Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
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 PubChem ID
CID: 9934458
SID: 14907522
Canonical SMILES
Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F
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Compound Formula C21H17F4NO3S2
Compound Structure
Protein Name
 Protein Info 
Peroxisome proliferator-activated receptor delta
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group C
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Nuclear hormone receptor subfamily 1 group C member 2
Uniprot ID
Q03181
Gene Name
PPARD
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
EC50 = 26.9 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 3.5 nM
   TI
   LI
   LO
   TS
2
EC50 = 13 nM
   TI
   LI
   LO
   TS
3
EC50 = 18 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 1 nM
2 EC50 = 2 nM
3 EC50 = 2.9 nM
4 EC50 = 4 nM
5 EC50 = 13 nM
6 EC50 = 67.11 nM
7 IC50 = 1 nM
8 Kd = 0.4 nM