| Compound ID |
Compound Name |
Compound Formula |
|
CP0386958
|
4-chloro-N-(2-methylpyrazol-3-yl)benzenesulfonamide
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C10H10ClN3O2S
|
3
|
| 1 |
EC50 = 0.1259 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki > 10000 nM
|
|
|
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CP0393939
|
4-chloro-N-(2-pyridin-2-ylpyrazol-3-yl)benzenesulfonamide
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|
C14H11ClN4O2S
|
3
|
| 1 |
EC50 = 0.1259 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki > 10000 nM
|
|
|
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CP0386696
|
N-(2-pyridin-2-ylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamide
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|
C15H11F3N4O2S
|
3
|
| 1 |
EC50 = 0.1585 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki > 10000 nM
|
|
|
|
CP0386944
|
N-(2-methylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamide
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|
C11H10F3N3O2S
|
3
|
| 1 |
EC50 = 0.1585 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki > 10000 nM
|
|
|
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CP0117986
|
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
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|
C43H66N12O12S2
|
6
|
| 1 |
EC50 = 0.18 nM
|
|
|
| 2 |
EC50 = 0.19 nM
|
|
|
| 3 |
EC50 = 10 nM
|
|
|
| 4 |
EC50 = 60 nM
|
|
|
| 5 |
IC50 > 10000 nM
|
|
|
| 6 |
Ki = 20 nM
|
|
|
|
CP0192572
|
AVP
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|
C46H65N15O12S2
|
2
|
| 1 |
EC50 = 0.24 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0383082
|
(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-[(4-fluorophenyl)methyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C47H67FN12O12S2
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0386874
|
CHEBI:59204
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|
C45H69N11O12S
|
3
|
| 1 |
EC50 = 2.3 nM
|
|
|
| 2 |
EC50 = 41 nM
|
|
|
| 3 |
IC50 > 10000 nM
|
|
|
|
CP0526361
|
(3R,6S,9S,12S,15S,18S)-18-amino-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-N-[(4-fluorophenyl)methyl]-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
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|
C48H69FN12O12S
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0452434
|
(2S)-N-[(2S)-5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7,10-bis(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-(furan-2-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
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|
C39H61N13O12S2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0379406
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-hexyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C46H73N11O12S2
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0379963
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-pentyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C45H71N11O12S2
|
2
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0374453
|
(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
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|
C43H65N11O12S2
|
2
|
| 1 |
EC50 = 21 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0379965
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-[(3-methylphenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C49H71N11O12S
|
2
|
| 1 |
EC50 = 71 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0386943
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-cyclobutyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C44H67N11O12S2
|
2
|
| 1 |
EC50 = 85 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0386873
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-N-pentyl-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
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|
C46H73N11O12S
|
2
|
| 1 |
EC50 = 86 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0483064
|
(2S)-N-(4-aminobutyl)-1-[(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-9-propan-2-yl-12-(thiophen-2-ylmethyl)-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]pyrrolidine-2-carboxamide
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|
C41H59N9O9S2
|
1
|
| 1 |
EC50 = 650 nM
|
|
|
|
CP0374449
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-(furan-2-ylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C45H65N11O13S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 390 nM
|
|
|
|
CP0374452
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-pentyl-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H73N11O12S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0374485
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-N,16-dibenzyl-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C48H69N11O11S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1600 nM
|
|
|
|
CP0374487
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-N-[(3-methylphenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C49H71N11O11S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 480 nM
|
|
|
|
CP0374490
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-butyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C44H69N11O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0374491
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-cyclopentyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C45H69N11O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0374493
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(oxolan-2-ylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
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|
C45H69N11O13S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1500 nM
|
|
|
|
CP0374495
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-N-butyl-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C45H71N11O11S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 740 nM
|
|
|
|
CP0379228
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-(3-hydroxypropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C43H67N11O13S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 3400 nM
|
|
|
|
CP0379229
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-[(4-fluorophenyl)methyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C47H66FN11O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 880 nM
|
|
|
|
CP0379240
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-(2-morpholin-4-ylethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H72N12O13S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0379243
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(2-pyridin-2-ylethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C47H68N12O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 730 nM
|
|
|
|
CP0379284
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-N-(2-phenylethyl)-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C49H71N11O11S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 330 nM
|
|
|
|
CP0379295
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-N-[(3-methylphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C49H71N11O12S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0379296
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-N-[(4-fluorophenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C48H68FN11O11S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
|
CP0379412
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(2-phenylethyl)-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C49H71N11O12S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 640 nM
|
|
|
|
CP0379415
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-N-benzyl-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C47H67N11O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0379417
|
(2S,4R)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-methoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]-4-methoxypyrrolidine-2-carboxamide
Show/Hide
|
C46H71N11O13S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
|
CP0379419
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-N-benzyl-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C48H69N11O12S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
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CP0379420
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-N-butyl-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C45H71N11O12S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
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CP0379421
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-N-(2-methoxyethyl)-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C44H69N11O12S
