Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

14C-5-hydroxy tryptamine creatinine disulfate

Show/Hide

PubChem ID

CID: 5202

SID: 15120541

Canonical SMILES	NCCc1c[nH]c2ccc(O)cc12 Show/Hide
Compound Formula	C10H12N2O

Compound Structure

Protein Name

Protein Info

5-hydroxytryptamine receptor 2A

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Serotonin receptor

Uniprot ID

P28223

Gene Name

HTR2A

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000068	A-549 Cell Line Info	Homo sapiens (Human)	2
1	Ki = 120 nM	TI LI LO TS
2	Ki = 160 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 11 nM	TI LI LO TS
2	EC50 = 70 nM	TI LI LO TS
3	Ki = 8.2 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 = 16 nM	TI LI LO TS
2	EC50 = 47 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	4
1	EC50 = 12.1 nM	TI LI LO TS
2	EC50 = 130 nM	TI LI LO TS
3	EC50 = 661 nM	TI LI LO TS
4	EC50 = 1672 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	12
1	EC50 = 1.6 nM	TI LI LO TS
2	EC50 = 1.88 nM	TI LI LO TS
3	EC50 = 5.8 nM	TI LI LO TS
4	EC50 = 7.6 nM	TI LI LO TS
5	EC50 = 125.89 nM	TI LI LO TS
6	EC50 = 302 nM	TI LI LO TS
7	Ki = 11.5 nM	TI LI LO TS
8	Ki = 17.2 nM	TI LI LO TS
9	Ki = 130 nM	TI LI LO TS
10	Ki = 150 nM	TI LI LO TS
11	Ki = 398.11 nM	TI LI LO TS
12	Ki = 690 nM	TI LI LO TS
CL000035	NIH 3T3 Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 18.62 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 27.9 nM	TI LI LO TS

Biochemical Assays

1	Ki = 8.2 nM
2	Ki = 14 nM