Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01108 , 11-beta-hydroxysteroid dehydrogenase type 2
Gene Name HSD11B2
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P80365
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01108
 
Compound ID Compound Name Compound Formula
CP0099120
(3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid
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C42H62O16
 2
1
EC50 = 1 nM
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2
IC50 = 1 nM
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CP0428441
N-(2-adamantyl)-4-[(7-chloro-1,1,3-trioxo-4H-1lambda6,2,4-benzothiadiazin-2-yl)methyl]-N-methylpiperidine-1-carboxamide
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C25H33ClN4O4S
 1
1
EC50 = 720 nM
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CP0428445
4-[(7-chloro-1,1,3-trioxo-4H-1lambda6,2,4-benzothiadiazin-2-yl)methyl]-N-cycloheptyl-N-methylpiperidine-1-carboxamide
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C22H31ClN4O4S
 1
1
EC50 = 860 nM
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CP0428842
4-[(7-chloro-1,1,3-trioxo-4H-1lambda6,2,4-benzothiadiazin-2-yl)methyl]-N-cyclohexyl-N-cyclopropylpiperidine-1-carboxamide
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C23H31ClN4O4S
 1
1
EC50 = 2200 nM
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CP0052039
18beta-glycyrrhetic acid
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C30H46O4
 3
1
IC50 = 1.2 nM
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2
IC50 = 1.3 nM
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3
IC50 = 257 nM
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CP0373256
(3beta,18beta,20beta)-3-Acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide
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C33H51NO5
 1
1
IC50 = 2.9 nM
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CP0845174
(3alpha,18beta,20beta)-3-Methoxyamino-11-oxo-olean-12-en-29-oic acid hydrochloride
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C31H50ClNO4
 1
1
IC50 = 4.9 nM
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CP0437486
(3beta,18beta,20beta)-[3-(1,2,4-Oxadiazole-5(2H)-one)]-11-oxoolean-12-en-29-oic acid
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C32H46N2O6
 1
1
IC50 = 11 nM
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CP0513050
(5aR,7aR,7bS,9aS,12S,13aR,15aR,15bS)-2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-Eicosahydro-5,5,7a,7b,9a,12,15b-heptamethyl-3,15-dioxo-N-hydroxy-N-methyl-1Hchryseno[2,1-c]azepine-12-carboxylic acid amid
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C31H48N2O4
 1
1
IC50 = 11 nM
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CP0848109
(3beta,18beta,20beta)-3-Methoxyamino-11-oxo-olean-12-en-29-oic acid hydrochloride
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C31H50ClNO4
 1
1
IC50 = 14.5 nM
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CP0378937
(3beta,18beta,20beta)-N-Hydroxy-N-methyl-[3-(1,2,4-oxadiazole-5(2H)-one)]-11-oxo-olean-12-en-29-amide
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C33H49N3O6
 1
1
IC50 = 15 nM
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CP0499058
[(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picen-2-yl]urea
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C30H48N2O3
 1
1
IC50 = 17 nM
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CP0378940
[(1R,2S,5S,8S,10R,14R,15S,21R)-1,2,5,8,15,20,20-heptamethyl-13,18-dioxo-19-azapentacyclo[12.9.0.02,11.05,10.015,21]tricos-11-en-8-yl]urea
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C30H47N3O3
 1
1
IC50 = 33 nM
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CP0500521
[(2S,4aS,6aR,6aS,6bR,8aR,12aS,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10,13-dioxo-1,3,4,5,6,6a,7,8,8a,11,12,14b-dodecahydropicen-2-yl]urea
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C30H46N2O3
 1
1
IC50 = 45 nM
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CP0379552
(3beta,18beta,20beta)-3-Acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide
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C32H49NO5
 1
1
IC50 = 61.1 nM
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CP0483148
4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl(cyclohexyl)methanone
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C16H23NO
 1
1
IC50 < 100 nM
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CP0486137
4-azatricyclo[5.2.2.02,6]undecan-4-yl(cyclohexyl)methanone
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C17H27NO
 1
1
IC50 = 100 nM
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CP0517959
4-azatricyclo[5.2.1.02,6]decan-4-yl(cyclohexyl)methanone
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C16H25NO
 1
1
IC50 < 100 nM
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CP0519698
4-azatricyclo[5.2.2.02,6]undec-8-en-4-yl(cyclohexyl)methanone
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C17H25NO
 1
1
IC50 = 100 nM
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CP0547901
4-azatetracyclo[5.3.2.02,6.08,10]dodecan-4-yl(cyclohexyl)methanone
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C18H27NO
 1
1
IC50 < 100 nM
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CP0499057