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 2500 nM
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|
|
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CP0379484
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-[(2-methylphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C48H69N11O12S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
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| 2 |
IC50 = 1900 nM
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CP0379486
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-[(4-methoxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C48H69N11O13S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 970 nM
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|
|
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CP0379489
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(2-phenylethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C48H69N11O12S2
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 = 270 nM
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CP0379490
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(thiophen-2-ylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C45H65N11O12S3
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2
|
| 1 |
EC50 > 10000 nM
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|
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| 2 |
IC50 = 1200 nM
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CP0379491
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(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-N-(2-methoxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
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C44H69N11O13S
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 > 10000 nM
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CP0379492
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-(3-hydroxypropyl)-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C44H69N11O13S
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 = 1800 nM
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CP0379493
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(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-N-(thiophen-2-ylmethyl)-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
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C46H67N11O12S2
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 = 2100 nM
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CP0379964
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(pyridin-2-ylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C46H66N12O12S2
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 = 2200 nM
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|
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CP0379976
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-[(4-methylphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C48H69N11O12S2
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 = 1400 nM
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|
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CP0379977
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(pyridin-4-ylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C46H66N12O12S2
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 = 3200 nM
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|
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CP0379978
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-N-pentyl-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H73N11O11S
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2
|
| 1 |
EC50 > 10000 nM
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|
|
| 2 |
IC50 > 10000 nM
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|
|
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CP0379979
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-[(4-fluorophenyl)methyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
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C48H68FN11O12S
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
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|
|
|
CP0381388
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-N-benzyl-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C48H69N11O12S
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0381390
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(thiophen-2-ylmethyl)-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H67N11O12S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 380 nM
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|
|
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CP0381413
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-N-(3-hydroxypropyl)-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C44H69N11O12S
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
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|
|
|
CP0381555
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-(cyclopropylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C44H67N11O12S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
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|
|
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CP0386854
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-N-(thiophen-2-ylmethyl)-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H67N11O11S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1200 nM
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|
|
|
CP0386875
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-(2-methoxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C43H67N11O13S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1800 nM
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|
|
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CP0386942
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(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-N-(2-phenylethyl)-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C49H71N11O12S
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 490 nM
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|
|
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CP0389135
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(pyridin-3-ylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H66N12O12S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1300 nM
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|
|
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CP0400333
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(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-butyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C45H71N11O12S
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
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|
|
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CP0400335
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-cyclohexyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H71N11O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 2000 nM
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|
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CP0410445
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(2-pyrrolidin-2-ylethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H72N12O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1300 nM
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|
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CP0410446
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-15-benzyl-12-[(2S)-butan-2-yl]-N-butyl-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C45H71N11O11S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
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CP0411518
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-[(3-methylphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C48H69N11O12S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
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|
|
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CP0418736
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(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(2-thiophen-2-ylethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C46H67N11O12S3
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 280 nM
|
|
|
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CP0425942
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-15-benzyl-12-[(2S)-butan-2-yl]-N-(2-methoxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C44H69N11O12S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0425948
