl-3a,4,5,7-tetrahydro-3H-2-benzofuran-1-one

2-[6-[(E)-2-[(3R,3aS,4S,5R,6R,6aS,9aR)-3,5,6-trimethyl-1-oxo-3a,4,5,6,6a,7,8,9-octahydro-3H-furo[3,4-d]isoindol-4-yl]ethenyl]pyridin-3-yl]benzonitrile

2-[6-[(E)-2-[(3R,3aS,4S,5R,6R,6aS,9aR)-3,5,6,8-tetramethyl-1-oxo-3,3a,4,5,6,6a,7,9-octahydrofuro[3,4-d]isoindol-4-yl]ethenyl]pyridin-3-yl]benzonitrile

VORAPAXAR

(3R,3aS,4R,5S,6R,7aR)-4-[5-(3-fluorophenyl)pyridin-2-yl]-3,3',5-trimethylspiro[3,3a,4,5,7,7a-hexahydro-2-benzofuran-6,5'-4H-1,2-oxazole]-1-one

(3R,3aS,4S,5S,7aR)-4-[5-(3-fluorophenyl)pyridin-2-yl]-3,5-dimethylspiro[3,3a,4,5,7,7a-hexahydro-2-benzofuran-6,5'-imidazolidine]-1,2',4'-trione

(2R,4aS,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-ol

(1S,2R,4aS,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-2-hydroxy-1,4a,6-trimethyl-2,3,4,5,6,7,8,8a-octahydronaphthalene-1-carbaldehyde

(1S,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-2-hydroxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carbaldehyde

methyl (1S,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-2-hydroxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carboxylate

(1R,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-(methoxymethyl)-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-2-ol

methyl (1S,2R,4aR,5S,6S,8aS)-2-carbamoyloxy-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carboxylate

(1R,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-(hydroxymethyl)-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-2-ol

(1R,2R,4aR,5S,6S,8aS)-1-(hydroxymethyl)-1,4a-dimethyl-5-[(E)-2-[5-[3-(trifluoromethyl)phenyl]pyridin-2-yl]ethenyl]spiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-2-ol

(1R,2R,4aR,5S,6S,8aS)-1-(hydroxymethyl)-1,4a-dimethyl-5-[2-[5-[3-(trifluoromethyl)phenyl]pyridin-2-yl]ethyl]spiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-2-ol

[(3aS,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] carbamate

[(1R,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-2-methoxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-yl]methanol

(1R,2R,4aR,5S,6S,8aS)-5-[2-[5-(3-fluorophenyl)pyridin-2-yl]ethyl]-1-(hydroxymethyl)-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-2-ol

(1R,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethyl-1-(methylaminomethyl)spiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-2-ol

(3aS,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7-hydroxy-6,9a-dimethyl-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[g][2]benzofuran-1-one

[(3aS,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] carbamate

[(3aS,5aS,6S,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] carbamate

(1R,2R,4aR,5S,6S,8aS)-1-(aminomethyl)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-2-ol

(1S,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-2-hydroxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carboxylic acid

[(2R,4aS,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] carbamate

(1S,2S,4aS,5R,6R,8aR)-1-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,6-diol

[(2R,4aS,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] methanesulfonate

[(3aS,5aS,6S,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] acetate

methyl (1S,2R,4aR,5S,6S,8aS)-2-acetyloxy-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carboxylate

(3aS,5aS,6R,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7-hydroxy-6,9a-dimethyl-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[g][2]benzofuran-1-one

[(3aS,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] acetate

[(3aS,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] methanesulfonate

[(3aS,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] butanoate

[(2R,4aS,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] acetate

[(3aS,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] methanesulfonate

(3aS,5aS,6S,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7-hydroxy-6,9a-dimethyl-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[g][2]benzofuran-1-one

(1S,2R,4aS,5R,6S,8aS)-6-(1,3-dithiolan-2-yl)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-2-hydroxy-1,4a-dimethyl-2,3,4,5,6,7,8,8a-octahydronaphthalene-1-carbaldehyde

(1S,2R,4aS,5R,6S,8aS)-1,6-bis(1,3-dithiolan-2-yl)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-ol

[(2R,4aS,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] ethyl carbonate

(1S,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]ethenyl]-2-hydroxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carbaldehyde

[(2R,4aS,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] butanoate

2-[(E)-2-[(1S,2S,4aR,8aS)-2,5,5,8a-tetramethyl-1,2,3,4,4a,8-hexahydronaphthalen-1-yl]ethenyl]-5-(3-fluorophenyl)pyridine

2-[(E)-2-[(4aR,6aR,7S,8S,10aS,10bR)-3,3,6a,10b-tetramethylspiro[1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxine-8,2'-oxirane]-7-yl]ethenyl]-5-[3-(trifluoromethyl)phenyl]pyridine

[(3aS,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] acetate

[(3aS,5aS,6R,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] carbamate

[(3aS,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] butanoate

methyl (1S,2R,4aR,5S,6S,8aS)-2-butanoyloxy-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carboxylate

(1R,2R,4aR,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]ethenyl]-2-hydroxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carbaldehyde

2-[(E)-2-[(4aR,6aR,7S,8S,10aS,10bR)-3,3,6a,10b-tetramethylspiro[1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxine-8,2'-oxirane]-7-yl]ethenyl]-5-(3-fluorophenyl)pyridine

(3aS,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7-hydroxy-6,9a-dimethyl-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[g][2]benzofuran-1-one