Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01791 , Delta-type opioid receptor
Gene Name OPRD1
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID P32300
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01791
 
Compound ID Compound Name Compound Formula
CP0041255
(+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide
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C28H39N3O2
 2
1
IC50 = 0.8 nM
   TI
   LI
   LO
   TS
2
Ki = 16.6 nM
   TI
   LI
   LO
   TS
CP0548660
(S)-4-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-4-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-butyric acid
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C38H53N7O11
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0464955
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-4-(2-amino-2-oxoethyl)-3-oxo-2,5-dihydro-1H-benzo[g][2]benzazepin-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C33H42N8O5
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0552739
(2S)-2-amino-N-[(2R)-1-[[(2S)-4-(2-amino-2-oxoethyl)-3-oxo-2,5-dihydro-1H-benzo[g][2]benzazepin-2-yl]amino]-1-oxopropan-2-yl]-3-(4-hydroxy-2,6-dimethylphenyl)-N-methylpropanamide
   Show/Hide
C31H37N5O5
 1
1
IC50 = 1.47 nM
   TI
   LI
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   TS
CP0550386
(2S)-2-amino-N-[(2R)-1-[[(2S)-4-(2-amino-2-oxoethyl)-3-oxo-2,5-dihydro-1H-benzo[g][2]benzazepin-2-yl]amino]-1-oxopropan-2-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C30H35N5O5
 1
1
IC50 = 2.07 nM
   TI
   LI
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   TS
CP0038385
3-(5-(4-tert-butylphenyl)-3-((dimethylamino)methyl)-1H-1,2,4-triazol-1-yl)phenol
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C21H26N4O
 1
1
IC50 = 5.8 nM
   TI
   LI
   LO
   TS
CP0386949
(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-(2-ethenylphenyl)propanamide
   Show/Hide
C27H35N5O5
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0545965
2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]acetic acid
   Show/Hide
C28H39N7O6
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0393121
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(2-ethenylphenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C30H42N8O5
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0413476
(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-(2-phenylphenyl)propanamide
   Show/Hide
C31H37N5O5
 1
1
IC50 = 19.8 nM
   TI
   LI
   LO
   TS
CP0488972
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-(2-phenylphenyl)propan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C34H44N8O5
 1
1
IC50 = 20.25 nM
   TI
   LI
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   TS
CP0552003
2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetic acid
   Show/Hide
C25H32N4O6
 1
1
IC50 = 22.6 nM
   TI
   LI
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   TS
CP0452579
3-(2-(3-tert-Butylphenyl)-5-((dimethylamino)methyl)-2H-1,2,4-triazol-3-yl)phenol
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C21H26N4O
 1
1
IC50 = 28.8 nM
   TI
   LI
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   TS
CP0545964
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-[4-(trifluoromethyl)phenyl]propan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C29H39F3N8O5
 1
1
IC50 = 39.2 nM
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   TS
CP0561937
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C34H44N8O5
 1
1
IC50 = 42.3 nM
   TI
   LI
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   TS
CP0390376
3-(5-(3-tert-Butylphenyl)-3-((dimethylamino)methyl)-1H-1,2,4-triazol-1-yl)phenol
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C21H26N4O
 1
1
IC50 = 48.9 nM
   TI
   LI
   LO
   TS
CP0548659
(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]-methylamino]-N-(2-amino-2-oxoethyl)-3-(2-ethenylphenyl)propanamide
   Show/Hide
C28H37N5O5
 1
1
IC50 = 59.4 nM
   TI
   LI
   LO
   TS
CP0563347
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(4S)-2-(2-amino-2-oxoethyl)-8-bromo-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C29H39BrN8O5
 1
1
IC50 = 60.7 nM
   TI
   LI
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   TS
CP0394278
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C29H42N8O6
 1
1
IC50 = 70.2 nM
   TI
   LI
   LO
   TS
CP0373889
3-(2-(4-tert-Butylphenyl)-5-((dimethylamino)methyl)-2H-1,2,4-triazol-3-yl)phenol
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C21H26N4O
 1
1
IC50 = 121 nM
   TI
   LI
   LO
   TS
CP0519987
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(4S)-2-(2-amino-2-oxoethyl)-3-oxo-4,5-dihydro-1H-benzo[i][2]benzazepin-4-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C33H42N8O5
 1
1
IC50 = 153 nM
   TI
   LI
   LO
   TS
CP0548657
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(3-ethenylphenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C30H42N8O5
 1
1
IC50 = 165 nM
   TI
   LI
   LO
   TS
CP0541894
(2S)-2-amino-N-[(2R)-1-[[(4S)-2-(2-amino-2-oxoethyl)-3-oxo-4,5-dihydro-1H-benzo[i][2]benzazepin-4-yl]amino]-1-oxopropan-2-yl]-3-(4-hydroxy-2,6-dimethylphenyl)propanamide
   Show/Hide
C30H35N5O5
 1
1
IC50 = 167 nM
   TI
   LI
   LO
   TS
CP0548658
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-(3-phenylphenyl)propan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C34H44N8O5
 1
1
IC50 = 268.8 nM
   TI
   LI
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   TS
CP0390387
3-(3-((Dimethylamino)methyl)-5-(2,4-dimethylphenyl)-1H-1,2,4-triazol-1-yl)phenol
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C19H22N4O
 1
1
IC50 = 273 nM
   TI
   LI
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   TS
CP0475297
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-(4-thiophen-3-ylphenyl)propan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C32H42N8O5S
 1
1
IC50 = 309 nM
   TI
   LI
   LO
   TS
CP0394279
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(4-chlorophenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C28H39ClN8O5
 1
1
IC50 = 346 nM
   TI
   LI
   LO
   TS
CP0426440
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C28H39FN8O5
 1
1
IC50 = 435 nM
   TI