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-N-(2-pyridin-4-ylethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C47H68N12O12S2
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2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
|
CP0459759
|
(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-N-cyclopropyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C43H65N11O12S2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0480508
|
(4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-(2-methoxyethyl)-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C44H69N11O13S
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 990 nM
|
|
|
|
CP0219136
|
4-[(3,5-dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide
Show/Hide
|
C32H35N7O4
|
6
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
| 3 |
IC50 = 613 nM
|
|
|
| 4 |
Ki = 12.5 nM
|
|
|
| 5 |
Ki = 27 nM
|
|
|
| 6 |
Ki = 113 nM
|
|
|
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CP0385080
|
7-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-one
Show/Hide
|
C31H42N6O3
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 194.7 nM
|
|
|
| 4 |
Ki = 195 nM
|
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|
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CP0385081
|
5-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-one
Show/Hide
|
C29H38N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 409 nM
|
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CP0385082
|
5-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-one
Show/Hide
|
C27H34N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 466 nM
|
|
|
|
CP0385371
|
8-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-one
Show/Hide
|
C30H40N6O3
|
4
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 4667 nM
|
|
|
| 3 |
Ki = 64 nM
|
|
|
| 4 |
Ki = 64.1 nM
|
|
|
|
CP0385372
|
4-[(3,5-dimethoxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide
Show/Hide
|
C34H39N7O4
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 1113 nM
|
|
|
| 3 |
Ki = 62 nM
|
|
|
|
CP0385374
|
8-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-one
Show/Hide
|
C32H44N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 7674 nM
|
|
|
| 3 |
Ki = 248 nM
|
|
|
|
CP0401206
|
6-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-one
Show/Hide
|
C28H36N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 449 nM
|
|
|
|
CP0417316
|
7-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-one
Show/Hide
|
C29H38N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 130 nM
|
|
|
|
CP0417317
|
6-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-one
Show/Hide
|
C30H40N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 = 8203 nM
|
|
|
| 3 |
Ki = 266 nM
|
|
|
|
CP0389627
|
2-[4-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone
Show/Hide
|
C32H36N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 1910 nM
|
|
|
|
CP0393045
|
3-[2-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)propan-1-one
Show/Hide
|
C31H34N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 250.7 nM
|
|
|
|
CP0393183
|
2-[3-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone
Show/Hide
|
C30H32N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 642.8 nM
|
|
|
|
CP0393185
|
2-[4-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone
Show/Hide
|
C30H32N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 795.1 nM
|
|
|
|
CP0393186
|
3-[4-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)propan-1-one
Show/Hide
|
C31H34N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 1756 nM
|
|
|
|
CP0409109
|
2-[3-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone
Show/Hide
|
C32H36N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 2095 nM
|
|
|
|
CP0430543
|
2-[2-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone
Show/Hide
|
C32H36N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 6807 nM
|
|
|
|
CP0430544
|
2-[2-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)ethanone
Show/Hide
|
C30H32N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 1938 nM
|
|
|
|
CP0456589
|
3-[4-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)propan-1-one
Show/Hide
|
C33H38N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 6250 nM
|
|
|
|
CP0456590
|
3-[2-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)propan-1-one
Show/Hide
|
C33H38N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 1062 nM
|
|
|
|
CP0474748
|
3-[3-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)propan-1-one
Show/Hide
|
C33H38N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 3343 nM
|
|
|
|
CP0474750
|
3-[3-[4-[(3,5-dihydroxyphenyl)methyl]piperazin-1-yl]phenyl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)propan-1-one
Show/Hide
|
C31H34N6O3
|
3
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
| 3 |
Ki = 874.1 nM
|
|
|
|
CP0426671
|
[4-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-19-(hexadecanoylamino)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]methyl]phenyl] N-tetradecylcarbamate
Show/Hide
|
C74H125N13O14S2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0528500
|
[4-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-19-(hexadecanoylamino)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]methyl]phenyl] N-hexadecylcarbamate
Show/Hide
|
C76H129N13O14S2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0548027
|
[4-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-19-(hexadecanoylamino)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]methyl]phenyl] pentadecyl carbonate
Show/Hide
|
C75H126N12O15S2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0548028
|
[4-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-19-(hexadecanoylamino)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]methyl]phenyl] tetradecyl carbonate
Show/Hide
|
C74H124N12O15S2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0548029
|
[4-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-19-(hexadecanoylamino)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]methyl]phenyl] N-pentadecylcarbamate
Show/Hide
|
C75H127N13O14S2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0550985
|
[4-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-19-(hexadecanoylamino)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]methyl]phenyl] hexadecyl carbonate
Show/Hide
|
C76H128N12O15S2
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0374494
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-N-(3-hydroxypropyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C44H69N11O13S
|
2
|
| 1 |
EC50 > 10 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0379418
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-N-[(4-fluorophenyl)methyl]-15-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C48H68FN11O12S
|
2
|
| 1 |
EC50 > 10 nM
|
|
|
| 2 |
IC50 = 1200 nM
|
|
|
|
CP0487989
|
(3R,6S,9S,12S,15S,18S)-18-amino-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-hydroxyphenyl)methyl]-N-(3-hydroxypropyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C44H70N12O13S
|
1
|
| 1 |
EC50 > 10 nM
|
|
|
|
CP0526362
|
(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-N-(3-hydroxypropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Show/Hide
|
C43H68N12O13S2
|
1
|
| 1 |
EC50 > 10 nM
|
|
|
|
CP0410443
|
(2S,4S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-ethoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]-4-methoxypyrrolidine-2-carboxamide
Show/Hide
|
C47H73N11O13S
|
2
|
| 1 |
EC50 > 100 nM
|
|
|
| 2 |
IC50 = 55 nM
|
|
|
|
CP0375555
|
(2S)-N-[(2S)-4-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxobutan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(1-benzothiophen-3-ylmethyl)-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Show/Hide
|
C43H63N13O11S3
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0388466
|
(2S)-N-[(2S)-4-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxobutan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Show/Hide
|
C35H59N13O11S2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0374451
|
(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-methoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carboxamide
Show/Hide
|
C42H65N11O12S
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0379414
|
(2S,4S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-ethoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]-4-hydroxypyrrolidine-2-carboxamide
Show/Hide
|
C46H71N11O13S
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0379479
|
(S)-1-((4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((R)-1-(2-amino-2-oxoethylamino)-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