(3beta,18beta,20beta)-N-[-3-(Acetoxy)-11-oxo-30-norolean-12-en-20-yl]urea
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C32H50N2O4
 1
1
IC50 = 104 nM
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CP0505543
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-N,10-dihydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide
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C30H47NO4
 1
1
IC50 = 122 nM
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CP0378935
[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-11-(trifluoromethylsulfonylcarbamoylamino)-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl] acetate
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C33H49F3N2O6S
 1
1
IC50 = 194 nM
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CP0402591
(2S,4aS,6aS,6bR,8aR,12aS,12bR,14bR,E)-10-(methoxyimino)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
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C31H47NO4
 1
1
IC50 = 268 nM
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CP0051196
(18beta,20beta)-3,11-Dioxo-olean-12-en-29-oic acid
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C30H44O4
 1
1
IC50 = 329 nM
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CP0677424
1-Oxo-2-pyridin-3-yl-hexahydro-1lambda*4*-thiopyran-2-carbothioic acid methylamide
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C21H30O3
 1
1
IC50 = 400 nM
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CP0378934
(3beta,18beta,20beta)-3-(Acetylamino)-11-oxo-olean-12-en-29-oicacid
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C32H49NO4
 1
1
IC50 = 458 nM
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CP0422544
11BETA-HYDROXYPROGESTERONE
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C21H30O3
 1
1
IC50 = 490 nM
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CP0378933
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
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C32H48O5
 2
1
IC50 = 750 nM
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2
IC50 = 6430 nM
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CP0483147
4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl(cyclohexyl)methanone
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C18H25NO
 1
1
IC50 = 1000 nM
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CP0912152
ethyl 3-((8S,9S,10R,11S,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-11-ylamino)-2-(hydroxyimino)propanoate
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C26H38N2O5
 1
1
IC50 = 1050 nM
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CP0374726
(3beta,18beta,20beta)-3-Hydroxy-N-methoxy-11-oxo-olean-12-en-29-amide
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C31H49NO4
 1
1
IC50 = 2130 nM
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CP0429183
11BETA-AMINOPROGESTERONE
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C21H31NO2
 1
1
IC50 = 2200 nM
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CP0433445
(R)-2-((2S,4aR,6S,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6,6a,6b,9,9,12a,14b-nonamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamido)-3-phenylpropanoic acid
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C41H59NO5
 1
1
IC50 = 2350 nM
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CP0422546
tert-butyl 2-[[(8S,9S,10R,11S,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl]amino]acetate
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C27H41NO4
 1
1
IC50 = 2410 nM
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CP0452571
4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-methylbenzamide
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C22H27ClN2O3S
 1
1
IC50 = 2487 nM
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CP0422545
2-[[(8S,9S,10R,11S,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl]amino]acetic acid
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C23H33NO4
 1
1
IC50 = 2690 nM
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CP0433448
4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentamethyl-7,11-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
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C29H42O6
 1
1
IC50 = 3950 nM
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CP0407104
tert-butyl N-[(2S)-1-[[(8S,9S,10R,11S,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl]amino]-3-hydroxypropan-2-yl]carbamate
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C29H46N2O5
 1
1
IC50 = 4210 nM
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CP0423210
tert-butyl (4S)-4-[[[(8S,9S,10R,11S,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl]amino]methyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
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C32H50N2O5
 1
1
IC50 = 5850 nM
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CP0433446
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-amino-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
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C30H47NO3
 1
1
IC50 = 6040 nM
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CP0396388
[(2S,4aR,4bR,6R,8S,8aR,10aR)-6-hydroxy-1,1,4a,8,8a-pentamethyl-7-oxo-8-(3-oxopentyl)-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthren-2-yl] acetate