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CP0417239
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-[2-(2-methylprop-1-enyl)phenyl]-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C32H46N8O5
 1
1
IC50 = 585 nM
   TI
   LI
   LO
   TS
CP0548661
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-(3-thiophen-3-ylphenyl)propan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C32H42N8O5S
 1
1
IC50 = 601 nM
   TI
   LI
   LO
   TS
CP0386948
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-(2-thiophen-3-ylphenyl)propan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C32H42N8O5S
 1
1
IC50 = 625 nM
   TI
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   TS
CP0557391
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(3S)-1-(2-amino-2-oxoethyl)-2-oxo-3,4-dihydroquinolin-3-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C28H38N8O5
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0475884
(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-(2-thiophen-3-ylphenyl)propanamide
   Show/Hide
C29H35N5O5S
 1
1
IC50 = 687 nM
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   TS
CP0452580
(1-(3-tert-Butylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
   Show/Hide
C22H28N4O
 1
1
IC50 = 1139 nM
   TI
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   TS
CP0545984
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(4-ethenylphenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
   Show/Hide
C30H42N8O5
 1
1
IC50 = 1415 nM
   TI
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   TS
CP0043301
(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide
   Show/Hide
C26H35N5O6
 1
1
IC50 = 1533 nM
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   LI
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   TS
CP0510367
(5-(3-tert-Butylphenyl)-1-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
   Show/Hide
C22H28N4O
 1
1
IC50 = 2195 nM
   TI
   LI
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CP0373884
(5-(4-tert-Butylphenyl)-1-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
   Show/Hide
C22H28N4O
 1
1
IC50 = 2307 nM
   TI
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CP0373269
(5-(2,4-Dimethylphenyl)-1-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
   Show/Hide
C20H24N4O
 1
1
IC50 > 10000 nM
   TI
   LI
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CP0417784
(1-(4-tert-Butylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
   Show/Hide
C22H28N4O
 1
1
IC50 > 10000 nM
   TI
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CP0514821
methyl (1S,9S,14E,15S,16R,19S)-14-ethylidene-2-methyl-18-oxa-2,12-diazahexacyclo[13.3.2.01,9.03,8.09,16.012,19]icosa-3,5,7-triene-16-carboxylate
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C22H26N2O3
 1
1
IC50 = 95600 nM
   TI
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CP0050068
(1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
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C26H26N2O3
 2
1
Ki = 0.19 nM
   TI
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   TS
2
Ki = 1.82 nM
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CP0054764
2-[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]guanidine
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C27H29N5O3
 2
1
Ki = 1.1 nM
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2
Ki = 46.2 nM
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CP0722817
SID56463016
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C26H27ClN2O3
 1
1
Ki = 2.63 nM
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CP0096567
7-(2'-spiroindanyl)oxymorphone
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C25H25NO4
 2
1
Ki = 4.1 nM
   TI
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2
Ki = 46.6 nM
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CP0041449
C18130
   Show/Hide
C40H43N3O6
 2
1
Ki = 5.2 nM
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   TS
2
Ki = 41.5 nM
   TI
   LI
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CP0854366
L4
   Show/Hide
C58H78ClN7O10
 1
1
Ki = 19.95 nM
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CP0497461
2-[2-[5-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]pentylamino]-2-oxoethoxy]-N-methylacetamide
   Show/Hide
C34H49N5O9
 1
1
Ki = 30.9 nM
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   TS
CP0048724
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(oxidanyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
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C20H23NO4
 2
1
Ki = 44.7 nM
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2
Ki = 55.7 nM
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CP0449535
(1S,2S,13R,21R)-9-amino-22-(cyclopropylmethyl)-16-(2-phenylethoxy)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-2-ol
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C34H35N3O3
 1
1
Ki = 91.2 nM
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CP0865937
L2
   Show/Hide
C64H76ClN7O12
 1
1
Ki = 204.17 nM
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CP0221707
1-{3-[4-(tert-butyl) phenyl]-5-N,N-dimethylaminomethyl-(1,2,4-triazol-4-yl)}-3-phenol
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C21H26N4O
 1
1
Ki = 460 nM
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CP0048256
10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
   Show/Hide
C17H19NO4
 3
1
Ki = 610 nM
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2
Ki = 724.44 nM
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3
Ki = 730 nM
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CP0134916
1-{3-[3-(tert-butyl) phenyl]-5-N,N-dimethylaminomethyl-(1,2,4-triazol-4-yl) }-3-phenol
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C21H26N4O
 1
1
Ki = 2600 nM
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CP0890998
4-{[2,6-Dimethyl-4-(2-{[5-(2-methylcarbamoylmethoxy-acetylamino)-pentylcarbamoyl]-methoxy}-acetylamino)-phenyl]-piperidin-4-ylidene-methyl}-N,N-diethyl-benzamide hydrochloride
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C39H57ClN6O7
 1
1
Ki = 2884.03 nM
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