Show/Hide
|
C46H64N14O12S2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0381414
|
(2S,4R)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-[(4-methoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacycloicosane-3-carbonyl]-4-methylsulfanylpyrrolidine-2-carboxamide
Show/Hide
|
C46H71N11O12S2
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
IC50 = 670 nM
|
|
|
|
CP0464288
|
(4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbenzene)amido]phenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxamide
Show/Hide
|
C39H40N4O3
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 45 nM
|
|
|
|
CP0124484
|
3'N-(2-dimethylaminoethyl)-1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
Show/Hide
|
C39H40N4O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0280289
|
3'N-(3-dimethylaminopropyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
Show/Hide
|
C35H39FN4O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0454321
|
(4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-methoxyphenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
Show/Hide
|
C30H26ClFN2O5
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 38 nM
|
|
|
|
CP0281438
|
3'N-(2-hydroxyethyl)-1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
Show/Hide
|
C37H35N3O4
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0444371
|
(4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-ethoxyphenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
Show/Hide
|
C31H28ClFN2O5
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0078819
|
(2S)-N-{2-Methyl-4-[(1-methyl-4,10-dihydropyrazolo[3,4-b]-[1,5]benzodiazepin-5(1H)-yl)carbonyl]benzyl}-2-[(4-methyl-1,4-diazepan-1-yl)carbonothioyl]pyrrolidine-1-carboxamide
Show/Hide
|
C32H40N8O2S
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
Ki = 196 nM
|
|
|
|
CP0454096
|
N-[4-[1'-(hydroxymethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1-carbonyl]phenyl]-2-phenylbenzamide
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C35H32N2O3
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1
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| 1 |
IC50 = 9 nM
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CP0410989
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1-[2-(dimethylamino)-2-sulfanylideneethyl]-3-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]urea
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C25H29N7O2S
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2
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| 1 |
IC50 = 9 nM
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| 2 |
Ki = 82 nM
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CP0464259
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(4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]phenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
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C29H24ClFN2O4
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2
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| 1 |
IC50 = 13 nM
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| 2 |
IC50 = 380 nM
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CP0464750
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methyl 1-[4-[(2-fluorobenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylate
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C30H27FN2O4
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2
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| 1 |
IC50 = 15 nM
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| 2 |
IC50 = 130 nM
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CP0489317
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N-[4-[1'-(methylaminomethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1-carbonyl]phenyl]-2-phenylbenzamide
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C36H35N3O2
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2
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| 1 |
IC50 = 18 nM
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| 2 |
IC50 = 630 nM
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CP0461665
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1-({4-[(2-chloro-5-fluorobenzene)amido]-3-methoxyphenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
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C30H26ClFN2O5
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2
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| 1 |
IC50 = 19 nM
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| 2 |
IC50 = 89 nM
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CP0433271
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1-({4-[(2-phenylbenzene)amido]phenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
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C35H30N2O4
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2
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| 1 |
IC50 = 20 nM
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| 2 |
IC50 = 37 nM
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CP0501743
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(4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-methoxyphenyl}carbonyl)-N-sulfamoyl-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxamide
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C30H28ClFN4O6S
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1
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| 1 |
IC50 = 27 nM
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CP0154509
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3'N-(3-dimethylaminopropyl)-1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
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C40H42N4O3
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1
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| 1 |
IC50 = 29 nM
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CP0304035
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3'N-(2-tetrahydro-1H-1-pyrrolylethyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
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C36H39FN4O3
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1
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| 1 |
IC50 = 29 nM
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CP0461696
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1-({4-[(2-chloro-5-fluorobenzene)amido]phenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
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C29H24ClFN2O4
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2
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| 1 |
IC50 = 32 nM
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| 2 |
IC50 = 780 nM
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CP0461695
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methyl 1-[4-[(2-chloro-5-fluorobenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylate
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C30H26ClFN2O4
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2
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| 1 |
IC50 = 40 nM
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| 2 |
IC50 = 190 nM
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CP0154510
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(4S)-N-[2-(dimethylamino)ethyl]-1-[4-[(2-phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamide
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C39H40N4O3
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1
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| 1 |
IC50 = 45 nM
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CP0042892
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3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
Show/Hide
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C37H41FN4O3
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2
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| 1 |
IC50 = 48 nM
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| 2 |
IC50 = 71 nM
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CP0410990
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N,N-dimethyl-2-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methylcarbamoylamino]acetamide
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C25H29N7O3
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2
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| 1 |
IC50 = 50 nM
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| 2 |
