| Compound ID |
Compound Name |
Compound Formula |
|
CP0023349
|
N-[3-[2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]phenyl]-3-(trifluoromethyl)benzamide
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|
C24H19F3N6O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
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CP0018079
|
1-propan-2-yl-3-[2-[3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl]ethynyl]pyrazolo[3,4-d]pyrimidin-4-amine
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|
C26H19F3N6
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
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CP0389189
|
3-cyano-N-[2,4-difluoro-3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]benzenesulfonamide
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|
C22H13F2N5O3S
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Kd = 50 nM
|
|
|
|
CP0113988
|
CEP-32496
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|
C24H22F3N5O5
|
2
|
| 1 |
Kd = 14 nM
|
|
|
| 2 |
Kd = 36 nM
|
|
|
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CP0495327
|
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- isopropyl- isoxazol-3- yl)urea
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|
C23H23N5O5
|
1
|
| 1 |
Kd = 19 nM
|
|
|
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CP0548519
|
1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy)phenyl)- 3-(5-(1- (trifluoromethyl) cyclopropyl) isoxazol-3-yl) urea
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|
C24H20F3N5O5
|
1
|
| 1 |
Kd = 27 nM
|
|
|
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CP0420835
|
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- (2- fluoropropan-2- yl)isoxazol- 5-yl) urea
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|
C23H22FN5O5
|
1
|
| 1 |
Kd = 29 nM
|
|
|
|
CP0385319
|
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- isopropyl- isoxazol- 5- yl)urea
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|
C23H23N5O5
|
1
|
| 1 |
Kd = 31 nM
|
|
|
|
CP0470527
|
1-(3-(6,7- dimethoxy- quinazolin- 4-ylthio)phenyl)- 3-(5-(1- (trifluoromethyl) cyclopropyl) isoxazol-3-yl) urea
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|
C24H20F3N5O4S
|
1
|
| 1 |
Kd = 31 nM
|
|
|
|
CP0443928
|
1-(3-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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|
C27H28N4O4
|
1
|
| 1 |
Kd = 36 nM
|
|
|
|
CP0522490
|
1-(5- cyclopentyl- isoxazol- 3-yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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|
C25H25N5O5
|
1
|
| 1 |
Kd = 37 nM
|
|
|
|
CP0436003
|
1-(3-(6,7- dimethoxy- quinazolin- 4- ylthio)phenyl)- 3- (3-(2- fluoropropan-2- yl)isoxazol-5-yl) urea
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|
C23H22FN5O4S
|
1
|
| 1 |
Kd = 39 nM
|
|
|
|
CP0935512
|
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-(2-fluoropropan-2-yl)isoxazol-5-yl)urea
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|
C23H22FN5O5
|
1
|
| 1 |
Kd = 44 nM
|
|
|
|
CP0443926
|
1-[5-(1,3- difluoro-2- methylpropan-2- yl)isoxazol- 3-yl]-3-[3- (6,7- dimethoxy- quinazolin- 4- yloxy)phenyl] urea
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|
C24H23F2N5O5
|
1
|
| 1 |
Kd = 45 nM
|
|
|
|
CP0863894
|
1-(3-(2-Cyanopropan-2-yl)isoxazol-5-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea
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|
C24H22N6O5
|
1
|
| 1 |
Kd = 48 nM
|
|
|
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CP0475364
|
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- (1- hydroxy-2- methylpropan-2- yl)isoxazol- 3-yl)urea
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|
C24H25N5O6
|
1
|
| 1 |
Kd = 49 nM
|
|
|
|
CP0416084
|
1-[5-(1,3- difluoro-2- methylpropan- 2- yl)isoxazol- 3-yl]-3- [3- (6,7- dimethoxy- quinazolin- 4- ylthio)phenyl] urea
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|
C24H23F2N5O4S
|
1
|
| 1 |
Kd = 50 nM
|
|
|
|
CP0863895
|
1-(3-tert-Butylisoxazol-5-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea
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|
C24H25N5O5
|
1
|
| 1 |
Kd = 51 nM
|
|
|
|
CP0443927
|
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- (1,1,1- trifluoro-2- methylpropan-2- yl)isoxazol-5-yl) urea
Show/Hide
|
C24H22F3N5O5
|
1
|
| 1 |
Kd = 66 nM
|
|
|
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CP0495328
|
1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimethoxy- quinazolin- 4-yloxy) phenyl) urea
