Brief Information of the Compound and Protein
| Compound Name |
SHP099
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PubChem ID | |||||
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Compound Structure |
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| Protein Name |
Tyrosine-protein phosphatase non-receptor type 11
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Protein Classification |
Enzyme
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Phosphatase
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Protein Phosphatase
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Tyrosine protein phosphatase
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| Uniprot ID | Gene Name | PTPN11 |
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Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000269 | KYSE-520 | Homo sapiens (Human) | 1 |
| 1 |
IC50 = 250 nM
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TI
LI
LO
TS
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|---|---|---|---|
| CL000091 | MV4-11 | Homo sapiens (Human) | 1 |
| 1 |
IC50 = 0.145 nM
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TI
LI
LO
TS
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Biochemical Assays
| 1 | IC50 = 39.7 nM | ||
|---|---|---|---|
| 2 | IC50 = 70 nM | ||
| 3 | IC50 = 71 nM | ||
| 4 | IC50 = 136.2 nM | ||
| 5 | IC50 > 10000 nM | ||
| 6 | Ki = 67 nM | ||
| 7 | Km = 89330 nM | ||
| 8 | Km = 90170 nM | ||
| 9 | Km = 135700 nM | ||