Ki > 1000 nM
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CP0454322
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2-chloro-5-fluoro-N-(2-methoxy-4-{[(4R)-3'-(1H-1,2,3,4-tetrazol-5-yl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-en-1-yl]carbonyl}phenyl)benzamide
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C30H26ClFN6O3
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1
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| 1 |
IC50 = 63 nM
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CP0056752
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3'N-(2-dimethylaminoethyl)-1-[4-(5-fluoro-2-methylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
Show/Hide
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C34H37FN4O3
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1
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| 1 |
IC50 = 65 nM
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CP0041307
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(4R)-N-[2-(dimethylamino)ethyl]-1-[4-[(2-fluorobenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamide
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C33H35FN4O3
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1
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| 1 |
IC50 = 78 nM
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CP0154159
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2-[1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3-ylcarboxamido]acetic acid
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C37H33N3O5
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1
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| 1 |
IC50 = 78 nM
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CP0438918
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2-chloro-5-fluoro-N-(4-{[(4R)-3'-(1H-imidazol-2-yl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-en-1-yl]carbonyl}-2-methoxyphenyl)benzamide
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C32H28ClFN4O3
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1
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| 1 |
IC50 = 95 nM
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CP0387124
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(2S)-2-N,2-N-dimethyl-1-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]pyrrolidine-1,2-dicarboxamide
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C28H33N7O3
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2
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| 1 |
IC50 = 95 nM
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| 2 |
Ki > 1000 nM
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CP0197121
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3'N-(2-hydroxyethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
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C31H30FN3O4
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1
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| 1 |
IC50 = 99 nM
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CP0393052
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N-[3-chloro-4-[1'-(hydroxymethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1-carbonyl]phenyl]-5-fluoro-2-methylbenzamide
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C30H28ClFN2O3
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1
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| 1 |
IC50 = 100 nM
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CP0454098
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1-({4-[(2-fluorobenzene)amido]phenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
Show/Hide
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C29H25FN2O4
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1
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| 1 |
IC50 = 100 nM
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CP0405331
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(2S)-2-(dimethylcarbamothioyl)-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]pyrrolidine-1-carboxamide
Show/Hide
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C28H33N7O2S
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2
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| 1 |
IC50 = 100 nM
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| 2 |
Ki = 1253 nM
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CP0387123
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methyl 2-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methylcarbamoylamino]acetate
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C24H26N6O4
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2
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| 1 |
IC50 = 110 nM
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| 2 |
Ki > 1000 nM
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CP0194057
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3'N-(2-dimethylaminoethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
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C33H35FN4O3
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1
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| 1 |
IC50 = 126 nM
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CP0289902
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methyl 2-[[1-[4-[(5-fluoro-2-methylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carbonyl]amino]acetate
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C33H32FN3O5
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1
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| 1 |
IC50 = 135 nM
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CP0040044
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3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-ylcarbonyl)-1-(5-fluoro-2-methylphenylcarboxamido)benzene
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C27H21ClFN3O2
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2
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| 1 |
IC50 = 150 nM
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| 2 |
IC50 > 5000 nM
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CP0105811
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3'N-(2-tetrahydro-1H-1-pyrrolylethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
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C35H37FN4O3
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1
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| 1 |
IC50 = 155 nM
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CP0279457
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4-{2-[1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3-ylcarboxamido]ethyl}-1,4-oxazinane
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C35H37FN4O4
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1
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| 1 |
IC50 = 227 nM
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CP0433272
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2-chloro-N-(4-{[(4R)-3'-(4,5-dihydro-1H-imidazol-2-yl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-en-1-yl]carbonyl}-2-methoxyphenyl)-5-fluorobenzamide
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C32H30ClFN4O3
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1
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| 1 |
IC50 = 320 nM
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CP0440682
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2-[5-[(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]-4-(6-methoxypyridin-3-yl)-1,2,4-triazol-3-yl]acetonitrile
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C21H18ClFN6O
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1
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| 1 |
IC50 = 769 nM
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CP0455169
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(1S,5R)-3-[4-(1,3-benzodioxol-5-yl)-5-(methoxymethyl)-1,2,4-triazol-3-yl]-1-(2-chloro-4-fluorophenyl)-3-azabicyclo[3.1.0]hexane
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C22H20ClFN4O3
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1
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| 1 |
IC50 = 810 nM
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CP0440684
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[5-(2-fluoroethoxymethyl)-4-(6-methoxypyridin-3-yl)-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C22H22ClF2N5O2
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1
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| 1 |