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|
C24H25N5O5
|
1
|
| 1 |
Kd = 73 nM
|
|
|
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CP0863959
|
1-(3-(6,7-Dimethoxyquinazolin-4-ylthio)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Show/Hide
|
C24H22F3N5O4S
|
1
|
| 1 |
Kd = 74 nM
|
|
|
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CP0436004
|
1-(1-tert- butyl-1H- pyrazol-4-yl)-3- (3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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|
C24H26N6O4
|
1
|
| 1 |
Kd = 75 nM
|
|
|
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CP0416085
|
1-(3-(1,1- difluoroethyl) isoxazol-5- yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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|
C22H19F2N5O5
|
1
|
| 1 |
Kd = 76 nM
|
|
|
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CP0420837
|
1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy)phenyl)- 3- (3- (trifluoromethyl) isoxazol-5- yl)urea
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|
C21H16F3N5O5
|
1
|
| 1 |
Kd = 78 nM
|
|
|
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CP0520607
|
1-(3-tert- butyl-1- isopropyl-1H- pyrazol-5-yl)- 3-(3- (6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)urea
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|
C27H32N6O4
|
1
|
| 1 |
Kd = 85 nM
|
|
|
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CP0420834
|
1-(3-tert- butyl-1- methyl-1H- pyrazol-5- yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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|
C25H28N6O4
|
1
|
| 1 |
Kd = 87 nM
|
|
|
|
CP0443929
|
1-(4-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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|
C27H28N4O4
|
1
|
| 1 |
Kd = 96 nM
|
|
|
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CP0410193
|
1-(3-tert-butyl- 1-isobutyl- 1H-pyrazol- 5-yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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|
C28H34N6O4
|
1
|
| 1 |
Kd = 101 nM
|
|
|
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CP0416086
|
1-(3- cyclopentyl- isoxazol- 5-yl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
|
C25H25N5O5
|
1
|
| 1 |
Kd = 122 nM
|
|
|
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CP0420538
|
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3- (3-(1- (trifluoromethyl) cyclobutyl) isoxazol- 5-yl)urea
Show/Hide
|
C25H22F3N5O5
|
1
|
| 1 |
Kd = 129 nM
|
|
|
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CP0520606
|
1-[3-(1,3- difluoro-2- methylpropan- 2- yl)isoxazol-5- yl]-3- [3- (6,7- dimethoxy- quinazolin- 4- yloxy]phenyl) urea
Show/Hide
|
C24H23F2N5O5
|
1
|
| 1 |
Kd = 132 nM
|
|
|
|
CP0470533
|
(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- phenylisoxazol- 3-yl) urea
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|
C26H21N5O5
|
1
|
| 1 |
Kd = 136 nM
|
|
|
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CP0420838
|
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- (1- methoxy-2- methylpropan-2- yl)isoxazol-3-yl) urea
Show/Hide
|
C25H27N5O6
|
1
|
| 1 |
Kd = 151 nM
|
|
|
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CP0432242
|
1-(3-tert- butyl-1- cyclohexyl- 1H-pyrazol- 5-yl)-3- (3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)urea
Show/Hide
|
C30H36N6O4
|
1
|
| 1 |
Kd = 174 nM
|
|
|
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CP0432219
|
1-(1-benzyl- 3-tert- butyl- 1H-pyrazol- 5-yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
|
C31H32N6O4
|
1
|
| 1 |
Kd = 175 nM
|
|
|
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CP0863937
|
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(1-phenyl-3-(1,1,1-trifluoro-2-methylpropan-2-yl)-1H-pyrazol-5-yl)urea
Show/Hide
|
C30H27F3N6O4
|
1
|
| 1 |
Kd = 271 nM
|
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CP0432241
|
1-(3-tert- butyl-1- phenyl-1H- pyrazol-5- yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
|
C30H30N6O4
|
1
|
| 1 |
Kd = 295 nM
|
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CP0870728
|
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-methylisoxazol-3-yl)urea
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|
C21H19N5O5
|
1
|
| 1 |
Kd = 678 nM
|
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CP0882272
|
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-phenylisoxazol-5-yl)urea
Show/Hide
|
C26H21N5O5
|
1
|
| 1 |
Kd = 1454 nM
|
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