Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol

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PubChem ID

CID: 176407

SID: 14777778

Canonical SMILES	Nc1nc(NCCc2ccc(O)cc2)nc2nc(nn12)-c1ccco1 Show/Hide
Compound Formula	C16H15N7O2

Compound Structure

Protein Name

Protein Info

Adenosine receptor A2a

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Nucleotide-like receptor (family A GPCR)

Adenosine receptor

Uniprot ID

P29274

Gene Name

ADORA2A

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	9
1	IC50 = 0.678 nM	TI LI LO TS
2	IC50 = 0.83 nM	TI LI LO TS
3	IC50 = 1.24 nM	TI LI LO TS
4	IC50 = 1.45 nM	TI LI LO TS
5	Ki = 0.87 nM	TI LI LO TS
6	Ki = 0.91 nM	TI LI LO TS
7	Ki = 0.93 nM	TI LI LO TS
8	Ki = 1.2 nM	TI LI LO TS
9	Ki = 1.3 nM	TI LI LO TS
CL000079	Expi293F Cell Line Info	Homo sapiens (Human)	2
1	Kd = 0.286 nM	TI LI LO TS
2	Ki = 0.395 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1.514 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 80.8 nM	TI LI LO TS
2	Kd = 0.5012 nM	TI LI LO TS
3	Ki = 0.1 nM	TI LI LO TS
4	Ki = 0.4 nM	TI LI LO TS
5	Ki = 1.995 nM	TI LI LO TS
6	Ki = 64 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	Ki = 1.9 nM	TI LI LO TS

Biochemical Assays