IC50 = 819 nM
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CP0304375
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3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide
Show/Hide
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C36H39FN4O3
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1
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| 1 |
IC50 = 950 nM
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CP0467938
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[5-(ethoxymethyl)-4-(6-methoxypyridin-3-yl)-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C22H23ClFN5O2
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1
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| 1 |
IC50 = 1757 nM
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CP0467939
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[5-(difluoromethyl)-4-(6-methoxypyridin-3-yl)-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C20H17ClF3N5O
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1
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| 1 |
IC50 = 1867 nM
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CP0467937
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[4-(6-methoxypyridin-3-yl)-5-[[(3R)-oxolan-3-yl]oxymethyl]-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C24H25ClFN5O3
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1
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| 1 |
IC50 = 1979 nM
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CP0169179
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[5-(methoxymethyl)-4-(6-methoxypyridin-3-yl)-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C21H21ClFN5O2
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1
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| 1 |
IC50 = 2885 nM
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CP0479500
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(1S,5R)-1-(2-chloro-3-fluorophenyl)-3-[5-(methoxymethyl)-4-(6-methoxypyridin-3-yl)-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C21H21ClFN5O2
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1
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| 1 |
IC50 = 3811 nM
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CP0440685
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[4-(6-methoxypyridin-3-yl)-5-(oxan-4-yloxymethyl)-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C25H27ClFN5O3
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1
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| 1 |
IC50 = 4697 nM
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CP0534259
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[4-(6-methoxypyridin-3-yl)-5-[[(3S)-oxolan-3-yl]oxymethyl]-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C24H25ClFN5O3
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1
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| 1 |
IC50 = 7520 nM
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CP0431543
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(1S,5R)-1-(2-chloro-4-fluorophenyl)-3-[5-cyclopropyl-4-(6-methoxypyridin-3-yl)-1,2,4-triazol-3-yl]-3-azabicyclo[3.1.0]hexane
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C22H21ClFN5O
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1
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| 1 |
IC50 = 10970 nM
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CP0433270
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1-({4-[(5-fluoro-2-methylbenzene)amido]-2-methoxyphenyl}carbonyl)-1,2,3,5-tetrahydrospiro[1-benzazepine-4,1'-cyclopentan]-2'-ene-3'-carboxylic acid
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C31H29FN2O5
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1
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| 1 |
IC50 = 11600 nM
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CP0400285
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2-[(1E,3E,5Z)-5-[3-[4-[2-[3-[4-[(4-chlorophenyl)-[2-[(2-hydroxy-1H-indol-3-yl)diazenyl]-2-oxoethyl]sulfamoyl]phenyl]propanoylamino]ethylamino]-4-oxobutyl]-1-ethyl-3-methyl-5-sulfoindol-2-ylidene]penta-1,3-dienyl]-1-ethyl-3,3-dimethylindol-1-ium-6-sulfonate
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C59H63ClN8O12S3
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1
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| 1 |
Kd = 19.7 nM
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CP0400286
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CHEMBL3416749
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C54H48ClN7O12S
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1
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| 1 |
Kd = 61 nM
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CP0847936
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2-(5-(3-(1-(5-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-4-(6-methoxypyridinium-3-yl)-4H-1,2,4-triazol-3-yl)-15-oxo-2,5,8,11-tetraoxa-14-azaoctadecan-18-yl)-1-ethyl-3-methyl-5-sulfoindolin-2-ylidene)penta-1,3-dienyl)-1-ethyl-3,3-dimethyl-3H-indolium-6-sulfonate 2,2,2-trifluoroacetate
Show/Hide
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C60H71ClF4N8O15S2
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1
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| 1 |
Kd > 1000 nM
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CP0847937
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2-(5-(3-(1-(5-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-4-(6-methoxypyridinium-3-yl)-4H-1,2,4-triazol-3-yl)-27-oxo-2,5,8,11,14,17,20,23-octaoxa-26-azatriacontan-30-yl)-1-ethyl-3-methyl-5-sulfoindolin-2-ylidene)penta-1,3-dienyl)-1-ethyl-3,3-dimethyl-3H-indolium-6-sulfonate 2,2,2-trifluoroacetate
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C68H87ClF4N8O19S2
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1
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| 1 |
Kd > 1000 nM
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CP0859026
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5-(3-(34-(3-carboxy-4-(3-oxo-3H-xanthen-9-yl)phenyl)-27,34-dioxo-2,5,8,11,14,17,20,23-octaoxa-26,33-diazatetratriacontyl)-5-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridinium 2,2,2-trifluoroacetate
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C63H72ClF4N7O19
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1
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| 1 |
Kd > 1000 nM
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CP0859027
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5-(3-(22-(3-carboxy-4-(3-oxo-3H-xanthen-9-yl)phenyl)-15,22-dioxo-2,5,8,11-tetraoxa-14,21-diazadocosyl)-5-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridinium 2,2,2-trifluoroacetate
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C55H56ClF4N7O15
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1
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| 1 |
Kd > 1000 nM
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CP0419751
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2-[6-chloro-3-(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)indol-1-yl]-N,N-dimethylacetamide
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C25H26ClN3O3
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1
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| 1 |
Ki = 0.5 nM
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CP0244529
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[6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C25H28ClN3O2
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1
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| 1 |
Ki = 1 nM
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CP0379184
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2-[6-chloro-3-(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)indol-1-yl]-1-(4-methylpiperazin-1-yl)ethanone
Show/Hide
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C28H31ClN4O3
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1
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| 1 |
Ki = 1 nM
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CP0441648
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[6-chloro-1-[[(2S)-1-methylpyrrolidin-2-yl]methyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C27H30ClN3O2
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1
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| 1 |
Ki = 1 nM
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CP0474312