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C26H42O5
 1
1
IC50 = 6261 nM
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CP0525606
(2S)-3-[[(8S,9S,10R,11S,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl]amino]-2-aminopropanoic acid
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C24H36N2O4
 1
1
IC50 = 6760 nM
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CP0396390
(3S,5R,8R,9R,10R,14S)-3-hydroxy-4,4,8,10,14-pentamethyl-1,2,3,5,6,7,9,11,15,16-decahydrocyclopenta[a]phenanthren-12-one
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C22H34O2
 1
1
IC50 = 9582 nM
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CP0131085
2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one
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C16H22N2OS
 1
1
IC50 > 10000 nM
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CP0374144
2-(cyclooctylamino)-5-methyl-5-propyl-4,5-dihydro-1,3-thiazol-4-one
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C15H26N2OS
 1
1
IC50 > 10000 nM
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CP0383771
2-Amino-1,3-thiazol-4(5H)-one, 5h
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C15H22N2OS
 1
1
IC50 > 10000 nM
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CP0383772
2-(cycloheptylamino)-5-methyl-5-propyl-4,5-dihydro-1,3-thiazol-4-one
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C14H24N2OS
 1
1
IC50 > 10000 nM
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CP0383817
2-(cyclooctylamino)-5,5-diethyl-4,5-dihydro-1,3-thiazol-4-one
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C15H26N2OS
 1
1
IC50 > 10000 nM
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CP0419184
2-Amino-1,3-thiazol-4(5H)-one, 6g
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C14H22N2OS
 1
1
IC50 > 10000 nM
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CP0419185
2-(cycloheptylamino)-5-ethyl-5-methyl-4,5-dihydro-1,3-thiazol-4-one
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C13H22N2OS
 1
1
IC50 > 10000 nM
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CP0433394
2-Amino-1,3-thiazol-4(5H)-one, 5f
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C13H20N2OS
 1
1
IC50 > 10000 nM
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CP0467981
2-Amino-1,3-thiazol-4(5H)-one, 7b
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C16H24N2OS
 1
1
IC50 > 10000 nM
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CP0524365
2-(cyclooctylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one
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C15H24N2OS
 1
1
IC50 > 10000 nM
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CP0532881
2-(cyclooctylamino)-5-ethyl-5-methyl-4,5-dihydro-1,3-thiazol-4-one
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C14H24N2OS
 1
1
IC50 > 10000 nM
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CP0933246
2-(o-toluidino)-5-ethylthiazol-4(5H)-one
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C12H14N2OS
 1
1
IC50 > 10000 nM
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CP0455309
4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptylbenzamide
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C21H25ClN2O3S
 1
1
IC50 > 10000 nM
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CP0392285
[(3S,5R,8R,9R,10R,12R,13S,14R,17S)-12,17-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
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C24H40O4
 1
1
IC50 > 10000 nM
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CP0448210
[(3S,5R,8R,9R,10R,12R,13R,14R)-3-hydroxy-4,4,8,10,14-pentamethyl-15-oxo-1,2,3,5,6,7,9,11,12,13-decahydrocyclopenta[a]phenanthren-12-yl] acetate
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C24H36O4
 1
1
IC50 = 11300 nM
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CP0450083
(3S,5R,8R,9R,10R,12R,13R,14R,17R)-3,12-dihydroxy-17-methoxy-4,4,8,10,14-pentamethyl-1,2,3,5,6,7,9,11,12,13,16,17-dodecahydrocyclopenta[a]phenanthren-15-one
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C23H38O4
 1
1
IC50 = 25500 nM
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CP0897971
4-(2,4-dichlorophenyl)-2-hydroxy-3-(4-methoxy-3-methylbenzoyl)-5-(2-methoxyethyl)cyclopent-2-enone
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C23H22Cl2O5
 1
1
IC50 > 30000 nM
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CP0415338
[(3S,5R,8R,9R,10R,12R,13S,14R,17R)-3-hydroxy-17-methoxy-4,4,8,10,14-pentamethyl-15-oxo-1,2,3,5,6,7,9,11,12,13,16,17-dodecahydrocyclopenta[a]phenanthren-12-yl] acetate
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C25H40O5
 1
1
IC50 = 40700 nM
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CP0433447
2-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-(methoxycarbonyl)-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yloxy)benzoic acid
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C38H52O6
 1
1
IC50 = 48000 nM
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CP0378936
1-((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-10-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yloxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicen-2-yl)urea
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C32H48N4O5
 1
1
IC50 > 4000 nM
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