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N-[4-[(5R)-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
Show/Hide
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C25H24N2O3
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1
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| 1 |
Ki = 1.03 nM
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CP0379185
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[6-chloro-1-[[(2S)-pyrrolidin-2-yl]methyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
Show/Hide
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C26H28ClN3O2
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1
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| 1 |
Ki = 1.4 nM
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CP0548474
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N-[4-(5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide
Show/Hide
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C25H24N2O3
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1
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| 1 |
Ki = 1.58 nM
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CP0474311
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N-[4-[(5S)-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
Show/Hide
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C25H24N2O3
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1
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| 1 |
Ki = 1.85 nM
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CP0246508
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(1-benzyl-2-methylindol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C29H28N2O2
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1
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| 1 |
Ki = 2 nM
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CP0379179
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2-[6-chloro-3-(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)indol-1-yl]-N-[2-(dimethylamino)ethyl]acetamide
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C27H31ClN4O3
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1
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| 1 |
Ki = 2 nM
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CP0573811
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N-[4-[(5S)-5-hydroxy-6-methyl-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
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C26H26N2O3
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1
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| 1 |
Ki = 2.06 nM
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CP0543049
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N-[4-[(5R)-5-hydroxy-9-methyl-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
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C26H26N2O3
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1
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| 1 |
Ki = 2.84 nM
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CP0379178
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[6-chloro-1-(1-methylpiperidin-4-yl)indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C27H30ClN3O2
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1
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| 1 |
Ki = 4 nM
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CP0441646
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(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C21H19ClN2O2
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1
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| 1 |
Ki = 4 nM
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CP0521728
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N-[4-[(5S)-5-hydroxy-9-methyl-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
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C26H26N2O3
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1
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| 1 |
Ki = 4.68 nM
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CP0379183
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(6-chloro-1H-indol-3-yl)-spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]-1'-ylmethanone
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C20H18ClN3O2
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1
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| 1 |
Ki = 5 nM
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CP0433525
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1'-(6-chloro-1H-indole-3-carbonyl)spiro[2-benzofuran-3,4'-piperidine]-1-one
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C21H17ClN2O3
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1
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| 1 |
Ki = 5 nM
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CP0548473
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N-[4-(5-hydroxy-9-methyl-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide
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C26H26N2O3
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1
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| 1 |
Ki = 6.26 nM
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CP0521729
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N-[4-(5-hydroxy-6-methyl-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide
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C26H26N2O3
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1
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| 1 |
Ki = 6.75 nM
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CP0379180
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3-[1-(6-chloro-1H-indole-3-carbonyl)piperidin-4-yl]-1H-benzimidazol-2-one
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C21H19ClN4O2
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1
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| 1 |
Ki = 8 nM
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CP0499768
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(6-chloro-1H-indol-3-yl)-spiro[1H-furo[3,4-c]pyridine-3,4'-piperidine]-1'-ylmethanone
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C20H18ClN3O2
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1
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| 1 |
Ki = 9 nM
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CP0419749
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(6-chloro-1H-indol-3-yl)-spiro[2H-1-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C21H19ClN2O2
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1
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| 1 |
Ki = 16 nM
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CP0196743
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1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-(4-methylphenyl)benzamide
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C35H32ClN3O2
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1
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| 1 |
Ki = 23 nM
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CP0498957
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(6-chloro-1H-indol-3-yl)-(4-phenylpiperidin-1-yl)methanone
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C20H19ClN2O
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1
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| 1 |
Ki = 23 nM
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CP0398079
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(6-chloro-1H-indol-3-yl)-(2,2-dioxospiro[1H-2-benzothiophene-3,4'-piperidine]-1'-yl)methanone
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C21H19ClN2O3S
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1
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| 1 |
Ki = 24 nM
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CP0379181
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(6-chloro-1H-indol-3-yl)-spiro[1,2-dihydroindole-3,4'-piperidine]-1'-ylmethanone
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C21H20ClN3O
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1
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| 1 |
Ki = 27 nM
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CP0430562
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(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(5R,8S,11S,14S,17S)-8-(2-amino-2-oxoethyl)-11-(3-amino-3-oxopropyl)-14-[(2S)-butan-2-yl]-17-[(4-hydroxyphenyl)methyl]-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18-pentazabicyclo[22.4.0]octacosa-1(28),24,26-triene-5-carbonyl]pyrrolidine-2-carboxamide
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C51H74N14O12S2
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1
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| 1 |
Ki = 30 nM
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CP0379186
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1'-(6-chloro-1H-indole-3-carbonyl)spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one
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C21H18ClN3O3
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1
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| 1 |
Ki = 32 nM
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CP0419752
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1H-indol-3-yl(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)methanone
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C21H20N2O2
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1
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| 1 |
Ki = 32 nM
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CP0379182
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(6-chloro-1H-indol-3-yl)-spiro[7H-furo[3,4-b]pyridine-5,4'-piperidine]-1'-ylmethanone
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C20H18ClN3O2
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1
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| 1 |
Ki = 39 nM
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CP0206403
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1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-trifluoromethylbenzamide
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C29H25ClF3N3O2
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1
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| 1 |
Ki = 40 nM
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CP0386760
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(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(5R,8S,11S,14S,17S)-8-(2-amino-2-oxoethyl)-11-(3-amino-3-oxopropyl)-14-[(2S)-butan-2-yl]-17-[(4-hydroxyphenyl)methyl]-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18-pentazabicyclo[22.4.0]octacosa-1(28),24,26-triene-5-carbonyl]pyrrolidine-2-carboxamide
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C51H73N11O12S2
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1
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| 1 |
Ki = 69 nM
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CP0543048
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N-[4-[(5R)-5-hydroxy-6-methyl-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
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C26H26N2O3
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1
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| 1 |
Ki = 78 nM
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CP0308266
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(2-ethoxynaphthalen-1-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
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C25H25NO3
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1
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| 1 |
Ki = 81 nM
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CP0433526
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(6-chloro-1H-indol-3-yl)-[4-(2-chlorophenyl)piperazin-1-yl]methanone
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C19H17Cl2N3O
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1
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| 1 |
Ki = 118 nM
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CP0106503
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3-chloro-4-[16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]-1-(2-phenylphenylcarboxamido)benzene
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C34H30ClN3O2
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1
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| 1 |
Ki = 130 nM
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CP0219489
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1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-chlorobenzamide
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C28H25Cl2N3O2
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1
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| 1 |
Ki = 130 nM
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CP0219211
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(4-benzyl-4-hydroxypiperidin-1-yl)-(1-benzyl-2-methylindol-3-yl)methanone
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C29H30N2O2
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1
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| 1 |
Ki = 295 nM
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CP0062116
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1N-{4-[6-chloro-16-ethyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-chlorobenzamide
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C29H27Cl2N3O2
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1
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| 1 |
Ki = 620 nM
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CP0365138
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2-Methyl-N-[4-(2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carbonyl)-phenyl]-benzamide
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C24H23N3O2
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1
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| 1 |
Ki = 890 nM
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CP0387328
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(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(5R,8S,11S,14S,17S)-8-(2-amino-2-oxoethyl)-11-(3-amino-3-oxopropyl)-14-[(2S)-butan-2-yl]-17-[(4-hydroxyphenyl)methyl]-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18-pentazabicyclo[22.3.1]octacosa-1(27),24(28),25-triene-5-carbonyl]pyrrolidine-2-carboxamide
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C51H73N11O12S2
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1
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| 1 |
Ki = 1681 nM
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CP0476263
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(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-2,21-dithia-5,8,11,14,17-pentazabicyclo[21.2.2]heptacosa-1(25),23,26-triene-4-carbonyl]pyrrolidine-2-carboxamide
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C50H71N11O12S2
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1
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| 1 |
Ki = 1954 nM
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CP0104567
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1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-fluorobenzamide
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C28H25ClFN3O2
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1
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| 1 |
Ki = 2600 nM
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CP0106713
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(4-benzyl-4-hydroxypiperidin-1-yl)-(2-ethoxynaphthalen-1-yl)methanone
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C25H27NO3
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1
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| 1 |
Ki = 2830 nM
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CP0441650
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[3-(4-benzyl-4-hydroxypiperidine-1-carbonyl)-2-methylindol-1-yl]-phenylmethanone
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C29H28N2O3
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1
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| 1 |
Ki = 3900 nM
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CP0433529
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[1-(benzenesulfonyl)-2-methylindol-3-yl]-(4-benzyl-4-hydroxypiperidin-1-yl)methanone
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C28H28N2O4S
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1
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| 1 |
Ki = 4990 nM
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CP0379188
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(4-benzyl-4-hydroxypiperidin-1-yl)-naphthalen-1-ylmethanone
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C23H23NO2
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1
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| 1 |
Ki = 6620 nM
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